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Electroacupuncture at Sensitized Acupoints Relieves Somatic Referred Pain in Colitis Rats by Inhibiting Sympathetic-Sensory Coupling to Interferewith 5-HT Signaling Pathway

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ch.nese Journal of Integrative Medicine 2024年第2期30卷 152-162页

作者： YAnG Ying QU jin-yu GUO Hua ZHOU Hai-ying RUAn Xia PEnG Ying-ch.n SHEn Xue-fang XIOnG jin WAnG Yi-li School of Clinical Medicine Chengdu Medical CollegeChengdu(610500)China Department of Rehabilitation Medicine the First Affliated Hospital of Chengdu Medical CollegeChengdu(610500)China Department of Rehabilitation Medicine West China HospitalSichuan University/West China School of NursingSichuan UniversityChengdu(610041)China Department of neurology the First Affiliated Hospital of Chengdu Medical CollegeChengdu(610500)China

Objective:To investigate whether electroacupuncture(EA) at sensitized acupoints could reduce sympathetic-sensory coupling(SSC) and neurogenic inflammatory response by interfering with 5-hydroxytryptamine(5-HT)ergic neural pathways to relieve colitis and somatic referred pain,and explore the underlying ***:Rats were treated with 5% dextran sodium sulfate(DSS) solution for 7 days to establish a colitis *** rats were randomly divided into the control and model groups according to a random number table(n=6).According to the Research on Rat Acupoint Atlas",sensitized acupoints and non-sensitized acupoints were *** were randomly divided into the control,model,Zusanli-EA(ST 36),Dach.ngshu-EA(BL 25),and Xinshu(BL 15) groups(n=6),as well as the control,model,EA,and EA+GR113808(a 5-HT inhibitor)groups(n=6).The rats in the control group received no *** was administered on 2 days after modeling using the stimulation pavameters:1 mA,2 Hz,for 30 min,with sparse and dense waves,for 14 consecutive ***113808 was injected into the tail vein at 5 mg/kg before EA for 10 min for 7 consecutive *** sensitivity was assessed with von Frey *** weight and disease activity index(DAI) scores of rats were *** and eosin staining was performed to observe colon *** was analyzed by immunofluorescence *** staining was performed to detect 5-HT and substance P(SP) *** calcitonin gene-related peptide(CGRP) in skin tissue and tyrosine hydroxylase(TH) protein levels in DRG were detected by Western *** levels of hyaluronic acid(HA),bradykinin(BK),prostaglandin I2(PGI2) in skin tissue,5-HT,tryptophan hydroxylase 1(TPH1),serotonin transporters(SERT),5-HT 3 receptor(5-HT3R),and 5-HT 4 receptor(5-HT4R) in colon tissue were measured by enzyme-linked immunosorbent assay(ELISA).Results:BL 25 and ST 36 acupoints were determined as sensitized acupoints,and BL 1

关键词： electroacupuncture sensitized acupoints sympathetic-sensory coupling 5-hydroxytryptamine neurogenic inflammation somaticreferredpain

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Sepsis one-hour bundle management combined with psychological intervention on negative emotion and sleep quality in patients with sepsis

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World Journal of Psychiatry 2024年第2期14卷 266-275页

作者： Ming Xia guang-Yan Dong Shi-chao Zhu Huan-Min Xing Li-Ming Li Department of Intensive Care Unit Henan Provincial Key Medicine Laboratory of NursingHenan Provincial People’s HospitalZhengzhou University People’s HospitalZhengzhou 450003Henan ProvinceChina Department of nursing Henan Provincial Key Medicine Laboratory of NursingHenan Provincial People’s HospitalZhengzhou University People’s HospitalZhengzhou 450003Henan ProvinceChina

