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Reverse effect of curcumin on CDDP-induced drug-resistance via Keap1/p62-Nrf2 signaling in A549/CDDP cell

Asian Pacific Journal of Tropical Medicine 2017年第12期10卷 1190-1196页

作者： Jie Shen Ya-Juan chen Yuan-Wei Jia Wen-Ying Zhao guang-hai chen Ding-Feng Liu Yun-Yu chen Chao Zhang Xiao-Ping Liu Anhui Provincial Center for Drug Clinical Evaluation Yijishan HospitalWannan Medical CollegeWuhuAnhui 241001China Pharmacy School Wannan Medical CollegeWuhuAnhui 241002China Department of Clinical Pharmacy Yijishan HospitalWannan Medical CollegeWuhuAnhui 241001China Anhui Provincial Engineering Research Center for Polysaccharides Drugs Wannan Medical CollegeWuhuAnhui 241001China oncology department yijishan hospital wannan medical college

Objective: To assess the effect of curcumin on CDDP-induced drug resistance and explore the underlying molecular mechanism through Nrf2 system and autophagy ***: A drug-resistant cell model was established by exposing A549/CDDP cell to2 μg/mL CDDP. A549/CDDP cell was treated with 20 μg/mL CDDP and 10 μM curcumin. The cell viability and apoptosis level, the signals of Keap1/P62-Nrf2 and autophagy pathway were ***: CDDP induction promoted drug-resistant phenotype in A549/CDDP cell and activated autophagy as well as Nrf2 signals in A549/CDDP cell. Meanwhile, curcumin combination attenuated autophagy and Nrf2 activation induced by CDDP, and reversed the drug-resistant phenotype. Notably, curcumin combination augmented Keap1 transcription. Furthermore, Keap1 ablation with short hairpin RNAs hampered the efficacy of curcumin, suggesting Keap1 played a crucial role on reversal effect of ***: The present findings demonstrate that CDDP promotes abnormal activation of Nrf2 pathway and autophagy, leading to drug resistance of A549/CDDP *** attenuates this process and combat drug-resistance through its potent activation on Keap1 transcription, which is essential for interplay between oxidative stress induced Nrf2 activation and autophagy/apoptosis switch.

关键词： Curcumin Drug-resistance Keap1 Nrf2 Autophagy

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Insight into vertical piezoelectric characteristics regulated thermal transport in van der Waals two-dimensional materials

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Rare Metals 2024年第2期43卷 770-779页

作者： Dong-hai Wei E Zhou Jin-Yuan Xu Hui-Min Wang chen Shen Hong-Bin Zhang Zhen-Zhen Qin guang-Zhao Qin State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha410082China Hunan Key Laboratory for Micro-Nano Energy Materials and Device and School of Physics and Optoelectronics Xiangtan UniversityXiangtan411105China Institute of Materials Science Technical University of DarmstadtAlarich-Weiss-Str.264287DarmstadtGermany School of Physics and Microelectronics Zhengzhou UniversityZhengzhou450001China

The urgent demand of extreme(ultra-high/low)thermal conductivity materials is triggered by the high-power device,where exploring the theories and mechanisms of regulating thermal transport properties plays a key ***,we elaborately investigate the effect of vertical(out-of-plane)piezoelectric characteristics on thermal transport,which is historically *** different stacking-order(AA and AB)bilayer boron nitride(Bi-BN)in two-dimensional(2D)materials are selected as study *** performing state-of-the-art first-principles calculations,it is found that the polarization charge along the out-of-plane orientation ascends significantly with the increasing piezoelectric response in AB stacked Bi-BN(Bi-BN-AB)followed by the enhanced interlayer B–N atomic ***,the amplitude of phonon anharmonicity in Bi-BN-AB increases larger than that in the AA stacked Bi-BN(Bi-BN-AA),resulting in the dramatic weakening of the thermal conductivity by 20.34%under 18%*** research reveals the significant role of the vertical(out-of-plane)piezoelectric characteristic in regulating thermal transport and provides new insight into accurately exploring the thermal transport performance of 2D van der Waals materials.

