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下肢高分辨力3D非对比剂增强、ECG门控、多步mR血管成像与对比增强mR血管成像的对照研究

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国际医学放射学杂志 2011年第2期 204-204页

作者： O.K.mohrs S.E.petersen m.C.Heidt T.Schulze P.Schmitt S.Bergemann 唐光健 Darmstadt Radiology Department of Cardiovascular Imaging at Alice-Hospital

目的确定怀疑周围血管病变(PVD)病人下肢采用扰相-自旋回波技术非对比剂增强、3D高分辨力、ECG门控、多步mR血管成像(non-cemRA)的价值,并与1.0mol对比

关键词： mRA 对比剂血管成像周围动脉疾病非增强

Cytokine responses in infants infected with respiratory syncytial virus

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Open Journal of Immunology 2012年第1期2卷 40-48页

作者： morten Breindahl Klaus Rieneck Claus Nielsen Tage Justesen Klaus Bendtzen Klaus müller Department of Pediatrics Hillerod HospitalHillerodDenmark Institute for Inflammation Research(IIR) Department of RheumatologyRigshospitalet University HospitalCopenhagenDenmark Department of Clinical microbiology Hillerod HospitalHillerodDenmark Pediatric Clinic II Rigshospitalet University HospitalCopenhagenDenmark

Introduction: Variability in severity of Respiratory Syncytial Virus (RSV) infection is reportedly due to differences in inflammatory response. Objective: To characterize the cytokine response in RSV+ infants aged 0 - 36 months and to relate their responses to disease severity. methods: Nasopharyngeal aspirations (NPAs) were analyzed for RSV and IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-1RA, IL-4R, IFN-γ, sTNFR1, sTNFR2, and TNF-α. Clinical data were collected from the medical records. Results: We included 331 infants of whom 214 were RSV+. In comparison to RSV- infants, they had significantly higher levels of TNF-α, IL-6, IL-1β, and IFN-γ (p α, IL-6, and IL-1β. sTNFR1/2 were significantly increased in RSV+ infants. Hospitalized patients had significantly higher levels of TNF-α, sTNFR2, and IL-10 (p mmune profile. Conclusion: In acute RSV disease, infected infants’ NPAs contain a significant amount of pro-inflammatory cytokines. Whether this response is beneficial or deleterious remains unanswered. Interpersonal variations in cytokine responses might be linked to an inherited tendency to variations in disease severity.

关键词： Respiratory Syncytial Virus Bronchiolitis Inflammation Cytokines Infants Aged 0-3 Years

Panda X-III： Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers

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Science China(Physics,mechanics & Astronomy) 2017年第6期60卷 8-47页

作者： Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao mei Li Hao Liang Huan Qiao Zhang ming Rui Zhao Jing Zhou Ya Jun mao Hao Qiao Si Guang Wang Ying Yuan meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz gloria Luz ′on Hector mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie maxence Vanderbroucke AnDi Tan Wick Haxton Yuan mei Chinorat Kobdaj Yu-Peng Yan NPAC and Department of Physics and Astronomy Shanghai Jiao Tong University Shanghai Laboratory for Particle Physics and Cosmology Shanghai 200240 China College of Physical Science and Technology Central China Normal University Wuhan 430079 China China Institute of Atomic Energy Beijing 102413 China School of Physics Peking University Beijing 100871 China School of Physics and Key Laboratory of Particle Physics and Particle Irradiation (mOE) Shandong University Jinan 250100 China School of Physics and Engineering Sun Yat-Sen University Guangzhou 510275 China Department of modern Physics University of Science and Technology of China Hefei 230026 China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of China Hefei 230026 China University ofZaragoza C/P Cerbuna 12 50009 Zaragoza Spain IRFU CEA Universite Paris-Saclay F-91191 Gif-sur-Yvette France Department of Physics University of Maryland College Park MD 20742 USA Nuclear Science Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA Center for Excellence in High Energy Physics and Astrophysics Suranaree University of Technology Nakhon Ratchasima 30000 Thailand

Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation *** X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 *** pitch micro-pattern gas detector(microbulk micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the *** signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial *** detector will be immersed in a large water tank to ensure～5 m of water shielding in all *** second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds.

