Cytokine responses in infants infected with respiratory syncytial virus

作     者：Morten Breindahl Klaus Rieneck Claus Nielsen Tage Justesen Klaus Bendtzen Klaus Müller 

作者机构：Department of PediatricsHillerod HospitalHillerodDenmark Institute for Inflammation Research(IIR)Department of RheumatologyRigshospitalet University HospitalCopenhagenDenmark Department of Clinical MicrobiologyHillerod HospitalHillerodDenmark Pediatric Clinic IIRigshospitalet University HospitalCopenhagenDenmark 

出 版 物：《Open Journal of Immunology》 (免疫学期刊（英文）)

年 卷 期：2012年第2卷第1期

页      面：40-48页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Funding has been granted from the Medical Research Foundation in Region III,East-Danish Medical Research Forum(ΦSFF) Frederiks-borg County Research Foundation Rosalie Petersen’s Foundation Captain Harald Jensen and Wife’s Foundation Mrs Olga Bryde Nielsen’s Foundation Tvergaard Foundation the Danish Medical Association’s Research Foundation the Danish Pediatric Society(DPS) 

主　　题：Respiratory Syncytial Virus Bronchiolitis Inflammation Cytokines Infants Aged 0-3 Years 

摘      要：Introduction: Variability in severity of Respiratory Syncytial Virus (RSV) infection is reportedly due to differences in inflammatory response. Objective: To characterize the cytokine response in RSV+ infants aged 0 - 36 months and to relate their responses to disease severity. Methods: Nasopharyngeal aspirations (NPAs) were analyzed for RSV and IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-1RA, IL-4R, IFN-γ, sTNFR1, sTNFR2, and TNF-α. Clinical data were collected from the medical records. Results: We included 331 infants of whom 214 were RSV+. In comparison to RSV- infants, they had significantly higher levels of TNF-α, IL-6, IL-1β, and IFN-γ (p α, IL-6, and IL-1β. sTNFR1/2 were significantly increased in RSV+ infants. Hospitalized patients had significantly higher levels of TNF-α, sTNFR2, and IL-10 (p 0.05) than non-hospitalized patients. The cytokine response could not be related to disease severity. We found no evidence of a skewed Th1/Th2 immune profile. Conclusion: In acute RSV disease, infected infants’ NPAs contain a significant amount of pro-inflammatory cytokines. Whether this response is beneficial or deleterious remains unanswered. Interpersonal variations in cytokine responses might be linked to an inherited tendency to variations in disease severity.