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Maternal Thyroid Disease and Neonatal Low Birth Weight: A Systematic Review and Meta-Analysis

Open Journal of Obstetrics and Gynecology 2017年第7期7卷 778-789页

作者： gin Chiu Xiaotian Zhang Enfa Zhao Baomin Liu Department of Ultrasound The Second Affiliated Hospital of Xi'an Jiaotong University Xi’an China Department of Epidemiology and Biostatistics School of Public Health Xi’an Jiaotong University Xi’an China

Objective: Thyroid disorder is a common endocrine complication in pregnant women: the association between neonatal low birth weight (LBW) and thyroid dysfunction during pregnancy has not been definitely confirmed. We conduct a systematic literature review and meta-analysis of the adverse fetal complication of LBW in maternal thyroid disease, including overt and subclinical hyperthyroidism and hypothyroidism. Methods: Relevant studies in English published between 1990 and 2016 were identified by searching PubMed, Medicine, and Embase databases. Cohort studies that evaluated the association between LBW infants and overt and subclinical hyperthyroidism or hypothyroidism during pregnancy and included a healthy pregnancy reference group were selected. The combined odds ratio (OR) with 95% confidence intervals (CI) were calculated to evaluate this relationship. Results: A total of 11 cohort studies (1,171,052 participants) assessed the association between maternal thyroid disease and LBW infants. An increased risk for LBW in hyperthyroidism pregnancies was demonstrated (OR: 1.30, 95% CI 1.11 - 1.54;p = 0.02). No significant increased risk for LBW was detected in subclinical hyperthyroidism (OR 1.03;95% CI 0.72 - 1.48;p = 0.87), or hypothyroidism pregnancies (overt: OR 0.98;95% CI 0.88 - 1.10;p = 0.75;subclinical: OR 1.29;95% CI 0.81 - 2.04;p = 0.28). Conclusion: Data show a higher trend towards an increased risk of LBW among infants from maternal hyperthyroidism pregnancies. No association was seen in subclinical cases of hyperthyroidism or hypothyroidism during pregnancy.

关键词： Low Birth Weight Pregnancy Hyperthyroidism Hypothyroidism Meta-Analysis

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Progress in searching for susceptibility gene for inflammatory bowel disease by positional cloning

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World Journal of Gastroenterology 2003年第8期9卷 1646-1656页

作者： Chang-QingZheng Gang-ZhengHu Zhao-ShuZeng LianJieLin gin-GeGu DepartmentofGastroenterology theSecondAffiliatedClinicalCollegeofChinaMedicalUniversityShenyang110001LiaoningProvinceChina DeoarlmentofSerology CollegeofForensicMedicineMedicalUniversityShenyang110001LiaoningProvinceChina

Inflammatory bowel disease (IBD) includes two clinical subtypes: Crohn disease (CD) and ulcerative colitis (UC). The general prevalence is about 1.0-2.0% in Western *** is predominantly regarded as a multifactorial disorder involving environmental factors and polygenic defects. The view was confirmed by a lot of evidences from clinicalattributions and animal models, especially from epidemiological investigations. So the etiological study of IBD has been focused on searching for susceptibility genes by positional cloning,which consists of two steps: linkage analysis and association analysis. Linkage analysis has been an important method of searching for susceptibility genes to polygenic diseases as well as single-gene disorders. IBD, as a polygenic disease, has been widely investigated by linkage analysis for susceptibility gene since 1996. The paper reviewed 38 arrides, which covered almost all original researches in relation to IBD and linkage analysis. So far, several loci, such as 16q, 12q, 6p and3p,have beenidentified by the studies. The most striking is 16q12(IBD1), which linked only with CD not UC in the majority of studies. Association analysis, as one essential step for positional cloning, is usually carried out by genotyping candidate genes selected by means of linkage analysis or other methods, forfiguring out the frequencies of alleles and comparing the frequencies between IBD group and healthy control group to identify the specific allele. It has been established that IBD is implicated in immune disorder. So the studies were centered on the genes of NOD2/CARD15, HLA-Ⅱ, cytokine, cytokine receptor and adhesion molecule. This paper reviewed 14 original articles on associationbetween NOD2 and IBD that have been published since 2001. All results, with the exception of one report from a Japanese group, provide evidences that the three kinds of variants of NOD2 are susceptibility factors for *** artide also comprehensively analyzed 18 original re