关键词： neutrinoless double beta decay lepton number violation underground experiment TPC micromegas

肝动脉及门静脉选择性自旋标记mRI灌注研究

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国际医学放射学杂志 2015年第4期 398-398页

作者： H.J.Schalkx E.T.petersen N.H.G.m.Peter W.B.Veldhuis m.S.van Leeuwen J.P.W.Pluim 李鹏 Department of Radiology University Medical Center Utrecht

摘要目的研究允许独立血供标记的选择性动脉及门静脉自旋标记(SL)mRI肝脏灌注成像的可行性。方法门静脉和动脉灌注分别应用EPISTAR脉冲技术和伪连续序列进

关键词：门静脉灌注自旋标记 mRI

Single vs dual(en bloc) kidney transplants from donors ≤ 5 years of age: A single center experience

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World Journal of Transplantation 2016年第1期6卷 239-248页

作者： Yousef Al-Shraideh Umar Farooq Hany El-Hennawy Alan C Farney Amudha Palanisamy Jeffrey Rogers Giuseppe Orlando muhammad Khan Amber Reeves-Daniel William Doares Scott Kaczmorski michael D Gautreaux Samy S Iskandar gloria Hairston Elizabeth Brim margaret mangus Robert J Stratta Department of Surgery Wake Forest School of Medicine Department of Internal medicine Wake Forest School of Medicine Department of Pharmacy Wake Forest School of Medicine Department of Pathology Wake Forest School of Medicine

AIm: To compare outcomes between single and dual en bloc(EB) kidney transplants(KT) from small pediatric donors. mETHODS: monocentric nonprospective review of KTs from pediatric donors ≤ 5 years of age. Dual EB KT was defined as keeping both donor kidneys attached tothe inferior vena cava and aorta, which were then used as venous and arterial conduits for the subsequent transplant into a single recipient. Donor age was less useful than either donor weight or kidney size in decision-making for kidney utilization as kidneys from donors m in length were not transplanted. Post-transplant management strategies were standardized in all ***: From 2002-2015, 59 KTs were performed including 34 dual EB and 25 single KTs. mean age of donors(17 mo vs 38 mo, P mean weight(11.0 kg vs 17.4 kg, P = 0.046) and male donors(50% vs 84%, P = 0.01) were lower in the dual EB compared to the single KT group, respectively. mean cold ischemia time(21 h), kidney donor profile index(KDPI; 73% vs 62%) and levels of serum creatinine(SCr, 0.37 mg/d L vs 0.49 mg/d L, all P = NS) were comparable in the dual EB and single KT groups, respectively. Actuarial graft and patient survival rates at 5-years follow-up were comparable. There was one case of thrombosis resulting in graft loss in each group. Delayed graft function incidence(12% dual EB vs 20% single KT, P = NS) was slightly lower in dual EB KT recipients. Initial duration of hospital stay(mean 5.4 d vs 5.6 d) and the one-year incidences of acute rejection(6% vs 16%), operative complications(3% vs 4%), and major infection were comparable in the dual EB and single KT groups, respectively(all P = NS). mean 12 mo SCr and abbreviated mDRD levels were 1.17 mg/d L vs 1.35 mg/d L and 72.5 m L/min per 1.73 m^2 vs 60.5 m L/min per 1.73 m^2(both P = NS) in the dual EB and single KT groups, respectively. CONCLUSION: By transplanting kidneys from young pediatric donors into adult recipients, one can effectively

关键词： Donor age Donor weight En bloc kidney transplant Kidney donor profile index Single kidney transplant Small pediatric donor

葡萄牙国家社科人文研究基础设施“ROSSIO”规划与实践

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数字人文研究 2023年第1期3卷 95-112页

作者：通萨洛·m.d.·西利亚阿娜·C.·格洛里亚安热拉·S.·莎尔格萝布鲁诺·艾梅达达涅尔·蒙特罗马科·R.d.·弗雷塔斯努诺·弗雷雷刘语丝(译) 新里斯本大学中世纪研究所新里斯本大学新里斯本大学当代历史研究所新里斯本大学语言学中心新里斯本大学科学和技术学院研究院里斯本INESC-ID信息和决策支持系统实验室美国布林莫尔学院考古系

ROSSIO基础设施(ROSSIO Infrastructure)是一个免费的开放获取的平台,旨在汇总、整理、连接葡萄牙高等教育机构和文化机构所提供的社会科学、艺术和人文领域的各类数字资源。文章介绍了ROSSIO基础设施的概况、其主要目标、参与机构,以... 详细信息