关键词： Thermal conductivity Piezoelectric effect 2D materials Bilayer BN Strain engineering

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Evaluation of the efficacy and safety of endoscopic band ligation in the treatment of bleeding from mild to moderate gastric varices type 1

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World Journal of Gastroenterology 2024年第5期30卷 440-449页

作者： Yue Deng Ya Jiang Tong Jiang Ling chen hai-Jun Mou Bi-guang Tuo Guo-Qing Shi Department of Gastroenterology Digestive Disease HospitalThe Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Gastroenterology Guizhou Hospital of the First Affiliated HospitalSun Yat-sen UniversityGuiyang 550000Guizhou ProvinceChina Department of Gastroenterology Yinjiang Autonomous County People’s HospitalTongren 554300Guizhou ProvinceChina

BACKGROUND According to practice guidelines,endoscopic band ligation(EBL)and endoscopic tissue adhesive injection(TAI)are recommended for treating bleeding from esophagogastric ***,EBL and TAI are known to cause serious complications,such as hemorrhage from dislodged ligature rings caused by EBL and hemorrhage from operation-related ulcers resulting from ***,the optimal therapy for mild to moderate type 1 gastric variceal hemorrhage(GOV1)has not been ***,the aim of this study was to discover an individualized treatment for mild to moderate *** To compare the efficacy,safety and costs of EBL and TAI for the treatment of mild and moderate *** A clinical analysis of the data retrieved from patients with mild or moderate GOV1 gastric varices who were treated under endoscopy was also *** were allocated to an EBL group or an endoscopic TAI *** differences in the incidence of varicose relief,operative time,operation success rate,mortality rate within 6 wk,rebleeding rate,6-wk operation-related ulcer healing rate,complication rate and average operation cost were compared between the two groups of *** The total effective rate of the two treatments was similar,but the efficacy of EBL(66.7%)was markedly better than that of TAI(39.2%)(P<0.05).The operation success rate in both groups was 100%,and the 6-wk mortality rate in both groups was 0%.The average operative time(26 min)in the EBL group was significantly shorter than that in the TAI group(46 min)(P<0.01).The rate of delayed postoperative rebleeding in the EBL group was significantly lower than that in the TAI group(11.8%vs 45.1%)(P<0.01).At 6 wk after the operation,the healing rate of operation-related ulcers in the EBL group was 80.4%,which was significantly greater than that in the TAI group(35.3%)(P<0.01).The incidence of postoperative complications in the two groups was *** average cost and other related economic factors were g

关键词： Gastric varices Type 1 gastric variceal hemorrhage Endoscopic band ligation Tissue adhesive injection

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Anti-inflammatory and DNA Repair Effects of Astragaloside IV on PC12 Cells Damaged by Lipopolysaccharide

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Current Medical Science 2024年第4期44卷 854-863页

作者： hai-long LI Li-hua SHAO Xi chen Meng WANG Qi-jie QIN Ya-li YANG guang-run ZHANG Yang hai Yi-hong TIAN Department of Geriatrics The Affiliated Hospital of Gansu University of Chinese MedicineLanzhou730000China Key Laboratory for Mining Innovation and Transformation of Traditional Chinese Medicine in Gansu Province and the New Product Creation Engineering Laboratory of Traditional Chinese Medicine in Gansu ProvinceLanzhou730000China Department of Neurology the First People’s Hospital of LanzhouLanzhouGansu730000China School of Public Health Gansu University of Chinese MedicineLanzhou730000China People’s Hospital of Gansu Province Lanzhou730000China Scientific Research and Experimental Center Gansu University of Chinese MedicineLanzhou730000China

