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Predictors of the placebo response in a nutraceutical randomized controlled trial for depression

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journal of Integrative Medicine 2024年第1期22卷 46-53页

作者： Rosemary Arnold jenifer Murphy-Smith Chee H.Ng David Mischoulon gerard j.Byrne Chad A.Bousman Con Stough Michael Berk jerome Sarris Professorial Unit the Melbourne ClinicDepartment of PsychiatryUniversity of MelbourneRichmond 3121Australia Depression Clinical and Research Program Department of PsychiatryMassachusetts General HospitalHarvard Medical SchoolBostonMA 02115USA Faculty of Medicine Discipline of PsychiatryCentre for Clinical ResearchRoyal Brisbane&Women’s HospitalHerstonthe University of QueenslandBrisbane 4006Australia Departments of Medical Genetics PsychiatryPhysiology&Pharmacology and Community Health SciencesUniversity of CalgaryCalgaryAB T2N 1N4Canada Department of Psychiatry the University of MelbourneMelbourne 3052Australia Centre for Human Psychopharmacology Swinburne UniversityMelbourne 3122Australia The Institute for Mental and Physical Health and Clinical Translation School of MedicineBarwon HealthDeakin UniversityGeelong 3220Australia The Centre of Excellence in Youth Mental Health the University of MelbourneParkville 3052Australia Florey Institute of Neuroscience and Mental Health the University of MelbourneParkville 3052Australia NICM Health Research Institute Western Sydney UniversityWestmeadNSW 2145Australia

Objective The placebo response in depression studies is the change in symptoms amongst those who receive an inactive *** well-designed randomized controlled trials(RCTs)of depression have a high proportion of placebo responders,with little understanding as to *** present study assesses characteristics associated with the placebo response in a nutraceutical trial with a large proportion of placebo *** This is a secondary analysis of a nutraceutical depression RCT which identified no overall treatment benefit relative to placebo(n=69 in placebo group).We investigated participant characteristics such as socio-demographics,clinical features,and recruitment methods,and their association with the placebo *** genetic polymorphisms were also *** response was measured based on change in Montgomery-Asberg Depression Rating Scale *** association of these hypothesis-driven variables of interest and the placebo response was examined using linear mixed effects *** Greater levels of education,particularly pursuing post-high school education,better self-reported general health,marriage/de facto,greater improvement in the first trial week,and more failed antidepressant therapies in the current depressive episode were associated with greater placebo *** increased placebo response was not found in those recruited via social media nor in those with concomitant antidepressant *** nucleotide polymorphisms from the tryptophan hydroxylase 1(TPH1)gene(A779C and A218C)were weakly associated with greater placebo response,although the evidence was attenuated after accounting for multiple *** This is,to our knowledge,the first study within nutraceutical research for depression to assess the association between participant characteristics and variation in the placebo *** variables appeared to predict the placebo *** findings may encourage future trial design

关键词： Randomized controlled trial Placebo Depression Nutraceutical Psychiatry

Translating radiology reports into plain language using ChatGPT and GPT-4 with prompt learning:results,limitations,and potential

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Visual Computing for Industry,Biomedicine,and Art 2023年第1期6卷 109-118页

作者： Qing Lyu josh Tan Michael E.Zapadka janardhana Ponnatapura Chuang Niu Kyle j.myers Ge Wang Christopher T.Whitlow Department of Radiology Wake Forest University School of MedicineWinston-SalemNC 27103United States Biomedical Imaging Center Rensselaer Polytechnic InstituteTroyNY 12180United States Puente Solutions LLC PhoenixAZ 85065United States

The large language model called ChatGPT has drawn extensively attention because of its human-like expression and reasoning *** this study,we investigate the feasibility of using ChatGPT in experiments on translating radiology reports into plain language for patients and healthcare providers so that they are educated for improved *** reports from 62 low-dose chest computed tomography lung cancer screening scans and 76 brain magnetic resonance imaging metastases screening scans were collected in the first half of February for this *** to the evaluation by radiologists,ChatGPT can successfully translate radiology reports into plain language with an average score of 4.27 in the five-point system with 0.08 places of information missing and 0.07 places of *** terms of the suggestions provided by ChatGPT,they are generally relevant such as keeping following-up with doctors and closely monitoring any symptoms,and for about 37%of 138 cases in total ChatGPT offers specific suggestions based on findings in the *** also presents some randomness in its responses with occasionally over-simplified or neglected information,which can be mitigated using a more detailed ***,ChatGPT results are compared with a newly released large model GPT-4,showing that GPT-4 can significantly improve the quality of translated *** results show that it is feasible to utilize large language models in clinical education,and further efforts are needed to address limitations and maximize their potential.

