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Food Science and Human Wellness 2024年第2期13卷 659-667页

作者： Lanlan Gui Shaokang Wang Jing Wang Wang Liao Zitong Chen Da Pan Hui Xia guiju sun Su Tian Department of Nutrition and Food Hygiene School of Public HealthSoutheast UniversityNanjing 210009China Nanjing Municipal Center for Disease Control and Prevention Nanjing 210003China Department of Nutrition and Food Hygiene School of Public HealthHebei Medical UniversityShijiazhuang 050017China

Forsythia suspensa,belonging to the deciduous shrubs of the Luteaceae family,a traditional Chinese medicine,has effects of alleviating swelling,clearing heat,detoxification and promoting blood *** leaves of *** contain multiple chemical components and have a long history of use in folk medicines and health *** purpose of this study was to explore the effects of forsythin extract from *** leaves on intestinal microbiota and short-chain fatty acid(SCFA)content in rats with obesity induced by a high-fat *** extract in *** leaves increased the abundance of the intestinal microbiota,ameliorated intestinal microbiota disorders and inhibited the increase in total SCFA content in the intestinal tract in rats with obesity induced by a high-fat *** results suggested that forsythin extract in *** leaves may slow the development of obesity induced by a high-fat diet;thus,its active components and efficacy are worthy of further study.

关键词： Forsythin High-fat diet Intestinal microbiota Short-chain fatty acid(SCFA)

Causal relationship between circulating vitamin C and 25-hydroxyvitamin D concentrations and common mental disorders-a Mendelian randomization study

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Food Science and Human Wellness 2024年第4期13卷 1877-1885页

作者： Yuanyuan Wang Lirong Dong Meng Zhao Shiyu Yin Pan Da Dengfeng Xu Yifei Lu Jiayue Xia Niannian Wang Shaokang Wang guiju sun Key Laboratory of Environmental Medicine and Engineering of Ministry of Education and Department of Nutrition and Food HygieneSchool of Public HealthSoutheast UniversityNanjing 210009China Department of Integrated Service and Management Jiangsu Provincial Center for Disease Control and PreventionNanjing 210009China

Mental disorders seriously affect people’s health and social *** Mendelian randomization(MR)study was designed to investigate the causal relationship between circulating vitamin C(VC)or 25-hydroxyvitamin D(25(OH)D)levels and mental *** data used for the MR analysis were derived from the summary genome-wide association studies(GWAS)database for VC and 25(OH)D and from the Finn Gen consortium for fourteen mental *** on the inverse variance weighted(IVW)method,we found a potential causal association between circulating VC and anxiety disorders(IVW:OR=1.139,95%CI:1.023-1.269,P=0.018).However,no causal association was found between VC or 25(OH)D and other mental disorders(P>0.05).In the reverse MR analysis,individuals with Alzheimer’s disease was causally associated with higher concentrations of circulating VC(P=0.012),while individuals with anxiety disorders had a negative association between the concentrations of 25(OH)D(P=0.012).However,the current evidence does not support a causal relationship between VC or 25(OH)D and other mental *** addition,there was no causal association between circulating VC and 25(OH)D(P>0.05).Future studies are needed to confirm these findings and to elucidate the mechanisms of potential causality.

关键词： Circulating vitamin C 25-Hydroxyvitamin D Mental disorder Mendelian randomization

低血糖生成指数饮食在2型糖尿病营养管理中的研究进展及应用现状

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食品科学 2024年第11期45卷 343-350页

作者：李蔼琪夏惠孙桂菊东南大学公共卫生学院环境医学工程教育部重点实验室江苏南京210009

血糖生成指数(glycemic index,GI)小于等于55的食品被称为低GI食品。低GI饮食是指一种饮食模式,该膳食模式中主要选择低GI食物,并注意调整烹调方式以控制膳食中整体的GI值。在糖尿病营养管理中应用低GI饮食干预有助于稳定糖尿病患者的... 详细信息

