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Co-administration of ursodeoxycholic acid with rosuvastatin/ezetimibe in a non-alcoholic fatty liver disease model

Gastroenterology Report 2022年第1期10卷 440-450页

作者： Sang Hyun Seo Da Hyun Lee Yu Seol Lee Kyung Joo Cho Hye Jung Park Hye Won Lee Beom Kyung kim Jun Yong Park Do Young kim Sang Hoon Ahn Soo Han bae Seung Up kim Department of Internal Medicine Graduate School of Medicine ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulRepublic of Korea Yonsei Liver Center Severance HospitalSeoulRepublic of Korea Severance Biomedical Science Institute Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulRepublic of Korea Severance Biomedical Science Institute Yonsei Biomedical Research InstituteYonsei University College of MedicineSeoulRepublic of Korea Department of Internal Medicine Institute of GastroenterologyYonsei University College of MedicineSeoulRepublic of Korea

Background Ursodeoxycholic acid(UDCA),statins,and ezetimibe(EZE)have demonstrated beneficial effects against nonalcoholic fatty liver disease(NAFLD).We investigated the efficacy of the combination of UDCA and the mix of rosuvastatin(RSV)/EZE in the treatment of *** NAFLD mouse models were developed by injecting thioacetamide,fasting,and high-carbohydrate refeeding,highfat diet,and choline-deficient L-amino acid-defined high-fat diet(CDAHFD).Low-dose UDCA(L-UDCA;15 mg/kg)or highdose UDCA(H-UDCA;30 mg/kg)was administered with RSV/*** also employed an in vitro model of NAFLD developed using palmitic acid-treated Hepa1c1c7 *** Co-administration of RSV/EZE with UDCA significantly decreased the collagen accumulation,serum alanine aminotransferase(ALT)levels,and mRNA levels of fibrosis-related markers than those observed in the vehicle group in thioacetamide-treated mice(all P<0.01).In addition,in the group fasted and refed with a high-carbohydrate diet,UDCA/RSV/EZE treatment decreased the number of apoptotic cells and serum ALT levels compared with those observed in the vehicle group(all P<0.05).Subsequently,H-UDCA/RSV/EZE treatment decreased the number of ballooned hepatocytes and stearoyl-CoA desaturase 1(SCD-1)mRNA levels(P=0.027)in the liver of high-fat diet-fed mice compared with those observed in the vehicle *** the CDAHFD-fed mouse model,UDCA/RSV/EZE significantly attenuated collagen accumulation and fibrosis-related markers compared to those observed in the vehicle group(all P<0.05).In addition,UDCA/RSV/EZE treatment significantly restored cell survival and decreased the protein levels of apoptosis-related markers compared to RSV/EZE treatment in palmitic acid-treated Hepa1c1c7 cells(all P<0.05).Conclusion Combination therapy involving UDCA and RSV/EZE may be a novel strategy for potent inhibition of NAFLD progression.

关键词： non-alcoholic fatty liver disease non-alcoholic steatohepatitis ursodeoxycholic acid rosuvastatin ezetimibe

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Risk factors for immediate post-operative fatal recurrence after curative resection of hepatocellular carcinoma

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World Journal of Gastroenterology 2006年第1期12卷 99-104页

作者： Bong-Wan kim Young-bae kim Hee-Jung Wang Myung-Wook kim Department of Surgery Ajou University School of MedicineWonchon dongYoungtong kuSuwonKyounggi ProvinceSouth Korea Department of Pathology Ajou University School of Medicine.Wonchon dongYoungtong kuSuwonKyounggi ProvinceSouth Korea

瞄准：调查 clinicopathological 风险因素因为肝细胞癌(HCC ) 的立即的手术后的致命的复发，它可以有实际牵连并且贡献高建立对 HCC 复发为外科手术前或手术后的预防措施冒病人的风险。方法：从 1994 年 6 月到 2004 年 5 月，为 HCC ... 详细信息

