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Preparation and Improvation of Nanophase Artificial Bone Composite Scaffold and Relevant Study on Properties

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Chinese Journal of Biomedical Engineering(English Edition) 2009年第3期18卷 129-138页

作者： DENG Yun gu han-qing Tianjin Medical University Tianjin 300070 China

Objective：To prepare nanophase artificial bone composite scaffold based on bionics theory, and probe into how different content ratio between collagen and inorganic part as well as different molecular weight of conglutinant agent influence microstrueture and properties of the scaffold. Methods： Lead calcic inorganic molecules to deposite onto self-assembled collagen template during coprecipitation under certain reactive conditions such as content ratio and pH value of environment, and then nanophase collagen/calcic salt is obtained. In order to improve the mechanical properties, poly lactic acid （PLLA） which has stable equal properties and controllable biodegradable activities is chosen as conglutinant agent, and then the aimed artificial bone scaffold （nanophase collagen/calcic salt/PLLA composite） is accomplished. After preparation liquid displacement method with isoproanol alcohol, scanning electron microscopic （SEM） , transmission electron microscope （TEM）, fourier transform infrared spectrometry （FTIR）, mechanical testing system are performed to test porosity and density, morphology, conformation, composition and mechanical property, respectively. Results：The artificial synthesized bone composite scaffold is mainly composed of collagen and calcium phosphate partly displaced with B-type carbonate. The crystallinity is low, and the crystal size reaches nanometer which is similar to natural bone. PLLA used effectively improves the mechanical property which can reach at the floor level of cancellous standard, and develops three-dimensional-porous structure with high porosity of 80%. According to the comparison it can be seen that content ratio between collagen and calcic inorganic salt as well as addition of conglutinant PLLA all have an effect on microstructure of the synthesized scaffold, additionally molecular weight of PLLA has an effect on mechanical properties. Conclusion ：The nanophase artificial bone composite scaffold synthesized by biomimetic process is o

关键词： biomineralization self-assemble nanophase collagen calcium phosphate PLLA

Study on Titanium Nitride Film Modified for Intraocular Lens

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Chinese Journal of Biomedical Engineering(English Edition) 2009年第4期18卷 171-177,184页

作者： ZhanG Bai-ming gu han-qing Tianjin Medical University Tianjin 300070 China

Objective:To study the characteristics of the intraocular lens using ion beam sputtering depositing titanium nitride thin film on the intraocular lens(IOLs).Methods:To deposite titanium nitride thin film on the top of intraocular lens by ion beam sputtering *** analyzed the surface morphology of intraocular lens through SEM and *** detected intraocular lens resolution through the measurement of intraocular *** of intraocular lens is preliminary evaluated in this ***:The surface morphology of intraocular lens material was not changed,and was in line with the requirements of *** was in line with national *** and modified IOLs's cytotoxicity were 1 and 0.6 grade *** rates of modified and unmodified were both less than 5%.Conclusion:Ion beam sputtering deposition of objects didn't only affect the surface morphology and the basic optical performance,but also can enhance the biocompatibility of intraocular *** beam sputtering deposition technique has provided new methods for the surface modification of IOLs and PMMA materials.

关键词： titanium nitride intraocular lens surface modification resolution biocompatibility

Study on Modification of Octyl-α-Cyanoacrylate Medical Adhesive

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Chinese Journal of Biomedical Engineering(English Edition) 2009年第4期18卷 162-170页

作者： WANG Yan-hong gu han-qing Tianfin Medical University Tianfin 300070 China

Objective:In order that the adhesive character could be improved to modify the octyl-α-cyanoacrylate(OCA) medical ***:Suitable modifiers involving polycaprolactone(PCL),dibutyl phthalate (DBP),dioctyl phthalate(DOP) and poly octyl methacrylat(POMA) have been chosen to modify the OCA adhesive,then tensile shear strength and adhesive strength are tested to evaluate the bond character of ***:The PCL group's tensile shear strength and adhesive strength in normal temperature are descended while the other groups'are all ***:The modification of properties of the other groups is effectively promoted in the aspect of the bond character,except the PCL group treated in normal temperature and the PCL modified group treated by rectification get a best improvement in the agglutinate intention, while the stability is expected to be improved.

