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Ascorbate peroxidase 1 confers resistance to southern corn leaf blight in maize

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Journal of Integrative Plant Biology 2022年第6期64卷 1196-1211页

作者： Jinghua Zhang Xingmeng Jia guan-feng wang Shijun Ma Shunxi wang Qin Yang Xueyan Chen Yuqian Zhang Yajing Lyu Xiaoxu wang Jiawei Shi Yangtao Zhao Yanhui Chen Liuji Wu National Key Laboratory of Wheat and Maize Crop Science Collaborative Innovation Center of Henan Grain CropsCollege of AgronomyHenan Agricultural UniversityZhengzhou 450002China The Key Laboratory of Plant Development and Environmental Adaptation Biologym Ministry of EducationSchool of Life SciencesShandong UniversityQingdao 266237China State Key Laboratory of Crop Stress Biology in Arid Areas College of AgronomyNorthwest A&F UniversityYangling 712100China School of Environmental and Rural Science University of New EnglandArmidale 2351NSWAustralia

Southern corn leaf blight (SCLB), caused by Bipolarismaydis, is one of the most devastatingdiseases affecting maize production. However,only one SLCB resistance gene, conferring partialresistance, is currently known, underscoring theimportance of isolating new SCLB resistancerelatedgenes. Here, we performed a comparativeproteomic analysis and identified 258 proteinsshowing differential abundance during the maizeresponse to B. maydis. These proteins included anascorbate peroxidase (Zea mays ascorbate peroxidase1 (ZmAPX1)) encoded by a gene locatedwithin the mapping interval of a previously identifiedquantitative trait locus associated with SCLBresistance. ZmAPX1 overexpression resulted inlower H_(2)O_(2) accumulation and enhanced resistanceagainst B. maydis. Jasmonic acid (JA)contents and transcript levels for JA biosynthesisand responsive genes increased in ZmAPX1-overexpressing plants infected with B. maydis,whereas Zmapx1 mutants showed the oppositeeffects. We further determined that low levels of H_(2)O_(2) are accompanied by an accumulation of JAthat enhances SCLB resistance. These resultsdemonstrate that ZmAPX1 positively regulatesSCLB resistance by decreasing H_(2)O_(2) accumulationand activating the JA-mediated defensesignaling pathway. This study identified ZmAPX1as a potentially useful gene for increasing SCLBresistance. Furthermore, the generated datamay be relevant for clarifying the functions ofplant APXs.

关键词： ascorbate peroxidase comparative proteomics disease resistance jasmonic acid maize southern corn leaf blight

Design and Simulation of High-power LED Array Packaging

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Semiconductor Photonics and Technology 2008年第1期14卷 56-60页

作者： TIAN Da-lei guan Rong-feng wang Xing Institute of Materials Science and Engineering Henan Polytechnic University Jiaozuo 454003 CHN

Thermal management is one of the key technologies for high-power Light emitting diode(LED)entering into the general illuminating *** thermal management depends on optimal packaging structure and selected packaging *** this paper,the aluminum is employed as a substrate of LED,3×3 array chips are placed on the substrate,heat dissipation performance is simulated using finite element analysis(FEA)software,analyzed are the influences on the temperature of the chip with different convection coefficient,and optical properties are simulated using optical analysis *** results show that the packaging structure can not only effectually improve the thermal performance of high-power LED array but also increase the light extraction efficiency.

关键词： high-power LED thermal management optical properties simulation

Optimized Design of LED Daylight Lamp Lighting System

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Semiconductor Photonics and Technology 2008年第2期14卷 121-123,135页

作者： TIAN Da-lei guan Rong-feng wang Xing Institute of Materials Science and Engineering Henan Polytechnic University Jiaozuo 454000 CHN

In order to meet the requirements of indoor illumination, a LED daylight lamp model was designed, it can replace traditional fluorescent lamp without insteading additional power supply establishment. The optical properties of the model were simulated using optical analysis software. Its luminous efficiency is about 30.4 lm/W, and the illuminance is about 38 lux when the distance is 1.5 m between the center of the model and measured spot. With the theoretically-optimized design of LED model, experiments based on the results of the optimal simulation in the laboratory were conducted to verify the performance of the proposed LED model, it reaches a power factor of about 0.8 at 6 W. The simulation results are very similar with the measured values. It is testified that simulative method is one of the effective tools for LED lighting optical design.

