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Characterization of particle deposition during crossflow filtration as influenced by permeate flux and crossflow velocity using a microfluidic filtration system

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Frontiers of Chemical Science and Engineering 2021年第3期15卷 552-561页

作者： Hongzhan Di gregory j.O.Martin Dave E.Dunstan Department of Chemical and Biomolecular Engineering University of MelbourneParkvilleVictoria 3010Australia

Particle deposition during crossflow filtration is significantly influenced by the operating conditions,in particular the permeate flux and crossflow ***,there is a lack of detailed knowledge about how deposit layer structures and distributions depend on operating *** study uses a microfluidic visualisation filtration system to examine the influence of operating conditions on the deposition process during crossflow ultrafiltration from a microscopic *** the permeate flux caused an increasing amount of deposition and a thicker deposit *** crossflow velocities reduced the extent of *** degree of deposition varied over a range of operating conditions due to the altered hydrodynamic forces exerted on the particles,which can be examined by the deposition probability according to an existing *** on this,an empirical correlation between the deposition probability and volume of deposition as a function of filtration time was developed,which gave good agreement with experimental *** effect of solution conditions was also involved in this correlation as a interaction *** could be useful for predicting the dynamic deposition process during crossflow filtration over a range of operating and solution conditions.

关键词： particle deposition crossflow filtration microfluidics confocal microscopy

Efficacy and dose response of Lactiplantibacillus plantarum in diarrhea-predominant irritable bowel syndrome

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World journal of Gastroenterology 2023年第28期29卷 4451-4465页

作者： Christopher j Martoni Shalini Srivastava Anders Damholt gregory j Leyer Clinical Development Human HealthChr.Hansen A/SHoersholm 2970Denmark Clinical Development Vedic LifesciencesMumbai 400053India Scientific Affairs Human HealthChr.Hansen A/SHoersholm 2970Denmark

BACKGROUND Probiotics have shown promise in alleviating symptoms of diarrhea-predominant irritable bowel syndrome(IBS-D);however,the certainty of evidence is *** randomized controlled dose-ranging trials are warranted on promising single-strain *** To investigate the clinical efficacy of Lactiplantibacillus plantarum(***)Lpla33(DSM34428)in adults with *** This is a randomized,double-blind,placebo-controlled,multi-center,and doseranging *** hundred and seven adults,18-70 years of age,with IBS-D,according to Rome IV criteria,were allocated(1:1:1)to receive placebo or *** Lpla33 at 1×10^(9)(1B)or 1×10^(10)(10B)colony-forming units/d over an 8-wk intervention *** primary outcome was the change in IBS severity scoring system(IBS-SSS)total score after 8 wk,while secondary and exploratory outcomes included abdominal pain severity,IBS related quality of life,stool and microbial profile,and perceived *** IBS-SSS was significantly reduced,after 8 wk,in participants receiving *** 1B(-128.45±83.30;P<0.001)and *** 10B(-156.77±99.06;P<0.001),compared to placebo(-58.82±74.75).Further,a dose-ranging effect was observed,with a greater absolute reduction in the *** 10B group(P<0.05).A reduction in sub-scores related to abdominal pain,abdominal distension,bowel habits,and quality of life was observed in both *** groups compared to placebo(P<0.001).Further,62.5%and 88.4%of participants administered *** 1B and 10B,respectively,were classified as stool consistency responders based on a reduction in diarrheal stool form,as compared to 26.3%in the placebo group(P<0.001).In contrast,no significant shifts were observed in microbial *** *** Lpla33(DSM34428)is well tolerated and improves IBS symptom severity with a dose-ranging effect and a corresponding normalization of bowel habits in adults with IBS-D.

关键词： Randomized clinical trial Diarrhea-predominant irritable bowel syndrome Microbiome Probiotic Lactiplantibacillus plantarum

Advancements in the mind-machine interface:towards re-establishment of direct cortical control of limb movement in spinal cord injury

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Neural Regeneration Research 2016年第7期11卷 1060-1061页

作者： jian Guan gregory W.j.Hawryluk Department of Neurosurgery Clinical Neurosciences CenterUniversity of Utah

Spinal cord injury（SCI）resulting in loss of motor function can be caused by a variety of conditions,ranging from traumatic to neoplastic to *** is estimated that nearly 300,000individuals live with the effects of SCI in the United States alone（National Spinal Cord Injury Statistical Center,2016）.Current treatment modalities for patients suffering from SCI are primarily supportive,

