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World Journal of Nano Science and Engineering 2012年第4期2卷 213-218页

作者： Jacobo Martínez-Reyes Lucia graciela Díaz Barriga-Arceo Luis Rendón-Vazquez Reynaldo Martínez-Guerrero Néstor Romero-Partida Eduardo Palacios-González Vicente Garibay-Febles Jaime Ortiz-López IMP-Molecular Engineering Program México City México National Polytechnic Institute (IPN) ESFM UPALM México City México National Polytechnic Institute (IPN) ESIQIE UPALM México City México ROMFER S.A. de C.V. México City México UNAM-FCiencias México City México

In the present work the synthesis of C60 produced in a conventional microwave oven from the decomposition of camphor resin is reported. The polycrystalline structure of the sample was determined by X-Ray Diffraction (XRD), the sample showed several phases, the main phase corresponds to fullerene C60 ordered in a Face-Centered Cubic structure (FCC), with two more structures: one orthorhombic system and the other the monoclinic system coexisting also with graphite 2H phase. It was observed in a Scanning Electron Microscopy (SEM), that the sample formed thin films of stacked carbon. Whereas in a High Resolution Transmission Electron Microscopy (HRTEM), measurements in Bright Field mode revealed that the main phase of the material is C60 ordered in FCC structure and the elemental composition and atomic bonding state can be determined by analyzing the energy with the electron microscope by Elesctron Energy- Loss Spectroscopy (EELS), technique allowed confirm all the phase C60 established with XRD observations.

关键词： Microwave-Assisted Synthesis Carbon Film Fullerene

The Pharmacologic Intensification of the Water Dissociation Process, or Human Photosynthesis, and Its Effect over the Recovery Mechanisms in Tissues Affected by Bloodshed of Diverse Etiology

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International Journal of Clinical Medicine 2011年第3期2卷 332-338页

作者： Arturo Solís Herrera María del Carmen Arias Esparza J. Jesús Alvarado Esquivel graciela Landín Miranda Ruth Isabel Solís Arias Paola Eugenia Solís Arias Martha Patricia Solís Arias 不详

The photoreceptor layer of the human retina has several characteristics that are unique. Their energy requirements are the highest in the organism;in proportion, rods and cones require 10-fold the energy consumed by the cerebral cortex, 6-fold more than the cardiac muscle, and 3-fold more than the renal cortex. Astonishingly, the photoreceptor layer has no blood vessels at all. So, where is the energy to this tissue coming from? In this article we’ll describe the hitherto unknown explanation.

关键词： Melanin Hydrogen Oxygen Water Energy Human Photosynthesis

Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?

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World Journal of Gastroenterology 2010年第25期16卷 3144-3152页

作者： Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai Small Bowel Section Department of Medicine Gastroenterology Hospital "Dr. C. Bonorino Udaondo" Caseros 2061 Ciudad de Buenos Aires Argentina Pathology Service Hospital de Gastroenter-ología "Dr. C. Bonorino Udaondo" Av. Caseros 2061 Ciudad de Buenos Aires Argentina USNMA HIGA "San Martín" La Plata B1900 Provincia de Buenos Aires Argentina Endoscopy Service Hospital de Gastroenter-ología "Dr. C. Bonorino Udaondo" Av. Caseros 2061 Ciudad de Buenos Aires Argentina Endoscopy Service HIGA "San Martín" La Plata

AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects.

