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世界核心医学期刊文摘（心脏病学分册） 2005年第9期1卷 19-20页

作者： Sabatine m.S. cannon c.P. gibson c.m. 任付先 Dr. TImI Study Group Cardiovascular Division Brigham and Women's Hospital 75 Francis St. Boston MA 02115 United States

BAcKGROUND: A substantial proportion of patients receiving fibrinolytic therapy for myocardial infarction with ST-segment elevation have inadequate reperfusion or reocclusion of the infarct-related artery, leading to an increased risk of c.m.lications and death. mETHODS: We enrolled 3491 patients, 18 to 75 years of age, who presented within 12 hours after the onset of an ST-elevation myocardial infarction and randomly assigned them to receive clopidogrel(300-mg loading dose, followed by 75 mg once daily) or placebo. Patients received a fibrinolytic agent, aspirin, and when appropriate, heparin(dispensed according to body weight) and were scheduled to undergo angiography 48 to 192 hours after the start of study medication. The primary efficacy end point was a c.m.osite of an occluded infarct-related artery(defined by a Thrombolysis in myocardial Infarction flow grade of 0 or 1) on angiography or death or recurrent myocardial infarction before angiography. RESULTS: The rates of the primary efficacy end point were 21.7 percent in the placebo group and 15.0 percent in the clopidogrel group, representing an absolute reduction of 6.7 percentage points in the rate and a 36 percent reduction in the odds of the end point with clopidogrel therapy(95 percent confidence interval, 24 to 47 percent; Pclopidogrel therapy reduced the odds of the c.m.osite end point of death from cardiovascular causes, recurrent myocardial infarction, or recurrent ischemia leading to the need for urgent revascularization by 20 percent(from 14.1 to 11.6 percent, P=0.03). The rates of major bleeding and intracranial hemorrhage were similar in the two groups. cONcLUSIONS: In patients 75 years of age or younger who have myocardial infarction with ST-segment elevation and who receive aspirin and a standard fibrinolytic regimen, the addition of clopidogrel improves the patency rate of the infarct-related artery and reduces ischemic c.m.lications.

关键词：溶栓疗法梗死相关动脉溶栓药物再通率血流分级负荷量联合终点急诊血运重建术血管造影术安慰剂

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初级趣味英语

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1991年

作者： I.A.·理查兹(I.A. Richards) 克里斯订.m.·吉布森(christine.m. gibson)

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初级趣味英语

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1991年

作者： I.A.·理查兹(I.A. Richards) 克里斯订.m.·吉布森(christine.m. gibson)

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比较应用裸金属支架与药物洗脱支架行经皮冠状动脉介入治疗非ST段抬高型急性冠状动脉综合征对生物标记物水平的影响

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世界核心医学期刊文摘（心脏病学分册） 2006年第7期2卷 11-12页

作者： gibson c.m. Karmpaliotis D. Kosmidou I. 杨海涛 TImI Study Group Cardiovascular Division Brigham and Women's Hospital Boston MA United States Dr.

Drug-eluting stents(DESs) deliver biphasic(early and late)-elution of anti-inflammatory c.m.ounds. We therefore hypothesized that DESs would be associated with early reductions in inflammatory biomarker release after percutaneous coronary intervention(PcI). A total of 741 patients with non-ST-elevation acute coronary syndrome underwent PcI in the Randomized Trial to Evaluate the Relative PROTEcTion against Post-PcI microvascular Dysfunction and Post-PcI Ischemia among Anti-Platelet and Anti-Thrombotic Agents(PROTEcT) Thrombolysis In myocardial Infarction 30 study of eptifibatide and reduced-dose antithrombin c.m.ared with bivalirudin. Serial biomarkers c-reactive protein, troponin, creatine kinase-mB, soluble cD40 ligand, interleukin-6, prothrombin fragment F1.2, and RANTES(regulated on activation, normal T-cell expressed and secreted) were assessed through 24 hours after PcI. DES use was at the investigator’s discretion. Patients treated with DESs(n=665) versus bare metal stents(n=139) were more likely to have patent arteries before PcI(92.0%vs 86.6%, p=0.04), Thrombolysis In myocardial Infarction myocardial perfusion grade 3(57.9%vs 47.7%, p=0.033), and the left anterior descending artery as the culprit artery(38.5%vs 18.3%, pcrease in c-reactive protein and troponin was lower among patients undergoing DES implantation(median 2.1 vs 3.5 mg/L for c-reactive protein, median 0.11 vs 0.41 ng/ml for troponin), even after adjustment for randomized treatment, clopidogrel before treatment, diabetes mellitus status, epicardial patency, left anterior descending artery location, and myocardial perfusion(p=0.036 and p=0.039, respectively). Interleukin-6 was lower with DESs on univariate analysis but not multivariate analysis. creatine kinase-mB, soluble scD40 ligand, prothrombin fragment F1.2, and RANTES did not differ by DES use. In conclusion, patients undergoing DES implantation achieved more reductions in periprocedural markers of inflammation and necrosis