瞄准：调查 clinicopathological 风险因素因为肝细胞癌(HCC ) 的立即的手术后的致命的复发，它可以有实际牵连并且贡献高建立对 HCC 复发为外科手术前或手术后的预防措施冒病人的风险。方法：从 1994 年 6 月到 2004 年 5 月，为 HCC 收到了药品切除术的 269 个病人被考察。这些病人，在外科以后在 6 瞬间以内表明了弥漫的 intra 肝或多重的全身的周期性的损害的那些被调查(致命的复发组) 。留下的病人被指定为控制组，并且二个组为临床病理风险因素被比较。结果：在考察的 269 个病人之中， 30 个病人在致命的复发组被注册。在后者之中， 20 个病人证明弥漫的 intra 肝的复发类型和 10 显示出的多重全身的复发打字。在致命的复发组和控制组之间的 Multivariate 分析证明那外科手术前的浆液 alpha-fetoprotein (法新社) 水平比 1,000 microg/L 大(P = 0.02；机会比率 = 2.98 ) ，比 6.5 厘米大的肿瘤尺寸(P = 0.03；或 = 2.98 ) ，并且微脉管的侵略的存在(P = 0.01；或 = 4.89 ) 是在致命的复发组的风险因素。有所有三个风险因素的 48.1% 病人和有二个风险因素的 22% 那些在外科以后在 6 瞬间以内经历了致命的复发。结论：为在药品切除术以后的 HCC 的立即的手术后的致命的复发的三个不同风险因素是外科手术前的浆液法新社水平 > 1,000 microg/L，肿瘤尺寸 > 6.5 厘米，和微脉管的侵略。有二的高风险病人或更多的风险因素应该是各种各样的辅助临床的试用的候选人。

关键词：肝细胞癌固化剂临床表现治疗

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Adenosine monophosphate enhances callus regeneration competence for de novo plant organogenesis

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Molecular Plant 2023年第12期16卷 1867-1870页

作者： Hong Gil Lee Seo Young Jang Eun Yee Jie Seung Hee Choi Ok-Sun Park Soon Hyung bae Hyun-Soon kim Suk Weon kim Geum-Sook Hwang Pil Joon Seo Department of Chemistry Seoul National UniversitySeoul 08826Korea Plant Genomics and Breeding Institute Seoul National UniversitySeoul 08826Korea Integrated Metabolomics Research Group Western Seoul CenterKorea Basic Science InstituteSeoul 03759Korea Biological Resource Center Korea Research Institute of Bioscience and BiotechnologyJeongeup56212Korea Plant Systems Engineering Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeon 34141Korea College of Pharmacy Chung-Ang UniversitySeoul 06974Korea

Dear Editor,Plant tissue culture involves callus formation and de novo shoot ***,explants from differentiated tissues are used to generate a pluripotent cell mass,called callus,on auxin-rich callus-inducing medium(CIM),followed by shoot regeneration on cytokinin-rich shoot-inducing medium(SiM).Callus results from division of pericycle-like cells(Atta et al.,2009;Sugimoto et al.,2010);its cellular identity resembles that of lateral root primordia(Atta et al.,2009;Sugimoto et al.,2010).Callus acquires cellular pluripotency by forming root stem cell niches on CIM(Sugimoto et al.,2010)。

关键词： Adenosine callus

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Flexible electronics based on one-dimensional and two-dimensional hybrid nanomaterials

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InfoMat 2020年第1期2卷 33-56页

作者： Jihun Park Jae Chul Hwang Gon guk kim Jang-Ung Park Department of Materials Science and Engineering Nano Science Technology InstituteYonsei UniversitySeoulRepublic of Korea Center for Nanomedicine Institute for Basic Science(IBS)Yonsei-IBS InstituteSeoulRepublic of Korea

Research on flexible or wearable electronics has been grown remarkably due to the advent of nanomaterials,such as metal nanowires,graphene,or transition metal *** each nanomaterial has mechanical and electrical characteristics that can be applied into flexible electronics,the limitations of each nanomaterial are also *** order to overcome the limitations of these nanomaterials,research on the hybrid structures of nanomaterials has been extensively *** this study,we introduce the properties of one-dimensional nanomaterials,twodimensional nanomaterials,and their hybrid *** then,we provide information concerning various flexible electronics based on these nanomaterials.