BACKGROUnD Sepsis is a serious infectious disease caused by various systemic inflammatory responses and is ultimately *** usually experience depression and anxiety,which affect their sleep quality and post-traumatic growth *** To investigate the effects of sepsis,a one-hour bundle(H1B)management was combined with psychological intervention in patients with *** This retrospective analysis included 300 patients with sepsis who were admitted to Henan Provincial People’s Hospital between June 2022 and June *** to different intervention methods,the participants were divided into a simple group(SG,n=150)and combined group(CG,n=150).H1B management was used in the SG and H1B management combined with psychological intervention was used in the *** ch.nges of negative emotion,sleep quality and post-traumatic growth and prognosis were compared between the two groups before(T0)and after(T1)*** After intervention(T1),the scores of the Hamilton Anxiety scale and Hamilton Depression scale in the CG were significantly lower than those in the SG(Pncy,daytime dysfunction,sleep disturbance dimension score,and the total score in the CG were significantly lower than those in the SG(Pn of life,mental ch.nges,relationship with others,personal strength dimension score,and total score of the CG were significantly higher than those of the SG(Pntal health,general health status,physiological function,emotional function,physical pain,social function,energy,and physiological function in the CG were significantly higher than those in the SG(Pch.nical ventilation time,intensive care unit stay time,and 28-d mortality of the CG were significantly lower than those of the SG(PnCLUSIOn H1B management combined with psychological intervention can effectively alleviate the negative emotions of patients with sepsis and inc

关键词： Cluster management Psychological intervention Sepsis negative emotions Sleep quality Post-traumatic growth

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考虑随机运能和送到时限的高铁快递运输计划优化方法

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控制与决策 2024年第8期39卷 2755-2764页

作者：徐光明郭婧陈婉茹秦进中南大学交通运输工程学院长沙410075

为充分利用高铁非高峰期的列车运能,高铁快运已成为铁路快捷货运发展新趋势.然而,受客运需求波动影响,载客动车组可用于高铁快递的运能呈现高度不确定性,给日常运营组织带来巨大挑战.为增强高铁快运系统应对随机运能的能力,提出一种考... 详细信息

为充分利用高铁非高峰期的列车运能,高铁快运已成为铁路快捷货运发展新趋势.然而,受客运需求波动影响,载客动车组可用于高铁快递的运能呈现高度不确定性,给日常运营组织带来巨大挑战.为增强高铁快运系统应对随机运能的能力,提出一种考虑随机运能的高铁快递运输计划优化方法.首先,采用离散场景刻画列车运能的不确定性,以最大化高铁快运期望总收益为目标,综合考虑快递的送到时限和运营约束,针对场景概率分布精确已知情形,构建两阶段随机规划模型(SP);然后,进一步考虑场景概率分布信息部分已知情形,构建两阶段分布鲁棒优化模型(DRO),基于盒式模糊集,借助对偶理论将DRO模型转化为等价的整数线性规划模型并利用GUROBI求解;最后,基于宁杭高铁设计数值实验验证模型的有效性,结果表明,相较于SP模型,DRO模型体现出较强的鲁棒性,只需付出较小的代价即可有效抵抗运能波动对运输计划的影响,并且能够改善最坏情形下解的质量,切实改善高铁快递实际运营中的稳定性.

关键词：高铁快递运输计划送到时限随机运能分布鲁棒优化整数线性规划

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坐骨神经阻滞联合持续股神经阻滞或持续收肌管阻滞对人工全膝关节置换术后疼痛与运动功能影响的比较研究

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中国修复重建外科杂志 2024年第5期38卷 556-561页

作者：朱光邹丽丽金群华宁夏医科大学临床医学院银川750001 宁夏医科大学总医院麻醉科银川750001 宁夏医科大学总医院宁夏骨关节炎(病)研究所银川750001 宁夏医科大学宁夏医学科学研究所银川750001