血糖生成指数(glycemic index,GI)小于等于55的食品被称为低GI食品。低GI饮食是指一种饮食模式,该膳食模式中主要选择低GI食物,并注意调整烹调方式以控制膳食中整体的GI值。在糖尿病营养管理中应用低GI饮食干预有助于稳定糖尿病患者的餐后血糖,提高饱腹感并减少血糖波动。本文系统综述了低GI饮食模式在糖尿病营养管理中的应用情况,阐述了影响膳食中GI值的因素,探讨了低GI食品的种类及其开发现况,进一步展望了构建低GI饮食模式中食品的未来发展趋势,并分析和提出了低GI食品未来的研究方向和潜在的挑战。

关键词：低血糖生成指数食物血糖生成指数 2型糖尿病营养管理血糖管理

Effects of probiotics， prebiotics and synbiotics supplementation on cardiovascular risk factors in patients with type 2 diabetes mellitus: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials

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Food Science and Human Wellness 2024年

作者： Yanyan Tian Jiayue Xia Lihua Li Ligang Yang Hua Xiao Guoping Gao Yuanyuan Wang Chen Zhang Tiange Bu guiju sun Department of Nutritional Sciences， University of Toronto Key Laboratory of Environmental Medicine and Engineering of Ministry of Education， Department of Nutrition and Food Hygiene， School of Public Health， Southeast University Lianshui People's Hospital Affiliated to Kangda College of Nanjing Medical University Gong'an County People's Hospital

A systematic review and meta-analysis study was conducted to assess the effectiveness of probiotic/prebiotic/synbiotic supplementation on the effects of cardiovascular risk factors in patients with type 2 diabetes mellitus (T2DM) based on data from randomized controlled trials (RCTs). We searched electronic databases including PubMed， Cochrane Library， Embase， and Web of Science to identify clinical trials published up to 31 March 2023. Data was pooled using a random-effects model if significant heterogeneity (I2> 50%)， otherwise use a fixed-effects model. Fifty-six trials that included 3 317 patients were enrolled for analysis. Meta-analysis reported that probiotic/prebiotic/synbiotic supplementation significantly reduced systolic blood pressure (SBP) (weighted mean difference (WMD): -3.57 mmHg， 95% confidence interval (CI): -5.36， -1.78; P = 0.000)， diastolic blood pressure (DBP) (WMD: -2.05 mmHg， 95% CI: -3.07， -1.04; P = 0.000)， triglycerides (TG) (WMD: -16.10 mg/dL， 95% CI: -20.16， -12.05; P = 0.000)， total cholesterol (TC) (WMD: -14.00 mg/dL， 95% CI: -20.46， -7.55; P = 0.000)， low-density lipoprotein cholesterol (LDL-C) (WMD: -7.03 mg/dL， 95% CI: -9.25， -4.81; P = 0.000)， fasting plasma glucose (FPG) (WMD: -16.57 mg/dL， 95% CI: -20.39， -12.74; P = 0.000)， hemoglobin A1c (HbA1c) (WMD: -0.44%， 95% CI: -0.68， -0.20; P = 0.000)， insulin (standardized mean difference (SMD): -0.37， 95% CI: -0.53， -0.21; P = 0.000)， homeostatic model assessment of insulin resistance (HOMA-IR) (WMD: -1.05， 95% CI: -1.56， -0.54; P = 0.000)， C-reactive protein (CRP) (SMD: -0.35， 95% CI: -0.57， -0.13; P = 0.002)， tumor necrosis factor-α (TNF-α) (SMD: -1.07， 95% CI: -1.57， -0.56; P = 0.000)， interleukin-6 (IL-6) (SMD: -0.37 ， 95% CI: -0.61， -0.13; P = 0.003) levels， they also increased the high-density lipoprotein cholesterol (HDL-C) (WMD: 3.70 mg/dL， 95% CI: 1.80， 5.60; P = 0.000) levels in T2DM patients， as compared to the placebo groups. This meta-analysis supports the use of probiotic

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南京市栖霞区2020-2022年≥65岁老年人代谢综合征患病率变化趋势

