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Dt1 inhibits SWEET-mediated sucrose transport to regulate photoperiod-dependent seed weight in soybean

Molecular Plant 2024年第3期17卷 496-508页

作者： Xiaoming Li Zhonghui Chen Haiyang Li Lin yue Cuirong Tan Hongjie Liu Yilong Hu Yuhua Yang Xiani Yao Lingping Kong Xiang Huangi Bin Yu Chunyu Zhang yuefeng guan Baohui Liu Fanjiang Kong Xingliang Hou guangdong Provincial Key Laboratory of Applied Botany&State Key Laboratory of Plant Diversity and Specialty Crops South China Botanical GardenChinese Academyof SciencesGuangzhou510650China guangdong Provincial Key Laboratory of Plant Adaptation and Molecular Design Guangzhou Key Laboratory of Crop Gene EditingInnovative Center of Molecular Genetics and EvolutionSchool of Life SciencesGuangzhou UniversityGuangzhou 510006China University of Chinese Academy of Sciences Beijing 100049China College of Agronomy and Biotechnology China Agricultural UniversityBeijing 100193China

Soybean is a photoperiod-sensitive short-day crop whose reproductive period and yield are markedly affected by day-length *** weight is one of the key traits determining the soybean yield;how-ever,the prominent genes that control the final seed weight of soybean and the mechanisms underlying the photoperiod's effect on this trait remain poorly *** this study,we identify SwW19 as a major locus controlling soybean seed weight by QTL mapping and determine Dt1,an orthologous gene of Arabidopsis TFL1 that is known to govern the soybean growth habit,as the causal gene of the SW19 *** showed that Dt1 is highly expressed in developing seeds and regulates photoperiod-dependent seed weight in *** analyses revealed that the Dt1 protein physically interacts with the sucrose transporter GmSWEET10a to negatively regulate the import of sucrose from seed coat to the embryo,thus modulating seed weight under long ***,Dt1 does not function in seed development under short days due to its very low ***,we discovered a novel natural allelic variant of Dt1(H4 haplotype)that decouples its pleiotropic effects on seed size and growth habit;i.e.,this variant remains functional in seed development but fails to regulate the stem growth habit of ***,our findings provide new insights into how soybean seed development responds to photoperiod at different latitudes,offering an ideal genetic component for improving soybean's yield by manipulating its seed weightandgrowth habit.

关键词： soybean seed weight photoperiod dt1 sucrose transport

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毛冬青甲素的核磁共振法分析

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分析测试学报 2005年第2期24卷 24-27页

作者：祝亚非关山越邵伟艳钟鸣中山大学测试中心广东广州510275 广州市医药工业研究所广东广州510240

采用1H、13C、DEPT(无畸变极化转移增益法)、1H-1H COSY(氢-氢化学位移相关谱)、HMQC(异核多量子相关谱)、HMBC(异核多键相关谱)、NOESY(二维核欧沃豪斯效应谱)等多种NMR分析方法, 对毛冬青甲素的1H和13C NMR谱信号进行了归属; 并对生... 详细信息

采用1H、13C、DEPT(无畸变极化转移增益法)、1H-1H COSY(氢-氢化学位移相关谱)、HMQC(异核多量子相关谱)、HMBC(异核多键相关谱)、NOESY(二维核欧沃豪斯效应谱)等多种NMR分析方法, 对毛冬青甲素的1H和13C NMR谱信号进行了归属; 并对生产过程常同时存在的丁二酸二钠也进行了谱线归属, 提出通过1H NMR法对产品中的丁二酸二钠进行定量测定。为其结构鉴定和生产过程中的质量控制提供了重要依据。

关键词：毛冬青甲素一维NMR谱二维NMR谱丁二酸二钠定量分析

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Ziwan-Taoren herb pair can exert an therapeutical effect in primary Sjogren’s syndrome through inhibiting the TLR/NF-κB pathway

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Traditional Medicine Research 2024年第8期9卷 11-22页

作者： Kuok-Tong Lei Yun-Xia Wu Yun Lu Zi-shan Wang Thi-Huong Nguyen Qiu-Ying Cai Wen Zhu yue Wang First Clinical Medical College Nanjing University of Chinese MedicineNanjing 210000China Faculty of Traditional Medicine Phenikaa UniversityHa Noi 100803Vietnam Department of Rheumatology and Immunology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000China