ROSSIO基础设施(ROSSIO Infrastructure)是一个免费的开放获取的平台,旨在汇总、整理、连接葡萄牙高等教育机构和文化机构所提供的社会科学、艺术和人文领域的各类数字资源。文章介绍了ROSSIO基础设施的概况、其主要目标、参与机构,以及所提供的服务--探索入口、数字展览与数据集、虚拟研究环境。这些服务依赖于元数据收集方案,将原机构所提供的数字对象的元数据引入到ROSSIO中。汇总的数据集被转换为关联数据,然后基于由ROSSIO开发和出版的受控词汇表进行数据丰富过程。文章将描述这一过程,包括其间所涉及的应用程序,以及它们如何交互操作。基于可发现、可访问、可互操作、可重用(FAIR)的原则,我们将进一步思考这些服务如何促进科学传播。

关键词：数字基础设施元数据聚合受控词汇表数字人文 ICT工具社会科学艺术和人文数字平台虚拟研究环境展览和数据集科学研究的公共传播

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Observatory science with eXTP

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Science China(Physics,mechanics & Astronomy) 2019年第2期62卷 97-138页

作者： Jean J.m.in 't Zand Enrico Bozzo JinLu Qu Xiang-Dong Li Lorenzo Amati Yang Chen Immacolata Donnarumma Victor Doroshenko Stephen A.Drake margarita Hernanz Peter A.Jenke Thomas J.maccarone Simin mahmoodifar Domitilla de martino Alessandra De Rosa Elena m.Rossi Antonia Rowlinson gloria Sala Giulia Stratta Thomas m.Tauris Joern Wilms XueFeng Wu Ping Zhou Iván Agudo Diego Altamirano Jean-Luc Atteia Nils A.andersson m.Cristina Baglio David R.Ballantyne Altan Baykal Ehud Behar Tomaso Belloni Sudip Bhattacharyya Stefano Bianchi Anna Bilous Pere Blay Joao Braga Sφren Brandt Edward F.Brown Niccolo Bucciantini Luciano Burderi Edward m.Cackett Riccardo Campana Sergio Campana Piergiorgio Casella Yuri Cavecchi Frank Chambers Liang Chen Yu-Peng Chen Jér?me Chenevez maria Chernyakova ChiChuan Jin Riccardo Ciolfi Elisa Costantini Andrew Cumming Antonino D'Aì Zi-Gao Dai Filippo D'Ammando massimiliano De Pasquale Nathalie Degenaar melania Del Santo Valerio D'Elia Tiziana Di Salvo Gerry Doyle maurizio Falanga XiLong Fan Robert D.Ferdman marco Feroci Federico Fraschetti Duncan K.Galloway Angelo F.Gambino Poshak Gandhi mingYu Ge Bruce Gendre Ramandeep Gill Diego G?tz Christian Gouiffès Paola Grandi Jonathan Granot manuel Güdel Alexander Heger Craig O.Heinke Jeroen Homan Rosario Iaria Kazushi Iwasawa Luca Izzo Long Ji Peter G.Jonker Jordi José Jelle S.Kaastra Emrah Kalemci Oleg Kargaltsev Nobuyuki Kawai Laurens Keek Stefanie Komossa Ingo Kreykenbohm Lucien Kuiper Devaky Kunneriath Gang Li En-Wei Liang manuel Linares Francesco Longo FangJun Lu Alexander A.Lutovinov Denys malyshev Julien malzac Antonios manousakis Ian mcHardy missagh mehdipour YunPeng men mariano méndez Roberto P.mignani Romana mikusincova m.Coleman miller Giovanni miniutti Christian motch Joonas Nättilä Emanuele Nardini Torsten Neubert Paul T.O'Brien mauro Orlandini Julian P.Osborne Luigi Pacciani Stéphane Paltani maurizio Paolillo Iossif E.Papadakis Biswajit Paul Alberto Pellizzoni Uria Peretz miguel A.Pérez Torres Emanuele Perinati Chanda Prescod-Weinstein Pablo Reig SRON Netherlands Institute for Space Research Department of Astronomy University of Geneva Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences School of Astronomy and Space Science Nanjing University INAF-IASF Bologna ASI Via del Politecnico snc INAF-Istituto di Astrofisica e Planetologie Spaziali Institut für Astronomie und Astrophysik Tübingen Universit?t Tübingen NASA Goddard Space Flight Center ICREA&Institute of Space Sciences(IEEC-CSIC) Campus UABCarrer de Can Magrans CSPAR SPA University of Alabama in Huntsville Department of Physics Texas Tech University INAF Osservatorio Astronomico di Capodimonte Leiden Observatory Leiden University Anton Pannekoek Institute University of Amsterdam ASTRON Netherlands Institute for Radio Astronomy Universitat Politecnica de Catalunya(UPC-IEEC) Universitádegli Studi di Urbino‘Carlo Bo’ max-Planck-Institut für Radioastronomie Dr.Karl-Remeis-Sternwarte and Erlangen Centre for Astroparticle Physics(ECAP) Friedrich Alexander Universit?t Erlangen-Nurnberg Purple mountain Observatory Chinese Academy of Sciences Instituto de Astrofysíca de Andalucia-CSIC Department of Physics and Astronomy University of Southampton IRAP Universitéde ToulouseCNRSUPSCNES mathematical Sciences and STAG Research Centre University of Southampton New York University Abu Dhabi Center for Relativistic Astrophysics School of PhysicsGeorgia Institute of Technology Physics Department Middle East Technical University Department of Physics Technion-Israel Institute of Technology INAF Osservatorio Astronomico di Brera Tata Institute of Fundamental Research Dipartimento di matematica e Fisica Universitàdegli Studi Roma Tre Instituto de Astrofísica de Canarias Instituto Nacional de Pesquisas Espaciais-INPE National Space Institute Technical University of Denmark(DTU Space) Department of Physics and Astronomy Michigan State University INAF Osservatorio Astrofisico di Arcetri Dipartimento di Fisica Universitádegli Studi di Cagliari Department of Physics and A

