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Clinical effect of acupuncture at ghost points combined with fluoxetine hydrochloride on mild-to-moderate depression

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World Journal of Psychiatry 2024年第6期14卷 848-856页

作者： Yi Wang Qun Lu Ittipalanukul Penpat Juan Wu Dilinuer Abulikemu Fei-Cui zeng Jia-Ying Huang zhi-Hai Hu Department of Acupuncture and Moxibustion Shanghai Hospital of Integrated Traditional Chinese and Western MedicineThe Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200082China Department of Laboratory Medicine Shanghai Hospital of Integrated Traditional Chinese and Western MedicineThe Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200082China Department of Postgraduate Student Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Radiology Shanghai Hospital of Integrated Traditional Chinese and Western MedicineThe Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200082China Department of General Practice Shanghai University of Traditional Chinese Medicine Affiliated Shuguang HospitalShanghai 200120China General Practice of Traditional Chinese Medicine North Bund Street Community Health Service CenterShanghai 200080China General Practice of Traditional Chinese Medicine Shanghai Hongkou District Jiaxing Road Community Health Service CenterShanghai 200082China

BACKGROUND Depression is a common,chronic,and recurrent mood disorder that has become a worldwide health *** hydrochloride,a common treatment method,can inhibit 5-hydroxytryptamine(5-HT)recycling in the presynaptic membrane;however,the efficacy of a single drug is *** present,mildto-moderate depression can be treated with acupuncture of ghost caves,but the clinical curative effect of combined therapy with fluoxetine hydrochloride has not been sufficiently *** To evaluate the clinical effect of acupuncture at ghost points combined with fluoxetine hydrochloride in the treatment of mild-to-moderate *** This retrospective study included 160 patients with mild-to-moderate depression who were admitted to Shanghai Hospital of Integrated Traditional Chinese and Western Medicine,Affiliated to Shanghai University of Traditional Chinese Medicine,between January 2022 and June *** were separated into a single-agent group(fluoxetine hydrochloride treatment,n=80)and a coalition group(fluoxetine hydrochloride treatment combined with acupuncture at ghost points,n=80).Pre-treatment symptoms were recorded,and the clinical curative effect and adverse reactions[Asberg Antidepressant Side Effects Scale(SERS)]were *** before and after treatment[Hamilton Depression Scale(HAMD)-24],neurotransmitter levels[5-HT,norepinephrine(NE),dopamine(DA)],oxidative stress indicators[superoxide dismutase(SOD),malondialdehyde(MDA)],and sleep quality[Pittsburgh Sleep Quality Index(PSQI)]were *** The total efficacy rate was 97.50%in the coalition group and 86.25%in the single-agent group(P<0.05).After 2,4,6,and 8 wk of treatment,the HAMD,self-rating depression scale,and SERS scores of the coalition and single-agent groups decreased compared with pre-treatment,and the decrease was more significant in the coalition group(P<0.05).After 8 wk of treatment,the levels of NE,DA,5-HT,and SOD in the coalition and single-agent group

关键词： Depression Prick Fluoxetine hydrochloride Curative effect Depressive symptoms Oxidative stress index

Curcumin inhibits the growth and invasion of gastric cancer by regulating long noncoding RNA AC022424.2

