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Harboring CAR-T cells using an injectable scaffold to treat solid tumors

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National Science Review 2024年第5期11卷 91-92页

作者： li tang Institute of Bioengineering (IBI) école polytechnique fédérale de Lausanne (EPFL)

Genetic expression of chimeric antigen receptors (CAR) enables T cells to target and kill cancer cells in an MHCindependent manner, resulting in a potent antitumor response [1]. To date, more than 10 CAR-T cell products have been approved globally for the treatment of hematologic disorders such as relapsed/refractory B-cell acute lymphoblastic leukemia, non-Hodgkin lymphoma, and multiple myeloma [2,3].

关键词： scaffold cells solid treat harboring injectable tumors using

Probiotic Paenibacillus polymyxa 10 and Lactobacillus plantarum 16 enhance growth performance of broilers by improving the intestinal health

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Animal Nutrition 2021年第3期7卷 829-840页

作者： Baikui Wang li gong Yuanhao Zhou li tang Zihan Zeng Qi Wang Peng Zou Dongyou Yu Weifen li Key Laboratory of Molecular Animal Nutrition of the Ministry of Education Key Laboratory of Animal Nutrition and Feed Science(Eastern of China)of the Ministry of AgricultureKey Laboratory of Animal Feed and Nutrition of Zhejiang ProvinceInstitute of Animal Nutrition and Feed SciencesCollege of Animal SciencesZhejiang University310058HangzhouChina Hainan Institute Zhejiang UniversitySanya 572000China

With the ever-growing strict prohibitions on antibiotic growth promoters(AGP)in animal production,in-feed probiotics are becoming attractive alternatives to antibiotics in the poultry *** investigate the effects of Paenibacillus polymyxa 10 and Lactobacillus plantarum 16 on the growth performance and intestinal health of broilers,540 male Cobb 500 broilers of 1 d old were randomly divided into 3 groups with 6 replicates per group and 30 chicks per *** were fed with either a basal diet or basal diets supplemented with 1×108 colony-forming units(CFU)/kg *** 10(BSC10)or *** 16(Lac16)for 42 *** showed that Lac16 treatment improved(Plightly improved(P>0.05)the growth performance of the starter phase *** increased villus height(Plial *** probiotic treatments up-regulated(Plicaecorum,Faecalibacterium prausnitzii,Lachnospira and Cop-rococcu,and significantly(Pli,Bacteroides fragilis and Shigella sonnei).Furthermore,the 2 probiotic treatments also increased the positive connection among the intestinal microbes and the carbohydrate metabolism-related pathways of the intes-tinal bacteria(P<0.05),with decreasing(P<0.05)nucleotides biosynthesis-related pathways of the intesti

关键词： Paenibacillus polymyxa Lactobacillus plantarum Growth performance Intestinal health Broiler

The initial attempt to reveal the emission processes of both mechanoluminescence and room temperature phosphorescence with the aid of circular dichroism in solid state

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Science China Chemistry 2021年第3期64卷 445-451页

作者： Yu Tian Xuekang Yang Yanbin gong Yunsheng Wang Manman Fang Jie Yang Zhiyong tang Zhen li Institute of Molecular Aggregation Science Tianjin UniversityTianjin 300072China Department of Chemistry Wuhan UniversityWuhan 430072China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhou 350207China CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China

A phenothiazine derivative PtzChol containing non-conjugated chiral cholesterol group was designed and synthesized. By analyzing the single crystal structure of PtzChol carefully, coupled with the circular dichroism(CD) signals before and after grinding, it was found that the introduction of cholesterol produced a positive effect on the production of chiral space group, on mechanoluminescence(ML) and room temperature phosphorescence(RTP), and throughout the entire light-emitting process, the CD signal could well reflect the changes of molecular arrangement.

