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Study,application and communication of traditional medicine among the Belt and Road Countries

中国药理学与毒理学杂志 2018年第4期32卷 241-242页

作者： guan-hua du Institute of Materia Medica Chinese Academy of Medical Science and Peking Union Medical College Chinese Pharmacological Society Beijing 100050 China

Most medicines used in the ancient people were the natural raw products,and most of them were discovered during the *** the differences of the geography,climate and living habits among the different regions,various medicines were used for treatment of diseases in local *** communication of medicines made a lot of benefits for people living in different *** of medicines promote the application of medicines and natural *** early as 2000 year ago,the ancient Chinese people had sent a lot of medicines to many countries among the Belt and Road during their visiting to these *** medicines were the main contents for communication besides of the silk and *** medicines has been used for treatment of diseases for local people till *** the Belt and Road,many spices,fruits,seeds produced in different regions were spread among the *** of them were planted and produced in *** the important events were the application of these special products,such as spices,fruits and seeds used as medicines under the guidance of traditional Chinese medical *** drugs have played major roles in the treatment of diseases and development of traditional Chinese *** of the medicines,including the medical theory and drugs,improved the medical standards in *** example,ancient Persian medicine had a significant impact on the use of traditional Chinese medicine in the prescription *** also,the medicines made important contributions to the health of people in the countries on the Belt and ***,the science and techniques have been *** principles and understandings are different from the ancient ***,the medicines developed in the countries on the Belt and Road still used for the health of human *** research the ancient medicines by the modern techniques and through co-operation will greatly contribute to human healthand promote the social progress and e

关键词：中医药物治疗化学分析临床分析

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Saffron： a potential immunological adjuvant in anti-tumor therapy

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中国药理学与毒理学杂志 2018年第4期32卷 304-305页

作者： Lin WANG guan-hua du Beijing Key Laboratory of Drug Targets Research and New Drug Screening Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China

A large and increasing number of patients in the world use medicinal plants and herbs for health ***,chemoprevention using readily available natural substances from ***,fruits,herbs and spices is one of the significantly important approaches for cancer prevention in the present *** is native to Iran and now recorded in "Chinese Pharmacopoeia" as a widely used Chinese medicine with good *** than several useful pharmacological effects such as anticonvulsant,antidepressant,anti-inflammation,saffron and its active components(crocin,crocetin and safranal) have been shown to induce apoptosis in several tumor cell lines and mouse tumors with beneficial properties including radical scavenging,anti-mutagenic and immuno-modulating *** addition,saffron was reported good potential to alleviate the toxicity ofcisplatin,including the ***,the application of these components in the clinic has been limited due poor clinical trials *** review aimed to provide a brief overview on clinical evaluation for anti-tumor potential and current molecule mechanism of saffron based on recent literature data.

关键词：藏红花铂毒性癌症预防措施

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Ramulus Cinnamomi extract attenuates neuroinflammatory responses via downregulating TLR4/MyD88 signaling pathway in BV2 cells

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Neural Regeneration Research 2017年第11期12卷 1860-1864页

作者： huan Yang Xiao Cheng Ying-lin Yang Yue-hua Wang guan-hua du Beijing Key Laboratory of Drug Target Identification and Drug Screening Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina

Ramulus Cinnamomi （RC）, a traditional Chinese herb, has been used to attenuate inflammatory responses. The purpose of this study was to investigate the effect of RC extract on lipopolysaccharide （LPS）-induced neuroinflammation in BV2 microglial cells and the underlying mechanisms involved. BV2 cells were incubated with normal medium （control group）, LPS, LPS plus 30 pg/mL RC extract, or LPS plus 100 pg/mL RC extract. The BV2 cell morphology was observed under an optical microscope and cell viability was detected by MTT assay. Nitric oxide level in BV2 cells was detected using Griess regents, and the levels of interleukin-6, interleukin-1 β, and tumor necrosis factor u in BV2 cells were determined by ELISA. The expression levels of cyclooxygenase-2, Toll-like receptor 4 and myeloid differentiation factor 88 proteins were detected by western blot assay. Compared with the LPS group, both 30 and 100 μg/mL RC extract had no significant effect on the viability of BV2 cells. The levels of nitric oxide, interleukin-6, interleukin-1β and tumor necrosis factor ct in BV2 cells were all significantly increased after LPS induction, and the levels were significantly reversed after treatment with 30 and 100 μg/mL RC extract. Furthermore, RC extract significantly inhibited the protein expression levels of cyclooxygenase-2, Toll-like receptor 4 and myeloid differentiation factor 88 in LPS-induced BV2 cells. Our findings suggest that RC extract alleviates neuroinflammation by downregulating the TLR4/MyD88 signaling pathway.

