Effect of Daily Consumption of <i>Lactobacillus reuteri </i>CRL 1098 on Cholesterol Reduction in Hypercholesterolemic Subjects
Effect of Daily Consumption of <i>Lactobacillus reuteri </i>CRL 1098 on Cholesterol Reduction in Hypercholesterolemic Subjects作者机构：IDIP—Instituto de Desarrollo e Investigaciones Pediá tricas “Prof. Dr. Fernando E. Viteri” (Hospital de Niñ os de La Plata Ministerio de Salud/Comisió n de Investigaciones Cientí ficas de la Pro-vincia de Buenos Aires) La Plata Argentina CERELA—Centro de Referencia para Lactobacilos (CONICET) Tucumá n Argentina Sancor CUL Departamento de Investigació n Innovació n y Desarrollo Sunchales Argentina
出 版 物：《Food and Nutrition Sciences》 (食品与营养科学（英文）)
年 卷 期：2015年第6卷第17期
页 面：1583-1590页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Lactobacillus reuteri Hypercholesterolemia Cardiovascular Risk Probiotics Functional Foods
摘 要：The effect of daily consumption of a yogurt containing Lactobacillus reuteri CRL 1098 on the lipid profile of hypercholesterolemic subjects was evaluated by performing a prospective, randomized, double-blind, cross-over placebo controlled clinical study. Participants consumed daily a yogurt containing L. reuteri CRL 1098 or a placebo for four weeks, separated by a wash-out period. Total cholesterol, triacylglycerol, high-density (HDL) and low-density (LDL) lipoprotein levels were assessed at the beginning and at the end of each period. We found a statistically significant reduction of total (–7.86 g/dl) and LDL (–7.02 g/dl) cholesterol in absolute changes (before-after) as well as a decreasing trend in the group receiving the yogurt containing L. reuteri with respect to the placebo group, without detecting changes in HDL-cholesterol and triacylglycerol levels. Our results suggest that low amounts of yogurt (125 g/day) and low doses of the CRL 1098 strain (106 CFU) are sufficient to reduce total and LDL-cholesterol levels in hypercholesterolemic subjects.
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