关键词： Artificial intelligence Large language model ChatGPT Radiology report Patient education

Analysis of ancient mass extinction recoveries in marine environments: generating strategies for managing outcomes of the current mass extinction

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National Science Review 2024年第1期11卷 8-10页

作者： David j.Bottjer Department of Earth Sciences University of Southern California

The defining feature of a mass extinction and its associated recovery is the global amount of extinction that occurred[1]. However, there is finer-scale detail to the story, as seen in the ongoing modern mass extinction(the sixth mass extinction), which exhibits variable effects among marine ecosystems and environments, and hence geographic areas [1].

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Elucidating the impact of the ionomer equivalent weight on a platinum group metal-free PEMFC cathode via oxygen limiting current

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SusMat 2023年第1期3卷 72-90页

作者： HaoWang Luigi Osmieri Haoran Yu Michael j.Zachman jae Hyung Park Nancy N.Kariuki Firat C.Cetinbas Sunilkumar Khandavalli Scott Mauger Deborah j.myers David A.Cullen Kenneth C.Neyerlin Chemistry and Nanoscience Center National Renewable Energy LaboratoryGoldenColoradoUSA Center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTennesseeUSA Chemical Sciences and Engineering Division Argonne National LaboratoryLemontIllinoisUSA Nuclear Science and Engineering Division Argonne National LaboratoryLemontIllinoisUSA

Leveraging the interactions between ionomer and catalyst can increase the performance of proton exchangemembrane fuel *** impacts of the equivalent weight(EW)of perfluorosulfonic acid-based ionomers on the platinum group metal-free electrode structure and fuel cell performance have not been fully *** membrane electrode assemblies(MEAs)were prepared by using a commercial Fe-N-C catalyst,two perfluorosulfonic acid ionomers with different EWs,that is,Aquivion 720(A720)and Nafion 1100(N1100),and two ionomer-tocatalyst(I/C)*** four MEAswere characterized to understand the impact of the ionomer EW and content on the capacitance,proton conductivity,and mass transport on the *** mass transport resistance was measured for the first time using a new oxygen reduction reaction limiting current method enabling to couple the effects of oxygen diffusion with liquid water *** EW ionomer combined with a moderate I/C results in improved performance due to its enhanced proton ***,when used at high I/C,it can cause severewater flooding at high current density due to the enhanced liquid water uptake,especially at high relative humidity,resulting in lower catalyst utilization and higher mass transport resistance.

关键词： ionomer equivalent weight limiting current mass transport oxygen reduction reaction PGMfree catalyst proton exchange membrane fuel cell

Pharmacological interventions targeting nuclear factor-kappa B signaling in multiple sclerosis

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Neural Regeneration Research 2021年第10期16卷 2023-2025页

作者： Kim M.A.De Kleijn gerard j.M.Martens Department of Molecular Animal Physiology Donders Institute for BrainCognition and BehaviourCentre for NeuroscienceFaculty of ScienceRadboud University6525AJ NijmegenThe Netherlands NeuroDrug Research Ltd 6525ED NijmegenThe Netherlands(De Kleijn KMAMartens GJM)Department of Molecular Animal PhysiologyDonders Institute for BrainCognition and BehaviourCentre for NeuroscienceFaculty of ScienceRadboud University6525AJ NijmegenThe Netherlands

Multiple sclerosis(MS)is an inflammatory neurodegenerative disease of the central nervous system(CNS).Pathological characteristics of the disease include activation of CNS-intrinsic immune cells,such as microglia and astrocytes,and loss of neuronal connections,myelin and blood-brain barrier(BBB)integrity as well as peripheral immune cell infiltration into the *** has long been considered a predominantly immunological disease,which has led to the development of essentially only immune-directed *** this traditional“outside-in”MS hypothesis,a dysregulation of the peripheral immune system causes immune cell infiltration into the CNS,leading to autoreactivity against myelin sheath components and secondary BBB ***,recent findings indicate that overactivation of microglia and astrocytes represents an important first step in MS pathology,as appears to be the case for other neurodegenerative diseases such as Alzheimer’s disease(AD)and Parkinson’s disease(PD).

关键词： sclerosis outside essentially

得克萨斯二迭纪含水层/半隔水层系统中深井注射处置酸性废水的地球化学模拟

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华东地质学院学报 1993年第2期16卷 163-166页

作者： M.A.Gardiner j.myers 全仁和

地球化学程序 EQ3NR/EQ6用来模拟西得克萨斯州某化工厂的酸性废物流体与 San Andres(常用的白云岩注入带)和 Grayburg 组(上覆硬石膏半隔水层)主体岩石之间的相互作用。该模拟使用了三种流体:混合废物、未稀释的酸性度物和天然 Grayburg... 详细信息

地球化学程序 EQ3NR/EQ6用来模拟西得克萨斯州某化工厂的酸性废物流体与 San Andres(常用的白云岩注入带)和 Grayburg 组(上覆硬石膏半隔水层)主体岩石之间的相互作用。该模拟使用了三种流体:混合废物、未稀释的酸性度物和天然 Grayburg 地下水。注入带内的白云岩迅速与废酸性反应,导致度物的全部或部分中和,及大量岩石的溶解。这种溶解作用增加了主体岩石的孔隙度和透水性,并使变质和未变质的任一种废物流体进入 Grayburg 组地层中与之接触。溶解硬石膏的能力是溶液中硫和钙的富集程度以及 pH 值、温度和离子强度的函数。废液不断地直接与白云岩、硬石膏反应模拟、化学演化过程提供了评价硬石膏的化学稳定性和半隔水层阻滞垂直流动能力的手段。

