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Total Glycosides of Ranunculus Japonius Prevent Hypertrophy in Cardiomyocytes via Alleviating Chronic Ca^(2+) Overload

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Chinese Medical Sciences Journal 2015年第1期30卷 37-43页

作者： Hong-liang Dai gui-zhi jia Song Zhao Department of Community Health Nursing Liaoning Medical University Department of Biochemistry and Molecular Biology Liaoning Medical University Centre of Scientific Experiment Liaoning Medical University

Objective To evaluate the in vitro anti-hypertrophic effect of total Glycosides of Ranunculus Japonius （TGRJ）. Methods Neonatal rat cardiomyocytes were cultured and hypertrophy was induced by adminis- trating isoproterenol （ISO, 10 gmol/L） or angiotensin Ⅱ （AngⅡ, 1 gmol/L） for 48 hours. In the treatment groups, cells were pretreated with TGRJ （0.3 g/L） for 30 minutes prior to hypertrophic stimuli. The anti-hypertrophic effects of TGRJ were examined by measuring cell size, total protein content, and protein synthesis. Intracellular free Ca2＋ concentration （[Ca2＋]i） was evaluated using fluorescence dye Fura-2/AM. Sacroplasmic/endoplasmic reticulum Ca2＋ ATPase 2a （SERCA2a）, atrial natriuretic peptide （ANP）, B-type natriuretic peptide （BNP）, and beta-myosin heavy chain （β-MHC） protein expression levels were measured by Western blotting. SERCA2a activity was assayed by p-nitrophenal phosphate disodium salt hexahydrate method. Results Increased cell size, total protein content, and protein synthesis following ISO or Ang II stimulation were significantly inhibited by pretreatment with TGRJ （all P〈0.05）. This anti-hypertrophic effect of TGRJ was confirmed by its suppressing effect on elevated expression of the three hypertrophic related genetic markers, ANP, BNP, and ^-MHC. In addition, TGRJ inhibited ISO or Ang Ⅱ induced up-regulation of [Ca2＋] under chronic but not acute conditions. And ISO or Ang Ⅱ induced down-regulation of SERCA2a expression and activity was also effectively rectified byTGRJ pretreatment. Conclusions The results of present study suggested that TGRJ could prevent ISO or Ang Ⅱ induced cardiac hypertrophy through improving chronic [Ca2＋]i disorder, might via normalizing SERCA2a expression and activity.

关键词： total Glycosides of RanunculusJaponius cardiac hypertrophy isoproterenol angiotensin Ⅱ Ca2+ sacroplasmic/endoplasmic reticulum Ca2+ ATPase 2a

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Physical Layer Security Scheme With AoI-Awareness for Industrial IoT Based on Covert Communications

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 276-278页

作者： Yaping Li zhi-Xin Liu jia-Wei Su Ya-Zhou Yuan the Key Laboratory of Industrial Computer Control Engineering of Hebei Province Yanshan University

Dear Editor,Industrial Internet of things(IIoT) is a typical application of cyberphysical system(CPS). In the IIoT, wireless communication is an inevitable trend to replace the deployment-limited wired transmission for cases with large-scale and mobile devices. However, wireless communication gives rise to critical issues related to physical security, such as malicious detections and attacks [1].

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Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： zhi-Hui Zheng Bo Shao Chao-Min Xu Ke Wang jia-Zhu Wen Li-Kang Luo jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

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ERK/CT-1通路对氧化应激致H9C2细胞凋亡的影响

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中国现代医学杂志 2019年第9期29卷 11-15页

作者：杜娜戴红良贾桂枝锦州医科大学附属第一医院心血管内科二病区辽宁锦州121001 锦州医科大学护理学院辽宁锦州121001 锦州医科大学生理学教研室辽宁锦州121001

目的观察在氧化应激情况下心肌营养因子-1(CT-1)的表达情况及其对心肌细胞凋亡的影响,探讨其相关机制。方法以过氧化氢刺激H9C2细胞建立氧化损伤模型,N-乙酰半胱氨酸或CT-1小干扰RNA(si RNA)与过氧化氢共同孵育以确定活性氧类(ROS)对CT-... 详细信息