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1437-1452页

作者： Bin-Sheng Wang Chen-Li Zhang Xiang Cui Qiang Li Lei Yang zhi-Yun He Ze Yang Miao-Miao zeng Nong Cao Department of General Surgery First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina School of Basic Medical Sciences Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Third Department of General Surgery First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Gastric cancer,characterized by a multifactorial etiology and high heterogeneity,continues to confound researchers in terms of its ***,a natural anticancer agent,exhibits therapeutic promise in gastric *** effects include promoting cell apoptosis,curtailing tumor angiogenesis,and enhancing sensitivity to radiation and *** noncoding RNAs(lncRNAs)have garnered significant attention as biomarkers for early screening,diagnosis,treatment,and drug response because of their remarkable specificity and *** investigations have revealed an association between aberrant lncRNA expression and early diagnosis,clinical staging,metastasis,drug sensitivity,and prognosis in gastric cancer.A profound understanding of the intricate mechanisms through which lncRNAs influence gastric cancer develop-ment can provide novel insights for precision treatment and tailored management of patients with gastric *** study aimed to unravel the potential of curcumin in suppressing the malignant behavior of gastric cancer cells by upregu-lating specific lncRNAs and modulating gastric cancer onset and *** To identify lncRNAs associated with curcumin treatment and investigate the role of lncRNA AC022424.2 in the effects of curcumin on gastric cancer cell apoptosis,proliferation,and ***,these findings were validated in clinical *** The study employed CCK-8 assays to assess the impact of curcumin on gastric cancer cell proliferation,flow cytometry to investigate its effects on apoptosis,and scratch and Transwell assays to evaluate its influence on the migration and invasion of BGC-823 and MGC-803 *** blotting was used to gauge changes in the protein expression levels of CDK6,CDK4,Bax,Bcl-2,caspase-3,P65,and the PI3K/Akt/mTOR pathway in gastric cancer cell lines after curcumin *** expression of lncRNAs before and after curcumin treatment was assessed using lncRNA seq

关键词： Gastric cancer Curcumin Long noncoding RNA AC022424.2 Apoptosis Akt/PI3K pathway Lymph metastasis

Highly efficient 1D p-Te/2D n-Bi_(2)Te_(3) heterojunction self-driven broadband photodetector

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Nano Research 2024年第3期17卷 1864-1874页

作者： Chenchen Zhao Dongbo Wang Jiamu Cao zhi zeng Bingke Zhang Jingwen Pan Donghao Liu Sihang Liu Shujie Jiao Tianyuan Chen Gang Liu Xuan Fang Liancheng Zhao Jinzhong Wang School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China School of Astronautics Harbin Institute of TechnologyHarbin 150001China Center for High Pressure Science and Technology Advanced Research Shanghai 201203China State Key Laboratory of High Power Semiconductor Lasers Changchun University of Science and TechnologyChangchun 130022China

Broadband photodetectors with self-driven functions have attracted intensive scientific interest due to their low energy consumption and high optical ***,high-performance broadband self-driven photodetectors are still a significant challenge due to the complex fabrication processes,environmental toxicity,high production costs of traditional 3D semiconductor materials and sharply raised contact resistance,severe interfacial recombination of 2D materials and 2D/3D mixed dimension ***,1D p-Te/2D n-Bi_(2)Te_(3) heterojunctions are constructed by the simple and low-cost hydrothermal method.1D p-Te/2D n-Bi_(2)Te_(3) devices are applied in photoelectrochemical(PEC)photodetectors,with their high performance attributed to the good interfacial contacts reducing interface *** device demonstrated a broad wavelength range(365–850 nm)with an Iph/Idark as high as *** R_(i),D^(*),and external quantum efficiency(EQE)values of the device were as high as 12.07 mA/W,5.87×10^(10) Jones,and 41.05%,respectively,which were significantly better than the performance of the prepared Bi_(2)Te_(3) and Te devices.A comparison of the freshly fabricated device and the device after 30 days showed that 1D p-Te/2D n-Bi_(2)Te_(3) had excellent stability with only 18.08%decay of *** is anticipated that this work will provide new emerging material for future design and preparation of a high-performance self-driven broadband photodetector.

关键词： topological insulating states interfacial recombination self-driven 1D p-Te/2D n-Bi_(2)Te_(3) photodetector

Advancing China’s Disease Control and Prevention System: A Strategic Roadmap for High-Quality Development

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China CDC weekly 2024年第38期6卷 975-978页

作者： zhi zeng Hao Chen Qingfeng Chen Yuan Wang Lieyu Huang Chengyu Lai Kaixuan Liu Haotian Pan Ying Cui Office of Policy and Planning Research Chinese Center for Disease Control and Prevention&Chinese Academy of Preventive MedicineBeijingChina

China’s Disease Control and Prevention(DCP)system has played a critical role in protecting population health and ensuring socioeconomic stability(1).Over the past two decades,China has made significant advancements in disease surveillance,response,and control,particularly following the 2003 severe acute respiratory syndrome(SARS)outbreak and the 2009 national healthcare reforms(2–3).These initiatives have substantially strengthened the national DCP system and led to improved public health outcomes,including the effective control of outbreaks such as avian influenza and coronavirus disease 2019(COVID-19).Consequently,the incidence of major epidemics has declined markedly(1).