关键词：药物洗脱支架 ST段抬高裸金属支架介入治疗生物标记物比伐卢定依替巴肽肌钙蛋白心肌灌注

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非ST段抬高的急性冠脉综合征患者肾小球滤过率与随后死亡率的关系:来自5个心肌缺血溶栓治疗临床试验的13307例患者的观察结果

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世界核心医学期刊文摘（心脏病学分册） 2005年第5期1卷 27-28页

作者： gibson c.m. Dumaine R.L. Gelfand E.V. 刘豫

To determine the association of glomerular filtration rate (GFR) with clinical outc.m.s in the setting of non-ST-segment elevation acute coronary syndromes(NSTE-AcS). Data were pooled from five NSTE-AcS TImI trials(TImI 11A and B, TImI 12, OPUS-TImI 16 and TAcTIcS-TImI 18) and were available in 13 307 patients. GFR was assessed as a continuous and a categorical variable(normal: ≥90 mL/min/1.73 m2,n=4952; mildly decreased: 60-89 mL/min/1.73 m2, n=6262; and moderately to severely decreased GFR: mL/min/1.73 m2, n=2093). There was an independent association between decreasing GFR and mortality at 30 days (OR 1.19, 95%cI 1.12-1.27, pmonths (OR 1.16, 95%cI 1.11-1.22, pc.m.ination of TImI risk score(TRS) and decreasing GFR provided further mortality risk stratification with highest 30-day and 6-month mortality rates among patients with the lowest GFR who also had a TRS ≥5(9.1%and 15.4%, respectively). Decreasing GFR was also independently associated with stroke and recurrent ischaemia at 30-days as well as with major bleeding (pcS, impaired GFR is associated with higher mortality as well as higher rates of thrombotic and major bleeding events, independent of TRS.

关键词：急性冠脉综合征 ST段抬高临床试验肾小球滤过率危险分层出血事件分类变量连续变量栓塞率 OPUS

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How neonatal diet affects the long-term development of rumination behavior,rumen fermentation and feed digestion in dairy calves fed a high milk level?

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Animal Nutrition 2024年第1期16卷 326-337页

作者： Jianxin Xiao Tianyu chen Rong Peng gibson m.Alugongo Hui Yang Shuai Liu Yulin ma Jingjun Wang Shengli Li Zhijun cao State Key Laboratory of Animal Nutrition and Feeding International Calf and Heifer OrganizationCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China Key Laboratory of Low carbon culture and Safety Production in cattle in Sichuan Animal Nutrition InstituteSichuan Agricultural UniversityChengdu 611130China