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中华疾病控制杂志 2024年第1期28卷 40-45页

作者：郭丽娟汪元元孙桂菊东南大学公共卫生学院营养与食品卫生学系环境医学工程教育部重点实验室南京210009 南京市栖霞区疾病预防控制中心南京210046

目的了解南京市栖霞区≥65岁老年人代谢综合征(metabolic syndrome,MS)患病率的变化趋势及其相关影响因素,为采取针对性的干预措施提供参考依据。方法采用分层随机抽样,选择2020―2022年在南京市栖霞区参与体检的≥65岁人群为研究对象,... 详细信息

目的了解南京市栖霞区≥65岁老年人代谢综合征(metabolic syndrome,MS)患病率的变化趋势及其相关影响因素,为采取针对性的干预措施提供参考依据。方法采用分层随机抽样,选择2020―2022年在南京市栖霞区参与体检的≥65岁人群为研究对象,分析其MS患病率变化趋势及相关影响因素。结果2020―2022年南京市栖霞区≥65岁人群的MS总患病率分别为36.72%、35.17%、33.80%,标化患病率分别为36.60%、35.11%、33.67%,呈下降趋势(趋势χ^(2)=41.021,P<0.001);城乡分层后,城市≥65岁人群MS患病率呈下降趋势(趋势χ^(2)=95.499,P<0.001);农村≥65岁人群MS患病率呈上升趋势(趋势χ^(2)=16.237,P<0.001)。结论南京市栖霞区≥65岁人群MS总患病率2020―2022年虽然呈下降趋势,但依然较高,尤其是农村地区MS患病率呈上升趋势,农村地区女性MS患病率增幅快,应重点关注。

关键词：代谢综合征老年人群患病率变化趋势

Effects of oat β-glucan–based prebiotic blended formulas on defecation and gut microbiota in Chinese adults: a randomized clinical trial

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Food Science and Human Wellness 2024年

作者： Aiqi Li Lei Jin Hui Xia Meiyuan Feng Xirui Zhou Yifang Chu Feng Liu Lanxing Jia Ximin Chen Dengfeng Xu Shanjie Ma Xiaofan Xu Xinyu Wang Xiaoqing Li guiju sun Liegang Liu Key Laboratory of Environmental Medicine and Engineering of Ministry of Education， and Department of Nutrition and Food Hygiene， School of Public Health Southeast University Department of Nutrition and Food Hygiene， Hubei Key Laboratory of Food Nutrition and Safety， School of Public Health， Tongji Medical College， Huazhong University of Science and Technology Department of R&D Life Science，PepsiCo Inc Nutrition and Healthy Food Committee of Chinese Nutrition Society Health Management Branch of Chinese Nutrition Society

Digestive health is important for overall well-being， but gut health problems are common in the Chinese population. The objective of this study was to investigate the effects of oat β-glucan–based prebiotic blended formulas in humans on digestive health by assessing defecation frequen-cy， defecation symptoms， stool quality， self-reported digestive feelings， defecation satisfaction， and gut bacteria. A parallel， randomized， double-blind， controlled trial was conducted in 168 eli-gible adults randomized to three groups for 14 days: Intervention Groups A and B received two different doses of oat β-glucan–based prebiotic blended formulas and a Control Group received oat β-glucan mixed with hydroxypropylmethyl-cellulose and microcrystalline cellulose. Partici-pants completed a defecation diary and Bristol stool chart daily and digestive system question-naires weekly. Fecal samples were collected on Day 0 and Day 14 to evaluate gut bacteria using 16S rDNA analysis. Both formulas improved defecation frequency， stool quality， defecation symptoms， defecation satisfaction， and on digestive health of human， compared with baseline (P < 0.05). Both formulas led to increased quantities of Bifidobacterium and Akkermansia bacteria， compared to control， on Day 14. This study therefore demonstrated the beneficial effects of oat β-glucan–based prebiotic blended formulas on gut health in generally healthy Chinese adults. These formulas are a feasible nutritional strategy for digestive health.