关键词： strengthened Quality Strategic

Preface:Development and utilization of pumped storage in closed/abandoned mines

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Journal of Central South University 2024年第8期31卷 2545-2548页

作者： WEN zhi-jie JIANG Yu-jing ZHAO guang-ming LI Li-ping PU Hai YANG Sheng-li Mining College Guizhou UniversityGuiyang 550025China Graduate School of Engineering Nagasaki UniversityNagasaki 852-8521Japan School of Safety Science and Engineering Anhui University of Science and TechnologyHuainan 232001China School of Qilu Transportation Shandong UniversityJi’nan 250002China State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China School of Energy and Mining China University of Mining and Technology-BeijingBeijing 100083China

China has embarked on an extensive and sustained endeavor to harness its coal resources for a substantial ***,the depletion of coal reserves in mining regions has necessitated the closure or abandonment of numerous mines,resulting in a marked increase in the number of such *** to this,China is vigorously advancing the development of a novel energy power system,aimed at transitioning the power sector from a high-carbon,fossil fuel-dependent paradigm to a low-carbon,clean energy footing.

关键词： pumped sustained closure

Experimental Study on Hydrodynamic Load Characteristics for A Typical Cross-Section of A Submerged Floating Tunnel

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China Ocean Engineering 2024年第05期38卷 893-903页

作者： ZHANG Hong-qian YANG zhi-wen LI Shao-wu YUAN Chun-guang ZHANG Hua-qing National Engineering Research Center for Port Hydraulic Construction Technology Tianjin University National Engineering Research Center for Port Hydraulic Construction Technology Tianjin Research Institute for Water Transport EngineeringM.O.T.

The typical cross-sectional form of a submerged floating tunnel plays a significant role in the dynamic response of the tunnel itself,which directly affects the overall *** this work,a series of experiments involving wave action on a submerged floating tube cross section is reported to study its hydrodynamic load *** typical cross section tube cylinders,circular and rectangular,are *** are carried out in a wave flume with waves of relatively low Keulegan-Carpenter（KC） *** relative depths of submergence of 0,0.25 and 0.5are *** measured wave forces in regular waves are used to analyze the horizontal force,vertical force and torque,and then the drag coefficient（Cd） and inertia coefficient（Cm） are *** results show that the drag coefficients at low KC numbers are large and decrease sharply with increasing KC *** inertial coefficient Cmvalues in the vertical direction are about 70% larger than those in the horizontal *** an increase in aspect ratio（the ratio of the height to width of the structure）,the ratio of inertia coefficient in the horizontal direction to that in the vertical direction increases *** inertia force coefficient is very sensitive to the submerged water depth and aspect *** existing results may overestimate the actual force value.

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BET inhibitors potentiate melanoma ferroptosis and immunotherapy through AKR1C2 inhibition

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Military Medical Research 2024年第4期11卷 620-624页

作者： Yu Meng Hui-Yan Sun Yi He Qian Zhou Yi-Huang Liu Hui Su Ming-Zhu Yin Fu-Rong zeng Xiang Chen guang-Tong Deng Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology Changsha 410008China Furong Laboratory Changsha 410008China Hunan Key Laboratory of Skin Cancer and Psoriasis Hunan Engineering Research Center of Skin Health and DiseaseXiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalChangsha 410008China Department of Breast Reconstruction Tianjin Medical University Cancer Institute and HospitalTianjin 300202China Department of Oncology Xiangya HospitalCentral South UniversityChangsha 410008China

