BET inhibitors potentiate melanoma ferroptosis and immunotherapy through AKR1C2 inhibition

作     者：Yu Meng Hui-Yan Sun Yi He Qian Zhou Yi-Huang Liu Hui Su Ming-Zhu Yin Fu-Rong Zeng Xiang Chen Guang-Tong Deng Yu Meng;Hui-Yan Sun;Yi He;Qian Zhou;Yi-Huang Liu;Hui Su;Ming-Zhu Yin;Fu-Rong Zeng;Xiang Chen;Guang-Tong Deng

作者机构：Department of DermatologyXiangya HospitalCentral South UniversityChangsha 410008China National Engineering Research Center of Personalized Diagnostic and Therapeutic TechnologyChangsha 410008China Furong LaboratoryChangsha 410008China Hunan Key Laboratory of Skin Cancer and PsoriasisHunan Engineering Research Center of Skin Health and DiseaseXiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric DisordersXiangya HospitalChangsha 410008China Department of Breast ReconstructionTianjin Medical University Cancer Institute and HospitalTianjin 300202China Department of OncologyXiangya HospitalCentral South UniversityChangsha 410008China 

出 版 物：《Military Medical Research》 (军事医学研究（英文版）)

年 卷 期：2024年第11卷第4期

页      面：620-624页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by grants from the National Natural Science Foundation of China(82103183,82102803,82272849) the Natural Science Foundation of Hunan Province(2022JJ40767,2021JJ40976) the Natural Science Fund for Outstanding Youths in Hunan Province(2023JJ20093) the National Key Research and Development Program(2022YFC2504700) 

主　　题：Melanoma Bromodomain and extra terminal domain(BET)inhibitor Ferroptosis Cell death AKR1C2 Immunotherapy 

摘      要：Dear Editor,Ferroptosis,an iron-dependent form of cell death driven by overwhelming lipid peroxidation,represents a vulnerability in cancers,and therapeutic strategies to further potentiate ferroptosis hold great potential for melanoma treatment.