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余甘子与茶多酚、左旋肉碱配伍对高脂饮食诱导大鼠肥胖的预防作用

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食品科学 2024年第8期45卷 96-104页

作者：任兴远王文博桂兰兰郝润华王少康陈希民孙桂菊东南大学公共卫生学院环境医学工程教育部重点实验室江苏南京210009 中国营养学会营养与保健食品分会北京100069

目的:研究余甘子、余甘子与茶多酚、左旋肉碱配伍对高脂饮食诱导大鼠肥胖的预防作用。方法:实验组、模型对照组和阳性对照组大鼠给予高脂饲料进行喂养,空白对照组大鼠给予普通饲料进行喂养;同时实验组分别灌胃余甘子、余甘子茶多酚混合... 详细信息

目的:研究余甘子、余甘子与茶多酚、左旋肉碱配伍对高脂饮食诱导大鼠肥胖的预防作用。方法:实验组、模型对照组和阳性对照组大鼠给予高脂饲料进行喂养,空白对照组大鼠给予普通饲料进行喂养;同时实验组分别灌胃余甘子、余甘子茶多酚混合物、余甘子左旋肉碱混合物。灌胃结束后称量大鼠体质量、体内肾周脂肪、睾周脂肪质量,检测大鼠血清及肝脏组织中血脂4项水平。测定血清中瘦素、抵抗素和脂联素水平,检测肝脏内相关酶活性、总蛋白水平及脂肪组织内mRNA的表达情况,观察余甘子、余甘子与茶多酚、左旋肉碱配伍对预防肥胖模型大鼠的减肥效果及肝损伤影响。结果:模型对照组大鼠体质量、体内脂肪含量相较于空白对照组有明显增加,且差异具有显著性(P<0.001)。在余甘子的调节作用下,余甘子干预组与余甘子左旋肉碱配伍干预组大鼠体质量显著下降,肾周脂肪和睾周脂肪质量及其系数也显著降低,血清和肝脏中总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平显著降低,高密度脂蛋白胆固醇水平显著升高,同时血清中瘦素、抵抗素水平显著降低,脂联素水平升高;肝脏中碱性磷酸酶、天冬氨酸转氨酶、丙氨酸转氨酶活性和丙二醛含量下降,超氧化物歧化酶活性增加;脂肪组织内单磷酸腺苷依赖蛋白激酶α-2 mRNA的表达显著上调。余甘子茶多酚配伍干预组预防肥胖效果并不显著。结论:余甘子能够预防高脂饮食诱导的大鼠肥胖,且单独使用效果优于余甘子与茶多酚或左旋肉碱配伍使用。

关键词：余甘子茶多酚左旋肉碱高脂饮食预防肥胖

A depressant for marmatite flotation:Synthesis,characterisation and floatation performance

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International Journal of Minerals,Metallurgy and Materials 2023年第6期30卷 1048-1056页

作者： Tichen Wang guiju sun Jiushuai Deng Hongxiang Xu Guoyong Wang Mingzhen Hu Qizheng Qin Xiaohao sun Key Laboratory of Separation and Processing of Symbiotic-Associated Mineral Resources in Non-ferrous Metal Industry Engineering Technology Research Center for Comprehensive Utilization of Rare Earth-Rare Metal-Rare Scattered in Non-ferrous Metal IndustrySchool of Chemical and Environmental EngineeringChina University of Mining and Technology(Beijing)Beijing 100083China Inner Mongolia Research Institute China University of Mining and Technology(Beijing)Ordos 017001China National Engineering Laboratory for Efficient Utilization of Indium and Tin Resources Liuzhou 545000China The Geological Museum of China Beijing 100034China

This study synthesised a zincic salt(ZS)as a depressant for marmatite-galena *** effect of ZS on the flotation of marmatite and galena was investigated through micro-flotation tests.88.89%of the galena was recovered and 83.39%of the marmatite was depressed with ZS dosage of 750 mg·L^(−1)at pH=*** depression mechanism of ZS on marmatite was investigated by a variety of techniques,including adsorption measurements,Fourier transform infrared(FTIR),X-ray photoelectron spectroscopic(XPS)analysis,and time of flight secondary ion mass spectrometry(ToF-SIMS).Results of adsorption tests and FTIR reveal that ZS adsorbed on marmatite surface and impeded the subsequent adsorption of butyl xanthate(BX).The results of XPS and ToF-SIMS indicate that the ZnO_(2)^(3-)released by ZS could be chemisorbed on the marmatite surface and depress marmatite flotation.