Dear Editor,Ferroptosis,an iron-dependent form of cell death driven by overwhelming lipid peroxidation,represents a vulnerability in cancers,and therapeutic strategies to further potentiate ferroptosis hold great pote... 详细信息

关键词： Melanoma Bromodomain and extra terminal domain(BET)inhibitor Ferroptosis Cell death AKR1C2 Immunotherapy

Observation of Low-Level Jets in the Eastern Tropical Indian Ocean Based on Shipborne Coherent Doppler Lidar

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Journal of Ocean University of China 2024年第5期23卷 1163-1172页

作者： WANG Haiyuan LIU Lin FAN Mengqi YANG Yang YANG guang DUAN Yongliang LIU Baochao SU Qinglei ZHANG Binbin WANG Fengjun SHI Xuliang LI Qiuchi zeng Ai First Institute of Oceanography Ministry of Natural Resources and Laboratory for Regional Oceanography and Numerical ModelingQingdao Marine Science and Technology CenterQingdao 266061China Southern Marine Science and Engineering guangdong Laboratory(Zhuhai) Zhuhai 519082China Key Laboratory of Marine Science and Numerical Modeling Ministry of Natural ResourcesQingdao 266061China Qingdao Leice Transient Technology Co. Ltd.Qingdao 266100China Qingdao Innovation and Development Base of Harbin Engineering University Qingdao 266404China

In contrast to the Pacific and Atlantic Oceans,the Indian Ocean has lacked in-situ observations of wind profiles over open sea areas for *** 2021,a shipborne coherent Doppler lidar(CDL)was used to observe in-situ wind profiles in the eastern tropical Indian *** equipment successfully captured low-level jets(LLJs)in the region,and their characteristics were thoroughly *** reveal that the observed wind speed of LLJs in the eastern Indian Ocean ranges from 6 m s^(-1) to 10 m s^(-1) during the boreal winter and spring seasons,showing a height range of 0.6 to 1 km and two peak times at 0800 and 2000 *** wind shear is weaker than that in land or offshore areas,ranging from 0 s^(-1) to 0.006 s^(-1).Moreover,the accuracy of the CDL data is compared to that of ERA5 data in the study *** results indicate that the zonal wind from ERA5 data significantly deviated from the CDL measurement data,and the overall ERA5 data are substantially weaker than the in-situ ***,ERA5 underestimates northwestward LLJs.

关键词： low-level jets coherent Doppler lidar ERA5 radiosonde eastern Indian Ocean

Laser-rewritable room temperature phosphorescence based on in-situ polymerized tartaric acid

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Science China Chemistry 2024年第9期67卷 3029-3038页

作者： Tuo-Yu Zhou Tai-Wen Li Hai-Fu Zhang Rui-Lin Chai Qian Zhao Penglin Zhang guang-Yue Li Qian-Wen Wang Chang Li Yu Shu zhi Fan Sheng-Hua Li College of Chemical Engineering and Materials Science College of SciencesTianjin University of Science&TechnologyTianjin 300457China College of Chemical Engineering North China University of Science and TechnologyTangshan 063210China Tianjin Key Laboratory of Multiplexed Identification for Port Hazardous Chemicals Tianjin University of Science&TechnologyTianjin 300457China

Organic room temperature phosphorescence(RTP)materials have potential applications in information technology and ***,the precise control of the afterglow in reversible manners remains challenging for organic ***,we report a kind of organic RTP material fabricated by simple heating mixtures of tartaric acid(TA)and aromatic acids,which can switch their phosphorescence by *** mixtures show tunable phosphorescence from indigo to orange with phosphorescence efficiency of up to 53.99% due to locking different organic luminogens by the TA-formed matrix through the noncovalent *** afterglow of those materials lasts a few seconds and disappears by water fumigation,which can be repeated in response to wet/heat *** drop-casting those materials on glass slides,a laser-repatternable phosphorescence is achieved by facile laser direct writing and quenched by water *** results open the opportunity for the design of smart stimuli-responsive phosphorescence materials from sustainable natural products.

关键词： room temperature phosphorescence tunable afterglows tartaric acid laser direct writing stimuli-response