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Screening of Anti-Infectives against Leishmania donovani

Advances in Microbiology 2016年第1期6卷 13-22页

作者： Henry Nettey grace Lovia Allotey-babington benoit banga Nguessan barima Afrane Mustafa Tagoe Anokye Ababio Patience botchway Yvonne Darko Clement Sasu Alexander Nyarko School of Pharmacy University of Ghana Legon Ghana School of Pharmacy Mercer University Atlanta GA USA

Aim: To evaluate in vitro the effectiveness of several anti-infective agents alone and in combination against Leishmania donovani. Method: A convenient stratified sampling method was used to obtain selected anti-infective agents. For individual drug samples, Half Maximal Inhibitory Concentrations (ICb>50b>) were obtained using the broth dilution method. The ICb>50’sb> of the drugs which were active against L. donovani were used as reference values to prepare drug combinations for the modified microdilution checkerboard method. Results: Five (5) out of the fifty-six (56) drugs used showed activity (inhibition of cell growth) against L. donovani cells. They include Quinine sulphate (ICb>50b> = 0.089 μg/ml), gentamicin (ICb>50b> = 8.1 μg/ml), amodiaquine (ICb>50b> = 138 μg/ml) and the two standard drugs: Amphotericin b (ICb>50b> = 6.3 μg/ml) and Pentamidine (ICb>50b> = 25 μg/ml). The remaining fifty-one (51) drugs did not show any inhibition within the range of concentrations used (1.25 - 160 μg/ml). The drug combinations of Pentamidine/Amodiaquine, Pentamidine/ Quinine sulphate, Pentamidine/Gentamicin, Amphotericin b/Quinine Sulphate, Amphotericin b/ Gentamicin, Amodiaquine/Quinine sulphate and Amodiaquine/Gentamicin showed synergistic effects against L. donovani whereas the Amphotericin b/Amodiaquine combination was antagonistic. Notable in the results obtained was the high effectiveness of quinine sulphate in inhibiting the growth of L. donovani. Quinine sulphate, though not indicated for leishmania treatment, was more effective than the two standard drugs and has a potential of playing a significant role in the treatment of leishmaniasis. Conclusion: This study has revealed five (5) anti-infective agents that by themselves or in combinations show activity against L. donovani. Some of the drug combinations which showed synergism should further be investigated. These results have to be confirmed by in vivo studies to d

关键词： Anti-Infectives Half Maximal Inhibitory Concentration Leishmania donovani

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Acceptance of COVID-19 vaccine and its related determinants in Nigeria:An online survey

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World Journal of Virology 2024年第4期13卷 89-110页

作者： Eyiuche D Ezigbo Seyi S Enitan Esther N Adejumo Abiodun E Durosinmi Richard Y Akele Michael O Dada grace E Itodo Abah M Idoko Okeoghene M Edafetanure-Ibeh Edwin N Okafor Adedeji A Abdulsalam Oyekan I Oyedoyin Polit U Yelpoji Ogunwola O Opeyemi Ogbuji S Nmesomachi Adesola O Oyekale Chisom b Onyeji Haemostasis and Thrombosis Unit Department of Medical Laboratory SciencesUniversity of NigeriaEnugu CampusEnuguEN 400241Nigeria Department of Medical Laboratory Science School of Public and Allied HealthBabcock UniversityIlishan-RemoOG 121109Nigeria Department of Medical Laboratory Science State HospitalIjebu-OdeOG 120221Nigeria Department of biomedical Science School of Applied ScienceUniversity of BrightonBrightonES BN24ATUnited Kingdom Department of Microbiology Federal Teaching Hospital LokojaLokojaKO 260006Nigeria Department of Hematology and blood Group Serology Federal College of Veterinary and Medical Laboratory TechnologyVomPL 930101Nigeria Department of Environmental and Occupational Health Texas A and M University School of Public HealthGarlandTX 75049United States Division of Chemical Pathology Department of Medical Laboratory SciencesUniversity of NigeriaEnugu CampusEnuguEN 400102Nigeria School of Molecular bioscience Sciences College of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowSCO G128QQUnited Kingdom Department of Medical Laboratory Science State Hospital Ijebu-OdeIjebu-OdeOG 360101Nigeria Department of Medical Laboratory Science Faculty of Health Sciences and TechnologyUniversity of JosJosPL 930103Nigeria Department of Medical Laboratory Science Bola Tinubu Health and Diagnostic CenterLagosLA 100102Nigeria Department of Pathology 68 Nigerian Army Reference HospitalYabaLA 1211001Nigeria Department of Medical Laboratory Science Ladoke Akintola University of TechnologyOgbomosoOS 2111105Nigeria

