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The Innovation 2021年第3期2卷 28-42页

作者： Pei Yu Suying guo Rongbin Xu Tingting Ye Shanshan Li Malcolm R.Sim Michael J.A.bramson yuming guo School of Public Health and Preventive Medicine Monash UniversityMelbourneVIC 3004Australia National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector Biology(National Institute of Parasitic DiseasesChinese Center for Disease Control and Prevention)Shanghai 200025China

Robust evidence is needed for the hazardous effects of outdoor particulate matter(PM)on mortality and morbidity from all types of *** summarize and meta-analyze the association between PM and cancer,published articles reporting associations between outdoor PM exposure and any type of cancer with individual outcome assessment that provided a risk estimate in cohort studies were identified via systematic *** 3,256 records,47 studies covering 13 cancer sites(30 for lung cancer,12 for breast cancer,11 for other cancers)were included in the quantitative *** pooled relative risks(RRs)for lung cancer incidence or mortality associated with every 10-mg/m^(3) PM2.5 or PM10 were 1.16(95%confidence interval[CI],1.10–1.23;I2=81%)or 1.22(95%CI,1.02–1.45;I2=96%),*** but non-significant risks were found for breast *** cancers were shown to be associated with PM exposure in some studies but not consistently and thus warrant further investigation.

关键词： mortality lung exposure

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产品开发网络中的设计变更传播风险预测

计算机集成制造系统 2018年第10期24卷 2547-2558页

作者：郭于明井冈山大学机电工程学院江西吉安343009 同济大学电子与信息工程学院上海200092

变型设计过程中,设计变更传播雪崩式效应带来设计资源过度消耗,使得设计变更传播风险预测成为变型设计中的关键问题之一。由此提出一种基于小世界网络的设计变更传播风险预测方法。该方法探讨产品开发网络固有特性对设计变更传播风险控... 详细信息

变型设计过程中,设计变更传播雪崩式效应带来设计资源过度消耗,使得设计变更传播风险预测成为变型设计中的关键问题之一。由此提出一种基于小世界网络的设计变更传播风险预测方法。该方法探讨产品开发网络固有特性对设计变更传播风险控制的影响规律,分析产品开发网络中设计变更传播扩散、设计节点依赖性以及设计变更传播强度,进而阐述了设计变更传播最大风险优化机理。通过实例验证了所提方法的可行性,结果表明,该方法能有效预测设计变更传播的脆弱环节,提高变型设计的效率。

关键词：变型设计产品开发网络小世界网络模型设计变更传播风险预测

Changes of hepatic biochemical parameters and proteomics in broilers with cold-induced ascites

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Journal of Animal Science and Biotechnology 2013年第4期4卷 278-286页

作者： Yongwei Wang yuming guo Dong Ning Yunzhi Peng Hong Cai Jianzhuang Tan Ying Yang Dan Liu State Key Lab of Animal Nutrition College of Animal Science and Technology China Agricultural University

Ascites syndrome is still a problem for chicken industry in various parts of the world. Despite the intensive investigations of this syndrome for many years, its pathogenesis remains unclear. The objective of this study was to analyze the difference in hepatic proteomics between ascites and healthy broilers by two-dimensional electrophoresis （2-DE） and matrix-assisted laser desorption/ionization-time of flight mass spectrometry （MALDI-TOF-MS）. Changes of biochemical parameters of liver and blood were also determined. The results indicated that red blood cell counts （RBC）, hematocrit （HCT） and haemoglobin （HGB） of ascites broilers were significantly greater than healthy broilers. Hepatic malondialdehyde （MDA） level of ascites broilers was significantly increased, and the activity of total superoxide dismutase （T-SOD） was significantly decreased. Hepatic lactic acid （LD） level of ascitic broilers were significantly lower than healthy ones, Serum glucose and cholesterol level of ascites broilers were significantly increased, and serum globulin level was significantly decreased in ascites broilers. There was no significant difference in triglyceride （TG） and blood urea nitrogen （BUN） level. The activity of liver hexokinase （HK） and succinodehydrogenase （SDH） in ascites broilers was significantly decreased, and there was no significant difference in the activity of liver pyruvate kinase （PK） and Na＋-K＋-ATPase. The hepatic proteomics analysis showed that 18 proteins expression difference were identified between ascites and healthy broilers. These proteins were mainly involved in： 1） cytoskeleton; 2） glucose, lipids and amino acid metabolism; 3） cell secretion; 4） cell apoptosis; 5） signal transduction; 6） immune and inflammatory response; and 7） cellular redox homeostasis. Mitochondrial isoform phosphoenolpyruvate carboxykinase （M-PEPCK） mainly participates in gluconeogenesis of chicken liver. In conclusion, liver oxidative damage was significantly aggravated, but antioxi