关键词： LED daylight lamp optical properties simulation

Protection of tight junction between RPE cells with tissue factor targeting peptide

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International Journal of Ophthalmology(English edition) 2018年第10期11卷 1594-1599页

作者： Xiu-Lan Zou guan-feng wang Dan-Dan Li Jing-Xia Chen Chun-Li Zhang Yong-Zhen Yu Wen-Jie Zhou Yu-Ping Zou Ben-Qiang Rao Department of Ophthalmology General Hospital of Guangzhou of PLA Guangzhou 510010 Guangdong Province China Department of Ophthalmology the Third Affiliated Hospital of Guangzhou Medical University Guangzhou 510150Guangdong Province China Zhongshan Ophthalmology Center of Sun Yat-sen University Guangzhou 510060 Guangdong Province China General Surgery Aviation General Hospital Beijing 100012China

AIM：To investigate the effect of tissue factor targeting peptide（TF-TP）on retinal pigment epithelium（RPE）cells tight ***：Cell counting kit-8（CCK-8）was used to measure the proliferation of ARPE-19 *** of tight junction,ZO-1 in ARPE-19 cells was measured by Western blot and immunofluorescent *** blot was also used to detect the expression of tissue factor（TF）.CEC Transmigration Assay was used to measure the migration of ARPE-19 *** transport of fluorescent markers [fluorescein isothiocyanate dextrans of 4,10,20（FD4,FD10,FD20） ]and the transepithelial electrical resistance（TEER）were used to measure in ARPE-19 cell RESULTS：CCK-8 assay showed that 5μmol/L TF-TP can inhibit ARPE-19 cells abnormally proliferation stimulated by lipopolysaccharide（LPS;P〈0.05）.LPS increased the transport of fluorescent markers（FD4,FD10,FD20）and decreased TEER levels in ARPE-19 cells,respectively,which were prevented by 5μmol/L TF-TP pretreatment（P〈0.05）. Furthermore,LPS significantly up-regulated the expression of TF and downregulated the expression of ZO-1（P〈0.05）in ARPE-19 cell which was inhibited by the TF-TP（P〈0.05）.In addition,TF-TP inhibited the abnormal migration induced by LPS in ARPE-19 cell（P〈0.05）.CONCLUSION：Our findings suggest that TF-TP suppressed proliferation and migration of ARPE-19 cells induced by LPS,and maintained the RPE tight junctions through inhibition of TF expression and increased expression of ZO-1.

关键词： tissue factor targeting peptide lipopolysaccharide tight junction ZO-1 retinal pigment epithelium

Protective effects of lipoic acid-niacin dimers against blue light-induced oxidative damage to retinal pigment epithelium cells

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International Journal of Ophthalmology(English edition) 2019年第8期12卷 1262-1271页

作者： Xiu-Lan Zou Yong-Zhen Yu Hong-Hua Yu guan-feng wang Rong-Biao Pi Zhe Xu Chu Zhang Wen-Jie Zhou Dan-Dan Li Xuan-Ge Chen Yu-Ping Zou Department of Ophthalmology General Hospital of SouthernTheatre Command of PLAGuangzhou510010GuangdongProvinceChina Department of Ophthalmology Guangdong ProvincialPeople’s HospitalGuangzhou510000Guangdong ProvinceChina Department of Ophthalmology Third Affiliated Hospitalof Guangzhou Medical UniversityGuangzhou510000Guangdong ProvinceChina School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou510000Guangdong ProvinceChina Department of Ophthalmology the First Affiliated HospitalGuangdong Pharmaceutical UniversityGuangzhou510000Guangdong ProvinceChina Zhongshan Ophthalmic Centre of Sun Yat-sen University Guangzhou510000Guangdong ProvinceChina

AIM: To evaluate the protective effects of lipoic acid-niacin(N2 L) dimers against blue light(BL)-induced oxidative damage to human retinal pigment epithelium(hRPE) cells in ***: h RPE cells were divided into a control group(CG), a BL group, an N2 L plus BL irradiation group, an α-lipoic acid(ALA) plus BL group, an ALA-only group, and an N2 L-only group. hRPE cellular viability was detected by performing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium(MTT) bromide assays, and apoptosis was evaluated by annexin-V-PE/7-AAD staining followed by flow cytometry. Ultrastructural changes in subcellular organelles were observed by transmission electron microscopy. Reactive oxygen species formation was assayed by flow cytometry. The expression levels of the apoptosis-related proteins BCL-2 associated X protein(BAX), B-cell leukmia/lymphoma 2(BCL-2), and caspase-3 were quantified by Western blot ***: BL exposure with a light density of 4±0.5 mW/cm2 exceeding 6 h caused hRPE toxicity, whereas treatment with a high dose of N2 L(100 mol/L) or ALA(150 mol/L) maintained cell viability at control levels. BL exposure caused vacuole-like degeneration, mitochondrial swelling, and reduced microvillus formation;however, a high dose of N2 L or ALA maintained the ultrastructure of hRPE cells and their organelles. High doses of N2 L and ALA also protected hRPE cells from BL-induced apoptosis, which was confirmed by Western blot analysis: BCL-2 expression significantly increased, while BAX and caspase-3 expression slightly decreased compared to the ***: High-dose N2 L treatment(>100 mol/L) can reduce oxidative damage in degenerating hRPE cells exposed to BL with an efficacy similar to ALA.