目的观察在氧化应激情况下心肌营养因子-1(CT-1)的表达情况及其对心肌细胞凋亡的影响,探讨其相关机制。方法以过氧化氢刺激H9C2细胞建立氧化损伤模型,N-乙酰半胱氨酸或CT-1小干扰RNA(si RNA)与过氧化氢共同孵育以确定活性氧类(ROS)对CT-1表达的影响,以及CT-1在细胞凋亡中的作用。以丝裂原活化细胞外信号调节激酶(MEK/ERK)特异性抑制剂PD98059预处理H9C2细胞,以确定过氧化氢诱导CT-1表达的机制。结果过氧化氢可剂量依赖性地诱导CT-1的过表达,N-乙酰半胱氨酸可显著抑制过氧化氢诱导的CT-1过表达。过氧化氢诱导的H9C2细胞凋亡可被N-乙酰半胱氨酸阻断,但CT-1 siRNA可加重过氧化氢诱导的H9C2细胞凋亡。过氧化氢可剂量依赖性地促进ERK的活化,PD98059预处理明显抑制过氧化氢诱导的CT-1上调。结论过氧化氢能活化ERK/CT-1通路,从而缓解氧化应激引起的细胞凋亡。

关键词：氧化应激 H9C2细胞心肌营养因子-1 凋亡 ERK

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Synthesis of chiral phosphine derivatives through a copper（I）-catalyzed desymmetric SNAr reaction

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Science China Chemistry 2025年

作者： Shuai Zhang Pei-zhi Liu Yan-Bo Li Qi Zhang Jun-Zhao Xiao Yi-Fan Wang Tian-Yu Wei jia-Wei jiang Ye Wang Qian Peng Liang Yin Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Biosensing and Molecular Recognition College of Chemistry Frontiers Science Center for New Organic Matter Nankai University Haihe Laboratory of Sustainable Chemical Transformations

Axially chiral phosphines are a class of extremely important ligands in asymmetric catalysis. Herein, an unprecedented copper（I）-catalyzed asymmetric SNAr reaction with HP（S）R2is uncovered, which delivers a series of axially chiral phosphine derivatives in high yields with excellent enantioselectivity. Furthermore, the diastereoselective reaction with the kinetic resolution of racemic HP（S）ArR proceeds smoothly, providing the products with moderate diastereoselectivity and excellent enantioselectivity. Control experiments indicate that HP（S）Ph2is much more active than HPPh2and HP（O）Ph2as the pronucleophile in the present reaction. It is found that the SNAr reaction （the first SNAr） proceeds in a desymmetric manner, providing the desired chiral products while a continued SNAr reaction （the second SNAr） slightly occurs in a kinetic resolution manner in the present catalytic system, which enhances the ee of the desired chiral products. DFTcalculations support a concerted reaction pathway rather than a step-wise mechanism. Finally, axially chiral olefin-phosphines produced by the present method work as suitable ligands in Pdcatalyzed asymmetric allylic substitution with C-, N-, and O-nucleophiles and Rh-catalyzed asymmetric addition of arylboronic acid to benzil.

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A REVERSE ORDER IMPLICIT Q-THEOREM AND THE ARNOLDI PROCESS

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Journal of Computational Mathematics 2002年第5期20卷 519-524页

作者： gui-zhi Chen Zhong-xiao jia Department of Mathematics Nanjing University Nanjing 210093China Department of Mathematical Sciences Tsinghua University Beijing 100084China

Presents a study that investigated the generalization of the reverse order implicit Q-theorem and its truncated version to the unsymmetric case. Background on the application of the Arnoldi process formulations for a ... 详细信息

关键词： implicit Q-theorem reverse order implicit Q-theorem truncated version Arnoldi process

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Thickness and sp3 bond modulation of（Ti/tetrahedral amorphous carbon）_n multilayer coatings

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Tungsten 2025年第1期 152-160页

作者： zhi-Jun Xie jia-Lin Li Ling Gong Xiang-Li Zhong Hong-jia Song Jin-Bin Wang National-Provincial Laboratory of Special Function Thin Film Materials School of Materials Science and Engineering Xiangtan University

The durability of wear-resistant tetrahedral amorphous carbon（ta-C） coatings is intimately linked to their thickness and the concentration of *** enhance the lifespan of the coatings,we have prepared a multilayer coating consisting of alternating layers of Ti and ta-C,denoted as（Ti/ta-C）_n,using arc ion plating.A multi-layer structure in conjunction with stage cooling is employed to enhance the thickness and promote *** results indicate that the ID/IGvalue,representing the ratio of the intensity of the D peak to that of the G peak in Raman spectroscopy,decreases from 0.85 when no stage cooling is applied to 0.35 when stage cooling is employed,suggesting an enhancement in the fraction of sp3bonds within the *** obtained（Ti/ta-C）_n multilayer coating without peeling off has a maximum thickness of 1.14 μm,which is almost double that of the ta-C coating single layer *** the same time,the coating has a low coefficient of friction,down to 0.069,and maintains excellent friction properties with a wear rate of 3.4×10-6mm3·N-1·*** results conclusively show that the preparation technology can enhance both thickness and sp3bonding in ta-C coatings,significantly expanding their utility across tools,molds,and precision engineering components.