关键词： Ascites Broilers Biochemical parameters Proteomics analysis

Methionine deficiency and its hydroxy analogue influence chicken intestinal 3-dimensional organoid development

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Animal Nutrition 2022年第1期8卷 38-51页

作者： Youli Wang Qihang Hou Yuqin Wu Yanwei Xu Yan Liu Jing Chen Lingling Xu yuming guo Shuai Gao Jianmin Yuan State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing100193China Key Laboratory of Animal Gene Breeding and Reproductivity National Engineering Laboratory of Animal BreedingCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing100193China Beijing Dafa Chia Tai Co.Ltd. Beijing101206China Sichuan New Hope Liuhe Co.Ltd Chengdu610100China

Methionine and its hydroxy analogue(MHA)have been shown to benefit mouse intestinal *** intestinal organoid is a good model that directly reflects the impact of certain nutrients or chemicals on intestinal ***,we aimed to establish a chicken intestinal organoid culture method first and then use the model to explore the influence of methionine deficiency and MHA on intestinal organoid *** results showed that 125-mm cell strainer exhibited the highest efficiency for chicken embryo crypt *** found that transforming growth factor-b inhibitor(A8301)supplementation promoted enterocyte differentiation at the expense of the proliferation of intestinal stem cells(ISC).The mitogen-activated protein kinase p38 inhibitor(SB202190)promoted intestinal organoid formation and enterocyte differentiation but suppressed the differentiation of enteroendocrine cells,goblet cells and Paneth ***,the suppression of enteroendocrine cell and Paneth cell differentiation by SB202190 was alleviated at the presence of *** glycogen synthase kinase 3 inhibitor(CHIR99021),valproic acid(VPA)alone and their combination promoted chicken intestinal organoid formation and enterocyte differentiation at the expense of the expression of Paneth cells and goblet *** serum significantly improved organoid formation,especially in the presence of A8301,SB202190,CHIR99021,and VPA,but inhibited the differentiation of Paneth cells and enteroendocrine *** serum at a concentration of 0.25%meets the requirement of chicken intestinal organoid development,and the beneficial effect of chicken serum on chicken intestinal organoid culture could not be replaced by fetal bovine serum and insulin-like growth ***,commercial mouse organoid culture medium supplemented with A8301,SB202190,CHIR99021,VPA,and chicken serum promotes chicken organoid *** on the chicken intestinal organoid model,we found that methionine deficienc

关键词： Chicken intestinal organoid Chicken serum Methionine

Restricted feeding regimens improve white striping associated muscular defects in broiler chickens

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Animal Nutrition 2023年第1期12卷 128-137页

作者： Hammed Ayansola Yanhui Luo Yan Wan Xiaoxiao Yu Jiaqi Lei Kewei Yu Chaoyong Liao yuming guo Bingkun Zhang Bo Wang State Key Laboratory of Animal Nutrition Department of Animal Nutrition and Feed ScienceCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing100193China