Objective This study aimed to establish a neural cell injury model in vitro by stimulating PC12 cells with lipopolysaccharide(LPS)and to examine the effects of astragaloside IV on key targets using high-throughput sequence technology and bioinformatics *** PC12 cells in the logarithmic growth phase were treated with LPS at final concentrations of 0.25,0.5,0.75,1,and 1.25 mg/mL for 24 *** morphology was evaluated,and cell survival rates were calculated.A neurocyte inflammatory model was established with LPS treatment,which reached a 50%cell survival ***12 cells were treated with 0.01,0.1,1,10,or 100µmol/L astragaloside IV for 24 *** concentration of astragaloside IV that did not affect the cell survival rate was selected as the treatment group for subsequent *** activity was detected by colorimetry;the expression levels of ERCC2,XRCC4,XRCC2,TNF-α,IL-1β,TLR4,NOS and COX-2 mRNA and protein were detected by RT-qPCR and Western *** differentially expressed genes(DEGs)between the groups were screened using a second-generation sequence(fold change>2,P0.05).However,after treatment with 0.5,0.75,1,or 1.25 mg/mL LPS for 24 h,the viability steadily decreased(P<0.01).The mRNA and protein expression levels of ERCC2,XRCC4,XRCC2,TNF-α,IL-1β,TLR4,NOS,and COX-2 were significantly increased after PC12 cells were treated with 1 mg/mL LPS for 24 h(P<0.01);however,these changes were reversed when PC12 cells were pretreated with 0.01,0.1,or 1µmol/L astragaloside IV in PC12 cells and then treated with 1 mg/mL LPS for 24 h(P<0.05).Second-generation sequencing revealed that 1026 genes were upregulated,while 1287 genes were downregulat

关键词： PC12 cells astragaloside IV inflammation DNA damage

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Optimizing mechanical properties of HIPS fabricated with low-cost desktop 3D printers:investigating the impact of process parameters

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Advances in Manufacturing 2024年第2期12卷 379-395页

作者： Jin-Ting Xu guang-Wei Zhang Man-Man chen School of Automotive Engineering Dalian University of TechnologyDalian116024People’s Republic of China

Recently,low-cost desktop three-dimensional(3D)printers,employing the fused deposition modeling(FDM)technique,have gained widespread ***,most users cannot test the strength of printed parts,and little information is available about the mechanical properties of printed high-impact polystyrene(HIPS)parts using desktop 3D *** this study,the user-adjustable parameters of desktop 3D printers,such as crisscross raster orientation,layer thickness,and infill density,were *** experimental plans were designed using the Box-Behnken method,and tensile,3-point bending,and compression tests were carried out to determine the mechanical responses of the printed *** prediction models of the process parameters were regressed to produce the optimal combination of process *** experimental results showcase that the crisscross raster orientation has significant effects on the flexural and compression strengths,but not on the tensile *** an increase in the layer thickness,the tensile,flexural,and compression strengths first decreased and then increased,reaching their minimum values at approximately 0.16 mm layer *** addition,they all increased with an increase of infill *** was demonstrated that when the raster orientation,layer thickness,and infill density were 13.08°/–76.92°,0.09 mm,and 80%,respectively,the comprehensive mechanical properties of the printed HIPS were *** results can help end-users of desktop 3D printers understand the effects of process parameters on the mechanical properties,and offer practical suggestions for setting proper printing parameters for fabricating HIPS parts.

关键词： Desktop three-dimensional(3D)printers Fused deposition modeling(FDM) High-impact polystyrene(HIPS) Process parameters

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Interaction mechanism between BaZrO_(3)/Y_(2)O_(3) refractory and Ti_(2)Ni alloy melts

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Journal of Iron and Steel Research International 2024年第6期31卷 1376-1388页

作者： Xiao Hou guang-yao chen Jian Liu Ming-rui Lv Fei-hai Yu Qi-sheng Feng Rong-bin Li Xiong-gang Lu Chong-he Li State Key Laboratory of Advanced Special Steel and Shanghai Key Laboratory of Advanced Ferromeallurgy and School of Materials Science and Engineering Shanghai UniversityShanghai 200072China Shanghai Special Casting Engineering Technology Research Center Shanghai 201605China Zhejiang Institute of Advanced Materials Shanghai UniversityJiashan 314100ZhejiangChina School of Materials Science and Engineering Shanghai DianJi UniversityShanghai 201306China