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Cosemisimple Coextensions and Homological Dimension of Smash Coproducts

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Acta Mathematica Sinica,English Series 2005年第3期21卷 563-568页

作者： jia gui ZHU Department of Mathematics University of Science and Technology of China Hefei 230026 P. R. China Department of Mathematics West Anhui University Lu'an 237012 P. R. China

Let H be a finite dimensional cosemisimple Hopf algebra, C a left H-comodule coalgebra and let C = C/C（H^＊）^＋ be the quotient coalgebra and the smash coproduct of C and H. It is shown that if C/C is a eosemisimple coextension and C is an injective right C-comodule, then gl. dim（the smash coproduct of C and H） = gl. dim（C） = gl. dim（C）, where gl. dim（C） denotes the global dimension of coalgebra C.

关键词： Coalgebra Homological dimension Smash coproduct Hopf algebra

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Malignant atrophic papulosis:Two case reports

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World Journal of Clinical Cases 2022年第35期10卷 12971-12979页

作者： zhi-gui Li jia-Ming Zhou Li Li Xiao-Dong Wang Department of Gastrointestinal Surgery West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Clinical Medicine West China School of MedicineSichuan UniversityChengdu 610207Sichuan ProvinceChina

BACKGROUND Malignant atrophic papulosis is a rare and potentially lethal thrombo-occlusive microvasculopathy characterized by cutaneous papules and gastrointestinal *** precise pathogenesis of this disease remains *** SUMMARY We describe the case of a 67-year-old male patient who initially presented with cutaneous aubergine papules and dull pain in the *** week after symptom onset,he was admitted to the hospital for worsening abdominal *** laparotomy showed patchy necrosis and subserosal white plaque lesions on the small intestinal wall,along with multiple *** examination of the small intestine showed extensive hyperemia,edema,necrosis with varying degrees of inflammatory reactions in the small bowel wall,small vasculitis with fibrinoid necrosis and intraluminal thrombosis in the *** on the mentioned evidence,a diagnosis of malignant atrophic papulosis was *** also present the case of a 46-year-old man with known cutaneous manifestations,abdominal pain,nausea and *** physical examination showed positive rebound tenderness.A computed tomography scan revealed free intraperitoneal *** required surgical intervention on admission and then developed an esophageal *** ultimately died of a massive *** In previously published cases of this disease,the cutaneous lesions initially appeared as small erythematous ***,the papules became porcelain-white atrophic depression lesions with a pink,telangiectatic peripheral *** one of the patients,the cutaneous lesions appeared as aubergine *** other patient developed multiple perforations in the gastrointestinal *** to malignant atrophic papulosis affecting multiple organs,many authors speculated that it is not a specific *** case series serves as additional evidence for our hypothesis.

关键词： Malignant atrophic papulosis Gastrointestinal perforation Papulosis Thrombo-occlusive microvasculopathy Case report

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Static and dynamic studies of adsorption by four macroporous resins to enrich oridonin from Rabdosia rubescens

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Chinese Journal of Chemical Engineering 2021年第4期34卷 151-158页

作者： Ling Meng Xia gui zhi Yun College of Chemical Engineering Nanjing Tech UniversityNanjing 211816China State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine Lunan Pharmaceutical Group Co.Ltd.Linyi 273400China

Oridonin,one of the active ingredients in Rabdosia rubescens(***),has been reported to induce cell apoptosis and cell cycle arrest in many *** extraction methods tend to result in unsatisfied enrichment and poor quality of oridonin present in a given *** paper aims to evaluate the performance and separation characteristics of four different macroporous resins to arrive at the most suitable methodology for the isolation and purification of highquality *** absorption kinetics,thermodynamic and dynamic adsorption were ***20 was selected for further study due to its high adsorption capacity of 32 mgg 1 and desorption ratio with 98.5%.The pseudosecondorder model was considered to be the most suitable for kinetic results,and Langmuir model was chosen to better describe the absorption *** optimum conditions(flow rate of 4 ml min 1,bed depth with 6 cm and initial concentration of 2.15 mg·ml^1),the effective content of oridonin increased from 33.9%to 79.1%in the dry extract with a recovery of 81%and the purity of oridonin improved from 76%to 93%.The results confirm that HP20 provides an efficient method to purify most oridonin from ***.

关键词： Rabdosia rubescens Oridonin Macroporous resin Adsorption Kinetics Thermodynamics

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