关键词： cortical modalities neoplastic alone traumatic restoration suffering cortex options infectious

A Rare Case of Concordant Atrioventricular Connection to L-Looped Ventricles in Situs Solitus:4-Dimensional Magnetic Resonance Imaging and 3D Printing

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Congenital Heart Disease 2022年第4期17卷 387-392页

作者： gregory Perens Takegawa Yoshida j.Paul Finn UCLA Mattel Children’s Hospital Children’s Heart CenterLos AngelesCAUSA Diagnostic Cardiovascular Imaging Laboratory Department of Radiology12222 David Geffen School of Medicine at UCLALos AngelesCAUSA

An infant male presented with the rare anatomy consisting of situs solitus,concordant atrioventricular connections to L-looped ventricles,double outlet right ventricle(DORV),and hypoplastic aortic arch.6 months after neonatal aortic arch repair,the morphologic right ventricle function deteriorated,and surgical evaluation was undertaken to determine if either biventricular repair with a systemic morphologic left ventricle or right ventricular exclusion was *** initial echocardiography,magnetic resonance imaging(MRI)was used to create detailed axial and 4-dimensional(4D)images and 3-dimensional(3D)printed *** detailed anatomy of this rare,complex case and its use in pre-surgical planning is presented.

关键词： Magnetic resonance imaging cardiac segments 3D printing

Cysteine proteases as therapeutic targets:does selectivity matter? A systematic review of calpain and cathepsin inhibitors

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Acta Pharmaceutica Sinica B 2015年第6期5卷 506-519页

作者： Marton Siklos Manel Ben Aissa gregory R.j.Thatcher Department of Medicinal Chemistry and Pharmacognosy University of Illinois College of Pharmacy

Cysteine proteases continue to provide validated targets for treatment of human *** neurodegenerative disorders,multiple cysteine proteases provide targets for enzyme inhibitors,notably caspases,calpains,and *** reactive,active-site cysteine provides specificity for many inhibitor designs over other families of proteases,such as aspartate and serine;however,a)inhibitor strategies often use covalent enzyme modification,and b)obtaining selectivity within families of cysteine proteases and their isozymes is *** review provides a general update on strategies for cysteine protease inhibitor design and a focus on cathepsin B and calpain 1 as drug targets for neurodegenerative disorders;the latter focus providing an interesting query for the contemporary assumptions that irreversible,covalent protein modification and low selectivity are anathema to therapeutic safety and efficacy.

关键词： Cysteine protease Calpain Cathepsin Enzyme inhibitors Neurodegeneration Alzheimer’s disease

Data-Driven Microstructure and Microhardness Design in Additive Manufacturing Using a Self-Organizing Map

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Engineering 2019年第4期5卷 730-735页

作者： Zhengtao Gan Hengyang Li Sarah j.Wolff jennifer L.Bennett gregory Hyatt gregory j.Wagner jian Cao Wing Kam Liu Department of Mechanical Engineering Northwestern UniversityEvanstonIL 60208USA DMG MORI Hoffman EstatesIL 60192USA

To design microstructure and microhardness in the additive manufacturing(AM)of nickel(Ni)-based superalloys,the present work develops a novel data-driven approach that combines physics-based models,experimental measurements,and a data-mining *** simulation is based on a computational thermal-fluid dynamics(CtFD)model,which can obtain thermal behavior,solidification parameters such as cooling rate,and the dilution of solidified *** on the computed thermal information,dendrite arm spacing and microhardness are estimated using well-tested mechanistic *** microstructure and microhardness are determined and compared with the simulated values for *** visualize process-structure-properties(PSPs)linkages,the simulation and experimental datasets are input to a data-mining model-a self-organizing map(SOM).The design windows of the process parameters under multiple objectives can be obtained from the visualized *** proposed approaches can be utilized in AM and other data-intensive ***-driven linkages between process,structure,and properties have the potential to benefit online process monitoring control in order to derive an ideal microstructure and mechanical properties.