Background:Ziwan and Taoren(ZT)is a classic medicine pair in the formula of Mai Dong Di Shao Decoction,has been used to treat primary Sjogren’s syndrome(pSS)for more than 20 *** its action mechanism is still *** study is aimed to reveal the potential mechanism of ZT treated pSS and discover its active compounds of ZT and therapeutic target for ***:Firstly,the potential pathways of ZT for pSS treatment were predicted through network pharmacology and GO and KEGG enrichment ***,the inter-structural relationships between active compounds of ZT and target proteins were visualized using molecular docking ***,efficacy and mechanism were conducted through in vivo experiments,such as water intake,spleen index,hematoxylin-eosin staining pathological changes,ELISA,Western Blot analysis,and immunofluorescence ***:Nine active compounds were extracted from network pharmacology,including quercitrin,luteolin,kaempferol,β-sitosterol,isorhamnetin,galangin,hederagenin,diosmetin and gibberellin *** disease targets were identified:RELA,TP53,AKT1,interleukin(IL)6,MAPK1,ESR1,IL10;with RELA being the most core *** and GO enrichment analysis indicated that ZT may act through the TLR/NF-κB/RELA inflammatory mechanism *** results of molecular docking showed that ZT’s active compounds bind well to the RELA(p65)*** vivo results demonstrated that a high dose of ZT significantly improved water intake and reduced lymphocytes infiltration in submandibular gland pathology in NOD *** expression content of AQP5 and vasoactive intestinal peptide in the submaxillary gland was significantly increased,while levels of inflammatory factors such as tumor necrosis factor-α,IL-6,and IL-1βalong with protein expressions including toll-like receptor4,p-p65 and p-IKKα/βin NF-κB pathway were ***:The ZT treatment exhibits a promising efficacy in mitigating dryness symptoms of pSS,potentially attr

关键词： traditional Chinese medicine primary Sjogren’s syndrome NF-κB RELA

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中学生物“思维导图”教学策略探究

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湖北师范大学学报（哲学社会科学版） 2020年第1期40卷 132-135页

作者：徐平冯斌关珊月湖北师范大学国家级生物学实验教学示范中心湖北黄石435002 湖北师范大学生命科学学院湖北黄石435002

思维导图是一种有效发散思维,并具有直观可视化的教学神器,在各科教学中都得到了广泛的应用和推广。教师运用思维导图进行知识梳理,可以加强学生直观感知体验,加强学生发散思维和创造思维能力的培养。高中生物概念多,理论与实践结合紧密... 详细信息

思维导图是一种有效发散思维,并具有直观可视化的教学神器,在各科教学中都得到了广泛的应用和推广。教师运用思维导图进行知识梳理,可以加强学生直观感知体验,加强学生发散思维和创造思维能力的培养。高中生物概念多,理论与实践结合紧密,这些都为思维导图在生物教学中的运用创造了条件,文章从思维导图的概念、特点、应用合理性、运用策略等方面,对思维导图在高中生物教学中的意义进行了探讨。

关键词：中学生物思维导图教学策略

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“共伯和”还是“共和”——关于周厉王被逐后贵族“共和”难以为继的讨论

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清华大学学报（哲学社会科学版） 2024年第2期39卷 92-102,236页

作者：李山张月北京师范大学文学院北京100875 澳门大学中国语言文学系中国澳门999078 澳门大学人文社科高等研究院中国澳门999078

出土文献“清华简”《系年》和《竹书纪年》都提到“共伯和干王位”,这与传世文献如《史记》中的“共和”存在差异。关于贵族参与驱逐周厉王的可能性,传世文献如《国语》《左传》《逸周书》的记载影绰,而出土文献及出土文物则表述明确... 详细信息

出土文献“清华简”《系年》和《竹书纪年》都提到“共伯和干王位”,这与传世文献如《史记》中的“共和”存在差异。关于贵族参与驱逐周厉王的可能性,传世文献如《国语》《左传》《逸周书》的记载影绰,而出土文献及出土文物则表述明确。虽然记载不同,但两者都表明贵族和国人合力驱逐了周厉王,共同佐证了驱逐事件的真实性。基于西周宗法制,“国人”关系到王朝政权基础,且与高级贵族关系紧密。正是西周封建制和宗法制的自身逻辑引发了贵族与国人驱逐周厉王的事件。而在此后,西周贵族势力转向内部的利益争夺,王朝畿内贵族与外诸侯也都会因王位空缺而产生矛盾,“共和”难以为继,“共伯和立”成为政治平衡的权宜之计。然而,受社会环境和文化意识难以协调以及私欲纷争的主导,共伯和很快“归宗”,王权恢复,贵族的联合执政彻底宣告失败。

关键词：共伯和贵族“共和” 周厉王国人暴动 “清华简”《系年》

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不稳定型心绞痛痰浊痹阻证与气虚血瘀证血浆代谢组学研究

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长春中医药大学学报 2013年第4期29卷 578-581页

作者：华何与崔凯关山越南方医科大学中医药学院广州510515 南方医科大学南方医院心内科广州510515 中山大学分析测试中心广州510275

目的研究冠心病不稳定型心绞痛痰浊痹阻证、气虚血瘀证患者的代谢组学特征,探讨代谢组学方法在研究不稳定型心绞痛中医证型中的应用。方法对12例不稳定型心绞痛痰浊痹阻证患者和12例不稳定型心绞痛气虚血瘀证患者的血浆样本进行氢核磁共... 详细信息