关键词： mechanoluminescence room temperature phosphorescence circular dichroism phenothiazine cholesterol

Long-term variation of Arctic Sudden Stratospheric Warmings(SSW)and potential causes

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Earth and Planetary Physics 2024年第5期8卷 742-752页

作者： QingRan li ShaoDong Zhang KaiMing Huang ChunMing Huang Yun gong WenTao tang Zheng Ma School of Electronic Information Wuhan UniversityWuhan 430072China Guizhou Normal University Guiyang 550001China Key Laboratory of Geospace Environment and Geodesy Ministry of EducationWuhan 430072China State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan 430072China School of Electronic Information Engineering Jingchu University of TechnologyJingmen 448000China

Utilizing the European Centre for Medium-Range Weather Forecast(ECMWF)Reanalysis v5(ERA5),for the first time,we have confirmed close links among Sudden Stratospheric Warmings(SSWs)in the Northern Hemisphere(NH),the polar vortices,and stratospheric Planetary Waves(PWs)by analyzing and comparing their ***,within overall increasing trends,the duration and strength of SSWs exhibit increasing and decreasing trends before and after the winter of 2002,*** reveal possible physical mechanisms driving these trends,we analyzed the long-term trends of the winter(from December to February)polar vortices and of stratospheric PWs with zonal wave number ***,our results show that in all three time periods(the entire period of 41winters,1980 to 2020,and the two subperiods—1980-2002 and 2002-2020)enhancing SSWs were always accompanied by weakening winter polar vortices and strengthening polar PWs like Stationary Planetary Waves(SPWs)and 16-day waves,and vice *** is the first proof,based on ERA5 long-term trend data,that weakening polar vortices and enhancing stratospheric PWs(especially SPWs)could cause an increase in SSWs.

关键词： sudden stratospheric warmings stationary planetary waves 16-day waves polar vortrices long-term trend correlation coefficient

A 31–45.5 GHz injection-locked frequency divider in 90-nm CMOS technology

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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第12期15卷 1183-1189页

作者： Fa-en liU Zhi-gong WANG Zhi-qun li Qin li Lu tang Ge-liang YANG Institute of RF- & OE-ICs Southeast University

We present a 31–45.5 GHz injection-locked frequency divider(ILFD) implemented in a standard 90-nm CMOS process. To reduce parasitic capacitance and increase the operating frequency, an NMOS-only cross-coupled pair is adopted to provide negative resistance. Acting as an adjustable resistor, an NMOS transistor with a tunable gate bias voltage is connected to the differential output terminals for locking range extension. Measurements show that the designed ILFD can be fully functional in a wide locking range and provides a good figure-of-merit. Under a 1 V tunable bias voltage, the self-resonant frequency of the divider is 19.11 GHz and the maximum locking range is 37.7% at 38.5 GHz with an input power of 0 d Bm. The power consumption is 2.88 m W under a supply voltage of 1.2 V. The size of the chip including the pads is 0.62 mm×0.42 mm.

关键词： CMOS Injection-locked frequency divider(ILFD) Millimeter wave Wide locking range Monolithic microwave integrated circuit(MMIC)

Combined heuristics for determining order quantity under time-varying demands

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Journal of Systems Engineering and Electronics 2008年第1期19卷 99-111页

作者： tang Jiafu Pan Zhendong gong Jun liu Shixin Dept. of Systems Engineering Key Lab of Integrated Automation of Process Industry of MOE Northeastern Univ. Shenyang 110004 P. R. China

The time-varying demands for a certain period are often assumed to be less than the basic economic order quantity （EOQ） so that total replenishment quantity rather than economic order quantity is normally considered by most of the heuristics. This acticle focuses on a combined heuristics method for determining order quantity under generalized time-varying demands. The independent policy （IP）, abnormal independent policy （AIP） and dependent policies are studied and compared. Using the concepts of normal/abnormal periods and the properties of dependent policies, a dependent policy-based heuristics （DPH） is proposed for solving the order quantity problems with a kind of time-varying demands pattern under which the first period is normal. By merging the Silver-Meal （S-M） heuristics and the dependent policy-based heuristics （DPH）, a combined heuristics （DPH/S-M） is developed for solving order quantity problems with generalized time-varying demands. The experimentation shows that （1） for the problem with one normal period, no matter which position the normal period stands, the DPH/S-M could not guarantee better than the S-M heuristics, however it is superior to the S-M heuristics in the case that the demands in the abnormal periods are in descending order, and （2） The DPH/S-M is superior to the S-M heuristics for problems with more than one normal period, and the more the number of normal periods, the greater the improvements.