bACKGROUND Vaccine hesitancy is a major challenge in the fight against the coronavirus disease 2019(COVID-19)*** the sociodemographic factors associated with vaccine acceptance among Nigerians is crucial for improving vaccine *** To assess the acceptance rate of COVID-19 vaccine and its related determinants among *** An online cross-sectional survey(observational study)was conducted between February 2021 and May 2021,using a questionnaire hosted on *** invitation to take part in the poll was sent out to participants through social networking platforms.A logistic regression was used to determine which sociodemographic factors were associated with vaccine acceptance *** A total of 1800 persons responded to the survey,a larger proportion of whom were males(53.9%)and within the age group of 21-30 years(29.4%)and earned an average income of less than$500 per month(43.3%).Only 0.56%of participants had a high perceived risk of COVID-19 infection,while only 1.11%had a perceived risk of dying from *** perception rate of the COVID-19 vaccine among participants was 51.1%,while the acceptance rate was 63.9%.There was no significant association between the COVID-19 vaccine acceptance rate and related determinants assessed,particularly age(χ²=3.049,P=0.550),sex(χ²=0.102,P=0.749),average income(χ²=3.802,P=0.875),and religion(χ²=2.819,P=0.420).Participants with chronic conditions demonstrated a higher acceptance rate compared to the general *** Despite the positive perception observed and substantial vaccine acceptance rate among the study participants,more public health interventions are still needed to enhance vaccine acceptability in Nigeria.

关键词： Acceptance COVID-19 Determinants Hesitancy Nigerians Online survey Vaccine

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bmNPV-ZJ iap1基因的克隆、序列分析及其对哺乳动物细胞NF-κb的调节作用研究(英文)

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蚕业科学 2003年第4期29卷 359-364页

作者：吴金美 Robert WLim 吴祥甫 grace Y Sun 吕鸿声华东船舶工业学院生物技术学院镇江212018 University of Missouri-Columbia 中国科学院生物化学与细胞生物学研究所中国农业科学院蚕业研究所

利用PCR法克隆得到家蚕核型多角体病毒镇江株 (bmNPV ZJ)的iap 1基因。序列同源分析表明 :bmNPV ZJ的iap 1全长为 85 8bp ,与bmNPV T3株的碱基同源性为 96 % ,与bmNPV T3株相比少了一段编码 7个氨基酸的区域 ,该缺失区域的两侧有着独特... 详细信息

利用PCR法克隆得到家蚕核型多角体病毒镇江株 (bmNPV ZJ)的iap 1基因。序列同源分析表明 :bmNPV ZJ的iap 1全长为 85 8bp ,与bmNPV T3株的碱基同源性为 96 % ,与bmNPV T3株相比少了一段编码 7个氨基酸的区域 ,该缺失区域的两侧有着独特的结构 :缺失区的 5′侧为连续编码 7个天冬氨酸的序列 ;缺失区的 3′侧为连续编码3个天冬氨酸的序列。NCbI的DART(DomainArchitectureRetrievalTool)功能域搜索表明 ;bmNPV ZJ的iap1含有 2个杆状病毒bIR功能域 ,但不含RING区域。bmNPV的iap是否具有抗凋亡作用迄今尚未见报道。利用以NF κb为探针的凝胶阻滞分析表明 ,bmNPV ZJ的iap1转染鼠的pc12细胞 ,可逆转肿瘤坏死因子TNFα处理pc12细胞引起的核因子 κb(NF κb)的激活。bmNPV ZJ的iap1对NF κb的作用途径及作用方式。

