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Effect of Chinese Medicine in Patients with COVID-19: A Multi-center Retrospective Cohort Study

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Chinese Journal of Integrative Medicine 2024年第11期30卷 974-983页

作者： ZHAO guo-zhen YAN Shi-yan LI Bo guo yu-hong SONG Shuang HU Ya-hui guo Shi-qi HU Jing DU yuan LU Hai-tian YE Hao-ran REN Zhi-ying ZHU Ling-fei XU Xiao-long SU Rui LIU Qing-quan Beijing Hospital of Traditional Chinese Medicine Capital Medical University Beijing Institute of Traditional Chinese Medicine School of Clinical Medicine Beijing University of Chinese Medicine School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese Medicine College of Integrated Chinese Medicine Tianjin University of Traditional Chinese Medicine

Objective: To evaluate the effectiveness and safety of Chinese medicine(CM) in the treatment of coronavirus disease 2019(COVID-19) in China. Methods: A multi-center retrospective cohort study was carried out, with cumulative CM treatment period of 3 days during hospitalization as exposure. Data came from consecutive inpatients from December 19, 2019 to May 16, 2020 in 4 medical centers in Wuhan, China. After data extraction, verification and cleaning, confounding factors were adjusted by inverse probability of treatment weighting(IPTW), and the Cox proportional hazards regression model was used for statistical analysis. Results:A total of 2,272 COVID-19 patients were included. There were 1,684 patients in the CM group and 588 patients in the control group. Compared with the control group, the hazard ratio(HR) for the deterioration rate in the CM group was 0.52 [95% confidence interval(CI): 0.41 to 0.64, P<0.001]. The results were consistent across patients of varying severity at admission, and the robustness of the results were confirmed by 3 sensitivity analyses. In addition, the HR for all-cause mortality in the CM group was 0.29(95% CI: 0.19 to 0.44, P<0.001).Regarding of safety, the proportion of patients with abnormal liver function or renal function in the CM group was smaller. Conclusion: This real-world study indicates that the combination of a full-course CM therapy on the basic conventional treatment, may safely reduce the deterioration rate and all-cause mortality of COVID-19patients. This result can provide the new evidence to support the current treatment of COVID-19. Additional prospective clinical trial is needed to evaluate the efficacy and safety of specific CM interventions.(Registration No. ChiCTR2200062917)

关键词： Chinese medicine all-cause mortality cohort study coronavirus disease 2019 deterioration rate

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蒽醌法生产过氧化氢工艺危险性分析

现代化工 2024年第6期44卷 209-212页

作者：远亚群郭红宇中国化学品安全协会北京100026 天津大学天津300072

通过梳理蒽醌法过氧化氢的生产工艺,将生产过程按单元进行划分,逐步分析出过氧化氢生产过程中的可能危险性,并剖析风险产生的原因,在此基础上提出了蒽醌法过氧化氢生产工艺危险的可行性防控措施。

关键词：蒽醌法过氧化氢生产工艺危险性风险分析管控措施

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锡伯图水库坝址工程地质条件分析及坝型比选

海河水利 2024年第10期 51-54,62页

作者：郭红雨新疆水利水电勘测设计研究院有限责任公司新疆乌鲁木齐830000

对选定的坝址坝线,在地形地质条件基础上进行坝型适应性综合分析是做好水库工程规划建设的重要环节。结合锡伯图水库工程,简要阐述了工程概况、坝址区地质概况,在此基础上,拟定沥青混凝土心墙坝、混凝土面板坝、混凝土重力坝3种坝型,各... 详细信息

对选定的坝址坝线,在地形地质条件基础上进行坝型适应性综合分析是做好水库工程规划建设的重要环节。结合锡伯图水库工程,简要阐述了工程概况、坝址区地质概况,在此基础上,拟定沥青混凝土心墙坝、混凝土面板坝、混凝土重力坝3种坝型,各坝型的坝轴线位置相同。针对各坝型的特点,详细分析评价了不同坝型建坝条件及地质适应性,经过比选,推荐该工程坝型为沥青混凝土心墙坝,可为类似工程坝型比选提供借鉴。

关键词：水库地质条件坝型比选沥青混凝土心墙坝

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央行抵押品框架的流动性创造效应

中央财经大学学报 2024年第9期 58-68,80页

作者：耿广杰陈明威郭红玉徐州工程学院金融学院对外经济贸易大学中国金融学院

央行抵押品框架具有量化宽松或信贷宽松政策的基本功能,成为金融危机后美联储和欧洲中央银行等发达经济体央行的货币政策工具和金融稳定工具。本文通过构建内嵌抵押品折扣率和流动性创造的金融中介利润最大化模型,并基于人民银行信贷资... 详细信息

