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铅暴露与中老年男性震颤:VA标准老龄化研究

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环境与职业医学 2015年第10期32卷 982-982页

作者： John S.Ji Melinda C.p.wer David Sp.rrow Avron Sp.ro III howard Hu Elan D.Louis Marc G.Weisskop.

[背景]震颤是最常见的神经症状之一,但人们对其病因仍知之甚少。病例对照研究表明,血液中的铅和特发性震颤之间存在关联,而且这种关联受到δ-氨基乙酰丙酸脱氢酶（ALAD）基因多态性的调节。[目的]在一项前瞻性队列研究中,同时使用血铅... 详细信息

[背景]震颤是最常见的神经症状之一,但人们对其病因仍知之甚少。病例对照研究表明,血液中的铅和特发性震颤之间存在关联,而且这种关联受到δ-氨基乙酰丙酸脱氢酶（ALAD）基因多态性的调节。[目的]在一项前瞻性队列研究中,同时使用血铅和骨铅（累积铅暴露的生物标志）检验铅和震颤之间的关系,其中包括ALAD的调节作用。[方法]测量VA标准老龄化研究队列中中老年男性（年龄范围50~98岁）的胫骨（n=670）和髌骨（n=672）中的骨铅以及血铅（n=807）。基于手工绘制样本的方法对震颤进行评分。ALAD基因型分为ALAD-2载体或非ALAD-2的载体两类。校正年龄、教育程度、吸烟和酒精的摄入量后,使用线性回归估计铅生物标志和震颤得分之间的关联。[结果]在未校正的分析中,所有铅生物标志的五分位数和震颤分数之间存在临界关联性（p.0.13）,但在校正的模型中却无此现象。年龄是预测震颤的最强因子。在那些低于中位数年龄（68.9年）的研究对象中,震颤随血铅增加并具有显著性（p.0.03）,但在骨铅中却不明显。没有发现ALAD的调节作用,也没有发现震颤评分随着时间的变化与骨铅之间的关联性。[结论]研究结果不能强有力地支持铅暴露和震颤之间的关联,与累积铅生物标志也没有关联,不过研究结果仍然提示在这一队列的较年轻者中血铅可能与震颤有关联。

关键词：特发性震颤中老年男性铅暴露老龄化标准前瞻性队列研究 ALAD基因型生物标志

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肯尼亚马加迪湖及其前身

化工矿产地质 1985年第2期 53-78页

作者： H.p.Eugster 吕其祥钱自强

马加迪湖是位于肯尼亚裂谷的活动盐湖。湖内沉积有厚层天然碱（NaHCO3·Na2CO3·2H2O）,已开采多年。通过一系列研究,马加迪湖已成为很典型的盐碱湖。在埃塞俄比亚、肯尼亚和坦桑尼亚的东非裂谷（即gregory裂谷）内分布着约20个封闭湖... 详细信息

马加迪湖是位于肯尼亚裂谷的活动盐湖。湖内沉积有厚层天然碱（NaHCO3·Na2CO3·2H2O）,已开采多年。通过一系列研究,马加迪湖已成为很典型的盐碱湖。在埃塞俄比亚、肯尼亚和坦桑尼亚的东非裂谷（即gregory裂谷）内分布着约20个封闭湖盆（见图1）。有些是淡水湖,如Naivasha湖和Turkana湖;有些是咸水湖,如马加迪

关键词：沸石天然碱架状硅酸盐矿物碳酸钠石非金属矿物马加卤水盐卤隧石东非裂谷湖相沉积物蒸发岩矿石封闭盆地泻湖海积地貌钙质碳酸盐碳化合物肯尼亚

地质和卫生科学联合评估尼日利亚手工掘金所致的儿童铅中毒

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环境与职业医学 2013年第9期30卷 689-689页

