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Simultaneous observation of quantum contextuality and quantum nonlocality

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Science Bulletin 2018年第17期63卷 1092-1095页

作者： Xiao-Min Hu Bi-Heng Liu Jiang-Shan Chen Yu guo Yu-Chun Wu Yun-Feng Huang Chuan-Feng Li guang-can guo CAS Key Laboratory of Quantum Information University of science and Technology of China Hefei 230026 China

Quantum nonlocality and quantum contextuality are the most curious properties that change our understanding of nature, and were observed independently in recent decades. One important question is whether both properties can be observed simultaneously. In this paper, we show that in a qutrit-qutrit system we can observe quantum nonlocality and quantum contextuality at the same time. From the perspective of quantum information, our experiment proves in principle that the two resources, quantum nonlocality and quantum contextuality, can be utilized simultaneously.

关键词：量子非局域性理论研究物理学

High resolution imaging with anomalous saturated excitation

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Photonics Research 2021年第1期9卷 21-26页

作者： BO DU XIANG-DONG CHEN ZE-HAO WANG SHAO-CHUN ZHANG EN-HUI WANG guang-can guo FANG-WEN SUN CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China

The nonlinear fluorescence emission has been widely applied for high spatial resolution optical ***,we studied the fluorescence anomalous saturating effect of the nitrogen vacancy defect in *** fluorescence reduction was observed with high power laser *** increased the nonlinearity of the fluorescence emission,and changed the spatial frequency distribution of the fluorescence *** used a differential excitation protocol to extract the high spatial frequency *** modulating the excitation laser’s power,the spatial resolution of imaging was improved approximately 1.6 times in comparison with the confocal *** to the simplicity of the experimental setup and data processing,we expect this method can be used for improving the spatial resolution of sensing and biological labeling with the defects in solids.

关键词： excitation resolution anomalous

The molecular genetics of PI3K/PTEN/AKT/mTOR pathway in the malformations of cortical development

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Genes & Diseases 2024年第5期11卷 252-271页

作者： Qing Ma guang Chen Ying Li Zhenming guo Xue Zhang NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics Harbin Medical UniversityHarbinHeilongjiang 150000China Department of Urology The Fourth Hospital of Harbin Medical UniversityHarbinHeilongjiang 150000China Department of Child and Adolescent Health School of Public HealthHarbin Medical UniversityHarbinHeilongjiang 150000China Institute for Regenerative Medicine Shanghai East HospitalFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200120China

Malformations of cortical development(MCD)are a group of developmental disorders characterized by abnormal cortical structures caused by genetic or harmful environmental *** kinds of MCD are caused by genetic *** is the common cause of intellectual disability and intractable *** rapid advances in imaging and sequencing technologies,the diagnostic rate of MCD has been increasing,and many potential genes causing MCD have been successively ***,the high genetic heterogeneity of MCD makes it challenging to understand the molecular pathogenesis of MCD and to identify effective targeted ***,in this review,we outline important events of cortical *** we illustrate the progress of molecular genetic studies about MCD focusing on the PI3K/PTEN/AKT/mTOR ***,we briefly discuss the diagnostic methods,disease models,and therapeutic strategies for *** information will facilitate further research on *** the role of the PI3K/PTEN/AKT/mTOR pathway in MCD could lead to a novel strategy for treating MCD-related diseases.

关键词： Epilepsy Gene mutation Genetics Malformations of cortical development PI3K/PTEN/AKT/mTOR pathway

Pure quantum gradient descent algorithm and full quantum variational eigensolver

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Frontiers of physics 2024年第2期19卷 221-234页

作者： Ronghang Chen Zhou guang Cong guo Guanru Feng Shi-Yao Hou College of Physics and Electronic Engineering Center for Computational SciencesSichuan Normal UniversityChengdu 610068China Shenzhen SpinQ Technology Co. Ltd.Shenzhen 518045China DEEPROUTE.AI

Optimization problems are prevalent in various fields,and the gradient-based gradient descent algorithm is a widely adopted optimization ***,in classical computing,computing the numerical gradient for a function with variables necessitates at least d+1 function evaluations,resulting in a computational complexity of O(d).As the number of variables increases,the classical gradient estimation methods require substantial resources,ultimately surpassing the capabilities of classical ***,leveraging the principles of superposition and entanglement in quantum mechanics,quantum computers can achieve genuine parallel computing,leading to exponential acceleration over classical algorithms in some *** this paper,we propose a novel quantum-based gradient calculation method that requires only a single oracle calculation to obtain the numerical gradient result for a multivariate *** complexity of this algorithm is just O(1).Building upon this approach,we successfully implemented the quantum gradient descent algorithm and applied it to the variational quantum eigensolver(VQE),creating a pure quantum variational optimization *** with classical gradient-based optimization algorithm,this quantum optimization algorithm has remarkable complexity advantages,providing an efficient solution to optimization *** proposed quantum-based method shows promise in enhancing the performance of optimization algorithms,highlighting the potential of quantum computing in this field.

关键词： quantum algorithm gradient descent variational quantum algorithm

Observation of high-Q optomechanical modes in the mounted silica microspheres

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Photonics Research 2015年第5期3卷 243-247页

作者： Zhen Shen Zhong-Hao Zhou Chang-Ling Zou Fang-Wen Sun guo-Ping guo Chun-Hua Dong guang-can guo Key Laboratory of Quantum Information Chinese Academy of SciencesUniversity of Science and Technology of ChinaHefei 230026China Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of ChinaHefeiAnhui 230026China

An efficient method to mount a coupled silica microsphere and tapered fiber system is proposed and demonstrated experimentally. For the purpose of optomechanical studies, high-quality-factor optical(Q_o～ 10~8) and mechanical modes(Q_m～ 0.87 × 10~4) are maintained after the mounting process. For the mounted microsphere, the coupling system is more stable and compact and, thus, is beneficial for future studies and applications based on optomechanical interactions. Especially, the packaged optomechanical system, which is tested in a vacuum chamber,paves the way toward quantum optomechanics research in cryostat.