央行抵押品框架具有量化宽松或信贷宽松政策的基本功能,成为金融危机后美联储和欧洲中央银行等发达经济体央行的货币政策工具和金融稳定工具。本文通过构建内嵌抵押品折扣率和流动性创造的金融中介利润最大化模型,并基于人民银行信贷资产质押再贷款试点这一“准自然实验”研究央行抵押品框架对银行流动性创造的因果影响。理论推导和实证研究表明:第一,央行抵押品框架扩容会显著提高银行流动性创造水平;第二,央行抵押品框架扩容通过资产配置机制和风险承担机制促进银行流动性创造。本文为货币当局通过央行抵押品框架促进流动性创造、增贷款促投资、不断巩固和增强经济回升向好态势提供可能的政策建议。

关键词：央行抵押品框架银行流动性创造信贷资产质押再贷款试点

大断面小净距隧道爆破施工合理间距及减振措施

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公路交通科技 2024年第6期41卷 165-172页

作者：林豪郭洪雨兰庆男王泽樑张志强浙江交投高速公路建设管理有限公司浙江金华321000 浙江义东高速公路有限公司浙江东阳322100 浙江数智交院科技股份有限公司浙江杭州310000 西南交通大学土木工程学院四川成都610031

小净距隧道在爆破施工过程中存在多次扰动问题,一方面隧道周边岩土体在多次爆破扰动下发生劣化,降低围岩承载能力,另一方面爆破振动会直接对既有隧道结构产生不同程度的影响甚至损坏,如衬砌结构开裂、剥落等。因此,合理设计隧道间距以... 详细信息

小净距隧道在爆破施工过程中存在多次扰动问题,一方面隧道周边岩土体在多次爆破扰动下发生劣化,降低围岩承载能力,另一方面爆破振动会直接对既有隧道结构产生不同程度的影响甚至损坏,如衬砌结构开裂、剥落等。因此,合理设计隧道间距以及采取必要的减振措施对于提升隧道整体安全性能以及延长隧道服役性能至关重要。为研究不同围岩级别下隧道的合理间距,以义东高速西甑山公路隧道小净距段为工程依托,采用ANSYS LS-DYNA有限元动力分析程序建立小净距隧道爆破施工三维数值模型,重点研究Ⅲ,Ⅳ,Ⅴ级围岩后行洞爆破施工下相邻先行洞振动响应规律,建立围岩级别、振速以及隧道间距内在关系式,结合衬砌结构振速限值划分合理间距,并探究减振孔在小净距隧道爆破施工中的应用,现场选取试验段开展先行洞振动监测并评价降振效果。研究表明:先行洞迎爆侧边墙位置振速值最大,以此为基础划分Ⅲ,Ⅳ,Ⅴ级围岩下隧道合理间距分别为5.8,8.2,11.1 m,当间距小于该值时应加强监测并采取相应减振、加固措施;后行洞设置减振孔后,振速计算值、监测值相比未设置的减振率分别提高18.7%,32.6%,二者相差不大表明减振孔降振效果明显;实际监测振速最大值为3.49 cm/s,远小于7 cm/s的限值,先行洞二次衬砌振速值满足安全控制要求。

关键词：隧道工程合理间距 ANSYS LS-DYNA动力分析结构爆破振速现场监测

Synthesis and Complexation Properties of Novel Chiral Calix[4]-1,3-aza-crown and Calix[4]arene Hydrazone Derivative

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Chemical Research in Chinese Universities 2010年第4期26卷 546-549页

作者： YANG Fa-fu HUANG Zhi-sheng guo hong-yu hong Bi-qiong ZHANG Xiao-yi College of Chemistry and Materials Science Fujian Normal University Fuzhou 350007 P R. China Fujian Key Laboratory of Polymer Materials Fuzhou 350007 P. R. China

Refluxing calix[4]-1,3-substituted benzaldehyde derivative（4） with glycine hydrazide derivative, we obtained a novel calix[4]arene hydrazone derivative（5） via ＂1＋2＂ condensation in a yield of 78%. In the reaction of compound 4 with L-leucine hydrazide derivative at room temperature, lariat calix[4]-1,3-aza-crown（6） with chiral amino acid group as branched chain was synthesized via ＂1＋ 1＂ addition in a yield of 70%. The preliminary extraction experiments suggested that hosting compounds 5 and 6 possessed good complexation abilities for a-amino acids.

关键词： Calixcrown Chiral Amino acid Hydrazone Extraction

On the Second Harmonic Generation through Bell-Plesset Effects in Cylindrical Geometry

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Chinese Physics Letters 2014年第4期31卷 85-88页

作者： guo hong-yu yu Xiao-Jin WANG Li-Feng YE Wen-Hua WU Jun-Feng LI Ying-Jun State Key Laboratory for Geomeehanics and Deep Underground Engineering China University of Mining and Technology Beijing 100083 Institute of Applied Physics and Computational Mathematics Beijing 100094 HEDPS Center for Applied Physics and Technology Peking University Beijing 100871 Department of Physics Zhejiang University Hangzhou 310027

Generation of the second harmonic initiated by Bell-Plesset effects in a cylindrical geometry is studied analytically. For an initial single-mode velocity perturSation, the second-order mode-coupling formula is obtained by expanding the perturbation displacement and velocity potential up to the second-order accuracy. It is found that the initially symmetric interface evolves into a significant bubble-spike asymmetric pattern. The second-order solutions clearly show that the amplitude of the spike grows faster than that of the buSble. The temporal evolutions of the amplitudes of the 5ubSie and spike are dependent on the interface velocity Vo. The larger interface velocity leads to the smaller amplitude of the perturbation at an arbitrary interface position in a cylindrically convergent geometry.