关键词： flexible electronics hybrid nanomaterials one-dimensional nanomaterials two-dimensional nanomaterials wearable electronics

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DESIGN AND IMPLEMENTATION OF REAL-TIME PHYSICS SIMULATION ENGINE FOR e-ENTERTAINMENT

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International Journal of Modeling, Simulation, and Scientific Computing 2013年第S1期4卷 20-39页

作者： MYUNGSOO bae YOUNG J.kim Computer Science and Engineering Ewha Womans University SeoulKorea

We present our recent research results regarding the designing and implementation of real-time physics simulation engines,which aim at developing physics-inspired e-entertainment such as computer games,mobile applications,interactive TV and other smart media in *** real-time physics engine consists of three functional components:rigid body dynamics simulation,deformable body simulation,and data-driven physics *** core simulation techniques to realize these simulation components include real-time collision detection and response,large-scale model simulation,and character model *** this paper,we highlight these features and demonstrate their *** also showcase some of the gaming applications that we have integrated our physics engine into.

关键词： Real-time physics simulation engine rigid body dynamics simulation deformable body simulation data-driven simulation.

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Effect of Solute Contents of Al-Ni-Sr Alloy on Glass Forming Ability and Thermal Stability

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Journal of Rare Earths 2004年第Z2期22卷 73-77页

作者： Taek Soo kim J K Lee H J kim J C bae Advanced Materials R&D Center Korea Institute of Industrial Technology994-32 Dongchun-dongYeonsu-kuIncheon 406-130Korea Advanced Materials R&D CenterKorea Institute of Industrial Technology994-32 Dongchun-dongYeonsu-kuIncheon 406-130Korea Advanced Materials R&D CenterKorea Institute of Industrial Technology994-32 Dongchun-dongYeonsu-kuIncheon 406-130Korea Advanced Materials R&D CenterKorea Institute of Industrial Technology994-32 Dongchun-dongYeonsu-kuIncheon 406-130Korea

Glass forming ability (GFA) and structural characterization of a new amorphous Al-Ni-Sr alloy melt spun were investigated on the theory of the factors for the glass formation. The GFA was varied with the ratio of Ni to Sr in detail and successful amorphous phase dispersed with 2 ～ 5 nm precipitates was prepared from Al-Ni5-Sr3. Thermal stability and crystallization behavior of the amorphous phase were determined by continuous and isothermal heating technique on DCS, resulting that the crystallization occurs by the growth of fcc Al nanocrystals on the preexistent nuclei.

关键词： glass formation crystallization Al base amorphous alloys rapid solidification

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Deposition and Characterization of (Ba, Sr)RuO3 Oxide Electrode Using TMHD-Based Single Cocktail Source

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Journal of Rare Earths 2004年第Z2期22卷 8-12页

作者： Hyun Chul kim Kyung Il Hong Young bae kim Duck Kyun Choi Department of Ceramic Engineering Hanyang University17 Haengdang-dongSeongdong-kuSeoul 133-791Korea Department of Ceramic EngineeringHanyang University17 Haengdang-dongSeongdong-kuSeoul 133-791Korea Department of Ceramic EngineeringHanyang University17 Haengdang-dongSeongdong-kuSeoul 133-791Korea Department of Ceramic EngineeringHanyang University17 Haengdang-dongSeongdong-kuSeoul 133-791Korea