关键词： nerve regeneration Ramulus Cinnamomi BV2 cells lipopolysaccharide neuroinflammation pro-inflammatory factors TLR4/ MyD88 signaling pathway nitric oxide interleukin-6 interleukin-1β tumor necrosis factor a neuronal regeneration

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Xiao-Xu-Ming decoction extract regulates differentially expressed proteins in the hippocampus after chronic cerebral hypoperfusion

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Neural Regeneration Research 2019年第3期14卷 470-479页

作者： Yue-hua Wang Ying-Lin Yang Xiao Cheng Jun Zhang Wan Li guan-hua du State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College Beijing Key Laboratory of Drug Target Identification and Drug Screening Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College

Xiao-Xu-Ming decoction has been widely used to treat stroke and sequelae of stroke. We have previously shown that the active fractions of Xiao-Xu-Ming decoction attenuate cerebral ischemic injury. However, the global protein profile and signaling conduction pathways regulated by Xiao-Xu-Ming decoction are still unclear. This study established a two-vessel occlusion rat model by bilateral common carotid artery occlusion. Rats were intragastrically administered 50 or 150 mg/kg Xiao-Xu-Ming decoction for 4 consecutive weeks. Learning and memory abilities were measured with Morris water maze. Motor ability was detected with prehensile test. Coordination ability was examined using the inclined screen test. Neuronal plasticity was observed by immunofluorescent staining. Differentially expressed proteins of rat hippocampus were analyzed by label-free quantitative proteomics. Real time-polymerase chain reaction and western blot assay were used to identify the changes in proteins. Results showed that Xiao-Xu-Ming decoction dramatically alleviated learning and memory deficits, and motor and coordination dysfunction, and increased the expression of microtubule-associated protein 2. Xiao-Xu-Ming decoction extract remarkably decreased 13 upregulated proteins and increased 39 downregulated proteins. The regulated proteins were mainly involved in oxidation reduction process, intracellular signaling cascade process, and protein catabolic process. The signaling pathways were mainly involved in ubiquitin mediated proteolysis and the phosphatidylinositol signaling system. Furthermore, there was an interaction among Rab2 a, Ptpn1, Ppm1 e, Cdk18, Gorasp2, Eps15, Capza2, Syngap1 and Mt-nd1. Protein analyses confirmed the changes in expression of MTND1. The current findings provide new insights into the molecular mechanisms of Xiao-Xu-Ming decoction extract's effects on chronic cerebral hypoperfusion.

关键词： nerve regeneration chronic cerebral hypoperfusion vascular dementia bilateral common carotid artery occlusion Xiao-Xu-Ming decoction label-free quantitative proteomics Morris water maze test Nano-LC-ESI LTQ-Orbitrap MS/MS technology neural regeneration

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Research advances in cardiovascular protective effects of flavonoids

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中国药理学与毒理学杂志 2018年第4期32卷 292-293页

作者： Xu-guang LI Lian-hua FANG guan-hua du Beijing Key Laboratory of Drug Targets Identification and Drug Screening Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China

Flavonoids are a large family of bioactive compounds widely found in foods and *** studies have proven the preventive and therapeutic effects of flavonoids in cardiovascular *** has a wide range of pharmacological effects,including antioxidant,anti-inflammatory,***,avoiding the thrombus formation,improving endothelial function,modifying lipid levels and regulating blood lipids through different mechanisms of *** cardiovascular protective mechanism of *** are the enzymes that inhibit the production of oxygen derived free radicals,inhibition of lipid *** and inflammatory factor,down-regulation of epoxy synthase activity and the activation of AMPK and nuclear factor kappa B signaling *** this review article we review and summarize the so far acquired knowledge of the most important mechanisms of action of flavonoids,to provide theoretical basis for the research and development of the active monomers in flavonoid and compound preparations.