关键词： Celiac disease Serology Gliadin peptide antibodies Tissue transglutaminase Antigliadin antibodies Small bowel biopsy Diagnostic accuracy

Effect of Daily Consumption of <i>Lactobacillus reuteri </i>CRL 1098 on Cholesterol Reduction in Hypercholesterolemic Subjects

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Food and Nutrition Sciences 2015年第17期6卷 1583-1590页

作者： Agustina Malpeli Marí a Pí a Taranto Ricardo C. Cravero Marina Tavella Victoria Fasano Dimas Vicentin Guillermina Ferrari Graciano Magrini Elvira Hé bert graciela Font de Valdez Ana M. Varea Julio M. Tavella Horacio F. Gonzá lez IDIP—Instituto de Desarrollo e Investigaciones Pediá tricas “Prof. Dr. Fernando E. Viteri” (Hospital de Niñ os de La Plata Ministerio de Salud/Comisi&oacute n de Investigaciones Cientí ficas de la Pro-vincia de Buenos Aires) La Plata Argentina CERELA—Centro de Referencia para Lactobacilos (CONICET) Tucum&aacute n Argentina Sancor CUL Departamento de Investigaci&oacute n Innovaci&oacute n y Desarrollo Sunchales Argentina

The effect of daily consumption of a yogurt containing Lactobacillus reuteri CRL 1098 on the lipid profile of hypercholesterolemic subjects was evaluated by performing a prospective, randomized, double-blind, cross-over placebo controlled clinical study. Participants consumed daily a yogurt containing L. reuteri CRL 1098 or a placebo for four weeks, separated by a wash-out period. Total cholesterol, triacylglycerol, high-density (HDL) and low-density (LDL) lipoprotein levels were assessed at the beginning and at the end of each period. We found a statistically significant reduction of total (–7.86 g/dl) and LDL (–7.02 g/dl) cholesterol in absolute changes (before-after) as well as a decreasing trend in the group receiving the yogurt containing L. reuteri with respect to the placebo group, without detecting changes in HDL-cholesterol and triacylglycerol levels. Our results suggest that low amounts of yogurt (125 g/day) and low doses of the CRL 1098 strain (106 CFU) are sufficient to reduce total and LDL-cholesterol levels in hypercholesterolemic subjects.

关键词： Lactobacillus reuteri Hypercholesterolemia Cardiovascular Risk Probiotics Functional Foods

Solid State Bioconversion for Producing Common Bean(Phaseolus vulgaris L.)Functional Flour with High Antioxidant Activity and Antihypertensive Potential

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Food and Nutrition Sciences 2013年第4期4卷 480-490页

作者： Maria Lilia Guzmán-Uriarte Luis Martín Sánchez-Magaña graciela Yaneth Angulo-Meza Edith Oliva Cuevas-Rodríguez Roberto Gutiérrez-Dorado Saraid Mora-Rochín Jorge Milán-Carrillo Angel Valdez-Ortiz Cuauhtémoc Reyes-Moreno Faculty of Chemical-Biological Sciences Autonomous University of SinaloaCuliacánMexico Northwest Regional Program for Doctorate in Biotechnology Autonomous University of SinaloaCuliacánMexico

The main objective of this investigation was to study the time effect during solid state bioconversion (SSB) on total phenolics content (TPC) and antioxidant activity (AoxA) of common beans to improve antihypertensive functionality. Cooked cotyledons of dehulled common beans were inoculated with a suspension of R. oligosporus NRRL 2710 (1 × 106 spores/mL), and incubated at 35℃ for times of 24, 36, 48, 60, 72, 84, 96 and 108 h (after 108 h the cotyledons showed off odor). Flours from bioprocessed dehulled common bean from each incubation time were blended with their corresponding milled seed coats. The best time for producing bioprocessed common bean (added with seed coats) functional flour with the highest AoxA (ORAC value = 17,468 μmol Trolox equivalents (TE)/100 gsample, dw;ABTS value = 13,505 μmol TE/100 gsample, dw) was 108 h. The SSB process substantially increased TPC and total hydrophilic AoxA and antihypertensive potential of common beans in 2.24, 2.45 - 2.73 and 6769 times, respectively. Proteins hydrolyzates from unprocessed whole and bioprocessed (108 h) common beans had IC50 [concentration needed to inhibit 50% the activity of angiotensin converting enzyme (ACE)] of 79.2 and 0.0117 μg/mL, respectively. The SSB is an efective strategy to improve the TPC of common beans for enhanced functionality with improved antioxidant activity and antihypertensive potential.