关键词： octyl-α-cyanoacrylate adhesive modification

Study on Biological Properties of HA-TMP Cross-linked Products

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Chinese Journal of Biomedical Engineering(English Edition) 2010年第2期19卷 56-65页

作者： LIU Xin HU guo-ying gu han-qing Tianjin Institute of Urological Surgery Tianjin 300211 China

Objective:In the medium of ethanol(non-polar),STMP and ADH as crosslinkers to HA,to prepare drug delivery microspheres by getting stable cross-linked products without a gel phase,and to study biocompatibility and biodegradability of cross-linked ***:ISO10993.1-Safety Evaluation of Biomedical materials as a reference,to make hemolysis test,percutaneous stimulation test,acute toxicity test,and analyze in vitro degradation test,and degradation ***:HA-STMP cross-linked product had no hemolysis,no irritation,no acute systemic toxicity,but HA-ADH had a mild skin irritation and adverse acute systemic ***-STMP cross-linked product had lower sensitivity on HAse and the curve is *** the increase of degradation time HA-STMP results were changed by the structure analysis,degradation products of these cells were no ***:HA-STMP cross-linked products with better biocompatibility and better resistance to hydrolysis could delay the degradation time,which is suitable for the preparation of biodegradable drug carriers.

关键词： drug delivery biocompatibility biodegradability

Study on Chemical Cross-linking Modification of Hyaluronan and the Biocompatibility of its Derivatives

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Chinese Journal of Biomedical Engineering(English Edition) 2006年第4期15卷 139-150页

作者： HU guo-ying LIU Xin gu han-qing The Second Hospital of Tianjin Medical University 300211 TianjinChina The Second Hospital of Tianjin Medical University300211 TianjinChina The Second Hospital of Tianjin Medical University300211 TianjinChina

Objective: Prepare cross-linked HA gels with higher mechanical stability, lower degradation velocity and desirable biocompatibility,so as to extend the usage of ***:*** molecular weight of HA (Mr_ HA ) by viscosimetry;*** cross-linked HA gels by DVS, GTA, DEC;*** the cross-linking and degradation procedure;*** the biocompatibility of the best HA gels. Results:The mechanical stability and durability to degradation of HA-DVS gels are superior to those of other gels, and when HA:DVS = 40:1(g/g), at 35℃ and in 0.2 M NaOH solution, the HA-DVS gel shows the best mechanical stability, and its cytotoxicity reaches class I, hemolysis ratio is lower than 5%. Conclusion:Our HA-DVS gel can be used to prepare biologic scaffolds.

关键词： Hyaluronic acid (Hyaluronan) Cross-linking Divinyl sulfone Diepoxy compound Glutaraldehyde Biocompatibility In vitro degradation

Study on Biocompatibility of Cross-linked Hyaluronic Acid Derivatives

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Chinese Journal of Biomedical Engineering(English Edition) 2009年第3期18卷 93-101页

作者： LIU Xin HU guo-ying gu han-qing Tianjin Institute of Urological Surgery Tianjin 300211 China

Objective:The cross-linked production,which was prepared by HA and cross-linking agent STMP,EDC,GP through cross-linking reaction,might be used in drug delivery system(DDS).To ensure the security of clinical application,the excellent properties such as none cell toxicity,nonirritant,none general toxicity,none immunological rejection are ***:In accordance with the request of GB/T 16886.1 on security evaluation of medical biomaterials,cell toxicity test,hemolysis test,intracutaneous stimulation test,acute toxicity test,and hypersensitive test were ***:Cell toxicity of HA-STMP,HA-EDC,HA-GP were all less than *** hypersensitive tests were *** HA-EDC,HA-GP produced different degrees of slight thrill,slight toxicity,hemolysis rate,which were larger than the standard ***:HA-STMP possesses favourable biocompatibility,which is a kind of ideal biomaterials and drug carriers.