This study was to investigate growth performance,rumination development,rumen fermentation and feed digestion in young calves provided high volumes(about 20%of calf birth weight)of milk with or without forage inclusion and how these parameters correlate with each *** after birth,160 newborn Holstein female calves(41.6±4.2 kg of initial BW)were randomly divided into 2 treatments:1)starter(cON,only starter)and 2)starter and hay(HAY,both starter and hay).The calves were fed their respective experimental diets from d 4 to 84,after which they were all introduced to similar diets until the end of the experiment on d *** had no effect on growth and structural measurements throughout the experimental ***,treatment had an effect on the other parameters,mainly during the post-weaning *** supplementation tended to reduce starter dry matter intake(P=0.05),while increasing the forage intake(Pcalves had increased neutral detergent fiber(NDF)and physically effective NDF(peNDF)intakes(Pch intake c.m.ared to cON *** HAY calves had a higher rumination time(Pminal pH(Pcetate-to-propionate ratio(P=0.05)c.m.ared to the cON *** correlation analysis showed that rumination time was positively related to the ruminal p H at d 84(P=0.01)and 196(P=0.02).The HAY calves had similar apparent total-tract digestibility of dry matter(Dm),NDF and ether extract(EE),but lower digestibility of organic.m.tter(Om,P=0.03),crude protein(cP,Pch(Pc.m.ared to those of the cON calves at week ***,there were no positive relationships between rumination time and nutrient digestibility or between rumination time per kilogram Dm and nutrient *** conclusion,feeding hay to calves fed a high milk level improved rumination during the post-weaning period only,without a conc.m.tant effect on growth performance thro

关键词： Neonatal calf Early forage feeding Rumination Rumen fermentation Nutrient digestibility

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consumer transparency in the production chain for plant varieties produced using new genomic techniques

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aBIOTEcH 2024年第2期5卷 239-246页

作者： J.m.Lukasiewicz c.c.m.van de Wiel L.A.P.Lotz m.J.m.Smulders Wageningen University&Research P.O.Box 386NL-6700 AJ WageningenThe Netherlands

Plants edited with new genomic techniques(NGTs)currently fall under the Genetically modified Organisms Directive(2001/18/Ec)in the European *** the proposal of the European c.m.ission,NGT plants are partially exempted from the regulations of this *** proposal makes a distinction between two categories of NGT plants:NGT-1 and ***-1 category plants are considered equal to plants obtained through conventional breeding *** plants will not be labelled for the consumer,although they will be labelled as ***-2 category plants may be labelled with additional information as a positive *** of seeds of varieties made with gene editing,but not the products,would mean that most steps in the production chain are transparent,but not the last step towards ***“right to know”and increasing knowledge of gene-edited food is a c.m.on theme in food labelling towards ***,we describe current labelling regimes and registers and how these may be applied to provide transparency on gene-edited products to ***,we also look into consumer studies,which indicate a greater acceptance of gene-edited food among consumers,especially when additional benefits such as sustainability are mentioned.

关键词： Labelling New genomic techniques consumer transparency Plant products

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Performance of evolutionary optimized machine learning for modeling total organic carbon in core samples of shale gas fields

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Petroleum 2024年第1期10卷 150-164页

作者： Leonardo Goliatt c.m.Saporetti L.c.Oliveira E.Pereira Department of c.m.utational and Applied mechanics Federal University of Juiz de Fora Department of c.m.utational modeling Polytechnic Institute Rio de Janeiro State University Petrobras Department of Stratigraphy and Paleontology Rio de Janeiro State University

Rock samples' TOc content is the best indicator of the organic.m.tter in source rocks. The origin rock samples' analysis is used to calculate it manually by specialists. This method requires time and resources because it relies on samples from many well intervals in source rocks. Therefore, research has been done to aid this effort. machine learning algorithms can estimate total organic carbon instead of well logs and stratigraphic studies. In light of these efforts, the current work present a study on automating the total organic carbon estimation using machine learning approaches improved by an evolutionary methodology to give the model flexibility and precision. Genetic algorithms, differential evolution, particle swarm optimization, grey wolf optimization, artificial bee colony, and evolution strategies were used to improve machine learning models to predict TOc. The six metaheuristics were integrated into four machine learning methods: extreme learning machine, elastic net linear model, linear support vector regression, and multivariate adaptive regression splines. core samples from the YuDong-Nan shale gas field, located in the Sichuan basin, were used to evaluate the hybrid strategy. The findings show that c.m.ining machine learning models with an evolutionary algorithms in a hybrid fashion produce flexible models that accurately predict TOc. The results show that, independent of the metaheuristic used to guide the model selection, optimized extreme learning machines attained the best performance scores according to six metrics. Such hybrid models can be used in exploratory geological research,particularly for unconventional oil and gas resources.

