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Surgery in biliary lithiasis: from the traditional “open” approach to laparoscopy and the“rendezvous” technique

Hepatobiliary & Pancreatic diseases International 2017年第6期16卷 595-601页

作者： giuseppe Tarantino Paolo Magistri Roberto Ballarin Giacomo Assirati Antonio di Cataldo Fabrizio di Benedetto Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit University of Modena and Reggio Emilia 41124 ModenaItaly Department of General Surgery Sapienza-University of Rome 00189 Rome Italy Department of Surgical Sciences Organ Transplantation and Advanced Technologies University of Catania95124 Catania Italy

BACKGROUND:According to the current literature, biliary lithiasis is a worldwide-diffused condition that affects almost 20% of the general population. The rate of common bile duct stones(CBDS) in patients with symptomatic cholelithiasis is estimated to be 10% to 33%, depending on patient’s *** to stones in the gallbladder, the natural history of secondary CBDS is still not completely understood. It is not clear whether an asymptomatic choledocholithiasis requires treatment or not. For many years, open cholecystectomy with choledochotomy and/or surgical sphincterotomy and cleaning of the bile duct were the gold standard to treat both pathologies. Development of both endoscopic retrograde cholangiopancreatography(ERCP) and laparoscopic surgery,together with improvements in diagnostic procedures, influenced new approaches to the management of CBDS in association with *** SOURCES:We decided to systematically review the literature in order to identify all the current therapeutic options for CBDS. A systematic literature search was performed independently by two authors using Pub Med, EMBASE, Scopus and the Cochrane Library ***:The therapeutic approach nowadays varies greatly according to the availability of experience and expertise in each center, and includes open or laparoscopic common bile duct exploration, various combinations of laparoscopic cholecystectomy and ERCP and combined laparoendoscopic ***:Although ERCP followed by laparoscopic cholecystectomy is currently preferred in the majority of hospitals worldwide, the optimal treatment for concomitant gallstones and CBDS is still under debate, and greatly varies among different centers.

关键词： biliary obstruction bile duct stones gallstones endoscopic retrograde cholangiopancreatography laparoscopic cholecystectomy

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Intraepithelial lymphocytes: bystanders or causative factors in functional gastrointestinal disorders?

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Cellular & Molecular Immunology 2021年第7期18卷 1620-1621页

作者： giuseppe Losurdo Domenico Piscitelli Enzo Ierardi Alfredo di Leo Section of Gastroenterology Department of Emergency and Organ TransplantationUniversity of BariBariItaly Ph.D.Course in Organs and Tissues Transplantation and Cellular Therapies Department of Emergency and Organ TransplantationUniversity of BariBariItaly Section of Pathology Department of Emergency and Organ TransplantationUniversity of BariBariItaly

Intraepithelial lymphocytes(IELs)are immune cells located in the epithelium of the mucosal layer of the gastrointestinal tract that typically show a CD3-positive *** are T lymphocytes that are involved in the primary immune response to several luminal antigens,such as food proteins and infectious *** this reason,their increase may be pathogenetic in several diseases,the most important being celiac ***,an increase above 25 IELs/100 enterocytes in the duodenum,which is considered the cutoff value for celiac disease,may occur in several conditions,such as nonceliac gluten sensitivity,food allergy,Helicobacter pylori(***)infection,gastroenteritis,and even irritable bowel syndrome(IBS).Therefore,the generic term“microscopic enteritis”or“duodenal lymphocytosis”has been proposed for this condition.