关键词： hyaluronan (HA) cross-linked production biocompatibility

Requirements for Evaluation on Drug-medical Device

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Chinese Journal of Biomedical Engineering(English Edition) 2009年第4期18卷 178-184页

作者： DENG Jie TIAN Jia-xin gu han-qing Center for Medical Device Evaluation State Food and Drug Administration Beifing 100044 China Tianjin Medical University Tianjin 300070 China

The administration of combination products in *** and Drug Administration(FDA)are analyzed and summarized in this ***,the technical evaluation on drug-medical device in the State Food and Drug Administration of China(SFDA)is also ***,this paper discusses how to promote the development of drug-medical device in the administration and technical evaluation.

关键词： drug-medical device combination products evaluation

Study on the Preparation of Decellularized Scaffold of Bovine Pericardium

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Chinese Journal of Biomedical Engineering(English Edition) 2010年第3期19卷 129-138页

作者： YAN Fei-yan WEI Yi-han LIU Xin gu han-qing Department of Biomedical Engineering Tianjin Medical University Tianjin 300211 China

Objective： To search for the best procedure on preparation ofacellular bovine pericardium,so to provide scaffolds for constructing tissue-engineering Methods： The bovine pericardiums were treated with 5 methods, which were divided into 6 groupsGroup A： Fresh bovinepericardium; Group B： Trypsin-detergent group;Group C： Freeze-thaw-detergent 24 h group; Group I）： Freeze-thaw-detergent 48 h group; Group Fz Freeze-thaw-nuclease group; Group F： Detergent-nuclease group. Then, by HE staining and scanning electron microscope to observe the effects ofdecellularization and fibrous changes among the 6 groups; by water content testingonechanical testing to observe the changes in physical properties of the matrix; by detecting the DNA content of each group to determine the effect of deeellularization qualitatively; by eytotoxieity test to detect the biocompatibility of bovine pericardium in each group. Results： The 5 methods can all remove the cellular components effectively, compared with the fresh bovine pericardium,the water content of each deeellularized group were increased （P〈0.05）, while the DNA content decreased （P〈0.05）, with statistically significant differences. Of group E, the fibers were a little disorder, with the largest tension and the elastic modulus increased, while the rupture tensile rate decreased. Compared with fresh bovine pericardium,the largest tension of the other decellularization groups were all decreased （P〈0.05）. The fibers of group B, group D were irregularly arranged and also with ruptures, both the elastic modulus and the rupture tensile rate decreased（P〈0.05）. In group C and F, the fibers were dense and their direction was normal, the elastic modulus and the rupture tensile rate were similar to the fresh bovine pericardium （P〉0.05）. Cytotoxicity results showed that the cell toxicity of group B, group C, group D, group E and group F were respectively 0.9, 0.6, 1.0, 1.0 and 0.5, each group were qualified toxicity test, in which group C and group

关键词： bovine pericardium deeellularization freeze-thaw method scaffold detergent

Crosslinking of Bovine Pericardia Using Procyanidins

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Chinese Journal of Biomedical Engineering(English Edition) 2011年第2期20卷 83-89页

作者： WAN Rong-xin TIAN Cong gu han-qing LIU Xin Tianjin Medical University Tianjin 300070 China Tianjin Institute of Urological Surgery Tianjin 300211 China

The aim of this study was to evaluate the crosslinking effect of a naturally crosslinking reagent-procyanidins （PA）-on the materials of bioprosthetic heart valves. After fixing bovine pericardial tissues by procyanidins, crosslikng characteristics, mechanical properties, in vitro enzymatic degradation resistance, the hydrophilicity and hemolysis tests were examined. The results showed that the fixation of biological tissue with glutaraldehyde （GA） or procyanidins increased its denaturation temperature, the surface hydrophilieity and mechanical properties as well as in vitro enzymatic degradation resistance. There were no significant differences in denaturation temperature, mechanical properties, the hydrophilicity and the in vitro enzymatic degradation between the glutaraldehyde and procyanidins fixed tissues. However, the ultimate tensile strength of the procyanidins fixed tissues was significantly superior to the glutaraldehyde fixed tissues. The hemolysis tests showed that hemolysis rate of the proeyanidins fixed tissues was lower than that of the glutaraldehyde fixed tissues. This study shows that procyanidins can crosslink which bovine pericardiaa effectively without toxicity. Our results suggest that this method might be a useful approach for the preparation of bioprosthetic heart valve.

关键词： bovine pericardia bioprosthetic heart valves glutaraldehyde procyanidins