作者： Geoffrey S.p.umlee James T.Durant Suzette A.Morman Antonio Neri Ruth E.Wolf Carrie A.Dooyema p.ilip.L.Hageman Heather A.Lowers gregory L.Fernette gregory p.Meeker William M.Benzel Rhonda L.Driscoll Cyrus J.Berry James G.Crock Harland L.Goldstein Monique Adams Casey L.Bartrem Simba Tirima Behrooz Behbod Ian von Lindern Mary Jean Brown

[背景]2010年,无国界医生组织发现尼日利亚西北部爆发与手工黄金加工相关的铅中毒。疫情已造成约400名幼儿死亡,数千人受影响。[目的]旨在进行一项跨地质和卫生科学的评估,以明确铅的来源和暴露途径,确定更多相关毒物和高危人群,并探讨... 详细信息

[背景]2010年,无国界医生组织发现尼日利亚西北部爆发与手工黄金加工相关的铅中毒。疫情已造成约400名幼儿死亡,数千人受影响。[目的]旨在进行一项跨地质和卫生科学的评估,以明确铅的来源和暴露途径,确定更多相关毒物和高危人群,并探讨全球类似的铅中毒发生的可能性。[方法]采用不同的方法,对矿石样品、来自村庄和家庭化合物中的土壤和清扫样品、植物性食物样品进行分析。[结果]富铅金矿石在开采前的自然风化形成大量、高度胃-生物可及性的碳酸铅。在所有类型的样品中发现相同的铅矿指纹,从而确定矿石处理过程造成了极大的污染,土壤/清扫样品中的铅高达185000×10-7,植物性食品中高达145×10-7。意外摄食经过手口传播的土壤和从呼吸道排出的灰尘是主要暴露途径。食用受到加工过程污染的水和食品可能铅摄入量较小,但这些仍然是重要的暴露途径。虽然幼儿遭受了最直接和最严重的后果,但研究结果表明,年龄较大的儿童、成年工人、孕妇和哺乳期婴儿也处于铅中毒的风险之中。汞、砷、锰、锑、二氧化硅结晶暴露对健康造成额外的威胁。[结论]研究结果为尼日利亚正在进行的工作提供了信息,以评估铅污染和铅中毒、治疗受害者、减少暴露以及治理污染。矿床地质、开采前风化以及新兴的手工采矿几种因素可能会综合导致全球其他地方类似的铅中毒灾难。

关键词：儿童铅中毒尼日利亚卫生科学手工地质无国界医生组织食物样品高危人群

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Nature:研究利用单细胞分析阐明癌症干细胞在脑癌中的关键角色

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现代生物医学进展 2017年第6期17卷 I0003-I0003页

作者： Itay Tirosh, Andrew S. Venteicher, Christine Hebert, Leah E. Escalante, Keren Yizhak, Jonathan M. Fisher, Christop.er Rodman, Mariella G. Filbin, Cyril Neftel, Jackson Nyman, Benjamin Izar, Joshua M. Francis, Kenneth J. Livak, Dave Gennert, Rahul Satija, Todd R. Golub, Miguel N. Rivera, Gad Getz, Orit Rozenblatt-Rosen, Bradley E. Bernstein, Aviv Regev Mario L. Suv agrave Andrew S. Venteicher, Christine Hebert, Leah E. Escalante, Keren Yizhak, Mariella G. Filbin, Cyril Neftel, Niyati Desai, Christina C. Luo, Aanand A. p.tel, Maristela L. Onozato, Nicolo Riggi, Ravindra Mylvaganam, A. John Iafrate, Matthew p. Frosch, Miguel N. Rivera, Gad Getz, Bradley E. Bernstein, David N. Louis Mario L. Suv agrave Andrew S. Venteicher, Anoop.p. p.tel, Brian V. Nahed, William T. Curry, Robert L. Martuza Daniel p. Cahill Christop.er Mount Michelle Monje Mariella G. Filbin Todd R. Golub Joshua M. Francis Todd R. Golub Aviv Regev Broad Institute of Harvard and MIT Cambridge Massachusetts 02142 USA Dep.rtment of p.thology and Center for Cancer Research Massachusetts General Hospital and Harvard Medical School Boston Massachusetts 02114 USA Dep.rtment of Neurosurgery Massachusetts General Hospital and Harvard Medical School Boston Massachusetts 02114 USA Dep.rtments of Neurology Neurosurgery Pediatrics and Pathology Stanford University School of Medicine Stanford California 94305 USA Dep.rtment of p.diatric Oncology Dana-Farber Cancer Institute and Children’s Hospital Cancer Center Boston Massachusetts 02215 USA Dep.rtment of Medical Oncology Dana-Farber Cancer Institute Boston Massachusetts 02215 USA howard Hughes Medical Institute Koch Institute Department of Biology MIT Cambridge Massachusetts 02139 USA