关键词：肠炎遗传易感性克隆病溃疡性结肠炎基因多态性

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Composition of common bile duct stones in Chinese patients during and after endoscopic sphincterotomy

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World Journal of Gastroenterology 2005年第27期11卷 4246-4249页

作者： Wei-Lun Tsai Kwok-Hung Lai Chiun-Ku Lin Hoi-Hung Chan Ching-Chu Lo Ping-I Hsu Wen-Chi Chen Jin-Shiung Cheng gin-Ho Lo Division of Gastroenterology Department of InternalMedicine Kaohsiung Veterans General Hospital School of MedicineNational Yang Ming University Taiwan China

AIM： Endoscopic sphincterotomy （ES） is a well-established therapeutic modality for the removal of common bile duct （CBD） stones. Alter ES there are still around 10% of patients that experience recurrent CBD stones. The aim of this study is to investigate the composition of CBD stones before and alter ES and its clinical significance in Chinese ***： From January 1996 to December 2003, 735 patients with CBD stones received ES at Kaohsiung Veterans General Hospital and stone specimens from 266 patients were sent for analysis. Seventy-five patients had recurrent CBD stones and stone specimens from 44 patients were sent for analysis. The composition of the stones was analyzed by infrared （IR） spectrometry and they were classified as cholesterol or bilirubinate stones according to the predominant composition. Clinical data were ***： In the initial 266 stone samples, 217 （82%） were bilirubinate stones, 42 （16%） were cholesterol stones,3 were calcium carbonate stones, 4 were mixed cholesterol and bilirubinate stones. Patients with bilirubinate stones were significantly older than patients with cholesterol stones （66＋13 years vs 56＋17 years, P = 0.001）. In the 44 recurrent stone samples, 38 （86%） were bilirubinate stones, 3 （7%） were cholesterol stones, and 3 were mixed cholesterol and bilirubinate stones. In 27 patients, both initial and recurrent stone specimens can be obtained,23 patients had bilirubinate stones initially and 2 became cholesterol stones in the recurrent attack. In the four patients with initial cholesterol stones, three patients had bilirubinate stones and one patient had a cholesterol stone in the recurrent ***： Bilirubinate stone is the predominant composition of initial or recurrent CBD stone in Chinese patients, The composition of CBD stones may be different from initial stones afl：er ES,

关键词： Endoscopic sphincterotomy Common bile ductstone Bilirubinate stone Cholesterol stone

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采用基于快速傅里叶变换的谱解法研究Mg-Y合金的变形机理

采用基于快速傅里叶变换的谱解法研究Mg-Y合金的变形机理

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作者： Clément Eliott gin 上海交通大学

学位级别：硕士

在镁中加入钇(Y)可以提高屈服强度和延展性,然而其机理尚不明确。采用模拟的方法可以更加有效的理解变形过程中Y元素的作用。本文采用了晶体塑性的快速傅里叶变换方法(CPFFT)模拟了原位拉伸过程中Mg-3wt.%Y合金在晶粒尺度的变形行为。... 详细信息

在镁中加入钇(Y)可以提高屈服强度和延展性,然而其机理尚不明确。采用模拟的方法可以更加有效的理解变形过程中Y元素的作用。本文采用了晶体塑性的快速傅里叶变换方法(CPFFT)模拟了原位拉伸过程中Mg-3wt.%Y合金在晶粒尺度的变形行为。结果表明,CPFFT成功预测了拉伸曲线,并可以预测特定晶粒在不同加载步下的取向演变和应力演变。相比于基于位错的弹性粘塑性自洽(EVPSC)模型,CPFFT有效的预测晶粒中的晶粒旋转和应力变化。最后,对模拟结果与实验结果在晶粒旋转和应力方面的误差原因进行了讨论

关键词：镁合金晶体塑性显微组织谱解法 CPFFT

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Ethanol consumption as inductor of pancreatitis

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2010年第1期1卷 3-8页

作者： José A Tapia ginés M Salido Antonio González Department of Physiology Faculty of Veterinary Sciences University of Extremadura Avenida Universidad s/n

Alcohol abuse is a major cause of pancreatitis, a condition that can manifest as both acute necroinflammation and chronic damage (acinar atrophy and f ibrosis). Pancreatic acinar cells can metabolize ethanol via the oxidative pathway, which generates acetaldehyde and involves the enzymes alcohol dehydrogenase and possibly cytochrome P4502E1. Additionally, ethanol can be metabolized via a nonoxidative pathway involving fatty acid ethyl ester synthases. Metabolism of ethanol by acinar and other pancreatic cells and the consequent generation of toxic metabolites, are postulated to play an important role in the development of alcohol-related acute and chronic pancreatic injury. This current work will review some recent advances in the knowledge about ethanol actions on the exocrine pancreas and its relationship to inflammatory disease and cancer.