关键词： heuristics EOQ time-varying demands inventory management

Corrosion performance of Al–Al2O3 cold sprayed coatings on mild carbon steel pipe under thermal insulation

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Chinese Journal of Chemical Engineering 2017年第4期25卷 533-539页

作者： Xiaomin Bai Jianqun tang Jianming gong Xiaoliang Lü School of Mechanical and Power Engineering Nanjing Tech UniversityNanjing 211816China

This paper focused on the corrosion resistance of cold spray Al–Al_2O_3composite coatings used on carbon steel pipe surfaces under thermal insulation. Al–Al_2O_3coatings were produced on the carbon steel pipe surface by cold spray(CS) technology. Experimental apparatus was built to test the corrosion resistance of coatings beneath mineral wool insulation under isothermal, thermal cycling and wet/dry conditions. The results showed that when α-Al_2O_3 was added in spraying powder, the coating could obtain higher hardness and a denser microstructure. From corrosionunder-insulation(CUI) tests, Al–Al_2O_3CS coatings were proven to be efficient in protecting carbon steel pipe from CUI mainly owning to lamellar microstructures of coatings. There was no evidence to show that α-Al_2O_3 might bring any negative effect on corrosion resistance. Al–Al_2O_3CS coatings were sensitive to the chloride ion concentration. When these coatings were exposed to higher concentrations of NaC l, the coating's exhibited faster degradation.

关键词： insulation spray lamellar cycling pipe hardness faster isothermal owning exposed

Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua Ge Yueyang Zhao Yuanjie liu Qinghua Zeng Qing tang Zhifang Dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

2011—2020年广州市肺结核死亡趋势及年龄-时期-队列模型分析

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中国防痨杂志 2025年第1期47卷 44-50页

作者：李雪秋刘群唐科吴迪广州市胸科医院结核病防治所一分所广州510095 广东省生物制品与药物研究所药理研究室广州510440 广州市疾病预防控制中心慢性非传染性疾病预防控制部广州510440 广东医科大学公共卫生学院东莞523808

目的:分析2011—2020年广州市肺结核患者的死亡情况和死亡率变化趋势,为制定防控策略和措施提供科学依据。方法:采用Joinpoint回归模型分析2011—2020年广州市全年龄段人群肺结核死亡率变化趋势,并计算年度变化百分比(annual percent ch... 详细信息

目的:分析2011—2020年广州市肺结核患者的死亡情况和死亡率变化趋势,为制定防控策略和措施提供科学依据。方法:采用Joinpoint回归模型分析2011—2020年广州市全年龄段人群肺结核死亡率变化趋势,并计算年度变化百分比(annual percent change,APC)和平均年度变化百分比(average annual percent change,AAPC);使用年龄-时期-队列模型分析广州市20~85岁人群肺结核死亡风险的年龄、时期和队列效应。结果:广州市2011—2020年报告肺结核死亡患者2144例,年均报告标化死亡率为2.57/10万;男性肺结核标化死亡率为4.19/10万,约为女性标化死亡率(0.96/10万)的4.4倍。10年间广州市肺结核年龄标化死亡率总体呈现下降趋势,AAPC为-4.15%(95%CI:-6.41%~-1.85%,P=0.003);其中,女性肺结核死亡率下降速度高于男性,AAPC分别为-6.72%(95%CI:-10.38%~-2.92%,P=0.004)和-3.55%(95%CI:-6.19%~-0.85%,P=0.017)。在不同年龄段人群中,0~49岁和≥65岁年龄段人群肺结核死亡率均呈现明显下降趋势,AAPC分别为-7.05%(95%CI:-11.52%~-2.34%,P=0.009)和-3.94%(95%CI:-6.22%~-1.62%,P=0.005)。年龄-时期-队列模型的年龄效应显示,随着年龄的增长,肺结核死亡风险不断上升,≥65岁人群尤为显著,发病率由66~67岁年龄组的2.93/10万增长至84~85岁年龄组的6.10/10万。时期效应显示,肺结核死亡风险随着时期的变化总体呈现下降趋势,相对危险度(risk ratio,RR)从2011—2012年时期组的1.35下降至2019—2020年时期组的0.81。队列效应显示,越晚出生的人群肺结核死亡风险越低,RR值从1926—1927年出生队列的5.91降低至1998—1999年出生队列的0.16。结论:广州市肺结核死亡率总体呈不断下降的趋势,但男性和女性肺结核死亡率差距较大。需重点关注男性和≥65岁年龄段的老年人群,并实施针对性的防控和治疗措施。

关键词：结核,肺死亡率回归分析队列研究