关键词： Total organic carbon Hybrid models Automated machine learning Evolutionary algorithms Geology

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An improved pulse coupled neural networks model for semantic IoT

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Digital c.m.unications and Networks 2024年第3期10卷 557-567页

作者： Rong ma Zhen Zhang Yide ma Xiping Hu Edith c.H.Ngai Victor c.m.Leung School of Information Science and Engineering Lanzhou UniversityLanzhou 730000China School of medical Technology Beijing Institute of TechnologyBeijing100081China Department of Electrical and Electronic Engineer The University of Hong KongHong Kong 999077China college of c.m.uter Science and Software Engineering Shenzhen UniversityShenzhen 518060China Department of Electrical and c.m.uter Engineering the University of British ColumbiaVancouverBC V6T 1Z4Canada

In recent years,the Internet of Things(IoT)has gradually developed applications such as collecting sensory data and building intelligent services,which has led to an explosion in mobile data ***,with the rapid development of artificial intelligence,semantic c.m.unication has attracted great attention as a new c.m.unication ***,for IoT devices,however,processing image information efficiently in real time is an essential task for the rapid transmission of semantic *** the increase of model parameters in deep learning methods,the model inference time in sensor devices continues to *** contrast,the Pulse coupled Neural Network(PcNN)has fewer parameters,making it more suitable for processing real-time scene tasks such as image segmentation,which lays the foundation for real-time,effective,and accurate image ***,the parameters of PcNN are determined by trial and error,which limits its *** overc.m. this limitation,an Improved Pulse coupled Neural Networks(IPcNN)model is proposed in this *** IPcNN constructs the connection between the static properties of the input image and the dynamic properties of the neurons,and all its parameters are set adaptively,which avoids the inconvenience of manual setting in traditional methods and improves the adaptability of parameters to different types of *** segmentation results demonstrate the validity and efficiency of the proposed self-adaptive parameter setting method of IPcNN on the gray images and natural images from the matlab and Berkeley Segmentation *** IPcNN method achieves a better segmentation result without training,providing a new solution for the real-time transmission of image semantic information.

关键词： Internet of things(IoT) Semantic information Real-time application Improved pulse coupled neural network Image segmentation

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Semi-analytical investigation of heat transfer in a porous convective radiative moving longitudinal fin exposed to magnetic field in the presence of a shape-dependent trihybrid nanofluid

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Applied mathematics and mechanics(English Edition) 2024年第1期45卷 197-216页

作者： c.G.PAVITHRA B.J.GIREESHA m.L.KEERTHI Department of PG Studies and Research in mathematics Kuvempu UniversityShankaraghatta 577451India Department of mathematics and Statistics M.S.Ramaiah University of Applied SciencesBengaluru 560058India

The thermal examination of a non-integer-ordered mobile fin with a magnetism in the presence of a trihybrid nanofluid(Fe_3O_4-Au-Zn-blood) is carried out. Three types of nanoparticles, each having a different shape, are considered. These shapes include spherical(Fe_3O_4), cylindrical(Au), and platelet(Zn) configurations. The c.m.ination approach is utilized to evaluate the physical and thermal characteristics of the trihybrid and hybrid nanofluids, excluding the thermal conductivity and dynamic viscosity. These two properties are inferred by means of the interpolation method based on the volume fraction of nanoparticles. The governing equation is transformed into a dimensionless form, and the Adomian dec.m.osition Sumudu transform method(ADSTm) is adopted to solve the conundrum of a moving fin immersed in a trihybrid nanofluid. The obtained results agree well with those numerical simulation results, indicating that this research is reliable. The influence of diverse factors on the thermal overview for varying noninteger values of γ is analyzed and presented in graphical representations. Furthermore, the fluctuations in the heat transfer concerning the pertinent parameters are studied. The results show that the heat flux in the presence of the c.m.ination of spherical, cylindrical, and platelet nanoparticles is higher than that in the presence of the c.m.ination of only spherical and cylindrical nanoparticles. The temperature at the fin tip increases by 0.705 759% when the value of the Peclet number increases by 400%, while decreases by 11.825 13% when the value of the Hartman number increases by 400%.

关键词： convection radiation moving longitudinal fin Adomian dec.m.osition Sumudu transform method(ADSTm) trihybrid nanofluid magnetic field

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