关键词： Solid State Bioconversion Common Bean Functional Flour Antioxidant Activity Antihypertensive Activity

Meningoencephalitis due to Listeria monocytogenes in a Young Immunocompetent Patient: Case Report with Literature Review

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Advances in Infectious Diseases 2024年第1期14卷 213-219页

作者： Janette Alejandra Gamiño Gutierrez Gustavo Adolfo Hernández Valdez Arleth Anahí Montaño Gómez Jorge Morales Rojas graciela Gaddy Robles Martinez Anahi Herrera Ruelas Alin Kaori Ferreyra Gudiño Jocelin Celeste Jurado Cardona Jimena Jexabeth Ibáñez Núñez Anahí Fierros Ramos Departmento de Neurocirugia Hospital Civil de Guadalajara Fray Antonio Alcalde Guadalajara México Departamento de Medicina Interna ISSSTE Tepic General Hospital APP Tepic México

Meningoencephalitis secondary to Listeria monocytogenes (L. monocytogenes) mainly affects newborns, the elderly and immunocompromised people;there are extremely rare cases in which said infection occurs in immunocompetent individuals. We present the case of a young adult patient without immunocompromise, who developed meningoencephalitis due to L. monocytogenes;This case is exceptional, since it occurred in an individual outside the classic age group, in addition to not having risk factors, which is why it should be considered an atypical causal agent.

关键词： Meningitis Encephalitis Rhombencephalitis Listeria monocytogenes Immunocompetent

Evaluation of the Antimicrobial Activity of Stryphnodendron barbatiman against Citrobacter freundii

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Materials Sciences and Applications 2013年第12期4卷 780-785页

作者： Nara Cde Souza Marcio N.Gomes Rafael R.G.Maciel Romário Jda Silva Tarquin F.Trescher Filipe D.S.Gorza graciela C.Pedro Kennedy C.S.Correa Marcio C.R.Souza Josmary R.Silva Grupo de Materiais Nanoestruturados Universidade Federal de Mato GrossoBarra do GarçasBrazil Faculdades Padrao GoianiaBrazil

Medicinal plants have been presented as a valuable source of preservation of human health. In special, Stryphnodendron barbatiman has been employed due to its antimicrobial activity. This plant is rich in tannins and has been used in popular medicine for the treatment of gastrointestinal disorder, treatment of lesions, and also as anti-inflammatory microbicide. Citrobacter freundii is a member of the family Enterobacteriaceae and is one of the major causes of opportunistic infections. This microorganism is a bacterium (bacillus) aerobic gram-negative with a length in the range of 1 to 5 mm. C. freundii is commonly found in water, soil, food and occasionally in the gastrointestinal tract of animals and humans. In this paper, we have demonstrated the antibacterial activity of S. barbatiman by observing cellular death by using inhibition halo approach. Atomic force microscopy and FT-IR spectroscopy results suggested that interaction between the main active components of S. barbatiman with cellular wall of C. freundii gives rise to cellular wall damage, and then leads this microorganism to death.

关键词： Stryphnodendron barbatiman Citrobacter freundii Atomic Force Microscopy Antimicrobial Activity

1,2,3-三氮唑类化合物的合成及抗病毒活性

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中国药物化学杂志 2016年第1期26卷 18-23页

作者：文逸宁袁伟媛吴勇巍陈雪相玉红张卓勇刘宁宁 ANDREI graciela SNOECK Robert SCHOLS Dominique 武钦佩北京理工大学化工与环境学院应用化学与制药工程系北京100081 首都师范大学化学系北京100048 Rega Institute for Medical Research KU Leuven