In this White Paper we present the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to Observatory Science targets. These include flaring stars, supernova remnants, accreting white dwarfs, low and high mass X-ray binaries, radio quiet and radio loud active galactic nuclei, tidal disruption events, and gamma-ray bursts. eXTP will be excellently suited to study one common aspect of these objects: their often transient nature. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Science, the eXTP mission is expected to be launched in the mid 2020s.

关键词： space research in struments nuclear astrophysics flare stars accretion and accretion disks mass loss and stellar winds cataclysmic binaries X-ray binaries supernova remnants active galactic nuclei X-ray bursts gamma-ray bursts gravitational waves

Species,growth form,and biogeographic diversity of summit vegetation along an elevation gradient in the tropical Andes:a baseline for climate change monitoring

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Journal of mountain Science 2022年第12期19卷 3441-3457页

作者： Luis D.LLAmBI Luis E.GAmEZ Roxibell PELAYO Carmen J.AZOCAR Jesus E.TORRES Nelson J.mARQUEZ monica B.BERDUGO Francisco CUESTA Lirey A.RAmIREZ Institute of Environmental and Ecological Sciences(ICAE) University of Los AndesMérida5101Venezuela Consorcium for Susteinable Development of the Andean Eco-Region(CONDESAN) Calle Germán Alemán E12-123Quito170504Ecuador Laboratory of Dendrology Environmental and Forestry FacultyUniversity of Los AndesMérida5101Venezuela Ecological Plant Geography Faculty of GeographyUniv.of MarburgDeutschhausstrasse 10Marburg35032Germany Group of Biodiversity Environment and Health Research(BIOMAS)University of Las AméricasQuito170125Ecuador

Tropical alpine ecosystems exhibit outstanding plant diversity and endemism while being particularly sensitive to the impacts of climate *** understanding spatiotemporal changes in plant species composition,richness and community structure along tropical alpine altitudinal gradients is of primary importance,both the functional and historical/biogeographic dimensions of vegetation diversity remain largely *** used Generalized Linear models and multivariate analyses to assess changes in species,growth forms,and biogeographic groups richness and abundance,in response to habitat variables along an elevation gradient in seven summits(3800 to 4600 m asl)in the Venezuelan Andes,studied using the standardized approach of the gloria-Andes monitoring *** habitat variables assessed were soil temperature(-10 cm),soil organic matter,slope inclination,and substrate *** found 113 species,representing72 genera,32 families,13 growth forms,and seven biogeographic origins,that included 25%of endemic *** observed richer vegetation,both in terms of species and growth forms,in summits with higher soil temperatures and higher SOm content,as well as higher biogeographic origin richness with increasing soil *** presence of holarctic elements increased toward higher elevations,while the occurrence of austral antarctic elements increased toward lower *** results indicate that biogeographic and functional approaches to vegetation diversity capture well the effect of abiotic filtering on community structuring in these tropical alpine *** findings constitute an important baseline for monitoring vegetation dynamics linked to climate change in the Venezuelan Andes by highlighting the functional and historical perspective on vegetation analyses,in contrast with more traditional approaches,based only on taxonomic species diversity.