关键词： Additive manufacturing Data science Multiphysics modeling Self-organizing map Microstructure Microhardness Ni-based superalloy

Critical review of strategies for CO_2 delivery to large-scale microalgae cultures

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Chinese journal of Chemical Engineering 2018年第11期26卷 2219-2228页

作者： Qi Zheng Xiaoyin Xu gregory j.O.Martin Sandra E.Kentish Peter Cook Centre for CCS Research Department of Chemical EngineeringThe University of Melbourne Algal Processing Group Department of Chemical EngineeringThe University of Melbourne

Microalgae have great, yet relatively untapped potential as a highly productive crop for the production of animal and aquaculture feed, biofuels, and nutraceutical products. Compared to conventional terrestrial crops they have a very fast growth rate and can be produced on non-arable land. During microalgae cultivation, carbon dioxide(CO_2) is supplied as the carbon source for photosynthesising microalgae. There are a number of potential CO_2 supplies including air, flue gas and purified CO_2. In addition, several strategies have been applied to the delivery of CO_2 to microalgae production systems, including directly bubbling CO_2-rich gas, microbubbles, porous membrane spargers and non-porous membrane contactors. This article provides a comparative analysis of the different CO_2 supply and delivery strategies and how they relate to each other.

关键词： Bubble Carbon dioxide Flue gas Bioreactors

Urban invaders are not bold risk-takers: a study of 3 invasive lizards in Southern California

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Current Zoology 2020年第6期66卷 657-665页

作者： Breanna j.Putman gregory B.Pauly Daniel T.Blumstein Department of Ecology and Evolutionary Biology University of CaliforniaLos AngelesCA90095-1606USA Department of Herpetology and Urban Nature Research Center Natural History Museum of Los Angeles County900 Exposition BoulevardLos AngelesCA90007USA Department of Biology California State UniversitySan BernardinoCA 92407USA

Biological invasions threaten biodiversity worldwide,and therefore,understanding the traits of successful invaders could mitigate their *** comm only invasive species do well in disturbed habitats,such as urban environments,and their abilities to effectively respond to disturbarices could con tribute to their ***,there are non invasive species that also do well in disturbed *** question remains whether urban invaders behave differently in urban environments than noninvaders,which could suggest an"urban-exploiting"*** Southern California,the co-occurrence of in vasive Italia n wall lizards Pod arc is siculus,brown anoles Anolis sagrei,and green anoles ***,and native western fence lizards Sceloporus occidentalis offers an opportunity to test whether invasives exhibit consistent differences in risk-taking within human-altered habitats compared with a native *** predicted that invasive lizards would exhibit more bold behavior by having shorter flight-initiation distances(FIDs)and by being found farther from a refuge(behaviors that would presumably maximize foraging in low-risk environments).Invasive populations had similar or longer FIDs,but were consistently found at distances closer to a ***,invasive lizards in urban habitats were not bolder than a native *** on nearby refuges might help species successfully invade urban habitats,and if a general pattern,may pose an added challenge in detecting or eliminating them.

关键词： antipredator boldness escape behavior invasion reptile urban ecology

Stability of unicortical locked fixation versus bicortical non-locked fixation for forearm fractures

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Bone Research 2014年第2期2卷 131-135页

作者： Timothy j Pater Steve I Grindel gregory j Schmeling Mei Wang Department of Orthopaedic Surgery Medical College of Wisconsin Milwaukee WI USA Orthopaedic & Rehabilitation Engineering Center Marquette University Milwaukee WI USA

Locking plate fixation is being widely applied for fixation of forearm fractures and has many potential advantages, such as fixed angle fixation and improved construct stability, especially in osteoporotic bone. Biomechanical data comparing locking devices to commonly used Low Contact Dynamic Compression （LCDCP） plates for the fixation of forearm fractures has been lacking. The purpose of this study was to compare the fixation stability of a 3.5-mm unicortical locked plate with bicortical non-locked LCDCP plates. Six matched pairs of fresh frozen cadaveric forearms were randomly assigned to unicortical locked and bicortical unlocked groups. Non-destructive four-point bending and torsional test was performed on the ulna and radius separately, using a servohydraulic testing system to obtain construct stiffness of the intact specimens and specimens after osteotomy and plating. The specimens were then loaded to failure to test the fixation strength. The locked unicortical fixation showed significantly higher bending stiffness than the unlocked bicortical fixation, but with significantly lower stiffness and strength in torsion. Fixation strength was comparable between the two groups under bending, but significantly greater in the bicortical non-locked group under torsion. Findings from this study suggest that postoperative rehabilitation protocols may need modification to limit torsional loading in the early stage when using locked unicortical fixation. The study also points out the potential advantage of a hybrid fixation that combines locked unicortical and unlocked bicortical screws.

关键词： Stability of unicortical locked fixation versus bicortical non-locked fixation for forearm fractures