关键词： Pancreas Calcium Ethanol Reactive oxygen species Pancreatitis

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Microwave Synthesis of Large Few-Layer Graphene Sheets in Aqueous Solution of Ammonia

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Nano Research 2010年第2期3卷 126-137页

作者： Izabela Janowska Kambiz Chizari Ovidiu Ersen Spyridon Zafeiratos Driss Soubane Victor Da Costa Virginie Speisser Christine Boeglin Matthieu Houllé Dominique Bégin Dominique Plee Marc-Jacques Ledoux Cuong Pham-Huu Laboratoire des Matériaux Surfaces et Procédés pour la Catalyse(LMSPC)UMR7515 CNRS-Universitéde Strasbourg 25rue Becquerel67087 Strasbourg Cedex 08France Institut de Physique et Chimie des Matériaux de Strasbourg(IPCMS) UMR7504 CNRS-Universitéde Strasbourg 23rue du Loess67037 Strasbourg Cedex 02France Arkema Groupement de Recherche de Lacq(GRL)BP 3464170 LACQFrance

Few-layer graphene (FLG) sheets with sizes exceeding several micrometers have been synthesized by exfoliation of expanded graphite in aqueous solution of ammonia under microwave irradiation, with an overall yield approaching 8 wt.%. Transmission electron microscopy (in bright-field and dark-field modes) together with electron diffraction patterns and atomic force microscopy confirmed that this graphene material consisted mostly of mono-, bi- or few-layer graphene (less than ten layers). The high degree of surface reduction was confirmed by X-ray photoelectron and infrared spectroscopies. In addition, the high stability of the FLG in the liquid medium facilitates the deposition of the graphene material onto several substrates via low-cost solution-phase processing techniques, opening the way to subsequent applications of the material.

关键词： Graphene transmission electron microscopy(TEM) expanded graphite exfoliation microwaves

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Institutional, Regulatory, and Municipality‐Specific Factors Affecting Wastewater Prices: The Case of North Carolina Municipalities

Institutional, Regulatory, and Municipality‐Specific Factor...

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资源型地区可持续发展与政策国际会议暨国际区域科学学会第三次年会

作者： Suho Bae Seong-gin Moon Sung-Woo Hong Graduate School of Governance Sungkyunkwan University 53 Myeongnyun-dong 3-ga Jongno-gu Seoul 110-745 Republic of Korea Department of Public Administration Inha University 253 Yonghyun-dong Nam-gu Incheon 402-751 Republic of Korea Social Science Research Institute Chungbuk National University 52 Naesudong-ro Heungdeuk-gu Cheongju-si Chungbuk 361-763 Republic of Korea

The public sector, including local governments, is mainly responsible for the delivery of wastewater services in the United States. But wastewater prices are considerably different from place to place. This paper examines what factors and characteristics contribute to those differences. To do so, it employs the price equation for wastewater services and utilizes North Carolina municipality data for years 2000 and 2002. Empirical findings indicate that several institutional arrangements and characteristics are important in explaining wastewater prices. When sewer bill is charged on a monthly basis or when a city delivers wastewater services to people outside the city limits and charges different rates to them compared with citizens inside the city limits, wastewater prices get decreased. On the contrary, when a city levies minimum charges, when an increasing rate structure is used, or when the Council-Manager form of government is adopted, wastewater prices get increased. Several supply factors and characteristics affect wastewater prices as well. When a city has large wastewater treatment capacity, when it has its own treatment facility, or when it has a grease reduction program, wastewater prices get decreased. When a city implements an infiltration and inflow (I&I) maintenance program or when it implements a stormwater management program, wastewater prices get increased.