目的设计合成一系列新型1,2,3-三氮唑类化合物,评价其抗人类巨细胞病毒和带状疱疹病毒活性。方法氰基乙酸乙酯与叠氮化物进行环加成反应得到5-氨基-1,2,3-三氮唑类化合物,再与胺类化合物反应将酯基转化为酰胺基得到目标化合物;苯基炔与... 详细信息

目的设计合成一系列新型1,2,3-三氮唑类化合物,评价其抗人类巨细胞病毒和带状疱疹病毒活性。方法氰基乙酸乙酯与叠氮化物进行环加成反应得到5-氨基-1,2,3-三氮唑类化合物,再与胺类化合物反应将酯基转化为酰胺基得到目标化合物;苯基炔与叠氮化物进行环加成反应得到另外一类1,4-双芳基-1,2,3-三氮唑类目标化合物。测试了部分目标化合物对人类巨细胞病毒(HCMV,AD-169 strain、Davis strain)和水痘-带状疱疹病毒(VZV,TK^+ strain、TK^- strain)的抗病毒活性。结果与结论合成了16个1,2,3-三氮唑类目标化合物,其中,12个是未见文献报道的新化合物。抗病毒活性测试结果显示,化合物4f能够有效地抑制HCMV(EC_(50)=11.7μmol·L^(-1))和VZV(EC_(50)>4μmol·L^(-1))病毒。

关键词： 1,2,3-三氮唑疱疹病毒抗病毒人类巨细胞病毒(HCMV) 带状疱疹病毒(VZV)

Portal Venous Thrombosis and Splenic Hemangioma, Secondary to Acute Pancreatitis: Case Report

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Open Journal of Gastroenterology 2024年第1期14卷 11-17页

作者： Gustavo Adolfo Hernández Valdez Harvey Yair Zamora Veliz Estefany Gilberty Mendoza Verdin Quitzia Mayanim Rentería Fonseca Itzel Velázquez Viniegra Janette Alejandra Gamiño Gutierrez Diana Rita Velázquez Jimenez Florencio Favian Andrade Luis Fernando Baez Bustos Jorge Morales Rojas María Jacqueline Martínez Tejeda graciela Gaddy Robles Martínez Juan Antonio Contreras Escamilla Departamento de Medicina Interna ISSSTE Tepic General Hospital APP Tepic Nayarit México General Surgery Department ISSSTE Tepic General Hospital APP Tepic Nayarit México Hospital Civil Fray Antonio Alcalde Guadalajara Jalisco México

We present an unusual case of portal vein thrombosis with a splanchnic hemangioma secondary to acute biliary pancreatitis. We report a 45-year-old patient, who has systemic arterial hypertension in treatment, was admitted for abdominal pain in the epigastrium, with irradiation to the right hypochondrium, accompanied by nausea and vomiting of 10 occasions of bile content, physical examination with pain in the right hypochondrium, Murphy positive. We have laboratory studies with a lipase of 788, so a diagnosis of pancreatitis is made with an etiology to be determined. The laboratories suggestive of acute biliary pancreatitis (lipase 788.71);an imaging study was subsequently performed (ultrasonography) with the result of stone in the common bile duct. A laparoscopy was performed with relative improvement, so he was discharged and returned 20 days after surgery due to abdominal pain of the same intensity in the left hypochondrium. Ending his hospitalization with a splenectomy for splenic hemangioma with portal vein thrombosis.

关键词： Pancreatitis Esplenic Hemangioma Esplenectomy Portal Vein Thrombosis Surgery

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用中微子透视宇宙

环球科学 2010年第6期 76-83页

作者：格拉谢拉·B·赫尔米尼（graciela B．Gelmini）亚历山大·库先科（Alexander Kusenko）托马斯·J·韦勒（Thomas J.Weller）虞骏（翻译）曹臻（审校）

中微子不再只是物理学里稀奇古怪的小玩意儿，而是探查太阳、超新星和其他天体特性的一件实用工具。

关键词：中微子宇宙物理学超新星