目的比较坐骨神经阻滞(sciatic nerve block,SnB)联合持续股神经阻滞(femoral nerve block,FnB)或持续收肌管阻滞(adductor canal block,ACB)对人工全膝关节置换术(total knee arthroplasty,TKA)术后疼痛和运动功能的影响。方法共纳入2020年12月—2021年2月收治且符合选择标准的60例行TKA治疗的膝关节骨关节炎患者,随机分为研究组(SnB联合持续ACB)和对照组(SnB联合持续FnB),每组30例。两组患者性别、年龄、体质量、身高、身体质量指数及术前膝关节美国特种外科医院(HSS)评分、胫股角、胫骨近端内侧角等基线资料比较差异均无统计学意义(P>0.05)。记录手术时间、初次下地时间、初次行走距离、术后住院时间;术后2、4、6、12、24、48 h,采用数字评分量表(nRS)评价患者膝关节周围静息疼痛情况,采用徒手肌力法评价股四头肌肌力变化,并测量膝关节屈曲及伸直角度。结果两组患者手术时间和初次行走距离比较差异无统计学意义(P>0.05);研究组初次下地时间和术后住院时间均明显短于对照组,差异有统计学意义(PnRS评分低于对照组(PnRS评分比较差异无统计学意义(P>0.05)。术后4~24 h研究组股四头肌肌力及2~6 h膝关节伸直角度均优于对照组,差异有统计学意义(P0.05)。结论SnB联合持续ACB或持续FnB均可有效缓解TKA术后患者疼痛,与联合持续FnB相比,联合持续ACB对股四头肌肌力影响更小,患者膝关节屈伸活动恢复更好。

关键词：人工全膝关节置换术坐骨神经阻滞股神经阻滞收肌管阻滞

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新媒体时代旅游资源持续关注损失测度及影响因素——基于网络舆情大数据的证据

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自然资源学报 2024年第7期39卷 1512-1530页

作者：邹永广雷振仙廖金斤李媛华侨大学旅游学院泉州362021 中国旅游研究院旅游安全研究基地泉州362021

旅游资源持续关注损失是旅游资源的关注度降低或转移的现象,对于提升旅游资源的抗风险能力具有重要意义。基于网络舆情大数据,综合运用情感分析、LDA主题模型、模糊集定性比较分析等研究方法,在建立综合评价指标测度旅游资源持续关注损... 详细信息

旅游资源持续关注损失是旅游资源的关注度降低或转移的现象,对于提升旅游资源的抗风险能力具有重要意义。基于网络舆情大数据,综合运用情感分析、LDA主题模型、模糊集定性比较分析等研究方法,在建立综合评价指标测度旅游资源持续关注损失的基础上,探讨了影响旅游资源持续关注损失的因素及路径。研究发现:(1)旅游资源的持续关注损失具有波动性,但内部趋于稳定的特征。(2)研究期内,山东淄博、重庆洪崖洞、哈尔滨国际冰雪节的持续关注损失呈下降趋势,茶卡盐湖、啤酒节、《印象·刘三姐》、大宋千古情等的持续关注损失呈上升趋势,大唐不夜城的持续关注损失呈先上升后下降的趋势。(3)旅游资源的持续关注损失受旅游供给、市场需求、新媒体传播等多种因素的交互影响,形成旅游资源低持续关注损失的组合路径为产品创新型和媒体营销型。研究结果为理解新媒体时代下旅游资源可持续发展的内在逻辑提供理论借鉴,并为有效匹配公共服务供给、提升资源品质与推广提供实践指导。

关键词：旅游资源可持续关注损失测度影响因素 fsQCA

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Multiplicity of solutions for the semilinear subelliptic Dirichlet problem

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Science ch.na Mathematics 2024年第3期67卷 475-504页

作者： Hua ch.n Hong-Ge ch.n jin-ning Li Xin Liao School of Mathematics and Statistics Wuhan UniversityWuhan 430072China Wuhan Institute of Physics and Mathematics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China

In this paper,we study the semilinear subelliptic equation{−△Xu=f(x,u)+g(x,u)inΩ,u=0 on∂Ω,where△X=−∑m i=1 Xi∗Xi is the self-adjoint Hormander operator associated with the vector fields X=(X_(1),X_(2),...,X_(m))satisfying the Hormander's condition,f(x,u)∈C(Ω×R),g(x,u)is a Carathéodory function onΩ×R,andΩis an open bounded domain in R~n with smooth *** the perturbation from the symmetry method with the approaches involving the eigenvalue estimate and the Morse index in estimating the minimax values,we obtain two kinds of existence results for multiple weak solutions to the problem ***,we discuss the difference between the eigenvalue estimate approach and the Morse index approach in degenerate *** with the classical elliptic cases,both approaches here have their own strengths in the degenerate *** new phenomenon implies that the results in general degenerate cases would be quite different from the situations in classical elliptic cases.

