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A Systematic Review of Cannabidiol Effects in Coronary Syndromes: Challenges to Clinical Translation

Journal of Biosciences and Medicines 2024年第4期12卷 246-263页

作者： Mario E. Zuñiga-Ayala Alejandra Meaney-Martínez Alejandro Alcocer-Chauvet Vidal Gonzalez-Coronado Nestor Rubio-Infante gerardo garcia-rivas Department of Cardiology Instituto de Seguridad Social and Trabajadores del Estado (ISSSTE) Hospital Regional Primero de Octubre Mexico City Mexico Department of Interventional Cardiology Instituto de Seguridad Social y Trabajadores del Estado (ISSSTE) Hospital Regional Primero de Octubre Mexico City Mexico Instituto Tecnó logico de Monerrey Escuela de Medicina and Ciencias de la Salud C&#225tedra de Cardiolog&#237a and Medicina Vascular Monterrey Mexico

Background: Myocardial ischemia in addition to other several cardiac syndromes represent a pathological proinflammatory state alongside a complex cellular microenvironment that can be modified by using cannabinoids. Cannabidiol (CBD), a non-psychoactive compound of cannabis has been recently proposed as an immudomodulatory and cardioprotective drug. Objectives: In this systematic review we sought to clarify and summarize the clinical and preclinical evidence of potential benefit of the use of CBD in coronary syndromes. Methods: We conducted a systematic search and review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Review of Animal Data from Experimental Studies (CAMARADES) guidelines, in the electronic database from PubMed, Web of Science and Scopus up to April 2022 using predefined search terms. Pre-specified exclusion and inclusion criteria were considered, finally 11 articles were chosen to be included for this peer review. Results: Currently there are no good-quality clinical trials with the use of CBD in acute or chronic coronary syndromes. A total of 11 preclinical studies where prescreened and 5 demonstrated reproducible positive cardiovascular outcomes on in-vivo models treated with CBD. Mechanisms of CBD cardioprotection observed: 1) reduction in oxidative stress and inflammation, 2) activation of adenosine receptors and 3) increased expression of angiotensin type 2-receptor. Experimental models included ischemia/reperfusion injury, myocardial infarction, arrhythmias, and metabolic syndrome-like conditions. Conclusion: No clinical recommendation can be issued with the current evidence, on the use of CBD in acute and chronic coronary syndromes. Based on preclinical evidence, we considered there is enough evidence to propose the development of well-designed clinical trials that include CBD in the management of coronary syndromes.

关键词： Cannabis Cannabidiol Acute Coronary Syndromes Myocardial Infarction Myocardial Ischemia and Oxidative Stress

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Gut microbiota in preterm infants receiving breast milk or mixed feeding

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World Journal of Clinical Pediatrics 2024年第2期13卷 135-145页

作者： Sandra Gabriela Sánchez-González Bárbara Gabriela Cárdenas-del-Castillo Elvira Garza-González gerardo R Padilla-rivas Isaías Rodríguez-Balderrama Consuelo Treviño-Garza Fernando Félix Montes-Tapia gerardo C Palacios-Saucedo Anthony Gutiérrez-Rodríguez Manuel Enrique de-la-O-Cavazos Department of Pediatrics Hospital Universitario“Dr.JoséEleuterio González”Universidad Autónoma de Nuevo LeónMonterrey 64460Nuevo LeónMéxico Departamento de Bioquímica y Medicina Molecular Universidad Autónoma de Nuevo LeónMonterrey 64460Nuevo LeónMéxico Department of Biochemistry and Molecular Medicine Universidad Autónoma de Nuevo LeónMonterrey 64460Nuevo LeónMéxico Department of Pediatric Surgery Hospital Universitario"Dr.JoséEleuterio González"Monterrey 64460Nuevo LeónMéxico

BACKGROUND Preterm birth is the leading cause of mortality in newborns,with very-low-birthweight infants usually experiencing several *** milk is considered the gold standard of nutrition,especially for preterm infants with delayed gut colonization,because it contains beneficial microorganisms,such as Lactobacilli and *** To analyze the gut microbiota of breastfed preterm infants with a birth weight of 1500 g or *** An observational study was performed on preterm infants with up to 36.6 wk of gestation and a birth weight of 1500 g or less,born at the University Hospital ***éEleuterio González at Monterrey,Mexico.A total of 40 preterm neonates were classified into breast milk feeding(BM)and mixed feeding(MF)groups(21 in the BM group and 19 in the MF group),from October 2017 to June *** samples were collected before they were introduced to any feeding *** full enteral feeding was achieved,the composition of the gut microbiota was analyzed using 16S rRNA gene *** variables were compared using Student’s t-test or using the Mann–Whitney U test for nonparametric ***,evenness,equitability,Margalef’s index,Fisher’s alpha,Chao-1 index,and Shannon’s diversity index were also *** No significant differences were observed at the genus level between the *** comparison indicated higher counts of Alphaproteobacteria and Betaproteobacteria in the initial compared to the final sample of the BM group(P<0.011).In addition,higher counts of Gammaproteobacteria were detected in the final than in the initial sample(P=0.040).According to the Margalef index,Fisher’s alpha,and Chao-1 index,a decrease in species richness from the initial to the final sample,regardless of the feeding type,was observed(P<0.050).The four predominant phyla were Bacteroidetes,Actinobacteria,Firmicutes,and Proteobacteria,with Proteobacteria being the most ***,no significant differences were

关键词： Gut microbiota Human milk Preterm infant Proteobacteria Very low birth weight 16S rRNA

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Residents'perception of sustainable tourism in protected mountain areas:the case of Asturias

