Saffron： a potential immunological adjuvant in anti-tumor therapy

作     者：Lin WANG Guan-hua DU 

作者机构：Beijing Key Laboratory of Drug Targets Research and New Drug Screening Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China 

出 版 物：《中国药理学与毒理学杂志》 (Chinese Journal of Pharmacology and Toxicology)

年 卷 期：2018年第32卷第4期

页      面：304-305页

核心收录：

学科分类：100703[医学-生药学] 1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：The project supported by National Natural Science Foundation of China (81503113) 

主　　题：藏红花 铂 毒性 癌症 预防措施 

摘      要：A large and increasing number of patients in the world use medicinal plants and herbs for health ***,chemoprevention using readily available natural substances from ***,fruits,herbs and spices is one of the significantly important approaches for cancer prevention in the present *** is native to Iran and now recorded in Chinese Pharmacopoeia as a widely used Chinese medicine with good *** than several useful pharmacological effects such as anticonvulsant,antidepressant,anti-inflammation,saffron and its active components(crocin,crocetin and safranal) have been shown to induce apoptosis in several tumor cell lines and mouse tumors with beneficial properties including radical scavenging,anti-mutagenic and immuno-modulating *** addition,saffron was reported good potential to alleviate the toxicity ofcisplatin,including the ***,the application of these components in the clinic has been limited due poor clinical trials *** review aimed to provide a brief overview on clinical evaluation for anti-tumor potential and current molecule mechanism of saffron based on recent literature data.