关键词： lymphocytes gastrointestinal epithelium

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Final results of the first phase of the PROTO-SPHERA experiment: obtainment of the full current stable screw pinch and first evidences of the jet + torus combined plasma configuration

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Plasma Science and Technology 2024年第2期26卷 31-43页

作者： Paolo MICOZZI Franco ALLAdiO Alessandro MANCUSO Vincenzo ZANZA Gerarda APRUZZESE Francesca BOMBARDA Luca BONCAGNI Paolo BURATTI Francesco FILIPPI giuseppe GALATOLA TEKA Francesco GIAMMANCO Edmondo GIOVANNOZZI Andrea GROSSO Matteo IAFRATI Alessandro LAMPASI Violeta LAZIC Simone MAGAGNINO Simone MANNORI Paolo MARSILI Valerio PIERGOTTI Giuliano ROCCHI Alessandro SIBIO Benedetto TILIA Onofrio TUdiSCO FSN dipartimento Fusione e tecnologie per la Sicurezza Nucleare ENEA Agenzia Nazionale per Le Nuove Tecnologie Energia e lo Sviluppo Economico SostenibileFrascati(Rome)00044Italy IAPS Istituto di Astrofisica e Planetologia Spaziali INAF Istituto Nazionale di AstrofisicaRome O133Italy Physics Department University of Pisa Faculty of Natural Sciences Mathematics and PhysicsPisa 56127 Italy

In astrophysics, the boundary conditions for plasma phenomena are provided by nature and the astronomer faces the problem of understanding them from a variety of observations [Hester J J et al 1996 Astrophys. J. 456 225], on the other hand, in laboratory plasma experiments the electromagnetic boundary conditions become a major problem in the set-up of the machine that produces the plasma, an issue that has to be investigated step by step and to be modified and adapted with great patience, in particular in the case of an innovative plasma confinement experiment. The PROTO-SPHERA machine [Alladio F et al 2006 Nucl. Fusion 46 S613] is a magnetic confinement experiment, that emulates in the laboratory the jet + torus plasma configurations often observed in astrophysics: an inner magnetized jet of plasma centered on the(approximate) axis of symmetry and surrounded by a magnetized plasma torus orthogonal to this jet. The PROTO-SPHERA plasma is simply connected, i.e., no metal current conducting rod is linked to the plasma torus, while instead it is the inner magnetized plasma jet(in the following always called the plasma centerpost) that is linked to the torus. It is mandatory that no spurious plasma current path modifies the optimal shape of the plasma centerpost. Moreover, as the plasma torus is produced and sustained, in absence of any applied inductive electric field, by the inner plasma centerpost through magnetic reconnections [Taylor J B and Turner M F 1989 *** 29 219], it is required as well that spurious current paths do not surround the torus on its outboard, in order not to lower the efficiency of the magnetic reconnections that maintain the plasma torus at the expense of the plasma centerpost. Boundary conditions have been corrected,up to the point that the first sustainment in steady state has been achieved for the combined plasma.

关键词： laboratory plasmas magnetic confinement astrophysical plasmas

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钙钛矿晶格重构实现高亮度、卓越的颜色稳定性及低效率滚降的混合卤化物蓝色钙钛矿发光二极管（英文）

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Science China Materials 2024年

作者：吴炯桦王仁杰张睿 giuseppe Portale Eduardo Solano 刘小可高峰 Department of Physics Chemistry and Biology (IFM) Link?ping University College of Physics and Information Engineering Institute of Micro-Nano Devices and Solar Cells Fuzhou University Zernike Institute for Advanced Materials University of Groningen Nijenborgh 4 Experiments division ALBA synchrotron Carrer de la Llum 2-260829 0-Cerdanyola del Vallès

本文展示了一种简单、有效且通用的晶格重构方法,利用具有高古特曼供体数(DNs)的非极性溶剂来提高钙钛矿薄膜的质量.我们发现高DN非极性溶剂,例如乙酸乙酯,可以与钙钛矿前驱体相互作用.这种溶剂可以使钙钛矿晶格更加有序和“更坚硬”,...