关键词： bmNPV—ZJiap基因克隆序列分析哺乳动物细胞 NF-κb 调节作用 PCR 家蚕核型多角体病毒镇江株碱基同源性凝胶阻滞分析 pcl2细胞凋亡

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Distribution,sources and risk of exposure to polycyclic aromatic hydrocarbons in indoor dusts from electronic repair workshops in southern Nigeria

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Emerging Contaminants 2019年第1期5卷 23-30页

作者： Chukwujindu M.A.Iwegbue grace Obi Stephen A.Uzoekwe Francis E.Egobueze Eze W.Odali Godswill O.Tesi Godwin E.Nwajei bice S.Martincigh Department of Chemistry Delta State UniversityP.M.B.1AbrakaNigeria Department of Chemistry Federal University of Petroleum ResourcesEffurunDelta StateNigeria Department of Chemistry Federal UniversityOtuokeBayelsa StateNigeria Nigerian Agip Oil Company Port HarcourtNigeria Department of Chemistry University of AfricaToru-OruaBayelsa StateNigeria School of Chemistry and Physics University of KwaZulu-NatalPrivate Bag X54001Durban4000South Africa

This study evaluates the characteristic levels,sources and risk of human exposure to polycyclic aromatic hydrocarbons(PAHs)in indoor dusts from electronic repair workshops in southern *** dust samples were collected by gentle sweeping with a brush and dustpan,and subsequently dried and extracted with hexane/dichloromethane by *** extracts were purified on a silica gel/alumina column,and then analysed for their PAH content by means of gas chromatography-mass *** concentrations of PAHs in the electronic repair workshop dusts ranged between 205 and 2963 mg kg*** compositional patterns indicate the dominance of 5-and 3-ring PAH *** estimated benzo[a]pyrene carcinogenic(baPTEQ)and mutagenic(baPMEQ)potency concentrations ranged from 67 to 401 mg kg^-1 and 56.5e277 mg kg^-1 *** non-cancer risk(hazard index,HI)arising from human contact with PAHs in the electronic repair workshop dusts were less than one for all human subject age groups indicating that there is no considerable non-cancer *** cancer risk values for the ingestion and dermal contact routes were greater than the acceptable risk of 10^-6,which suggests that there is a considerable cancer risk associated with unconscious ingestion and dermal contact with dust particles from these electronic repair *** isomeric ratios for the PAHs in the dust samples and principal component analysis suggest that combustion of biomass and vehicular emissions were responsible for the presence of PAHs in the electronic repair workshop dusts.

关键词： PAHs Health risks Indoor dust Electronic repair workshops Southern Nigeria

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Medical Morbidity Profile of Adults in a Rural Community in Enugu, Southeast Nigeria: A Cross Sectional Survey

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Health 2023年第7期15卷 711-727页

作者： Nkeiruka Chigekwu Mbadiwe birinus Adikaibe Ezeala-Adikaibe Celestine Chibuzor Okwara Monday Umeh Nwobodo Fintan C. Ekochin Casmir Orjioke Nkiruka P. Onodugo Titus Okpara Denise Paul Okoli Uzoma C. Okechukwu Mark Ezeme Obumneme b. Anyim grace O. Eneh Obinna Donatus Onodugo Innocent Okoye Uchenna N. Ijoma Department of Medicine Enugu State University Teaching Hospital Enugu Nigeria Department of Medicine University of Nigeria Teaching Hospital Enugu Nigeria Memfys Hospital for Neurosurgery Enugu Nigeria Anambra State University Teaching Hospital Awka Nigeria