关键词： marmatite zincic salt flotation separation depression mechanism time of flight secondary ion mass spectrometry

Tissue distribution of Lycium barbarum polysaccharides in rat tissue by fluorescein isothiocyanate labeling

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Food Science and Human Wellness 2022年第4期11卷 837-844页

作者： Chao Yang Hui Xia Huali Tang Ligang Yang guiju sun Key Laboratory of Environmental Medicine and Engineering of Ministry of Education and Department of Nutrition and Food hygieneSchool of Public HealthSoutheast UniversityChina-DRIs Expert Committee on Other Food SubstancesNanjing 210009China

To date, in vivo investigations of polysaccharide’s pharmacokinetics are significantly restricted by the difficulty in their detection. This study was conducted to establish the quantitative determination of Lycium barbarum polysaccharides(LBPs) based on fluorescein isothiocyanate(FITC) pre-labeling and to investigate their tissue distribution in rat. We obtained the calibration curves linear over the range of 0.0–25 μg/m L in rat tissue samples with correlation coefficients greater than 0.99. The inter-day and intra-day precisions(RSD, %) were within 15%, and the relative recovery ranged 95.2%–102.4%, with RSD range 1.48%–9.58%, indicating that this experiment was suitable for the determination of LBPs. The fluorescence intensity was measured after 24 h storage at room temperature, 3 times of freeze-cycle and cryopreservation at –20 ℃ for 15 day, these results indicated that the stability of the samples was good. LBP-FITC was mainly absorbed by the small intestine and stomach, and mainly excreted in the urine through the kidney;this distinct difference in the tissue distribution of LBPs could be attributed to the size of these LBPs in relation to the pore sizes of the vascular beds in the kidney and liver. Results showed in this study enable us to comprehensively understand the biological effects of LBPs following its oral ingestion.

关键词： Lycium barbarum polysaccharides Fluorescein isothiocyanate Tissue distribution

Influence of luteolin on the apoptosis of esophageal cancer Eca109 cells and its mechanism of action

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Food Science and Human Wellness 2019年第2期8卷 189-194页

作者： Shaokang Wang Lingmeng Fu Yi Wu Hongmei Xiao Jing Wang guiju sun Key Laboratory of Environmental Medicine and Engineering of Ministry of Education and Department of Nutrition and Food HygieneSchool of Public HealthSoutheast UniversityNanjing 210009PR China

The present study was conducted to verify the influence of luteolin on apoptosis of Eca109 cells and to further investigate the possible mechanisms underlying its effect on *** cells were exposed to different concentrations of luteolin(0,40,80,120,160,200,240M)for 24,48,and 72 h *** influence of luteolin on proliferation of Eca109 cells was detected using MTT ***109 cells were then treated with luteolin(0,40,160,240M)for 24 *** effect of luteolin on cell cycle progression and apoptosis was assayed by using flow cytometry(FCM).Expression of caspase9 and caspase3 mRNA and protein was analyzed by real-time PCR and Western blot *** results showed that luteolin could inhibit the proliferation of Eca109 cells at all concentrations in a time-dependent manner and the relative inhibition rate showed an inverted U-shaped association with the concentration of ***,the cell cycle was arrested in the S phase following treatment with *** analysis indicated that luteolin could induce the apoptosis of Eca109 cells across the three concentration groups,which exhibited a trend of first promotional and then inhibitory with the increases in luteolin *** effect of luteolin on the mRNA and protein expression of caspase 9 and caspase3 first manifested as promotion,then ***,luteolin may serve a role in promoting cell apoptosis by inducing Eca109 cell apoptosis that involves the expression of caspase3,caspase9 mRNA and *** study provides theoretical basis for further study and clinical application of *** specific mechanism has not yet been clarified and the other activation pathways inducing apoptosis need to be further studied.

关键词： Esophageal cancer Luteolin Apoptosis