本文展示了一种简单、有效且通用的晶格重构方法,利用具有高古特曼供体数(DNs)的非极性溶剂来提高钙钛矿薄膜的质量.我们发现高DN非极性溶剂,例如乙酸乙酯,可以与钙钛矿前驱体相互作用.这种溶剂可以使钙钛矿晶格更加有序和“更坚硬”,并促使钙钛矿表面形成一种2D/3D的钙钛矿异质结构.晶格重构的钙钛矿薄膜表现出较低的缺陷密度并且其钙钛矿离子迁移受到了抑制.最终得到的混合卤化物蓝色钙钛矿发光二极管(PeLEDs)显示出极高的驱动电流密度和电压的耐受性,表现出高亮度和卓越的颜色稳定性.我们的工作深入研究了非极性溶剂与钙钛矿相互作用,并为进一步开发高性能的PeLEDs提供了启发.

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Chasing the right path: tips, tricks and challenges of robotic approach to posterior segments

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Hepatobiliary Surgery and Nutrition 2019年第5期8卷 512-514页

作者： Fabrizio di Benedetto giuseppe Tarantino Paolo Magistri Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit University of Modena and Reggio EmiliaModenaMOItaly

The advent of minimally invasive technologies to approachliver diseases changed some paradigms of liver surgeryduring the last two *** allow to safely treatpatients with poor liver function,portal hypertension andcirrhosis,reducing the risk of decompensation(1).However,those potential benefits resulted to be in contrast with theactual application of such technologies in the real-life(2,3).

关键词： liver diseases surgery

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Novel frontiers of agents for bowel cleansing for colonoscopy

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World Journal of Gastroenterology 2021年第45期27卷 7748-7770页

作者： Milena di Leo Andrea Iannone Monica Arena giuseppe Losurdo Maria Angela Palamara giuseppe Iabichino Pierluigi Consolo Maria Rendina Carmelo Luigiano Alfredo di Leo Unit of digestive Endoscopy San Paolo HospitalMilan 20090Italy Section of Gastroenterology Department of Emergency and Organ TransplantationUniversity of BariBari 70124Italy Unit of digestive Endoscopy University of MessinaHospital"G.Martino"Messina 98121Italy

The incidence of colorectal cancer(CRC)is characterized by rapid declines in the wake of widespread *** is the gold standard for CRC screening,but its accuracy is related to high quality of bowel preparation(BP).In this review,we aimed to summarized the current strategy to increase bowel cleansing before *** bowel cleansing agents were developed with the same efficacy of previous agent but requiring less amount of liquid to improve patients’*** role of the diet before colonoscopy was also changed,as well the contribution of educational intervention and the use of adjunctive drugs to improve patients’tolerance and/or quality of *** review also described BP in special situations,as lower gastrointestinal bleeding,elderly people,patients with chronic kidney disease,patients with inflammatory bowel disease,patients with congestive heart failure,inpatient,patient with previous bowel resection,pregnant/lactating *** review underlined the quality of BP should be described using a validate scale in colonoscopy report and it explored the available ***,the review explored the possible contribution of bowel cleansing in post-colonoscopy syndrome that can be related by a transient alteration of gut ***,the study underlined several points needed to further investigations.

关键词： Colonoscopy Bowel preparation Cleansing agents Polyethylene glycol Adequate cleansing Constipation

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Neoadjuvant strategies for pancreatic cancer

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World Journal of Gastroenterology 2014年第28期20卷 9374-9383页

作者： Francesco Polistina giuseppe di Natale Giorgio Bonciarelli Giovanni Ambrosino Mauro Frego Department of General Surgery Monselice Hospital Rome University "La Sapienza" School of Surgery Piazzale Aldo Moro Department of Clinical Oncology Monselice Hospital Department of Surgery Malzoni Hospital