关键词： Alpine vegetation Biogeography Elevation gradient Functional diversity Páramo Soil organic matter Temperature Tropical Andes

血管性因素对认知损害和痴呆的促成作用美国心脏协会／美国卒中协会对医疗卫生专业人员的声明

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国际脑血管病杂志 2012年第2期20卷 85-124页

作者：无无无无无曹雯炜（译）糜建华（译）宋叶平（译）余寿芬（译）王飞（译）李焰生（译）美国心脏协会卒中委员会流行病学与预防委员会心血管护理委员会心血管放射学和介入委员会心血管外科和麻醉学委员会上海交通大学医学院附属仁济医院神经科上海200127

背景与目的本科学声明提供了血管性因素对认知损害（co,airiveimpairment）和痴呆促成作用证据的纵览。血管性因素在老年认知损害和痴呆中的作用十分普遍。本文对血管性认知损害（vascularcognitiveimpairment，VCI）的定义、神经病理... 详细信息

背景与目的本科学声明提供了血管性因素对认知损害（co,airiveimpairment）和痴呆促成作用证据的纵览。血管性因素在老年认知损害和痴呆中的作用十分普遍。本文对血管性认知损害（vascularcognitiveimpairment，VCI）的定义、神经病理学、基础科学和病理生理学研究、神经影像学的作用、血管性和其他相关危险因素的作用以及潜在的防治方法进行了回顾，旨在为临床医生提供一份总体指导，以进一步加深对VCI和痴呆及其防治的理解。方法写作组成员由写作组联合主席基于先前在相关领域的研究成果提名，并经美国心脏协会（AmericanHeartAssociation，AHA）卒中委员会科学声明监督委员会、流行病学和预防委员会以及文稿监督委员会批准。写作组采用系统文献回顾（主要涵盖1990年至2010年5月期间的文献）、以往公布的指南、个人资料以及专家观点总结现有证据，提出当前知识的不足，并对适当的问题根据AHA标准制定推荐意见。所有写作组成员均有机会对推荐意见进行评论并认可了最终版本。经AHA的同行评议以及卒中委员会领导阶层、流行病学和预防委员会以及科学声明监督委员会审阅后，最终获得AHA科学咨询和协调委员会批准。结果VCI概念的提出涵盖了与所有类型脑血管性脑损害（而不仅仅是卒中）相关的整个认知障碍（cognitivedisorder）谱，其范围从轻度认知损害到完全痴呆。神经血管单元和脑血流调节机制障碍可能是VCI的潜在病理生理学过程的重要组成部分。脑淀粉样血管病已成为阿尔茨海默病（Alzheimerdisease，AD）、微梗死、微出血、脑出血以及VCI风险的一个重要标志。老年认知损害的神经病理学改变常常是AD与微血管性脑损害的混合状态，二者可叠加和协同增高认知损害风险。就此而言，mRI和其他神经影像学技术在VCI的确定和识别中起着重要作用，并提供证据说明以白质高信号和小的深部梗死为特征的皮质下型VCI很常见。在许多情况下，VCI的风险标志同样也是卒中的传统危险因素。这些危险因素包括但不仅限于心房颤动、高血压、糖尿病和高胆固醇血症。而且，这些血管危险因素也可能是AD的风险标志。颈动脉内膜一中膜厚度和动脉僵硬度是动脉老化的标记物，也可能成为VCI的风险标志。目前，美国食品药物管理局尚未批准任何VCI的特异性治疗方法。不过，对卒中和心血管病传统危险因素的评价和控制，可能对包括老年人群在内的VCI的预防具有作用。结论血管性因素在认知损害和痴呆中的促成作用很重要。近年来，在临床前、神经病理学、神经影像学、生理学和流行病学研究基础上，对VCI的认识得到了不断提高。推荐使用跨学科的、转化的以及交互的方法进一步加深对此领域的了解，并更好地掌握其神经心理学特征。需要开展前瞻性定量临床一病理学一神经影像学研究，以提高对神经影像学改变的病理学基础，以及血管病变和AD病变在VCI和AD临床演变中的复杂的丰互作用的认识。可能需要在中年期尽早肝始对血管危险标志进行长期干预，以预防或延迟VCI或AD发病的研究。住高危人群I}1强化控制血管危险因素则是另一个重要的研究方向。

关键词： AHA科学声明血管性痴呆阿尔茨海默病危险因素预防治疗