关键词： lipoic acid-niacin dimers retinal pigment epithelium cell lipoic acid oxidative stress reactive oxygen species apoptosis

Enhancing insights into Global Cancer Statistics 2022: implications for cancer control

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Science China Life Sciences 2025年第1期 294-296页

作者： Jingtong Xu Runtian wang Xiaoxiang guan Department of Oncology the First Affiliated Hospital of Nanjing Medical University Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Personalized Cancer MedicineNanjing Medical University

Globally, there has been a marked escalation in tumor morbidity and mortality,cementing tumors as the predominant cause of death in numerous *** the current tumor burden across various regions is imperative to discern potential risk factors and formulate efficacious strategies for tumor ***, the International Agency for Research on Cancer(IARC) provided a status report on the global tumor burden,estimating the incidence and mortality of 36 cancers in 185 countries(Bray et al.,2024).

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A High Speed FFT Processor for OFDM System

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A High Speed FFT Processor for OFDM System

第十三届全国青年通信学术会议

作者： Wu Xinchun guan feng Mao Zhigang wang Jinxiang School of Astronautics,Harbin Institute of Technology,Harbin 150001,China

＜正＞Orthogonal Frequency Division Multiplexing（OFDM）play a very important role in modern wireless communication and the Fast Fourier Transforrn（FFT）processor is the key part for OFDM *** this paper,we propose a higher speed FFT processor architecture suitable for Ultra-Wideband（UWB）*** order to satisfy the requirements of high throughout rote and small area consumption in OFDM systems,mixed radix 2/4/8 algorithm,pipeline and multiply data-path architecture are *** pro- posed FFT architecture can meet the requirement of Wireless PAN（IEEE 802.15）standard.

关键词： Orthogonal Frequency Division Multiplexing(OFDM) Ultra-Wideband(UWB) Fast Fourier Transform(FFT)

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系统思维下高等教育改革的困境与突破

教育理论与实践 2017年第30期37卷 3-6页

作者：薛凤冠王立新南京理工大学公共事务学院江苏南京210094 南京特殊教育师范学院江苏南京210038

我国高等教育的改革面临改革步伐缓慢化、改革问题积累化、改革措施碎片化、改革行为孤立化、改革成效放大化以及改革环境复杂化等问题。究其原因在于改革与稳定的矛盾、独立与依附的矛盾、学术与市场的矛盾以及数量与质量的矛盾。深化... 详细信息

我国高等教育的改革面临改革步伐缓慢化、改革问题积累化、改革措施碎片化、改革行为孤立化、改革成效放大化以及改革环境复杂化等问题。究其原因在于改革与稳定的矛盾、独立与依附的矛盾、学术与市场的矛盾以及数量与质量的矛盾。深化高等教育改革是一项系统的社会工程,应处理好大学与政府、社会的关系,转变政府职能;改革高度集权的政府管理体制及其教育行政管理体制,权力充分下放;完善内部治理结构;实施统筹兼顾战略。

关键词：高等教育改革系统思维政府职能转变内部治理结构统筹兼顾

Copper homeostasis and neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3124-3143页

作者： Yuanyuan wang Daidi Li Kaifei Xu Guoqing wang feng Zhang International Research Laboratory of Ethnomedicine of Ministry of Education Key Laboratory of Basic Pharmacology of Ministry of EducationLaboratory Animal Center and Key Laboratory of Basic Pharmacology of Guizhou ProvinceZunyi Medical UniversityZunyiGuizhou ProvinceChina

Copper,one of the most prolific transition metals in the body,is required for normal brain physiological activity and allows various functions to work normally through its range of *** homeostasis is meticulously maintained through a complex network of copper-dependent proteins,including copper transporters(CTR1 and CTR2),the two copper ion transporters the Cu-transporting ATPase 1(ATP7A)and Cu-transporting beta(ATP7B),and the three copper chaperones ATOX1,CCS,and *** in copper homeostasis can lead to either the deficiency or accumulation of copper in brain *** evidence suggests that abnormal copper metabolism or copper binding to various proteins,including ceruloplasmin and metallothionein,is involved in the pathogenesis of neurodegenerative ***,the exact mechanisms underlying these processes are not *** is a potent oxidant that increases reactive oxygen species production and promotes oxidative *** reactive oxygen species levels may further compromise mitochondrial integrity and cause mitochondrial *** oxygen species serve as key signaling molecules in copper-induced neuroinflammation,with elevated levels activating several critical inflammatory ***,copper can bind aberrantly to several neuronal proteins,including alphasynuclein,tau,superoxide dismutase 1,and huntingtin,thereby inducing neurotoxicity and ultimately cell *** study focuses on the latest literature evaluating the role of copper in neurodegenerative diseases,with a particular focus on copper-containing metalloenzymes and copper-binding proteins in the regulation of copper homeostasis and their involvement in neurodegenerative disease *** synthesizing the current findings on the functions of copper in oxidative stress,neuroinflammation,mitochondrial dysfunction,and protein misfolding,we aim to elucidate the mechanisms by which copper contributes to a wide range of heredit

关键词： Alzheimer's disease amyotrophic lateral sclerosis disease copper homeostasis copper toxicity Huntington's disease Menkes'disease multiple sclerosis neurodegenerative disease Parkinson's disease Wilson's disease