Pancreatic cancer(PC)is the fourth cause of cancer death in Western countries,the only chance for long term survival is an R0 surgical resection that is feasible in about 10%-20%of all *** years cumulative survival is less than 5%and rises to 25%for radically resected *** 40%has locally advanced in PC either borderline resectable(BRPC)or unresectable locally advanced(LAPC).Since LAPC and BRPC have been recognized as a particular form of PC neoadjuvant therapy(NT)has increasingly became a valid treatment *** aim of NT is to reach local control of disease but,also,it is recognized to convert about40%of LAPC patients to R0 resectability,thus providing a significant improvement of prognosis for responding *** R0 resection is achieved,survival is comparable to that of early stage PCs treated by upfront *** it is crucial to look for a proper patient *** strategies are multiples and include neoadjuvant chemotherapy(nCT),and the association of nCT with radiotherapy(nCRT)given as either a combination of a radio sensitizing drug as gemcitabine or capecitabine or and concomitant irradiation or as upfront nCT followed by nRT associated to a radio sensitizing *** latter seem to be most promising as it may select patients who do not go on disease progression during initial treatment and seem to have a better *** clinical relevance of nCRT may be enhanced by the application of higher active protocols as FOLFIRINOX.

关键词： Pancreatic cancer Neoadjuvant Chemotherap Radiotherapy Chemoradiation

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How antibiotic resistances could change Helicobacter pylori treatment:A matter of geography?

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World Journal of Gastroenterology 2013年第45期19卷 8168-8180页

作者： Enzo Ierardi Floriana Giorgio giuseppe Losurdo Alfredo di Leo Mariabeatrice Principi division of Gastroenterology Department of Emergency and Organ Transplantation 70124 Bari Italy

Therapeutic management of Helicobacter pylori(***)remains an unsolved ***,no therapeutic regimen is able to cure the infection in all treated patients,and in many the infection persists despite the administration of several consecutive standard *** antibiotic resistance reports describe alarming results,the outcome of therapeutic regimens does not seem to parallel this scenario in most cases,since a successful performance is often reached in more than 80%of ***,the phenomenon of increasing antibiotic resistance is being closely studied,and the results show controversial aspects even in the same geographic *** the continents of Europe,America,Asia,Africa,and Oceania,minimal and maximal values of resistance to the main antibiotics(clarithromycin,amoxicillin,metronidazole,and levofloxacin)feature wide ranges in different *** real enigma is therefore linked to the several different therapeutic regimens,which show results that often do not parallel the in vitro findings even in the same areas.A first aspect to be emphasized is that some regimens are limited by their use in very small geographic ***,not all therapeutic trials have considered bacterial and host factors affecting the therapeutic *** additional use of probiotics may help to reduce adverse events,but their therapeutic impact is *** conclusion,the"ideal therapy",paradoxically,appears to be a"utopia",despite the unprecedented volume of studies in the field and the real breakthrough in medical practice made by the discovery and treatment of *** ample discrepancies observed in the different areas do not encourage the development of therapeutic guidelines that could be valid *** these bases,one of the main challenges for the future might be identifying a successful solution to overcome antibiotic *** this context,geography must be considered a relevant matter.

关键词： Helicobacter pylori Antibiotic resistance Geography Therapeutic regimens Therapeutic outcome

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This pain drives me crazy:Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome

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World Journal of Psychiatry 2024年第6期14卷 954-984页

作者： Marianna Mazza Stella Margoni giuseppe Mandracchia Guglielmo Donofrio Alessia Fischetti Georgios D Kotzalidis giuseppe Marano Alessio Simonetti Delfina Janiri Lorenzo Moccia Ilaria Marcelli Greta Sfratta Domenico De Berardis Ottavia Ferrara Evelina Bernardi Antonio Restaino Francesco Maria Lisci Antonio Maria D'Onofrio Caterina Brisi Flavia Grisoni Claudia Calderoni Michele Ciliberto Andrea Brugnami Sara Rossi Maria Chiara Spera Valeria De Masi Ester Maria Marzo Francesca Abate Gianluca Boggio Maria Benedetta Anesini Cecilia Falsini Anna Quintano Alberto Torresi Miriam Militenda Giovanni Bartolucci Marco Biscosi Sara Ruggiero Luca Lo Giudice Giulia Mastroeni Elisabetta Benini Luca di Benedetto Romina Caso Francesco Pesaresi Francesco Traccis Luca Onori Luca Chisari Leonardo Monacelli Mariateresa Acanfora Eleonora Gaetani Monia Marturano Sara Barbonetti Elettra Specogna Francesca Bardi Emanuela De Chiara Gianmarco Stella Andrea Zanzarri Flavio Tavoletta Arianna Crupi Giulia Battisti Laura Monti Giovanni Camardese Daniela Chieffo Antonio Gasbarrini Giovanni Scambia Gabriele Sani Department of Neurosciences Fondazione Policlinico Universitario A Gemelli IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy Department of Psychiatry UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Neurosciences Section of PsychiatryFondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Mental Health NHSASL 4 TeramoTeramo 64100Italy Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy division of Gynecologic Oncology UniversitàCattolica del Sacro CuoreRome 00168Italy UOS Psicologia Clinica Governo ClinicoFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy CEMAD digestive disease Center Fondazione Policlinico Universitario A.Gemelli-IRCCSRome 00168Italy Department of Woman and Child Health Catholic UniversityRome 00168Italy UOC Psichiatria Clinica e d’Urgenza Dipartimento di Scienze Dell’InvecchiamentoNeurologicheOrtopediche e Della Testa-colloFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy

BACKGROUND Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic *** the term cystitis suggests an inflammatory or infectious origin,no definite cause has been *** occurs in both sexes,but women are twice as much *** To systematically review evidence of psychiatric/psychological changes in persons with IC/*** Hypothesizing that particular psychological characteristics could underpin IC/BPS,we investigated in three databases the presence of psychiatric symptoms and/or disorders and/or psychological characteristics in patients with IC/BPS using the following strategy:("interstitial cystitis"OR"bladder pain syndrome")AND("mood disorder"OR depressive OR antidepressant OR depression OR depressed OR hyperthymic OR mania OR manic OR rapid cyclasterisk OR dysthymiasterisk OR dysphoriasterisk).RESULTS On September 27,2023,the PubMed search produced 223 articles,CINAHL 62,and the combined PsycLIT/PsycARTICLES/PsycINFO/Psychology and Behavioral Sciences Collection search *** on *** produced 14 studies,of which none had available *** were peer-reviewed articles reporting psychiatric/psychological symptoms in patients with IC/BPS,i.e.63 articles spanning from 2000 to October *** studies identified depression and anxiety problems in the IC/BPS population,along with sleep problems and the tendency to *** Psychotherapies targeting catastrophizing and life stress emotional awareness and expression reduced perceived pain in women with IC/*** concepts should be considered when implementing treatments aimed at reducing IC/BPS-related pain.

关键词： Interstitial cystitis/bladder pain syndrome Psychiatric symptoms Psychological symptoms Catastrophizing Anxiety Depression

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Breakthroughs and challenges in the management of pediatric viral hepatitis

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World Journal of Gastroenterology 2021年第20期27卷 2474-2494页

作者： Emanuele Nicastro Lorenzo Norsa Angelo di Giorgio giuseppe Indolfi Lorenzo D'Antiga Department of Pediatric Gastroenterology Hepatology and Transplantation ASST Papa Giovanni XXIIIBergamo 24127Italy Department of Neurofarba Meyer Children's University Hospital of FlorenceFlorence 50137Italy

Chronic infections by hepatitis B virus(HBV)and hepatitis C virus(HCV)major causes of advanced liver disease and mortality *** regarded as benign infections in children,their persistence through adulthood is undoubtedly of *** advances in HCV treatment have restored the visibility of these conditions and raised expectations for HBV treatment,which is currently far from being *** we describe direct-acting antivirals available for pediatric HCV(sofosbuvir/ledipasvir,sofosbuvir/velpatasvir,glecaprevir/pibrentasvir)and their real-world use.A critical review of the HBV pediatric classification is ***-HBV investigational compounds are reviewed in light of the pathophysiology in the pediatric population,including capsid assembly modulators,antigen secretion inhibitors,silencing RNAs,and immune *** for screening and management of immunosuppressed children or those with other risk factors or comorbidities are also summarized.

关键词： Hepatitis C Hepatitis B direct acting antivirals Liver cirrhosis Children

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