The titanium alloys with highly chemical activity require stable crucible refractories that can withstand the erosion of alloy *** phase composition and microstructure are crucial factors that affect the stability of the refractory *** effect of Y_(2)O_(3) on the composition and microstructure of BaZrO_(3) crucible was systematically investigated,and the improved mechanism of the stability of BaZrO_(3)/Y_(2)O_(3) crucible was clarified in comparison with the BaZrO_(3) *** results showed that the erosion layer thickness of the BaZrO_(3)/Y_(2)O_(3) crucible was only 63μm,which was far less than that in the BaZrO_(3) crucible(485μm),and the erosion layer in the BaZrO_(3)/Y_(2)O_(3) crucible also exhibited a higher density than that in the BaZrO_(3) *** the sintering,Y_(2)O_(3) could improve the densification of the BaZrO_(3) crucible due to the solid solution effect between Y_(2)O_(3) and ZrO_(2),which also caused the evaporation of BaO,resulting in the generation of a Y_(2)O_(3)(ZrO_(2))film on the surface of the ***,the Y_(2)O_(3)(ZrO_(2))had higher thermodynamic stability than Y_(2)O_(3),confirming that the BaZrO_(3)/Y_(2)O_(3) crucible with high density exhibited a superior erosion resistance to titanium *** dual-phase structure provides a strategy to design a long-life and stable refractory for melting titanium alloys.

关键词： Barium zirconate Yttrium oxide Dual-phase refractory Titanium alloy Interaction

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State estimation for delayed switched positive systems: delayed radius approach

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Science China(Information Sciences) 2024年第8期67卷 190-205页

作者： Weizhong chen Zhongyang FEI Xudong ZHAO Zheng-guang WU School of Electronics and Information Xi'an Polytechnic University Research Institute of Intelligent Control and Systems Harbin Institute of Technology Key Laboratory of Intelligent Control and Optimization for Industrial Equipment of Ministry of Education Dalian University of Technology School of Control Science and Engineering Dalian University of Technology State Key Laboratory of Industrial Control Technology Institute of Cyber-Systems and ControlZhejiang University

In this paper, an interval estimation scheme is developed for delayed switched positive systems（DSPS） with mode-dependent average dwell time switching. A lossless zonotopic estimation approach is proposed for the delayed intersection zonotope with the positive generator matrix. First, considering the existence of asynchronism between the system mode and the correction matrix mode, the mismatched intersection zonotope is constructed for DSPS to verify the consistency between the system model and ***, by utilizing the introduced radius definitions, the ?∞performance is addressed to optimize the size of delayed intersection zonotopes. Subsequently, we present a joint-design approach of switching signals and the mode-dependent correction matrix by constructing positive generator matrix-based delayed radius functions. Furthermore, guaranteed nonnegative state bounds are derived for the considered DSPS based on the proposed lossless zonotopic estimation criteria. Finally, detailed simulations are conducted to validate the feasibility and superiority of the developed methods.

关键词： delayed switched positive systems interval estimation asynchronous correction matrix zonotopes mode-dependent average dwell time

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Development and validation of a nomogram to predict allograft survival after pediatric liver transplantation

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World Journal of Pediatrics 2024年第3期20卷 239-249页

作者： guang-Xiang Gu Shu-Ting Pan Yi-chen Fan chen chen Qiang Xia Department of Liver Surgery Renji HospitalShanghai Jiaotong University School of MedicineNo.160 Pujian RoadPudong New DistrictShanghai 200128China Department of Liver Transplantation Sun Yet-Sen Memorial HospitalSun Yat-Sen UniversityNo.107 Yanjiang West RoadGuangzhou 510080China Clinical Center for Investigation Renji HospitalShanghai Jiaotong University School of MedicineShanghaiChina Department of Anesthesiology Renji HospitalShanghai Jiaotong University School of MedicineShanghaiChina

