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TcPO_(2)changes are more pronounced than SpO_(2)changes during simulated altitude changes in a hypobaric oxygen chamber:a nonrandomized controlled trial

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Emergency and Critical Care Medicine 2024年第3期4卷 105-110页

作者： Yang Li Liang Chen Ziyu Fu Zhiwei Wang Shijun Sun Xiaorong luan Dedong Ma Tianliang Hu School of Nursing and Rehabilitation Shandong UniversityJinanShandongChina Department of Emergency and Critical Care Medicine Qilu Hospital of Shandong UniversityJinanShandongChina Department of Pulmonary and Critical Care Medicine Qilu Hospital of Shandong UniversityJinanShandongChina Emergency Management Center of State Grid Shandong Electric Power Company JinanShandongChina School of Nursing and Rehabilitation Cheeloo College of MedicineUniversity of ShandongDepartment of Infection ControlQilu Hospital of Shandong UniversityJinanShandongChina School of Mechanical Engineering Shandong UniversityKey Laboratory of the Ministry of Education for Efficient and Clean Machinery ManufacturingNational Experimental Teaching Demonstration Center for Mechanical EngineeringJinanShandongChina

Background:Hypoxia is a significant risk factor of ***,no studies have used transcutaneous tissue partial pressure of oxygen(TcPO_(2))and partial pressure of carbon dioxide(TcPCO_(2))monitors to measure the respective partial pressures in healthy *** saturation(SpO_(2))is often used for traditional monitoring of vital *** study investigated the changes in TcPO_(2)and SpO_(2)values during rapid changes in *** trial was registered at ***(registration ***06076057).Methods:Healthy adult volunteers were instructed to sit vertically in a hypobaric oxygen chamber,which ascended from 0 m to 2500 m at a uniform speed within 10 *** Danish Radiometer TCM4 was used to measure TcPO_(2)and TcPCO_(2)with the ventral side of the upper arm as the measurement *** Shenzhen Kerokan P0D-1 W pulse oximeter was used to measure heart rate and SpO_(2),with values recorded once every 500 ***:Altogether,49 healthy volunteers were recruited between March 2023 and August *** increasing altitude,TcPO_(2)and SpO_(2)decreased significantly(P500 m,statistical significance was identified between TcPO_(2)in both sexes(P<0.05).Statistical significance in TcPCO_(2)and heart rate was observed at the different elevations(P<0.05).Conclusion:In acutely changing low-pressure hypoxic environments,TcPO_(2)changed more dramatically than SpO_(2).

关键词： Altitude change Low-pressure oxygen chamber Transcutaneous oxygen saturation Transcutaneous partial pressure of oxygen

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Overexpression of the transcription factor MdWRKY115 improves drought and osmotic stress tolerance by directly binding to the MdRD22 promoter in apple

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Horticultural Plant Journal 2024年第3期10卷 629-640页

作者： Qinglong Dong Yi Tian Xuemei Zhang Dingyue Duan He Zhang Kaiyu Yang Peng Jia Haoan luan Suping Guo Guohui Qi Ke Mao Fengwang Ma College of Forestry Hebei Agricultural UniversityBaodingHebei 071001China National Engineering Research Center for Agriculture in Northern Mountainous Areas Agricultural Technology Innovation Center in Mountainous Areas of Hebei ProvinceHebei Agricultural UniversityBaodingHebei 071001China State Key Laboratory of Crop Stress Biology for Arid Areas Shaanxi Key Laboratory of AppleCollege of HorticultureNorthwest A&F UniversityYanglingShaanxi 712100China College of Horticulture Hebei Agricultural UniversityBaodingHebei 071001China

Abiotic stress reduces plant yield and *** transcription factors play key roles in abiotic stress responses in plants,but the molecular mechanisms by which WRKY transcription factors mediate responses to drought and osmotic stresses in apple(Malus×domestica Borkh.)remain ***,we functionally characterized the apple GroupⅢWRKY gene ***-PCR analysis showed that MdWRKY115 expression was up-regulated by drought and osmotic *** activity analysis revealed that the promoter activity of MdWRKY115 was enhanced under osmotic *** localization and transactivation assays indicated that MdWRKY115 was localized to the nucleus and had a transcriptional activity domain at the N-terminal *** analysis revealed that the overexpression of MdWRKY115 in Arabidopsis plants and in apple callus markedly enhanced their tolerance to drought and osmotic *** affinity purification sequencing showed that MdWRKY115 binds to the promoter of the stress-related gene *** binding was further verified by an electrophoretic mobility shift ***,these findings suggest that MdWRKY115 is an important regulator of osmotic and drought stress tolerance in apple.