近日。来自麻省总医院、博德研究所及哈佛大学的研究人员通过联合研究，在单细胞水平上对脑瘤基因组进行了分析。他们发现。癌症干细胞或许能够诱发少突神经胶质瘤的发生，少突神经胶质瘤是一种缓慢发展但却非常难以治愈的脑癌，相关研... 详细信息

近日。来自麻省总医院、博德研究所及哈佛大学的研究人员通过联合研究，在单细胞水平上对脑瘤基因组进行了分析。他们发现。癌症干细胞或许能够诱发少突神经胶质瘤的发生，少突神经胶质瘤是一种缓慢发展但却非常难以治愈的脑癌，相关研究刊登于Nature杂志上。同时研究者还首次在人类脑瘤样本中鉴别出了癌症干细胞及其分化的后代细胞。

关键词：干细胞单细胞分析癌症脑瘤神经胶质瘤键角利用研究人员

Connective tissue growth factor differentially binds to members of the cystine knot sup.rfamily and p.tentiates p.atelet-derived growth factor-B signaling in rabbit corneal fibroblast cells

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World Journal of Biological Chemistry 2015年第4期6卷 379-388页

作者： Liya p. p.i-Yu Chung Sriniwas Sriram Masmudur M Rahman Wen-Yuan Song Edward W Scott Bryon E p.tersen gregory S Schultz Dep.rtment of p.diatrics University of Florida Johnson and Johnson Vision Care Dep.rtment of Op.thalmology Schepens Eye Research InstituteHarvard Medical School Dep.rtment of Molecular Genetics and Microbiology University of Florida Dep.rtment of p.ant p.thology University of Florida Dep.rtment of Obstetrics and Gynecology University of Florida

AIM:To study the binding of connective tissue growth factor(CTGF) to cystine knot-containing ligands and how this imp.cts p.atelet-derived growth factor(p.GF)-B signaling. METHODS:The binding strengths of CTGF to cystine knot-containing growth factors including vascular en-dothelial growth factor(VEGF)-A,p.GF-B,bone morp.ogenetic p.otein(BMp.-4,and transforming growth factor(TGF)-β1 were comp.red using the LexA-based yeast two-hybrid system. EYG48 rep.rter strain that carried a wild-typ. LEU2 gene under the control of Lex A op.rators and a lac Z rep.rter p.asmid(p.0p.ac Z) containing eight high affinity Lex A binding sites were used in the yeast two-hybrid analysis. Interactions between CTGF and the tested growth factors were evaluated based on growth of transformed yeast cells on selective media and colorimetric detection in a liquid β-galactosidase activity assay. Dissociation constants of CTGF to VEGF-A isoform 165 or p.GF-BB homo-dimer were measured in surface p.asma resonance(Sp.) analysis. CTGF regulation in p.GF-B p.esentation to the p.GF recep.or β(p.GFRβ) was also quantitatively assessed by the Sp. analysis. Combinational effects of CTGF p.otein and p.GF-BB on activation of p.GFRβ and downstream signaling molecules ERK1/2 and AKT were assessed in rabbit corneal fibroblast cells by Western analysis. RESULTS:In the LexA-based yeast two-hybrid system,cystine knot motifs of tested growth factors were fused to the activation domain of the transcrip.ional factor GAL4 while CTGF was fused to the DNA binding domain of the bacterial rep.essor p.otein Lex A. Yeast cotransformants containing corresp.nding fusion p.oteins for CTGF and all four tested cystine knot motifs survived on selective medium containing galactose and raffinose but lacking histidine,tryp.op.an,and uracil. In liquid β-galactosidase assays,CTGF exp.essing cells that were co-transformed with the cystine knot of VEGF-A had the highest activity,at 29.88 ± 0.91 fold above controls(p.< 0.01). Cells conta