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Journal of Mountain Science 2022年第12期19卷 3597-3614页

作者： MAGADAN-DIAZ Marta rivas-garcia Jesus I. Faculty of Business and Communication Universidad Internacional de La RiojaAvda.de la Paz 137Logrono 26o06Spain

Spain is the country with the most Biosphere Reserves in the world,52,and Asturias,with 7,ranks first among the single-province Autonomous *** tourist interest in these natural spaces is increasing,but little or nothing is known about how the residents of these natural spaces perceive the tourist *** main objective of this research was to evaluate the residents’perceived changes in protected mountain areas in Asturias concerning the environmental,sociocultural,and economic dimensions related to tourism activity with survey methods and various quantitative *** findings obtained were the following:firstly,there were significant differences between the residents’sociodemographic characteristics and their perceptions of tourism impacts;secondly,there were positive relationships between the residents’perceived tourism economic,environmental and sociocultural impacts and their general attitude towards tourism development;and thirdly,the more positive the residents’attitude towards tourism development,the more likely residents actively support its further *** findings indicate the willingness of residents to get involved and participate in the tourism activity,so policymakers should implicate residents in decisionmaking on local tourism *** conclusion,long-term monitoring of residents’evolution of their perceptions and attitudes is necessary to achieve sustainable tourism development.

关键词： Sustainable tourism Tourists’perception Survey method Regression analysis Asturias

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Analysis and Validation for an Inverter-side Current Controller in LCL Grid-connected Power Systems

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Journal of Modern Power Systems and Clean Energy 2020年第2期8卷 387-398页

作者： Jose MSosa Panfilo R.Martinez-Rodriguez gerardo Escobar gerardo Vazquez Andres A.Valdez-Fernandez Juan F.Martinez-garcia the Tecnologico Nacional de Mexico/ITS de Irapuato(TecNM/ITESI) IrapuatoGTO 36821Mexico the School of Sciences Autonomous University of San Luis Potosi(UASLP)San Luis PotosiSLP 78290Mexico Tecnologico de Monterrey N.L.64849Mexico

Transformerless grid-connected inverters offer greater efficiencies when transferring power from renewable energy sources to the electrical *** the grid-inverter connection is done with an LCL filter,high attenuation of switching harmonics is achieved while preserving a small-size output ***,damping must be included in the controller to assure closed-loop *** paper proposes a reference computation methodology for the inverter-side current feedback in a photovoltaic(PV)generation system connected to the grid through an LCL *** analysis of the closed-loop system stability and of the steady-state performance are presented as well as experimental validation of the closed-loop *** feedback controller includes active damping and relies on a resonant control structure which improves the ability of dealing with grid harmonic *** controller uses a reduced set of measurements,which requires the inverter-side current and grid voltage only,and assures a power factor close to unity.

关键词： LCL filter transformerless inverter grid connection inverter-side current feedback

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Diversity, Endemism and Conservation of Ferns(Polypodiales) in the Mexican Mountain Component

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Journal of Mountain Science 2015年第4期12卷 891-904页

作者： SANGINéS-FRANCO Celia LUNA-VEGA Isolda CONTRERAS-MEDINA Raúl ESPINOSA David TEJERO-DíEZ José Daniel rivas gerardo Laboratorio de Biogeografía y Sistemática Departamento de Biología Evolutiva Facultad de Ciencias Universidad Nacional Autónoma de México (UNAM) Escuela de Ciencias Universidad Autónoma "Benito Juárez" de Oaxaca (UABJO) Av.Universidad s/n Ex Hacienda de Cinco Se?ores Oaxaca de Juárez CP 68120 Oaxaca México Facultad de Estudios Superiores Zaragoza Unidad Multidisciplinaria de Investigación Experimental ZaragozaUniversidad Nacional Autónoma de México (UNAM) Carrera de Biología Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México MéxicoAvenida de los Barrios Número 1 Colonia Los Reyes Iztacala Tlalnepantla CP 54090 Estado de México México Laboratorio de Biogeografía Acuática Departamento de Biología Comparada Facultad de Ciencias Universidad Nacional Autónoma de México (UNAM)

We analyzed the distributional patterns of95 selected species of leptosporangiate ferns inhabiting the Mexican Mountain Component, using grid-cells of one geographical degree as unit areas,applying endemism indices and richness and beta diversity *** data were obtained from several herbaria and specialized *** grid-cells appear to be important for fern species richness, as they contain 35 to 49 *** gridcells are located in the Sierra Madre Oriental(SMO),Trans-Mexican Volcanic Belt(TMVB) and the Sierra Madre del Sur(SMS).Mean richness by latitudinal belts of one degree showed that the belts with highest values are related to the TMVB and SMS.A total of 13grid-cells were recognized as important from theperspective of endemism; most of them are located also in the SMO, TMVB and *** richest gridcells coincided with one of the main centres of endemism for ferns obtained in this study, located in the convergence of the southern part of the SMO, the eastern portion of the TMVB and the northern part of the SMS, reflecting the high humidity existing on the mountain slopes facing the Gulf of *** important grid-cells recognized from richness and endemism analyses coincide with Mexican Natural Protected *** beta diversity analysis showed a low degree of similarity among grid-cells, implying a high species replacement, as the result of environmental heterogeneity occurring in the Mexican mountain *** the other hand, the spatial analysis suggested a pattern of phytogeographical regionalization comprising twomain areas: the Mexican Transition Zone and the Mexican Central *** play an important role in the Mexican biodiversity and contributing to the beta diversity of Mexico.

关键词： Biogeography Distributional patterns Leptosporangiate ferns Mexico

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