目的研究冠心病不稳定型心绞痛痰浊痹阻证、气虚血瘀证患者的代谢组学特征,探讨代谢组学方法在研究不稳定型心绞痛中医证型中的应用。方法对12例不稳定型心绞痛痰浊痹阻证患者和12例不稳定型心绞痛气虚血瘀证患者的血浆样本进行氢核磁共振(1HNMR)检测。通过偏最小二乘判别分析(PLS-DA)方法研究不稳定型心绞痛痰浊痹阻证患者与气虚血瘀证患者之间血浆代谢产物谱及的差异。结果各组血浆核磁共振氢谱的PCA结果显示,不稳定型心绞痛证痰浊痹阻患者与不稳定型心绞痛气虚血瘀患者能够被区分,2组血浆样本之间的代谢物含量存在明显差异。不稳定型心绞痛痰浊痹阻证组血浆中乳酸、葡萄糖、半乳糖、N-乙酰糖蛋白、低密度脂蛋白、脂类化合物、酮体、天门冬氨酸、谷氨酞胺、酪氨酸、脯氨酸的含量高于气虚血瘀证组,而柠檬酸、高密度脂蛋白、不饱和脂肪酸、氧化三甲胺的含量低于气虚血瘀证组。结论 2组血浆样本的1HNMR代谢谱存在差异,能从代谢组学分析中找出特异的标志性代谢产物。血浆代谢物变化能在一定程度上区分冠心病不稳定型心绞痛的这两种中医证型。

关键词：代谢组学氢核磁共振不稳定型心绞痛中医证候

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Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy:A Multicenter Double-Blind Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第3期30卷 195-202页

作者： HUANG Hao-yue LIN Yu-ping WEI Hua FU Yu ZHOU yue-hong FANG Zhao-hui QIU Xiao-tang WANG Mei LI Qing-bo LI shan-shan WANG Shi-dong DAI Fang LIU Zhen-jie ZHAO Ling WEN Jian-xuan WU Li-yan ZENG Hui-yan ZHANG Jin-ming LU Qi-yun HE Liu SONG Wei SUN Lu LUO Lu-lu HE Jia-li XIE Wen-wen LIANG Qing-shun HUANG Yuan ZHU Sheng-ling LONG Jie-er GAO Zhi-juan WEN Ze-huai LI Chun-ji OUYANG Wen-wei LI Geng WU Ming-hui LI An-xiang HUANG Jin-zhu Sanjoy K Paul TANG Xian-yu FAN guan-jie Department of Endocrinology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China The Second Clinical College of guangzhou University of Chinese Medicine Guangzhou510120China Department of Endocrinology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China guangdong Provincial Academy of Chinese Medical Sciences Guangzhou510120China Department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Endocrinology Liuyang Hospital of Chinese MedicineChangsha410000China Department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230000China Department of Endocrinology Hainan Provincial Hospital of Traditional Chinese MedicineHaikou570100China Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000China Department of Geriatric Luoyang No.1 Hospital of Traditional Chinese MedicineLuoyangHenan Province471000China Department of Endocrinology The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Department of Endocrinology Beijing University of Chinese Medicine Affiliated Dongzhimen HospitalBeijing100000China Department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Melbourne EpiCentre The University of Melbourne and Melbourne HealthMelbourne3013Australia

Objective:To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction(TW)in treating patients with diabetic peripheral neuropathy(DPN).Methods:It is a multicenter double-blinded randomized controlled *** with DPN were recruited between November 18,2016 and May 30,2018 from 8 hospitals in *** patients received basic treatments for glycemic *** received foot baths with TW herbal granules either 66.9 g(intervention group)or 6.69 g(control group)for 30 min once a day for 2 weeks and followed by a 2-week rest,as a therapeutic *** the Toronto Clinical Scoring System total score(TCSS-TS)6 points,the patients received a total of 3 therapeutic courses(for 12 weeks)and were followed up for 12 *** primary outcome was change in TCSS-TS score at 12 and 24 *** outcomes included changes in bilateral motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of the median and common peroneal *** was also ***:Totally 632 patients were enrolled,and 317 and 315 were randomized to the intervention and control groups,*** the 12-week intervention,patients in both groups showed significant declines in TCSSTS scores,and significant increases in MNCV and SNCV of the median and common peroneal nerves compared with pre-treatment(P0.05),and no serious adverse event was related with ***:Treatment of TW foot baths was safe and significantly benefitted patients with DPN.A low dose of TW appeared to be more effective than a high dose.(Registry *** CTR-IOR-16009331)