关键词： Apple MdWRKY115 Osmotic stress Drought stress Function analysis

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Logic-gated tumor-microenvironment nanoamplifier enables targeted delivery of CRISPR/Cas9 for multimodal cancer therapy

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Acta Pharmaceutica Sinica B 2024年第2期14卷 795-807页

作者： Yongchun Pan Xiaowei luan Fei Zeng Xuyuan Wang Shurong Qin Qianglan Lu Guanzhong He Yanfeng Gao Xiaolian Sun Xin Han Bangshun He Yujun Song Department of Laboratory Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006China College of Engineering and Applied Sciences State Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNanjing 210023China State Key Laboratory of Natural Medicines Key Laboratory of Drug Quality Control and PharmacovigilanceDepartment of Pharmaceutical AnalysisChina Pharmaceutical UniversityNanjing 211198China School of Medicine&Holistic Integrative Medicine Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationNanjing University of Chinese MedicineNanjing 210023China

Recent innovations in nanomaterials inspire abundant novel tumor-targeting CRISPR-based gene ***,the therapeutic efficiency of traditional targeted nanotherapeutic strategies is limited by that the biomarkers vary in a spatiotemporal-dependent manner with tumor ***,we propose a self-amplifying logic-gated gene editing strategy for gene/H_(2)O_(2)-mediated/starvation multimodal cancer *** this approach,a hypoxia-degradable covalent-organic framework(COF) is synthesized to coat a-ZIF-8 in which glucose oxidase(GOx) and CRISPR system are *** intensify intracellular redox dyshomeostasis,DNAzymes which can cleave catalase mRNA are loaded as *** the nano system gets into the tumor,the weakly acidic and hypoxic microenvironment degrades the ZIF-8@COF to activate GOx,which amplifies intracellular H^(+)and hypoxia,accelerating the nanocarrier degradation to guarantee available CRISPR plasmid and GOx release in target *** tandem reactions deplete glucose and oxygen,leading to logic-gated-triggered gene editing as well as synergistic gene/H_(2)O_(2)-mediated/starvation ***,this approach highlights the biocomputing-based CRISPR delivery and underscores the great potential of precise cancer therapy.

关键词： CRISPRdelivery Enzymeencapsulation Logic gate Hybridmaterial Hypoxia Gene editing Precise nanomedicine Multimodal therapy

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大数据能力对供应链韧性的影响--供应链整合的中介作用

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现代工业经济和信息化 2024年第5期14卷 184-189页

作者：袁峦中南民族大学管理学院湖北武汉430074

探讨了大数据能力对供应链韧性的影响机制,并同时分析供应链在这一过程中的中介作用。研究结果表明:企业的大数据能力对于供应链的整合与供应链韧性都发挥显著的正向影响;供应链整合在大数据能力影响供应链韧性的过程中发挥部分中介作... 详细信息

探讨了大数据能力对供应链韧性的影响机制,并同时分析供应链在这一过程中的中介作用。研究结果表明:企业的大数据能力对于供应链的整合与供应链韧性都发挥显著的正向影响;供应链整合在大数据能力影响供应链韧性的过程中发挥部分中介作用。研究结果对于探究大数据能力对供应链韧性的影响机制具有的理论启示意义,同时对数字化转型背景下推动企业高质量发展具有现实指导价值。

关键词：大数据能力供应链整合供应链韧性

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Asymmetric reduction of conjugated C=C bonds by immobilized fusion of old yellow enzyme and glucose dehydrogenase

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Green Synthesis and Catalysis 2024年第2期5卷 80-87页

作者： Yongxing Li Pengqian luan Lele Dong Jianqiao Liu Luying Jiang Jing Bai Fufeng Liu Yanjun Jiang School of Chemical Engineering and Technology Hebei University of TechnologyTianjin 300130China College of Food Science and Biology Hebei University of Science&Technology26 Yuxiang StreetYuhua DistrictShijiazhuang 050018China Key Laboratory of Industrial Fermentation Microbiology of Ministry of Education Tianjin Key Laboratory of Industrial MicrobiologyCollege of BiotechnologyTianjin University of Science&TechnologyTianjin 300457China