(Ba, Sr)RuO3 has been paid an attention as a promising electrode for (Ba, Sr)TiO3 dielectric material due to its similarity in structure and chemical composition with BST. In this study, (Ba, Sr)RuO3 conductive oxide film was deposited on a 4 inch p-type Si wafer by metal organic chemical vapor deposition (MOCVD) using single cocktail source for the practical device application. Ba(TMHD)2, Sr(TMHD)2, Ru(TMHD)3 precursors and solvent [1-EtylePiPerdine (C7H15 N) ] as starting materials were mixed together for single cocktail source. A liquid delivery system (LDS) and a vaporization cell were utilized for the delivery and vaporization of single cocktail source, respectively. The source feeding rate was controlled by a liquid mass flow controller (LMFC). Deposition parameters, such as the oxygen flow and the source flow rate,were sensitive to phase formation, resistivity and the composition ratio of (Ba, Sr)RuO3 films. Highly (110)-textured (Ba,Sr)RuO3 film was obtained vhen the Ar/O2 ratio was 200/140 sccm at a source flow rate of 0.05 sccm. The process window of stoichiometric composition of BSR film was observed with varying the source flow rate from 0.05 sccm to 0.1 sccm.

关键词： (Ba, Sr)RuO3 (Ba, Sr)TiO3 MOCVD liquid delivery system(LDS) nozzle type injector

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Circulating immune cell landscape in patients who had mild ischaemic stroke

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Stroke & Vascular Neurology 2022年第4期7卷 319-327,I0020-I0022页

作者： Young-Eun Cho Hyangkyu Lee Heekyong R.bae Hyungsuk kim Sijung Yun Rany Vorn Ann Cashion Mary Jo Rucker Mariam Afzal Lawrence Latour Jessica Gill College of Nursing The University of IowaIowa CityIowaUSA National Institute of Nursing Research National Institutes of HealthBethesdaMarylandUSA Mo-Im kim Nursing Research Institute College of NursingYonsei UniversitySeoulSouth Korea National Eye Institute National Institutes of HealthBethesdaMarylandUSA Predictiv Care IncSunnyvaleCaliforniaUSA School of Nursing Johns Hopkins UniversityBaltimoreMarylandUSA College of Nursing University of Tennessee Health Science CenterMemphisTennesseeUSA Suburban Hospital BethesdaMarylandUSA National Institute of Neurological Disorders and Stroke National Institutes of HealthBethesdaMarylandUSA

Introduction Patients who had a mild ischaemic stroke who present with subtle or resolving symptoms sometimes go undiagnosed,are excluded from treatment and in some cases clinically *** immune cells are potential biomarkers that can assist with diagnosis in ischaemic *** the transcriptomic changes of each cell population caused by ischaemic stroke is critical because they work closely in a complicated *** this study,we investigated peripheral blood mononuclear cells(PBMCs)transcriptomics of patients who had a stroke using a single-cell RNA sequencing to understand peripheral immune response after mild stroke based on the gene expression in an unbiased *** Transcriptomes of PBMCsfrom 10 patients who had an acute ischaemic stroke within 24 hours after stroke onset were compared with 9 race-matched/age-matched/gender-matched *** PBMCs were prepared with ddSeqTM(Illumina-BioRad)and sequenced on the Illumina NovaSeq 6000 *** Notable population changes were observed in patients who had a stroke,especially in NK cells and CD14+*** number of NK cells was increased,which was further confirmed by flow *** analysis implied that the activity of NK cells also is enhanced in patients who had a ***14+monocytes were clustered into two groups;dendritic cell-related CD14+monocytes and NK cell-related CD14+*** found CD14+monocyte subclusters were dramatically reduced in patients who had a *** This is the first study demonstrating the increased number of NK cells and new monocyte subclusters of mild ischaemic stroke based on the transcriptomic *** findings provide the dynamics of circulating immune response that could assist diagnosis and potential therapeutic development of mild ischaemic stroke.