The current study investigated the effects of intermittent feeding(IF)and fasting strategies at different times post–hatch on muscle growth and white striping(WS)breast *** the first trial,32 one-day-old Abor Acre broilers were fed ad libitum(AL)for 3 d post–hatch and then randomly allotted into 4 feeding strategies including AL,1h-IF group(1 h IF,4 times feeding/d,1 h each time),1.5h-IF(1.5 h IF,4 times feeding/d,1.5 h each time),and fasting(1d acute fasting,6 d free access to feed)groups and fed for 7 *** angiogenic genes including VEGFA,VEGFR1,and VEGFR2,and myogenic genes including MYOG and MYOD were upregulated(P0.05).In the second trial,384 one-day-old birds were fed AL for 1 wk and then randomly allotted to the above 4 feeding strategies starting at 8 d of age until 42 d of ***,IF and fasting strategies upregulated the expression of angiogenic and myogenic genes(P0.05).Fasting and 1h-IF reduced the expression of adipogenic genes ZNF423 and PDGFRα(P<0.05).Moreover,IF and fasting strategies reduced fibrosis in breast muscle and reduced skeletal muscle-specific E3 ubiquitin ligases(TRIM63 and MAFBX)(P<0.05).Fasting significantly reduced CASPASE-3 in breast muscle(P<0.05).In conclusion,IF starting in the first week decreases SC *** to AL,IF or fasting promotes muscular angiogenesis,increases SC number

关键词： Broiler chickens Intermittent feeding Angiogenesis Satellite cells White striping

Enzymatically prepared alginate oligosaccharides improve broiler chicken growth performance by modulating the gut microbiota and growth hormone signals

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畜牧与生物技术杂志:英文版 2023年第5期14卷 2107-2127页

作者： A La Teng Zhu La Yuqing Feng Die Hu Yimei Feng Xiaolu Jin Dan Liu yuming guo Gong Cheng Yongfei Hu State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China

Background Alginate oligosaccharide(AOS)holds great potential as a novel feed supplement in farm ***,the effects of AOS on chicken health and the underlying mechanisms are not fully *** study aimed to optimize the enzymatic preparation of AOS by using bacterial alginate lyases expressed in yeast,investigate the effects of the prepared AOS on the growth performance and gut health of broiler chickens,and reveal the underlying *** Five alginate lyases from bacteria were cloned into Pichia pastoris GS115 and the alginate lyase PDE9 was expressed at relatively high yield,activity and stability in *** trials were carried out using 3201-day-old male Arbor Acres broilers(four groups;8 replicates/group×10 chicks/replicate)receiving either a basal diet or the same diet supplemented with 100,200 and 400 mg/kg PDE9-prepared AOS for 42 *** results showed that dietary supplementation of 200 mg/kg AOS displayed the highest activity in promoting the birds’ADG and ADFI(P<0.05).AOS ameliorated the intestinal morphology,absorption function and barrier function,as indicated by the enhanced(P<0.05)intestinal villus height,maltase activity,and the expression of PEPT,SGLT1,ZNT1,and *** also increased serum insulin-like growth factor-1,ghrelin(P<0.05),and growth hormone(P<0.1).Moreover,the concentrations of acetate,isobutyrate,isovalerate,valerate,and total SCFAs in cecum of birds fed AOS were significantly higher than the control birds(P<0.05).Metagenomic analysis indicated that AOS modulated the chicken gut microbiota structure,function,and microbial interactions and promoted the growth of SCFAs-producing bacteria,for example,Dorea sp.002160985;SCFAs,especially acetate,were found positively correlated with the chicken growth performance and growth-related hormone signals(P<0.05).We further verified that AOS can be utilized by Dorea *** grow and to produce acetate in *** We demonstrated that the enzymatically

关键词： Acetate Alginate lyases Alginate oligosaccharides Dorea sp. Gut microbiota

Supplementation of amylase combined with glucoamylase or protease changes intestinal microbiota diversity and benefits for broilers fed a diet of newly harvested corn

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Journal of Animal Science and Biotechnology 2018年第2期9卷 467-479页

作者： Dafei Yin Xiaonan Yin Xingyu Wang Zhao Lei Maofei Wang yuming guo Samuel E.Aggrey Wei Nie Jianmin Yuan State key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijingChina NutriGenomics Laboratory Department of Poultry ScienceUniversity of GeorgiaAthensGAUSA