关键词： degenerate elliptic equations Hormander operators perturbation method Morse index

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n,O-Bidentated difluoroboron complexes based on pyridine-ester enolates:Facile synthesis,post-complexation modification,optical properties,and applications

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ch.nese chemical Letters 2024年第9期35卷 169-174页

作者： chaochao jin Kai Li Jiongpei Zhang Zhihua Wang Jiajing Tan College of chemistry Beijing University of Chemical Technology(BUCT)Beijing 100029China College of Materials Science and Engineering Shenzhen UniversityShenzhen 518055China

An array of pyridine-ester enolate based organoboron complexes has been designed and synthesized via a one-pot cascade of Pd-catalyzedα-arylation and *** rapid structure-activity relationship(SAR)studies indicated that unsymmetrical n,O-chelated BF2complexes were highly fluorescent in solid state,and exhibited large Stokes shifts,excellent photostability,along with insensitivity to p ***α-aryl group could not only modulate the electronic effect but also inhibit the intermolecularπ-πstacking to promote the aggregation-induced emission(AIE)*** calculations and experiments identified that the intramolecular charge transfer properties of these n,O-chelates could be switched by the modification of substituents,resulting tunable fluorescence ***,post-complexation modification was accomplished,including Suzuki-Miyaura cross-coupling,Buchwald-Hartwig amination,oxidative cleavage,along with a unique triple substitution reaction involving propargyl Grignard *** exemplificative application of dimethylamine substituted boron complex as a reversible acidic vapor sensor was also demonstrated.

关键词： n,O-Bidentate BF2 complexes Aggregation-induced emission Large Stokes shift Post-complexation modification Reversible acidic vapor sensor

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Synergistic effect between Er-doped MoS_(2)nanosheets and interfacial Mo-n coupling phases for enhanced electrocatalytic hydrogen evolution

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Rare Metals 2024年第3期43卷 1301-1308页

作者： nian-Peng Li Lei Zhang Hua Zhang Fan-Fei Min Lei Wang Sam Toan Xi-Jun Liu guang-Zhi Hu State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines School of Materials Science and EngineeringAnhui University of Science and TechnologyHuainan232001China Donghai Laboratory Zhoushan316021China Department of chemical Engineering University of Minnesota-DuluthDuluthMN55812USA School of Ecology and Environmental Science Institute for Ecological Research and Pollution Control of Plateau LakesYunnan UniversityKunming650504China MOE Key Laboratory of new Processing Technology for non-Ferrous Metals and Materials Guangxi Key Laboratory of Processing for Non-Ferrous Metals and Featured MaterialsGuangxi UniversityNanning530004China

Hydrogen production via electrochemical water splitting is a promising and green *** one of the most representative transition metal sulfides layered materials,Molybdenum disulfide(MoS_(2))has immense potential for the hydrogen evolution reaction(HER).We successfully prepared a nitrogen-doped carbon(nC)in situ-grown erbium-doped MoS_(2)polyhedral structure(Er-MoS_(2)/nC)that incorporates an interfacial Mo-n coupling phase.

关键词： hydrogen interfacial coupling

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Superior Anodic Lithium Storage in Core–Shell Heterostructures Composed of Carbon nanotubes and Schiff-Base Covalent Organic Frameworks

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Energy & Environmental Materials 2024年第6期7卷 150-157页

作者： nan Jiang Mengpei Qi Yalong Jiang Yin Fan Shiwei jin Yingkui Yang School of chemistry and Materials Science South-Central Minzu UniversityWuhan 430074China State Key Laboratory of new Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200China