Background Liver transplantation is the main treatment for cholestatic liver disease and some metabolic liver diseases in ***,no accurate prediction model to determine the survival probability of grafts prior to surgery *** study aimed to develop an effective prognostic model for allograft survival after pediatric liver *** This retrospective cohort study included 2032 patients who underwent pediatric liver transplantation between January 1,2006,and January 1,2020.A nomogram was developed using Cox regression and validated based on bootstrap *** and discriminatory accuracies were determined using the concordance index and visualized using calibration curves;net benefits were calculated for model *** online Shiny application was developed for easy access to the *** Multivariable analysis demonstrated that preoperative diagnosis,recipient age,body weight,graft type,preoperative total bilirubin,interleukin-1β,portal venous blood flow direction,spleen thickness,and the presence of heart disease and cholangitis were independent factors for survival,all of which were selected in the *** of the nomogram indicated that the 1-,3-,and 5-year predicted survival rates agreed with the actual survival *** concordance indices for graft survival at 1,3,and 5 years were 0.776,0.757,and 0.753,respectively,which were significantly higher than those of the Pediatric End-Stage Liver Disease and Child-Pugh scoring *** allograft dysfunction risk of a recipient could be easily predicted using the following URL:https://***/ASPELT/l Conclusion The allograft survival after pediatric liver transplantation(ASPELT)score model can effectively predict the graft survival rate after liver transplantation in children,providing a simple and convenient evaluation method for clinicians and patients.

关键词： Allograft survival Nomogram Pediatric liver transplantation

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Capturing carbon dioxide from air by using amine-functionalized metal-organic frameworks

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Chinese Journal of Structural Chemistry 2024年第5期43卷 3-4页

作者： Jian Yang guang Yang Zhijie chen Stoddart Institute of Molecular Science Department of ChemistryState Key Laboratory of Silicon and Advanced Semiconductor MaterialsZhejiang UniversityHangzhou310058PR China Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials ZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang UniversityHangzhou311215PR China

Along with the rapid rise of industry and technology,carbon dioxide(CO_(2))is released as a major by-product of fossil fuels *** continuous CO_(2)emission results in a steep increase of atmospheric CO_(2)concentrations and precipitated severe environmental and climatic ***,it is of great importance to reduce CO_(2)emission and atmospheric CO_(2)*** CO_(2)directly from air is one of the most straightforward strategies to mitigate atmospheric CO_(2)concentrations[1].

关键词： dioxide straight carbon

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Jianpi Qinghua Formula Alleviates Diabetic Myocardial Injury Through Inhibiting JunB/c-Fos Expression

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Current Medical Science 2024年第1期44卷 144-155页

作者： Lin WANG Qing-guang chen Hao LU Department of Endocrinology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China

Objective Diabetic cardiomyopathy(DCM)represents a substantial risk factor for heart failure and increased mortality in individuals afflicted with diabetes mellitus(DM).DCM typically manifests as myocardial fibrosis,myocardial hypertrophy,and impaired left ventricular diastolic *** the clinical utility of the Jianpi Qinghua(JPQH)formula has been established in treating diabetes and insulin resistance,its potential efficacy in alleviating diabetic cardiomyopathy remains *** study aims to investigate the impact and underlying molecular mechanisms of the JPQH formula(JPQHF)in ameliorating myocardial injury in nonobese diabetic rats,specifically focusing on apoptosis and *** Wistar rats were assigned as the normal control group(CON),while Goto-Kakizaki(GK)rats were randomly divided into three groups:DM,DM treated with the JPQHF,and DM treated with metformin(MET).Following a 4-week treatment regimen,various biochemical markers related to glucose metabolism,cardiac function,cardiac morphology,and myocardial ultrastructure in GK rats were *** sequencing was utilized to analyze differential gene expression and identify potential therapeutic *** vitro experiments involved high glucose to induce apoptosis and inflammation in H9c2 *** viability was evaluated using CCK-8 assay,apoptosis was monitored via flow cytometry,and the production of inflammatory cytokines was measured using quantitative real-time PCR(qPCR)and *** expression levels were determined by Western blotting *** investigation also incorporated the use of MAPK inhibitors to further elucidate the mechanism at both the transcriptional and protein *** The JPQHF group exhibited significant reductions in interventricular septal thickness at end-systole(IVSs)and left ventricular internal diameter at end-systole and end-diastole(LVIDs and LVIDd).JPQHF effectively suppressed high glucose-induced activation of IL-1βand caspase 3 in

关键词： Jianpi Qinghua formula diabetic cardiomyopathy AP-1 transcription factor apoptosis inflammation

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