Background: The effect of amylases combined with exogenous carbohydrase and protease in a newly harvested corn diet on starch digestibility, intestine health and cecal microbiota was investigated in broiler ***: Two hunderd and eighty-eight 5-day-old female chickens were randomly divided into six treatments: a newly harvested corn-soybean meal diet(control); control supplemented with 1,500 U/g α-amylase(Enzyme A);Enzyme A + 300 U/g amylopectase + 20,000 U/g glucoamylase(Enzyme B); Enzyme B + protease 10,000 U/g(Enzyme C); Enzyme C + xylanase 15,000 U/g(Enzyme D); and Enzyme D + cellulase 200 U/g + pectinase 1,000 U/g(Enzyme E). Growth performance, starch digestibility, digestive organ morphology, and intestinal microbiota were evaluated in the birds at 16 and 23 d of ***: Compared with the control diet, supplementation with Enzyme A significantly decreased ileum lesion scoring at 16 d of age(P < 0.05); supplementation with Enzyme B or Enzyme C showed positive effects on ileal amylopectin and total starch digestibility(P < 0.05); Broilers fed with a diet supplemented with Enzyme D had a tendency to decrease body weight gain at 23 d. Enzyme E supplementation improved lesion scoring of jejunum and ileum at 16 d(P < 0.05), and increased ileal amylopectin or total starch digestibility at 23 d(P < 0.05).Supplementation of enzymes changed cecal microbiota diversity. High numbers of Campylobacter, Helicobacter and Butyricicoccus, Anaerostipes and Bifidobacterium, Sutterella and Odoribacter were the main genera detected in supplementations with Enzymes B, C, D, and E ***: Supplementation with amylase combined with glucoamylase or protease showed a beneficial effect on starch digestibility and intestinal microbiota diversity, and increased growth of broilers fed with newly harvested corn.

关键词： Amylase Broiler Glucoamylase Microbiota diversity Newly harvested corn Protease

Associations of particulate matter with dementia and mild cognitive impairment in China: A multicenter cross-sectional study

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The Innovation 2021年第3期2卷 118-125页

作者： Jiping Tan Nan Li Xiaoxiao Wang Gongbo Chen Lailai Yan Luning Wang Yiming Zhao Shanshan Li yuming guo Geriatric Neurology Department of The Second Medical Center&National Clinical Research Center for Geriatric Diseases Chinese PLA General HospitalBeijing 100039China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 100191China Guangdong Provincial Engineering Technology Research Center of Environmental and Health risk Assessment Department of Occupational and Environmental Health School of Public HealthSun Yat-sen UniversityGuangzhou 510080China Department of Laboratorial Science and Technology School of Public HealthPeking UniversityBeijing 100191China Department of Epidemiology and Preventive Medicine School of Public Health and Preventive MedicineMonash UniversityMelbourneAustralia

Ambient air pollution has been shown to be associated with the pathogenesis of dementia and mild cognitive impairment(MCI).However,few studies have examined these associations in well-characterized populations with low residential mobility,similar living habits,and a standardized assessment of both air pollution exposure and clinical *** study examined the associations of long-term exposure to particulate matter(PM)air pollution with dementia and MCI,using data from the Chinese Veteran Clinical Research *** cognitive function of elderly veterans from 277 communities in 18 Chinese cities was ***’daily exposures to aerodynamic diameters%2.5 mm(PM2.5)and%10 mm(PM10)during the 3 years prior to the survey were estimated using a satellite-based *** adjusted odds ratios(ORs)and 95%confidence intervals of MCI associated with each 10 mg/m^(3) increase in PM2.5 and PM10 were 1.52(1.39,1.67)and 1.04(1.00,1.08),and those of dementia associated with PM2.5 and PM10 were 1.27(1.11,1.46)and 1.13(1.05,1.21),*** demonstrates that long-term exposure to PM2.5 and PM10 can increase the prevalence of dementia/MCI among veterans in *** ORs were observed for those with%9 years of educational attainment,those who actively attended physical activities,those who never smoked,former drinkers,and those who did not suffer from cerebral *** of ambient air quality,especially decreasing levels of PM2.5,may help to decrease the risk of dementia/*** the statistically significant association between PM and cognitive impairment demonstrated here,future studies should focus on examining the causal effect of PM pollution on dementia and MCI.