关键词： price of wastewater services institutional arrangements and characteristics North Carolina municipalities

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Investigation of the transcriptomic and metabolic changes associated with superficial scald physiology impaired by lovastatin and 1-methylcyclopropene in pear fruit(cv.“Blanquilla”)

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Horticulture Research 2020年第1期7卷 2229-2245页

作者： Jordi giné-Bordonaba Nicola Busatto Christian Larrigaudière Violeta Lindo-García Gemma Echeverria Urska Vrhovsek Brian Farneti Franco Biasioli Concetta De Quattro Marzia Rossato Massimo Delledonne Fabrizio Costa XaRTA-Postharvest Institute for Food and Agricultural Research and Technology(IRTA)Edifici FruitcentreParc Científic i Tecnològic Agroalimentari de Lleida25003 LleidaSpain Department of Genomics and Biology of Fruit Crops Research and Innovation CentreFondazione Edmund Machvia Mach 138010 San Michele all’AdigeTrentoItaly Department of Food Quality and Nutrition Research and Innovation CentreFondazione Edmund Machvia Mach 138010 San Michele all’AdigeTrentoItaly Department of Biotechnology University of VeronaStrada le Grazie 1537134 VeronaItaly Center Agriculture Food Environment University of Trentovia Mach 138010 San Michele all’AdigeTrentoItaly

To elucidate the physiology underlying the development of superficial scald in pears,susceptible“Blanquilla”fruit was treated with different compounds that either promoted(ethylene)or repressed(1-methylcyclopropene and lovastatin)the incidence of this disorder after 4 months of cold *** data show that scald was negligible for the fruit treated with 1-methylcyclopropene or lovastatin,but highly manifested in untreated(78%incidence)or ethylenetreated fruit(97%incidence).The comparison between the fruit metabolomic profile and transcriptome evidenced a distinct reprogramming associated with each *** all treated samples,cold storage led to an activation of a cold-acclimation-resistance mechanism,including the biosynthesis of very-long-chain fatty acids,which was especially evident in 1-methylcyclopropane-treated *** the treatments applied,only 1-methylcyclopropene inhibited ethylene production,hence supporting the involvement of this hormone in the development of ***,a common repression effect on the PPO gene combined with higher sorbitol content was found for both lovastatin and 1-methylcyclopropene-treated samples,suggesting also a non-ethylene-mediated process preventing the development of this *** results presented in this work represent a step forward to better understand the physiological mechanisms governing the etiology of superficial scald in pears.

关键词： superficial impaired hence

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畅游梦幻之星的蓝色世界

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中学生电脑 2005年第2期 56-57页

作者： gin

"梦幻之星"是日本著名游戏公司SEGA公司在8位机时代开始推出的RPG游戏,这个拥有科幻与魔法并存的世界观非常适合开发网络游戏,SEGA公司自然不会错过.2004年SEGA公司推出了全新的PC版本--(PSOB),全面冲击网络市场.PSOB在国内由朝华数字... 详细信息

"梦幻之星"是日本著名游戏公司SEGA公司在8位机时代开始推出的RPG游戏,这个拥有科幻与魔法并存的世界观非常适合开发网络游戏,SEGA公司自然不会错过.2004年SEGA公司推出了全新的PC版本--(PSOB),全面冲击网络市场.PSOB在国内由朝华数字娱乐负责运营,我们也有机会感受到日本高水平的网络游戏了.

关键词： SEGA公司 PC版本《梦幻之星在线蓝色脉冲》网络游戏游戏介绍游戏方式

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浙江省区域旅游业发展差异成因及对策

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国土与自然资源研究 2010年第5期 76-77页

作者：何小勤湖州师范学院社会发展学院浙江湖州313000

以1998年到2007年为研究时段,全面分析了浙江省11地市旅游收入与旅游人次的差异;并从11地市旅游资源、旅游服务设施、经济发展状况三个主要方面探讨了产生区域旅游发展差异的原因。最后,基于浙江省省情与区域特征,提出加快浙江省旅游业... 详细信息

以1998年到2007年为研究时段,全面分析了浙江省11地市旅游收入与旅游人次的差异;并从11地市旅游资源、旅游服务设施、经济发展状况三个主要方面探讨了产生区域旅游发展差异的原因。最后,基于浙江省省情与区域特征,提出加快浙江省旅游业整体发展和提高各地区旅游业综合实力的相应对策:一、适当整合各市旅游资源。二、实施区域联动发展。三、培育核心区域与核心景区,通过核心区带动边缘区发展。四、优先扶持金温带与杭金衢旅游带发展,促进浙江省各市旅游业协调快速发展。

关键词：浙江省旅游业区域差异对策

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