Asymmetric reduction of the conjugated C=C bonds by the old yellow enzymes(OYEs)presents a promising field in the synthesis of chiral ***,few natural OYEs have been applied in large-scale applications due to the requirement of costly NADPH and low operational ***,a stable and efficient fusion of YqjM from Bacillus subtilis and glucose dehydrogenase(GDH)from Bacillus megaterium was constructed to stereoselectively reduce the conjugated C=C bonds in a self-sufficient continuous *** effects of the enzyme order and different linkers on the fusions were investigated by structural analysis and all-atom molecular dynamics *** best fusion YqjM_G_GDH gave 98% conversion of 100 mmol/L 2-methylcyclopentenone with an excellent ee value(>99%)in 3 h,while the mixture of individual enzymes only obtained 68% conversion after more than 8 *** improved substrate conversion of YqjM_G_GDH fusion was probably attributed to the increased flexibility of each fused enzyme and the shortening of the diffusion distance of NADPH regenerated.A one-pot process was designed to purify and immobilize the fusion on the Ni2t-nitrilotriacetic acid functionalized magnetic mesoporous silica *** resulting immobilized biocatalyst not only catalyzed the asymmetric reduction of various α,β-unsaturated ketones(20 mmol/L)continuously with only 50μmol/L NADPt to initiate the whole process,but also retained more than 82%of the initial activity after seven cycles,serving as a good candidate for the industrial applications.

关键词： Enzyme fusion Old yellowenzymes Asymmetricreduction C=C bond Cofactor regeneration Immobilization

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Natural variation in maize gene ZmSBR1 confers seedling resistance to Fusarium verticillioides

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The Crop Journal 2024年第3期12卷 836-844页

作者： Yunxia Song Peipei Ma Jingyang Gao Chaopei Dong Zhao Wang Yifan luan Jiafa Chen Doudou Sun Pei Jing Xuecai Zhang Weibin Song Zijian Zhou Jianyu Wu College of Agronomy Henan Agricultural UniversityZhengzhou 450002HenanChina College of Life Sciences Henan Agricultural UniversityZhengzhou 450002HenanChina Global Maize Program International Maize and Wheat Improvement Center(CIMMYT)Apdo 6-64106600 MexicoDFMexico National Maize Improvement Center Department of Plant Genetics and BreedingChina Agricultural UniversityBeijing 100193China

Maize seedling blight caused by Fusarium verticillioides is a widely occurring maize disease,but the genetics and mechanisms of resistance are not well *** this study,GWAS performed by MLM and 3VmrMLM identified 40 and 20 QTNs,associated with seedling blight *** methods identified 49 and 36 genes,*** verification of candidate gene ZmSBR1 identified by both methods showed that the resistance of a mutant line to seedling blight decreased by 0.37 grade points after inoculation with ***,compared with the *** length of the stem rot lesion caused by *** increased by 86%in mutant seedlings,and the relative length of the adult plant stalk rot increased by 35%in mutant plants compared to the wild type after inoculation with Fusarium *** analysis showed that expression of defense-related genes after inoculation was down-regulated in the mutant compared to the wild type,synthesis of secondary metabolites associated with resistance was reduced,and the immune response triggered by PAMP decreased,resulting in decreased resistance of mutant maize *** gene association analysis showed that most maize inbred lines carried the susceptible haplotype.A functional PCR marker was *** results demonstrated that ZmSBR1 conferred resistance to multiple Fusarium diseases at the seedling and adult growth stages and had important application value in breeding.

关键词： Seedling blight Stalk rot Multiple disease resistance

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寒地城市老幼群体不同季节住区户外活动特征及其影响因素研究

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西部人居环境学刊 2024年第2期39卷 41-48页

作者：冷红栾佳艺袁青哈尔滨工业大学建筑与设计学院自然资源部寒地国土空间规划与生态保护修复重点实验室

住区是承载老幼群体户外活动的主要场所,寒地城市特殊气候条件下的季节变化对老幼群体的活动特征影响显著,本文根据其影响因素提出满足老幼群体全季节活动需求的共享型户外活动空间营造策略。利用实地调研与问卷结合的方式对哈尔滨市6... 详细信息

住区是承载老幼群体户外活动的主要场所,寒地城市特殊气候条件下的季节变化对老幼群体的活动特征影响显著,本文根据其影响因素提出满足老幼群体全季节活动需求的共享型户外活动空间营造策略。利用实地调研与问卷结合的方式对哈尔滨市6个样本住区452组老幼群体进行调查,研究不同季节老幼群体住区户外活动的时间与空间分布特征,并通过多元回归分析的方法分别提取不同季节下老幼群体活动频率、活动时长和活动类型的影响因素。基于研究结果,从优化目标、优化机制、环境营造三方面提出寒地住区户外活动空间的优化策略。

关键词：寒地城市老幼群体季节户外活动特征住区优化策略

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新型农村集体经济助力中国特色农业强国建设:作用机理与路径选择

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天津社会科学 2024年第3期3卷 57-67页

作者：栾江中共天津市委党校经济学教研部

农业强国是社会主义现代化强国的根基,特殊的国情农情决定了我国要建设的农业强国既要有世界农业强国的一般特征,更要体现中国特色。新型农村集体经济作为社会主义公有制经济的重要实现形式,能够在中国特色农业强国建设中发挥重要作用,... 详细信息