关键词： patients diagnosis Circulating

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Comprehensive Analysis of Caching Performance under Probabilistic Traffic Patterns for Content Centric Networking

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China Communications 2016年第3期13卷 127-136页

作者： Dabin kim Young-bae Ko Sung-Hwa Lim Department of Computer Engineering Graduate School of Ajou University Department of Multimedia Namseoul University

The phenomenon of data explosion represents a severe challenge for the upcoming big data ***,the current Internet architecture is insufficient for dealing with a huge amount of traffic owing to an increase in redundant content transmission and the end-point-based communication ***-centric networking(ICN)is a paradigm for the future Internet that can be utilized to resolve the data explosion *** this paper,we focus on content-centric networking(CCN),one of the key candidate ICN *** has been studied in various network environments with the aim of relieving network and server burden,especially in name-based forwarding and in-network caching *** paper studies the effect of several caching strategies in the CCN domain from the perspective of network and server ***,we comprehensively analyze the in-network caching performance of CCN under several popular cache replication methods(i.e.,cache placement).We evaluate the performance with respect to wellknown Internet traffic patterns that follow certain probabilistic distributions,such as the Zipf/Mandelbrot–Zipf distributions,and *** the experiments,we developed an OPNET-based CCN simulator with a realistic Internet-like topology.

关键词：通信网络缓存性能概率分布交通模式网络拓扑结构爆炸现象流量模式 OPNET

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Cancer-associated fibroblast-derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib

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Cancer Communications 2023年第4期43卷 455-479页

作者： JungWoo Eun Jung Hwan Yoon Hye Ri Ahn Seokhwi kim Young bae kim Su Bin Lim Won Park TaeWook Kang Geum Ok baek Moon Gyeong Yoon Ju A Son Ji HyangWeon Soon Sun kim Hyo Jung Cho Jae Youn Cheong Department of Gastroenterology Ajou University School of MedicineSuwonSouth Korea Department of Pathology College of MedicineThe Catholic University of KoreaSeoulSouth Korea Department of Biomedical Sciences AjouUniversity Graduate School of MedicineSuwonSouth Korea Department of Pathology Ajou University School of MedicineSuwonSouth Korea Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea The Moagen IncDaejeonSouth Korea

Background:Cancer-associated fibroblasts(CAFs)play an important role in the induction of *** study aimed to clarify the mechanism underlying CAF-mediated resistance to two tyrosine kinase inhibitors(TKIs),sorafenib and lenvatinib,and to identify a novel therapeutic target for overcoming TKI resistance in hepatocellular carcinoma(HCC).Methods:We performed a systematic integrative analysis of publicly available gene expression datasets and whole-transcriptome sequencing data from 9 pairs of CAFs and para-cancer fibroblasts isolated from human HCC and para-tumor tissues,respectively,to identify key molecules that might induce resistance to *** then performed in vitro and in vivo experiments to validate selected targets and related *** associations of plasma secreted phosphoprotein 1(SPP1)expression levels before sorafenib/lenvatinib treatment with progression-free survival(PFS)and overall survival(OS)of 54 patients with advanced HCC were evaluated using Kaplan-Meier and Cox regression ***:Bioinformatic analysis identified CAF-derived SPP1 as a candidate molecule driving TKI ***1 inhibitors reversed CAF-induced TKI resistance in vitro and in ***-derived SPP1 activated rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase(MAPK)and phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)through the integrin-protein kinase C-alpha(PKCα)signaling pathway and promoted epithelial-to-mesenchymal transition(EMT).A high plasma SPP1 level before TKI treatment was identified as an independent predictor of poor PFS(P=0.026)and OS(P=0.047)in patients with advanced HCC after TKI ***:CAF-derived SPP1 enhances TKI resistance in HCC via bypass activation of oncogenic signals and EMT *** inhibition represents a promising therapeutic strategy against TKI resistance ***,plasma SPP1 level before TKI treatment represents a potential biomar

关键词： drug resistance epithelial-to-mesenchymal transition hepatocellular carcinoma secreted phosphoprotein 1

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