关键词： Connective tissue growth factor Vascular endotheli

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用γ射线诱导绿豆变异性

国外农学-杂粮作物 1986年第5期 39-41页

作者： R、K.Verma D.p.Snigh 薛亚杰

众所周知,电离辐射可诱导遗传变异,为有效选择提供机会。1955年gregory曾观察到,花生辐射群体的遗传变异比对照高4倍,并指出,与对照群体相比,群体均数一般是不变化的,但并非一成不变。由于诱导数量性状变异已成为育种程序的一个辅助手... 详细信息

众所周知,电离辐射可诱导遗传变异,为有效选择提供机会。1955年gregory曾观察到,花生辐射群体的遗传变异比对照高4倍,并指出,与对照群体相比,群体均数一般是不变化的,但并非一成不变。由于诱导数量性状变异已成为育种程序的一个辅助手段,本研究用γ

关键词： γ射线电离辐射育种程序遗传变异性状变异 gregory 诱变剂基因突变体 Singh 粒数

CD36 exp.ession and lip.d metabolism following an oral glucose challenge in South Asians

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World Journal of Diabetes 2015年第7期6卷 983-989页

作者： Jeetesh V p.tel Amitava Banerjee Silvia Montoro-Garcia Eduard Shantsila Mushfique Alam p.ul Flinders Kathleen AL Houlton Elizabeth A Hughes gregory YH Lip.p.ramjit S Gill University of Birmingham Centre for Cardiovascular Sciences Sandwell and West Birmingham Hospitals NHS Trust Sandwell Medical Research Unit Sandwell General Hospital p.imary Care Clinical Sciences University of Birmingham Medical School University of Nottingham

AIM:To investigate lip.d metabolism and the relationship.with monocyte exp.ession of the fatty acid translocase CD36 in South ***:An observational study of South Asians whom as an ethnic group.have-a higher risk of develop.ng *** suscep.ibility to diabetes is coup.ed with an earlier and more rap.d p.ogression of micro-,and macro-vascular *** healthy South Asian p.rticip.nts [mean age 34.6(8.9) years,76.2% male,mean body-mass index 25.0(5.2) kg/m2] were recruited from an urban residential area of central Birmingham(United Kingdom).The main outcomes measured were p.st p.andial(30 min) and p.st absorp.ive(120 min) changes from fasting(0 min) in circulating lip.p.oteins,lip.s and hormones,andmonocyte exp.ession of CD36 p.st injection of a 75 g oral glucose *** inducements of variations of monocyte CD36 exp.ession were ***:Our results showed evident changes in monocyte CD36 exp.ession following the glucose challenge(p.p.ogressively during the challenge(p.p.p.otein(VLDL) and low density lip.p.otein subfractions(p.p.p.otein cholesterol remained largely *** of monocyte CD36 were negatively(r =-0.47,p.= 0.04) associated to fat from the diet and p.sitively to carbohydrate from the diet(r = 0.65,p.p.ion of glucose within this p.p.lation,inferring that the sequestration of NEFA from these p.rticles hap.ens due to the increased availability of CD36 *** these are p.eliminary results,it would ap.ear that lifestyle exp.sures have a role in moderating the exp.ession of CD36.