关键词：黄酮类化合物过氧化剂临床分析药物化学

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Fingerprinting Analysis of Saposhnikovia divaricata using ~1H Nuclear Magnetic Resonance Spectroscopy and High Performance Liquid Chromatography

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Journal of Integrative Plant Biology 2010年第9期52卷 782-792页

作者： Yue-Yang Xin An-Jun Deng guan-hua du Jin-Lan Zhang Hai-Lin Qin Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of Education & Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China

The 1H nuclear magnetic resonance （1H NMR） fingerprints of fractionated non-polar and polar extracts （control substance for plant drug [CSPD] A and B） from the roots of 12 specimens of Saposhnikovia divaricata （Turcz.） Schischk were achieved with Fourier Transform （FT）-NMR spectrometer and assigned by comparison to each other and to the 1H NMR spectra of the isolated individual compounds. These fingerprints were found to be uniform in terms of the specificity for the implication of all 12 specimens being systematically of the same origin. The uniformity was further affirmed by high performance liquid chromatography （HPLC）, which also revealed exactly identical specificity for the identified S. divaricata species with the 1H NMR appearances of corresponding CSPD on the part of the composition of characteristic constituents when comparing to corresponding individual compounds. This investigation unambiguously shows that the specific signals from the chemotaxonomically significant compounds of chromones and coumarins in S. divaricata are exhibited distinctively in the composite features of both 1H NMR fingerprints and HPLC profiles. The 1H NMR and HPLC profiles established can successfully be used as reference for the authentication of the origin of S. divaricata species as well as for chemotaxonomic studies.

关键词： Polarity Optical properties individual Provenance Species Hplc

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A new alkaloid from Stemona sessilifolia

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Chinese Chemical Letters 2007年第2期18卷 152-154页

作者： Peng Wang Hai Lin Qin Zhi Hong Li Ai Lin Liu guan hua du [a]Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050 China

A new alkaloid, named sessilistemonamine D, was isolated from the roots of Stemona sessilifolia and the structure and relative configuration were determined on the basis of NMR and MS spectrometric data analysis.

关键词： Sessilistemonamine D Stemona sessilifolia

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Comparison of preventive and therapeutic effect on cardio-cerebral ischemic disease between salvianolic acids and aspirin

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中国药理学与毒理学杂志 2018年第4期32卷 334-335页

作者： Jun-tian ZHANG Shi-feng CHU guan-hua du Institute of Materia Medica Chinease Academy of Medical Sciences Beijing 100050 China

Aspirin(AS) has been widely used globally for preventing incidence of cardio-cerebral ischemic disease for nearly 100 *** people who takes AS for long term may reach several *** million,but many persons were died from interned *** found salvianolic acids(salvianolic acid B 57%,salvianolic acid A 1%,rosmarinic acid,35%,SA) was much better than AS in preventing *** of cardio-cerebral ischemic disease,and may avoid hemorrhage risk in clinical *** research are summary briefly as follows:(1) both AS and AS have same anti-platelet aggregation ***,but their mechanism is *** inhibited both TXA2 and PGI2,SA inhibited TXA2 only;(2) For established thrombosis,SA could dissolved it,AS showed no *** thrombolytic mechanism of SA has been elucidated.(3) In SHRSP rats,the incidence of stroke and death rate in SA group was distinct less that of AS group;(4) In MCAO rats,SA and Sal B decreased stroke index and neural *** showed no such ability;(5) There is microcirculatory disturbance in cardio-cerebral ischemic *** could improve circulatory disturbance induced by LPS,adrenaline,ROS and I/*** is no any paper reported AS could have beneficial effect on above mentioned microcirculatory *** models;(6) Hyperlipidemia is an independent risk factor for cardio-cerebral vascular *** could significant hypolipidemic effect which is similar to that of statins(atovastin and simvastin) and ten times stronger than *** has no inhibitory effect on hyperlipidemia.(7) Thereis *** of ROS induced by ischemic/reperfusion in cardio-cererbal vascular *** showed more ***,anti-oxidant capacity than VitC,Vit E,melatonin,edalavone and resveratrol,*** is one of the most powerful anti-oxidant in the world so far.(8) According to literatures,1/3 patients who take AS for long time will have hemorrhage,we found in normal rats and mice(coagulating and hemodynamics)SA had no apparent effect