关键词： particulate matter dementia MCI air pollution

A Comprehensive Survey on Deep Learning Multi-Modal Fusion:Methods,Technologies and Applications

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Computers, Materials & Continua 2024年第7期80卷 1-35页

作者： Tianzhe Jiao Chaopeng guo Xiaoyue Feng yuming Chen Jie Song Software College Northeastern UniversityShenyang110819China

Multi-modal fusion technology gradually become a fundamental task in many fields,such as autonomous driving,smart healthcare,sentiment analysis,and human-computer *** is rapidly becoming the dominant research due to its powerful perception and judgment *** complex scenes,multi-modal fusion technology utilizes the complementary characteristics of multiple data streams to fuse different data types and achieve more accurate ***,achieving outstanding performance is challenging because of equipment performance limitations,missing information,and data *** paper comprehensively reviews existing methods based onmulti-modal fusion techniques and completes a detailed and in-depth *** to the data fusion stage,multi-modal fusion has four primary methods:early fusion,deep fusion,late fusion,and hybrid *** paper surveys the three majormulti-modal fusion technologies that can significantly enhance the effect of data fusion and further explore the applications of multi-modal fusion technology in various ***,it discusses the challenges and explores potential research ***-modal tasks still need intensive study because of data heterogeneity and *** complementary information and eliminating redundant information between modalities is critical in multi-modal *** data fusion methods may introduce extra noise and lead to worse *** paper provides a comprehensive and detailed summary in response to these challenges.

关键词： Multi-modal fusion representation translation alignment deep learning comparative analysis

Microbiome and ileum transcriptome revealed the boosting effects of selenium yeast on egg production in aged laying hens

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Animal Nutrition 2022年第3期10卷 124-136页

作者： Zhexi Liu Yutao Cao Yue Ai Xiaonan Yin Linli Wang Mengyao Wang Bingkun Zhang Zhengxing Lian Keliang Wu yuming guo Hongbing Han Beijing Key Laboratory of Animal Genetic Improvement College of Animal Science and TechnologyChina Agricultural UniversityBeijingChina National Engineering Laboratory for Animal Breeding College of Animal Science and TechnologyChina Agricultural UniversityBeijingChina Key Laboratory of Animal Genetics Breeding and Reproduction of the Ministry of Agriculture and Rural AffairsCollege of Animal Science and TechnologyChina Agricultural UniversityBeijingChina Beijing Alltech Biological Products(China)Co. Ltd.BeijingChina State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijingChina

The declines in laying performance during the late productionperiod have adverse effects on the length of theproduction cycle. Improving the nutrition of laying hens is a crucialmeasure to reverse this declination. Thisstudy investigatedthe effect of seleniumyeast (SY)on egg production, ileal gene expressionandmicrobiota, aswell as elucidating their associations in aged laying hens. A total of 375 Jinghong laying hens at 76weeks oldwere randomly assigned into 5 dietary treatments, which included a selenium-deficient basal diet based oncorn-soybean meal, and dietary supplementation of SY at 0.15, 0.30 and 0.45 mg/kg, and sodium selenite at0.45mg/*** results showed that SYamelioratedthe depressionin aged layingperformance inthe 0.30mg/kg group (P < 0.01). Selenium yeast significantly increased ileum selenium concentration (P < 0.05), and SYgroups had higher seleniumdeposition efficiency than the sodiumselenite group. Functional enrichment andShort Time-series Expression Miner (STEM) analysis indicated that SY activated metabolic progress (e.g.,glycerolipidmetabolism, glycerophospholipidmetabolism, andfattyacidmetabolism),immune responseandoxidative stress response. Four hub genes including thioredoxin reductase 1 (TXNRD1), dihydrolipoamidedehydrogenase (DLD), integrin linked kinase (ILK) and leucine zipper tumor suppressor 2 (LZTS2) wereinvolved in intestinal metabolismwhich was closely associated with selenium deposition/status. Moreover,the relative abundance of Veillonella, Turicibacter and Lactobacillus was significantly increased, but the relativeabundance of Stenotrophomonas was significantly decreased by SY supplementation. Multi-omics dataintegration and Canonical correspondence analysis (CCA) showed that both the ileumselenium content andthe laying rate were highly correlated with pathways and bacteria enriched in metabolism and immuneresponse. Meanwhile, the “switched on” gene prostate stem cell antigen (PSCA) had a positive relationshipwith Veillonella a

关键词： Selenium yeast Egg production Gut microbiota Aged laying hen Transcriptome