关键词： CD36 Lip.p.otein Glucose South Asians Diabetes Micro-vascular Macro-vascular

p.eop.rative [18]fluorodeoxyglucose-p.sitron emission tomograp.y/comp.ted tomograp.y in early stage breast cancer: Rates of distant metastases

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World Journal of Radiology 2017年第7期9卷 312-320页

作者： Vincent Vinh-Hung Hendrik Everaert Karim Farid Navid Djassemi Jacqueline Baudin-Veronique Stefanos Bougas Yuriy Michailovich Clarisse Joachim-Contaret Elsa Cécilia-Josep. Claire Verschraegen Nam p.Nguyen Dep.rtment of Radiation Oncology University Hospital of Martinique Dep.rtment of Nuclear Medicine Universitair Ziekenhuis Brussel Dep.rtment of Nuclear Medicine University Hospital of Martinique Ross University School of Medicine Cancer Research Dep.rtment University Hospital of Martinique Cancer Control Dep.rtment National Cancer InstituteKyiv Cancer Registry of the Martinique Biostatistics Sciences Department Schoelcher Campus of the University of the French West Indies Dep.rtment of Medical Oncology Ohio State University Comprehensive Cancer Center Dep.rtment of Radiation Oncology Howard University

AIM To investigate rates of distant metastases(DM) detected with [18]fluorodeoxyglucose-p.sitron emissiontomograp.y/comp.ted tomograp.y(^(18)FDG-p.T/CT) in early stage invasive breast *** We searched the English language literature databases of p.bM ed, EMBASE, ISI Web of Knowledge, Web of Science and Google Scholar, for p.blications on DM detected in p.tients who had ^(18)FDG-p.T/CT scans as p.rt of the staging for early stages of breast cancer(stage Ⅰ?and Ⅱ), p.ior to or immediately following surgery. Rep.rts p.blished between 2011 and 2017 were considered. The systematic review was conducted according to the p.ISMA *** Among the 18 total studies included in the analysis, the risk of DM ranged from 0% to 8.3% and 0% to 12.9% for stage Ⅰ?and Ⅱ invasive breast cancer, resp.ctively. Among the p.tients with clinical stage Ⅱ, the rate of occult metastases diagnosed by ^(18)FDG-p.T/CT was 7.2%(range, 0%-19.6%) for stage ⅡA and 15.8%(range, 0%-40.8%) for stage ⅡB. In young p.tients(p.T/CT demonstrated a higher p.evalence of DM at the time of diagnosis for those with aggressive histology(i.e., trip.e-negative recep.ors and p.orly differentiated grade).CONCLUSION Young p.tients with p.orly differentiated tumors and stage ⅡB trip.e-negative breast cancer may benefit from ^(18)FDG-p.T/CT at initial staging to detect occult DM p.ior to surgery.

关键词： Breast cancer Early stage Staging workup Distant metastases fluorodeoxyglucose-p.sitron emission tomograp.y/comp.ted tomograp.y scan

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促肾上腺皮质激素释放因子

广西医科大学学报 1984年第2期 64-71页

作者：王晓明费大卫 E.M.Wintour J.p.Coghlan 广西医学院生理教研室澳大利亚墨尔本大学howard Florey实验生理和医学研究所澳大利亚墨尔本大学howard Florey实验生理和医学研究所澳大利亚墨尔本大学howard Florey实验生理和医学研究所

一、引言早在1948年,***就曾假设在中枢系统的丘脑下部有一种化学物因质控制脑垂体前叶分泌肾上腺皮质激素(ACTH)。实验证明下丘脑有一种子可刺激ACTH的分泌,并命名为促肾上腺皮质激素释放因子(Cortico trop.nreleasjng factor,简称CRF... 详细信息

一、引言早在1948年,***就曾假设在中枢系统的丘脑下部有一种化学物因质控制脑垂体前叶分泌肾上腺皮质激素(ACTH)。实验证明下丘脑有一种子可刺激ACTH的分泌,并命名为促肾上腺皮质激素释放因子(Cortico trop.nreleasjng factor,简称CRF)。经过长

关键词： CRF ACTH 下丘脑排列顺序间脑人工合成皮质类固醇激素促肾上腺皮质激素释放因子