Introduction: People in rural communities are exposed to the risk factors for non-communicable disease as those in urban areas. Correct interpretation and management of symptoms are important in primary care especially in rural communities where diagnostic facilities are not readily available. Materials and Methods: This was a cross-sectional study carried out in a village in Enugu South Local Government area of Enugu State. Thorough medical history was taken from all eligible participants who gave their consent. Data were analyzed using SPSS version 26. Results: Data from a total of 1019 (64.7%) out of 1576 participants were analysed. Fever was by far the most common presenting complaint 580 (56.9%) of all participants and 67.9% of medical complaints seen in the clinic. This was followed remotely by musculoskeletal problems and neurological problems 15.6% and 3.8% of the participants respectively. Across all age groups, febrile illness was more than non-febrile illness except in those 65 years. Generalized body pains 74 (7.3%), back pains 55 (5.1), headache 33 (3.2%) and abdominal pains 24 (2.4%) were the commonest symptoms presented by the participants. About 15 (1.5%) of the population surveyed had had trauma/surgery in the past. This was twice the number who presented to the clinic with symptoms related to injury and trauma 7 (0.7%). Conclusions: Fever and musculoskeletal pains are the dominant medical complaints presented by adults in a rural community clinic. This may be related to the season of the year and the occupation of the population studied.

关键词： Symptoms Infectious Diseases Non-Communicable Diseases Rural Community Southeast Nigeria

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从边缘到中心——媵妾们的文学志业

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跨文化研究 2016年第1期 175-206页

作者：方秀洁董伯韬(译) 加拿大麦吉尔大学东亚学系新华网教育频道外语教学与研究出版社

讽刺的是,明清蔚然一时的纳妾之风竟将这些在社会、家庭等级中身处边缘、身份卑微的媵妾们的文学作品带入了人们的视界。因此,借由探讨媵妾们的文学作品,笔者冀图强调在社会臣服与文本实践的交集中建构主体姿态的可能。笔者意欲探讨媵... 详细信息

讽刺的是,明清蔚然一时的纳妾之风竟将这些在社会、家庭等级中身处边缘、身份卑微的媵妾们的文学作品带入了人们的视界。因此,借由探讨媵妾们的文学作品,笔者冀图强调在社会臣服与文本实践的交集中建构主体姿态的可能。笔者意欲探讨媵妾们如何透过反复的书写来营构文学身份,确立权威,展现别样的主体姿态,体认自我实现。由是,透过阅读媵妾们的文学作品,本文旨在阐明处身卑微阶层的女性借由书写所彰显的能动性与主体性。在从语言、社会、文化等维度概述媵妾制历史后,笔者将考察17世纪以来勃兴的媵妾文学,并讨论《撷芳集》的意义,这是一部由汪启淑(1728—1799)编纂的卷帙浩繁的诗集,收录了17世纪中叶以降的女性作者的诗。书中,汪启淑以很大篇幅记录了媵妾阶层的生活与写作。而在本文第二部分,笔者将深入分析沈彩文集,沈彩是位极富才情的侍妾,她的诗作令隶属与能动性之间任何简而化之的关联都问题重重。

关键词：媵妾制媵妾文学社会臣服主体建构自我实现

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家蚕核多角体病毒iap基因的克隆、序列分析及其对哺乳动物细胞核因子-κb的调节作用的研究

家蚕核多角体病毒iap基因的克隆、序列分析及其对哺乳动物细胞核...

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华东六省一市生物化学与分子生物学会2003年学术交流会

作者：吴金美 R.W.Lim 吴祥甫 grace Sun 吕鸿声江苏科技大学(筹)生物技术学院 University of Missouri-Columbia Columbia65212 USA 中国科学院生物化学与细胞生物学研究所中国农业科学院蚕业研究所

利用PCR法克隆得到家蚕核型多角体病毒-镇江株(bmNPV-ZJ)的两个iap基因,bmNPV-ZJ iapl和bm-NPV-ZJiap2。序列同源分析表明:bmNPV-ZJ的iapl全长为858个碱基对,与bmNPV-T3株的碱基同源性为96%,且与bmNPV-T3株相比少了一段编码7个氨基酸的...