关键词：阿司匹林心脑血管发展现状治疗方法

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Fingerprinting Analysis of Rhizoma Chuanxiong of Commercial Types using ~1H Nuclear Magnetic Resonance Spectroscopy and High Performance Liquid Chromatography Method

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Journal of Integrative Plant Biology 2009年第6期51卷 537-544页

作者： Hai-Lin Qin An-Jun Deng guan-hua du Peng Wang Jin-Lan Zhang Zhi-Hong Li Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Key Laboratory of Bioactive Substances and Resources of Chinese Herbal Medicine Ministry of Education Beijing 100050 China

The ^1 H nuclear magnetic resonance （^1 H NMR） fingerprints of fractionated non-polar extracts （control substance for a plant drug （CSPD） A） from Rhizoma chuanxiong, the rhizomes of Ligusticum chuanxiong Hort., of seven specimens from different sources were measured on Fourier Transform （FT）-NMR spectrometer and assigned by comparing them with the ^1 H NMR spectra of the isolated pure compounds. The ^1 H NMR fingerprints showed exclusively characteristic resonance signals of the major special constituents of the plant. Although the differences in the relative intensity of the ^1H NMR signals due to a discrepancy in the ratio of the major constituents among these samples could be confirmed by high performance liquid chromatography analysis, the general features of the ^1H NMR fingerprint established for an authentic sample of the rhizomes of L. chuanxiong e. hibited exclusive data from those special compounds and can be used for authenticating L. Chuanxiong species.

关键词： control substance for a plant drug A ^1 H nuclear magnetic resonance fingerprint high performance liquid chromatography Ligusticumchuanxiong phenylpropenoid phthalides.

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Pharmacokinetic study of salvianolic acid D after oral and intravenous administration in rats

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Acta Pharmaceutica Sinica B 2015年第3期5卷 246-253页

作者： Junke Song Wen Zhang Jialin Sun Xiaona Xu Xue Zhang Li Zhang Zhangying Feng guan-hua du State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Beijing Key Laboratory of Drug Target Identification and Drug ScreeningInstitute of Materia MedicaChinese Academy of Medical Sciences & Peking Union Medical College Pharmacy Department of the Affiliated Hospital of Medical College of Qingdao University The Fourth Hospital of Hebei Medical University

A sensitive, specific and rapid LC-MS method was developed and validated for the determination of salvianolic acid D (SAlD) in rat plasma. This method used a single quadrupole mass spectrometer with an electrospray ionization (ESI) source. A single ion monitoring scanning (SIM) mode was employed. it showed good linearity over the concentration range from 3.3 to 666.7 ngfint. for the determination of Sala The R.S.D.% of intra-day and inter-day precision values were no more than 7.69%, and the accuracy was within 91%-104% at all quality control Levels. This LC MS method was applied to the pharmacokinetic study of SaID in rats. A two-compartmental model analysis was employed. The plasma concentrations at 2 mm (C-2min) were 5756.06 +/- 719.61, 11,073.01 +/- 1783.46 and 21,077.58 +/- 5581.97 nit, for 0.25, 0.5 and I mg/kg intravenous injection, respectively. The peak plastna concentration (C-max) was 333.08 +/- 61.21 pg/L for 4 mg/kg oral administration. The area under curve (AUC(0-t)) was 14,384.379 +/- 8443.t84. 22,813.369 +/- 11,860.823, 46,406.122 +/- 27,592.645 and 8201.740+4711.961 mu g/L.h for intravenous injection (0.25, 0.5 and 1 mg/kg) and oral administration (4 mg/kg), respectively. The bioavailability of SalD) was calculated to be 4.159% +/- 0.517%. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia IMedica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

关键词： Salvianolic acid D LC-MS Pharmacokinetics Bioavilability Dose proportiionality salvia miltiorrhiza Danshen Analysis method

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