关键词： mode rate Observation of high-Q optomechanical modes in the mounted silica microspheres high

Fabrication of the high-Q Si_(3)N_(4) microresonators for soliton microcombs

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Chinese Optics Letters 2022年第3期20卷 111-116页

作者：万帅牛睿彭金兰李锦郭光灿邹长铃董春华 CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center For Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Center for Micro and Nanoscale Research and Fabrication University of Science and Technology of ChinaChinese Academy of SciencesHefei 230026China

The microresonator-based soliton microcomb has shown a promising future in many *** this work,we report the fabrication of high quality[Q]Si_(3)N_(4)microring resonators for soliton microcomb *** developing the fabri-cation process with crack isolation trenches and annealing,we can deposit thick stoichiometric Si3N4 film of 800 nm without cracks in the central *** highest intrinsic Q of the Si_(3)N_(4)microring obtained in our experiments is about 6×10^(6),corresponding to a propagation loss as low as 0.058 dBm/*** such a high Q film,we fabricate microrings with the anomalous dispersion and demonstrate the generation of soliton microcombs with 100 mW on-chip pump power,with an optical parametric oscillation threshold of only 13.4 *** Si_(3)N_(4)integrated chip provides an ideal platform for researches and applications of nonlinear photonics and integrated photonics.

关键词： silicon nitride microresonator optical frequency comb dissipative Kerr soliton

Generation of multiphoton quantum states on silicon

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Light(Science & Applications) 2019年第1期8卷 811-817页

作者： Ming Zhang Lan-Tian Feng Zhi-Yuan Zhou Yang Chen Hao Wu Ming Li Shi-Ming Gao guo-Ping guo guang-can guo Dao-Xin Dai Xi-Feng Ren State Key Laboratory for Modern Optical Instrumentation Centre for Optical and Electromagnetic ResearchZhejiang Provincial Key Laboratory for Sensing TechnologiesCollege of Optical Science and EngineeringZhejiang UniversityZijingang CampusHangzhou 310058China Ningbo Research Institute Zhejiang UniversityNingbo 315100China Key Laboratory of Quantum Information CASUniversity of Science and Technology of ChinaHefeiAnhui 230026China Synergetic Innovation Center of Quantum Information&Quantum Physics University of Science and Technology of ChinaHefeiAnhui 230026China

Multiphoton quantum states play a critical role in emerging quantum technologies and greatly improve our fundamental understanding of the quantum *** photonics is well recognized as an attractive technology offering great promise for the generation of photonic quantum states with high-brightness,tunability,stability,and ***,we demonstrate the generation of multiphoton quantum states using a single-silicon nanophotonic *** detected four-photon rate reaches 0.34 Hz even with a low-pump power of 600μ*** multiphoton quantum state is also qualified with multiphoton quantum interference,as well as quantum state *** the generated four-photon states,the quantum interference visibilities are greater than 95%,and the fidelity is 0.78±***,such a multiphoton quantum source is fully compatible with the on-chip processes of quantum manipulation,as well as quantum detection,which is helpful for the realization of large-scale quantum photonic integrated circuits(QPICs)and shows great potential for research in the area of multiphoton quantum science.

关键词： quantum multiphoton realization

The E3 ubiquitin ligase TRAF6 controls CTLA-4 turnover and promotes T-cell-mediated antitumor immunity

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Cellular & Molecular Immunology 2024年第1期21卷 97-99页

作者： Xiao-Liang Jie Hua guo guang-Biao Zhou State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College100021 BejingChina

Yu et al.[1]reported that the tumor necrosis factor(TNF)receptor OX40(CD134)-TNF receptor-associated factor 6(TRAF6)axis mediates Lys63-linked ubiquitination and subsequent lysosomal degradation of cytotoxic T-lymphocyte antigen 4(CTLA-4),leading to the enhancement of CD8^(+)T-cell-mediated antitumor *** findings unveil a previously unknown mechanism in controlling the stability of the immune checkpoint CTLA-4 and provide a potential therapeutic target for the improvement of Tcell-based immunotherapy.

关键词： immunity OX40 ubiquitin

Correlation between longitudinal crack occurrence and mold heat transfer in continuous casting based on process data mining

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Journal of Iron and Steel Research(International) 2024年第5期31卷 1139-1152页

作者： Zhi-qiang Peng Zi-bing Hou Kai Yi Kun-hui guo Dong-wei guo guang-hua Wen College of Materials Science and Engineering Chongqing UniversityChongqing400044China Chongqing Key Laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing400044China

The correlation between the longitudinal crack occurrence and integrated heat transfer of the mold with data mining methods was ***,three kinds of support vector machine models based on principal component analysis with different input features were established to explore the effect of integrated heat transfer on the accuracy of the prediction model for the longitudinal *** results show that the accuracy was improved while features including mean and standard deviation of integrated heat transfer were ***,the difference in integrated heat transfer between defect and normal samples under the same process parameters was quantitatively *** with normal samples,the temperature difference of cooling water for defect samples decreased by 0.65%,and the temperature difference fluctuation increased by 31.1%.Finally,the literature data were used to provide support for the quantitative correlation according to defect formation mechanism.A new criterion for the prediction of longitudinal crack and a discovering method for correlation between product quality and process parameters in the manufacturing industry have been provided.

关键词： Continuous casting slab Longitudinal surface crack Heat transfer Data mining Quantitative correlation