关键词： diabetic peripheral neuropathy herbal medicine foot baths Chinese medicine randomized controlled trial Tangbi Waixi Decoction

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中小学教师教科研科学化的定位、标准及实现路径

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教学与管理 2024年第12期 16-20页

作者：任玥姗郑州大学体育学院郑州450000

中小学教科研科学化的主要衡量标准是符合客观性、符合逻辑性、符合实用性、符合推广性。教科研科学化的实现面临着教师教科研角色的“边缘化”,教师研究能力的“有限化”,教科研过程监管的“虚空化”,教科研成果评价的“去特色化”等... 详细信息

中小学教科研科学化的主要衡量标准是符合客观性、符合逻辑性、符合实用性、符合推广性。教科研科学化的实现面临着教师教科研角色的“边缘化”,教师研究能力的“有限化”,教科研过程监管的“虚空化”,教科研成果评价的“去特色化”等问题。为此,需要从以下四个方面推进中小学教科研的科学化:依托科学的理论基础,多维度提高教师教科研的专业化水平;面向事实本身,树立科学、探究的教科研精神;通过科学的制度设计和建构,全方位推进教科研制度创新;基于教科研成果评价的“立”与“破”,驱动特色评价方式改革。

关键词：中小学教科研科学化

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中小学课堂教学定性诊断的基本范式及其实践路径

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教学与管理 2024年第27期 17-21页

作者：任玥姗河南体育学院郑州450000

定性诊断和定量诊断是课堂教学中两个相互对垒又彼此联系的重要诊断方法。定性诊断是在对定量诊断质疑的基础上提出来的,并主要表现为两种共存的课堂诊断范式,即经验—反馈的实践范式、体验—归纳的解释范式。经验—反馈范式存在教师主... 详细信息

定性诊断和定量诊断是课堂教学中两个相互对垒又彼此联系的重要诊断方法。定性诊断是在对定量诊断质疑的基础上提出来的,并主要表现为两种共存的课堂诊断范式,即经验—反馈的实践范式、体验—归纳的解释范式。经验—反馈范式存在教师主体意识旁落、诊断结论片面、诊断效用弱化、诊断价值失灵等局限;体验—归纳范式存在对诊断者专业性要求过高、诊断过程的现代性不足、诊断方法普适性较差、诊断双方矛盾性较强等缺陷。课堂教学有效的定性诊断需要从诊断主体多元化,形成专业化的诊断共同体;诊断取向实践化,助推教师专业发展;诊断方法多样化,促进方法与对象的适切发展三条路径着手。

关键词：定性诊断课堂教学教学诊断教师专业发展

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Identification of risk factors and construction of a nomogram predictive model for post-stroke infection in patients with acute ischemic stroke

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World Journal of Clinical Cases 2024年第20期12卷 4048-4056页

作者： Xiao-Chen Liu Xiao-Jie Chang Si-Ren Zhao shan-shan Zhu Yan-Yan Tian Jing Zhang Xin-yue Li Department of Neurosurgery Shandong Provincial Third HospitalJinan 250031Shandong ProvinceChina Department of Neurology Shandong Provincial Third HospitalJinan 250031Shandong ProvinceChina

BACKGROUND Post-stroke infection is the most common complication of stroke and poses a huge threat to *** addition to prolonging the hospitalization time and increasing the medical burden,post-stroke infection also significantly increases the risk of disease and *** the risk factors for post-stroke infection in patients with acute ischemic stroke(AIS)is of great *** can guide clinical practice to perform corresponding prevention and control work early,minimizing the risk of stroke-related infections and ensuring favorable disease *** To explore the risk factors for post-stroke infection in patients with AIS and to construct a nomogram predictive *** The clinical data of 206 patients with AIS admitted to our hospital between April 2020 and April 2023 were retrospectively *** data and post-stroke infection status of all study subjects were assessed,and the risk factors for poststroke infection in patients with AIS were *** Totally,48 patients with AIS developed stroke,with an infection rate of 23.3%.Age,diabetes,disturbance of consciousness,high National Institutes of Health Stroke Scale(NIHSS)score at admission,invasive operation,and chronic obstructive pulmonary disease(COPD)were risk factors for post-stroke infection in patients with AIS(P<0.05).A nomogram prediction model was constructed with a C-index of 0.891,reflecting the good potential clinical efficacy of the nomogram prediction *** calibration curve also showed good consistency between the actual observations and nomogram *** area under the receiver operating characteristic curve was 0.891(95%confidence interval:0.839–0.942),showing predictive value for post-stroke *** the optimal cutoff value was selected,the sensitivity and specificity were 87.5%and 79.7%,*** Age,diabetes,disturbance of consciousness,NIHSS score at admission,invasive surgery,and COPD are risk factors for post-st

关键词： Acute ischemic stroke Infection Risk factors Nomogram prediction model Chronic obstructive pulmonary disease

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