Covalent organic frameworks(COFs)after undergoing the superlithiation process promise high-capacity anodes while suffering from sluggish reaction kinetics and low electrochemical utilization of redox-active ***,integrating carbon nanotubes(CnTs)with imine-linked covalent organic frameworks(COFs)was rationally executed by in-situ Schiff-base condensation between 1,1′-biphenyl]-3,3′,5,5′-tetracarbaldehyde and 1,4-diaminobenzene in the presence of CnTs to produce core–shell heterostructured composites(CnT@COF).Accordingly,the redox-active shell of COF nanoparticles around one-dimensional conductive CnTs synergistically creates robust three-dimensional hybrid architectures with high specific surface area,thus promoting electron transport and affording abundant active functional groups accessible for electrochemical utilization throughout the whole ***,upon the full activation with a superlithiation process,the as-fabricated CnT@COF anode achieves a specific capacity of 2324 mAh g^(−1),which is the highest specific capacity among organic electrode materials reported so ***,the superior rate capability and excellent cycling stability are also *** redox reaction mech.nisms for the COF moiety were further revealed by Fourier-transform infrared spectroscopy in conjunction with X-ray photoelectron spectroscopy,involving the reversible redox reactions between lithium ions and C=n groups and gradual electrochemical activation of the unsaturated C=C bonds within COFs.

关键词： heterostructured anode core-shell nanostructures carbon nanotubes polymeric Schiff-bases covalent organic frameworks

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ch.nese Medicine Prolongs Overall Survival of ch.nese Patients with Advanced Gastric Cancer: Treatment Pattern and Survival Analysis of a 20-Year Real-World Study

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ch.nese Journal of Integrative Medicine 2024年第6期30卷 489-498页

作者： CAO ni-da ZHU Xiao-hong MA Fang-qi XU Yan DOnG Jia-huan QIn Meng-meng LIU Tian-shu ZHU ch.n-chao GUO Wei-jian DInG Hong-hua GUO Yuan-biao LIU Li-kun SOnG jin-jie WU Ji-ping ch.nG Yue-lei ZEnG Lin ZHAO Ai-guang Oncology Department I Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai200032China Oncology Department Zhongshan HospitalFudan UniversityShanghai200032China Gastrointestinal Surgery Department Renji HospitalShanghai Jiaotong University School of MedicineShanghai200127China Oncology Department Fudan University Shanghai Cancer CenterShanghai200032China Oncology Department Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai200080China Traditional ch.nese Medicine Department Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai200025China Oncology Department Shanxi Traditional Chinese Medicine HospitalTaiyuan030012China Oncology Department Xiyuan HospitalChina Academy of Chinese Medical ScienceBeijing102445China Oncology Department Yunnan Province Hospital of Traditional Chinese MedicineKunming650021China Oncology Department Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai201203China Shanghai newCore Biotechnology Co. Ltd.Shanghai200240China

Objective To describe the treatment patterns and survival status of advanced gastric cancer(AGC)in ch.na in the past two decades,and objectively evaluate the impact of standardized ch.nese medicine(CM)treatment on the survival of AGC *** This multicenter registry designed and propensity score analysis study described the diagnosis characteristics,treatment-pattern development and survival status of AGC from 10 hospitals in ch.na between January 1,2000 and July 31,*** survival(OS)was evaluated between non-CM cohort(standard medical treatment)and CM cohort(integrated standard CM treatment≥3 months).Propensity score match.ng(PSM)and inverse probability of treatment weighting(IPTW)were performed to adjust any difference in average outcomes for *** A total of 2,001 patients histologically confirmed locally advanced and/or metastasis stomach and gastroesophageal junction adenocarcinoma were *** them,1,607 received systemic chemotherapy,215(10.74%)accepted molecular targeted therapy,44(2.2%)received checkpoint inhibitor therapy,and 769(38.43%)received ***-drug regimen was the main choice for first-line treatment,with fluoropyrimidine plus platinum as the most common regimen(530 cases,60.09%).While 45.71%(16 cases)of patients with HER2 amplification received trastuzumab in *** application of apatinib increased(33.33%)in *** application of checkpoint inhibitors has increased since *** analysis showed that Lauren mixed type(P=0.017),cycles of first-line treatment>6(P=0.000),CM(P=0.000),palliative gastrectomy(P=0.000),trastuzumab(P=0.011),and apatinib(P=0.008)were independent prognostic factors for the OS of *** PSM and IPTW,the median OS of CM cohort and non-CM cohort was 18.17 and 12.45 months,respectively(Pnclusions In real-world practice for AGC in ch.na,therapy choices consisted with ***-drug regimen was the main first-line *** CM treatment was an independent

关键词： advancedgastriccancer real-world study treatment pattern survival analysis ch.nese medicine

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