利用PCR法克隆得到家蚕核型多角体病毒-镇江株(bmNPV-ZJ)的两个iap基因,bmNPV-ZJ iapl和bm-NPV-ZJiap2。序列同源分析表明:bmNPV-ZJ的iapl全长为858个碱基对,与bmNPV-T3株的碱基同源性为96%,且与bmNPV-T3株相比少了一段编码7个氨基酸的区域,该缺失区域的两侧有着独特的结构:缺失区的5’侧为连续编码7个天冬氨酸的序列,缺失区的3’侧为连续编码3个天冬氨酸的序列。iap2基因的全长为750个碱基对,与bmNPV-T3株的iap2有99%的序列同源性。NCbI的DART(Domain Architecture Re-trieval Tool)功能域搜索表明bmNPV-ZJ的iapl含有2个杆状病毒bIR功能域,但不含RING区域。Iap2则

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巴斯夫阿里巴巴1688旗舰店正式上线

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上海化工 2018年第5期43卷 56-56页

作者： grace

巴斯夫在中国重要的b2b电子商务服务平台阿里巴巴***上推出的旗舰店4月20日正式上线,客户可直接在线采购优质的巴斯夫产品,同时还能享受同等的物流服务。巴斯夫将通过网上旗舰店为中小型企业客户提供更为灵活快捷的服务。在杭州阿里巴... 详细信息

巴斯夫在中国重要的b2b电子商务服务平台阿里巴巴***上推出的旗舰店4月20日正式上线,客户可直接在线采购优质的巴斯夫产品,同时还能享受同等的物流服务。巴斯夫将通过网上旗舰店为中小型企业客户提供更为灵活快捷的服务。在杭州阿里巴巴总部举行的上线仪式中,巴斯夫高级副总裁、负责大中华区业务与市场发展的郑大庆博士表示：“在我们的生活中电子商务无所不在,鼠标一点就能买到几乎所有的商品。

关键词：阿里巴巴巴斯夫旗舰店 b2b电子商务服务平台企业客户物流服务市场发展

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宗教美国，世俗欧洲？

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作者： (美)彼得·伯格(Peter berger) (英)格瑞斯·戴维(grace Davie) (英)埃菲·霍卡斯(Effie Fokas)

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Linking Groundwater Quality and Quantity： An Assessment of Satellite-based Groundwater Storage Anomalies from grace against Ground Measurements of Contaminants in California

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Journal of Environmental Science and Engineering(b) 2012年第11期1卷 1271-1284页

作者： Mohammad Hassan Rezaie-boroon Josh b. Fisher Geosciences and Environment Department California State University Los Angeles CA 90032 USA California Institute of Technology Jet Propulsion Laboratory Pasadena CA 91109 USA

Groundwater comprises a large portion of irrigation for California＇s agriculture, and sustains a wide diversity of ecosystems as well as consumptive use, but pumping is occurring faster than replenishment. At the same time, contaminants from fertilizers and pesticides are infiltrating into the groundwater, becoming increasingly concentrated as water is extracted. It compared space-based observations of groundwater anomalies from California＇s San Joaquin Valley using the grace （gravity recovery and climate experiment） against measurements of 42 organic and inorganic chemicals from 41,667 wells in the valley from 2003 to 2010. It compared Arsenic, boron, Cadmium, Chloride, Selenium, Trichloroethylene, and TDS （total dissolved solid） concentrations with the groundwater storage anomaly from 2003 to 2010. The results show strong correlations for groundwater depletion against increasing chloride （r2= 0.78, p 〈 0.05） and boron （r2 = 0.88, p 〈 0.05）. This indicates increasing contaminant concentrations while groundwater was depleting over the last eight years. Solubilization by complexation with Cl, CO3 and/or organic chelates may account for the increasing concentration of some heavy metals when groundwater depletion occurs. These results are the first to link space-based groundwater mass change with groundwater contaminant concentration change.

关键词： Ground water environment San Joaquin Valley groundwater geochemistry

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