农业强国是社会主义现代化强国的根基,特殊的国情农情决定了我国要建设的农业强国既要有世界农业强国的一般特征,更要体现中国特色。新型农村集体经济作为社会主义公有制经济的重要实现形式,能够在中国特色农业强国建设中发挥重要作用,包括通过发挥组织动员作用打造农业强国产业体系,发挥制度牵引作用确保农业强国建设方向,发挥文化建设作用丰富农业强国文化内涵等。当前,我国新型农村集体经济面临发展动力低下、市场化运营机制不健全、收益分配机制不完善、文化功能发挥不充分等问题。未来应进一步激发新型农村集体经济发展的内生动力、完善市场化运营机制和发展成果共享机制、提升共同富裕带动效果、强化文化功能建设,加强中国特色农业强国建设的物质保障力、主体支撑力、价值驱动力和文化影响力,加速推进农业农村现代化。

关键词：农业强国中国特色新型农村集体经济农业农村现代化

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Efficacy evaluation and survival analysis of the combination of oxaliplatin plus Teysuno (SOX) with immune checkpoint inhibitors in the conversion therapy of locally advanced gastric cancer

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Oncology and Translational Medicine 2024年第4期10卷 190-197页

作者： Shuai Liu Kai Zhang Xiaoqing Zhang Wei luan Inner Mongolia Medical University Graduate School Urumchi 010000China The Inner Mongolia autonomous region people's hospital and oncology Urumchi 010000China

Background:The efficacy of combining immune checkpoint inhibitors(ICIs)with chemotherapy in neoadjuvant therapy for locally advanced gastric cancer has been ***,limited research exists on its effectiveness in conversion therapy,and its superiority over standalone chemotherapy remains to be *** study aims to investigate the efficacy and survival outcomes of patients treated with ICIs in combination with conversion therapy for locally advanced gastric ***:Retrospective data from patients with locally advanced gastric cancer treated with either oxaliplatin+S-1(SOX)alone or in combination with ICIs in conversion therapywere *** andpathological characteristics,disease-free survival,andefficacy assessments in nonoperable patients were compared between the 2 treatment *** was further evaluated through dynamic changes in serum markers,and patients’quality of life was assessed using the QLQ-STO22(Gastric Cancer–Specific Quality of Life Questionnaire)quality-of-life measurement ***:A total of 140 patients underwent conversion therapy:80 in the SOX alone group and 60 in the SOX combined with the ICIs *** were no significant differences in baseline characteristics between the 2 *** with the SOX alone group,the SOX combined with ICIs group exhibited a higher conversion rate(83.3%vs 75%,P=0.23),R0 resection rate(90.0%vs 83.3%,P=0.31),pathological complete response(pCR)rate(18%vs 5%,P=0.02),median disease-free survival(21.4 vs 16.9 months,P=0.007),the objective response rate in nonoperable patients(60%vs 40%,P=0.301),and median progression-free survival time(7.9 vs 5.7 months,P=0.009).The QLQ-STO22 quality-of-life assessment revealed statistically significant improvements in pain,swallowing difficulties,and dietary restrictions in the combination therapy group compared with those in the monotherapy *** enhanced efficacy of immune combination with SOX is evident,as demonstrated by the

关键词： Conversion therapy Locally advanced gastric cancer Immune checkpoint inhibitors Gastrectomy Efficacy evaluation Survival analysis Quality-of-life measurement

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应对10 kV配电网电流保护失配问题的整定优化方案

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电力系统保护与控制 2024年第15期52卷 155-166页

作者：栾琨戴志辉史琛新能源国家重点实验室(华北电力大学) 河北保定071003

针对现有辐射型配电网多级电流保护因速动段保护范围重合而引起的保护误动问题,提出一种电流保护整定优化方案。首先以配电网整体故障切除时间最短、保护灵敏度最高、故障影响负荷最少等为目标函数,考虑上下级线路保护配合等约束条件,... 详细信息

针对现有辐射型配电网多级电流保护因速动段保护范围重合而引起的保护误动问题,提出一种电流保护整定优化方案。首先以配电网整体故障切除时间最短、保护灵敏度最高、故障影响负荷最少等为目标函数,考虑上下级线路保护配合等约束条件,建立保护整定优化数学模型。然后,采用含约束的多目标骨干粒子群算法和K-means聚类算法求解、分析最优解特征并得到最终优化定值。其次,针对特定拓扑优化筛选后无最终优化定值的“死区”问题,提出加入主干线分段断路器位置优化的解决方案。最后,在Matlab中进行仿真验证,结果表明所提方案能够解决保护失配问题并适应不同配电网结构,有效提升配电网保护整体性能。

关键词：继电保护多目标优化骨干粒子群配电网

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