关键词： INERTIAL confinement fusion PERTURBATION (Mathematics) SUPERNOVAE LAPLACE'S equation STOCHASTIC convergence

Reduning Injection versus Neuraminidase Inhibitors in Treatment of Influenza:A Systematic Review and Meta-Analysis

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Chinese Journal of Integrative Medicine 2022年第11期28卷 1023-1031页

作者： ZHAO guo-zhen LI Bo WANG Ya-fan guo Shi-qi DU yuan MA Qiu-xiao guo yu-hong LIU Qing-quan School of Clinical Medicine Beijing University of Chinese MedicineBeijing(100029)China Department of Emergency Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing(100010)China Beijing Evidence-Based Chinese Medicine Center Beijing(100010)China Beijing Institute of Chinese Medicine Beijing(100010)China School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing(100029)China Department of Respiratory Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing(100700)China

Objective:To perform a systematic review to assess the effectiveness and safety of Reduning Injection versus neuraminidase inhibitors in treatment of ***:The MEDLINE,Embase,the Cochrane Central Register of Controlled Trials(CENTRAL),Chinese Bio-medical Literature and Retrieval System(Sinomed),China National Knowledge Infrastructure Database(CNKI),China Science and Technology Journal Database(VIP),Wanfang Data Knowledge Service Platform and *** were systematically searched from inception dates to May 2021 for randomized controlled trials(RCTs)exploring Reduning Injection alone or in combination with neuraminidase inhibitors in patients with *** analysis was performed using RevMan 5.4 and Stata *** qualities of the involved studies were assessed by the risk of bias according to the Cochrane *** evidence quality of each outcome was evaluated by GRADEpro ***:Twelve trials with 1,460 patients were *** included studies had a certain unclear or high risk of *** Injection appeared to be more effective in shortening the fever clearance time(MD:-16.20 h,95%CI:-19.40 to-12.99,7 trials,814 patients,I^(2)=94%,very low certainty),fever alleviation time(MD:-4.09 h,95%CI:-4.22 to-3.96,3 trials,366 patients,I^(2)=0%,low certainty),cough alleviation time(MD:-21.34 h,95%CI:-41.56 to-1.11,2 trials,228 patients,I^(2)=89%,very low certainty),fatigue alleviation time(MD:-31.83 h,95%CI:-36.88 to-26.77,2 trials,270 patients,I^(2)=0%,low certainty),sore throat alleviation time(MD:-28.66 h,95%CI:-32.23 to-25.10,1 trial,150 patients,low certainty),and improving the total effective rate(RR:1.15,95%CI:1.06 to 1.25,10 trials,1,074 patients,I^(2)=76%,very low certainty).Besides,Reduning Injection seemed generally ***:This study provided low or very low evidence indicating Reduning Injection may be effective in the treatment of influenza and might be *** rigorously designed studies are need

关键词： Chinese patent medicine Reduning Injection influenza meta-analysis systematic review

Ulinastatin Exerts the Protective Effects of Lung by UpRegulating Aquaporins Expression in a Two-Hit Porcine Model of Acute Respiratory Distress Syndrome

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Biomedical and Environmental Sciences 2021年第12期34卷 1029-1032页

作者： HANG Chen Chen guo yu hong LI Chun Sheng WANG Shuo Emergency medicine clinical research center of Beijing Chao-Yang Hospital Capital Medical UniversityBeijing Key Laboratory of Cardiopulmonary Cerebral ResuscitationBeijing 100020China Medical Affairs Office Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China Department of emergency medicine Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of infectious diseases(Fever clinic) Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China

Acute respiratory distress syndrome(ARDS)is a syndrome characterized by significant lung edema,impaired permeability of lung microvascular endothelial cells with the mal-expression of aquaporins(AQPs).In this study,a two-hit porcine model of ARDS induced by smoking and methicillinresistant Staphylococcus aureus(MRSA)was developed,we investigate the AQPs expression and the influence of Ulinastatin(UTI)to ***-nine healthy male domestic pigs aged 8–10 weeks and weighing 30±2 kg were used for the *** was maintained through continuous intravenous infusion of pentobarbital[8 mg/(kg∙h)].A 5-Fr PiCCO catheter(Pulsiocath PV2015L20;Pulsion Medical Systems,Munich,Germany)and a central venous catheter was inserted for hemodynamic monitoring,including mean arterial pressure(MAP),cardiac index(CI),systemic vascular resistance index(SVRI)and extravascular lung water index(ELWI).

关键词： Acute lung impaired