关键词：废水地球化学含水层深井处理

Enhanced dual plasmonic photocatalysis through plasmonic coupling in eccentric noble metal-nonstoichiometric copper chakogenide hetero-nanostructures

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Nano Research 2022年第2期15卷 1579-1586页

作者： Mariia Ivanchenko Vida Nooshnab Alline F.myers Nicolas Large Andrew j.Evangelista Hao jing Department of Chemistry and Biochemistry George Mason UniversityFairfaxVirginia 22030USA Department of Physics and Astronomy The University of Texas at San AntonioSan AntonioTX 78249USA National Institute of Standards and Technology(NIST) 100 Bureau Dr.GaithersburgMaryland 20899USA

The extension of plasmonics to materials beyond the conventional noble metals opens up a novel and exciting regime after the inspiring discovery of characteristic localized surface plasmon resonances(LSPRs)in doped semiconductor nanocrystals originating from the collective oscillations of free holes in the valence *** herein prepare colloidal monodisperse eccentric dual plasmonic noble metal-nonstoichiometric copper chalcogenide(Au@Cu_(2-x)Se)hybrid hetero-nanostructures with precisely controlled semiconductor shell size and two tunable LSPRs in both visible(VIS)and near-infrared(NIR)regions associated with Au and Cu_(2-x)Se,*** systematic evaluations of the photocatalytic performance of Au@Cu_(2-x)Se upon sole NIR and dual VIS+NIR simultaneous excitations,we are capable of unambiguously elucidating the role of plasmonic coupling between two dissimilar building blocks on the accelerated photocatalytic reactions with greater rate constants from both experimental and computational *** significantly enhanced strength of the electromagnetic field arising from efficient plasmonic coupling under the excitation of two LSPRs results in the superior activities of dual plasmonic Au@Cu_(2-x)Se in *** new physical and chemical insights gained from this work provide the keystone for the rational design and construction of high-quality dual-or even multi-plasmonic nano-systems with optimized properties for widespread applications ranging from photocatalysis to molecular spectroscopies.

关键词： dual plasmonic nonstoichiometric copper chalcogenides time-domain(FDTD) photocatalysis

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Fe-Si-O系统中各矿物的热力学性质

宝石和宝石学杂志(中英文) 1985年第2期 20-34页

作者： j.myers H.P.Eugster 张昌明

序言Fe-Si-O系统包括三个重要的元素.人们对该系统的矿物平衡作深入研究,是了解许多地壳、地幔和地核环境的先决条件.而这方面的资料对有关陨石、月球和行星的问题也是有意义的.Bowen等（1932）首先在1个大气压下对FeO-SiO2系统作熔融实... 详细信息

序言Fe-Si-O系统包括三个重要的元素.人们对该系统的矿物平衡作深入研究,是了解许多地壳、地幔和地核环境的先决条件.而这方面的资料对有关陨石、月球和行星的问题也是有意义的.Bowen等（1932）首先在1个大气压下对FeO-SiO2系统作熔融实验,并表明了实验结果在岩石学上的意义.为了防止氧化作用,所用原料应盛在铁坩埚内,并在炉内通入氮.在

关键词：方铁矿铁矿物 Fe-Si-O 磁铁矿尖晶石热力学性质物理性能矿物 Si

Association between admission haematocrit and mortality among men with acute ischaemic stroke

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Stroke & Vascular Neurology 2018年第3期3卷 160-168页

作者： jason j Sico Laura j.myers Brenda j Fenton john Concato Linda S Williams Dawn M Bravata Neurology Service VA Connecticut Healthcare SystemWest HavenConnecticutUSA Department of Neurology Center for NeuroEpidemiological and Clinical Neurological ResearchYale University School of MedicineNew HavenConnecticutUSA Department of Internal Medicine Yale University School of MedicineNew HavenConnecticutUSA Clinical Epidemiology Research Center(CERC) VA Connecticut Healthcare SystemWest HavenConnecticutUSA Pain Research InformaticsMultimorbidities and Education(PRIME)Center of InnovationVA Connecticut Healthcare SystemWest HavenConnecticutUSA Communication and the HSR&D Stroke Quality Enhancement Research Initiative(QUERI) Richard L Roudebush VA Medical CenterIndianapolisIndianaUSA VA Health Services Research and Development(HSR&D) Center for Healthcare InformaticsRichard L Roudebush VA Medical CenterIndianapolisIndianaUSA Division of Chronic Disease Epidemiology Yale School of Public HealthWest HavenConnecticutUSA Medical Service VA Connecticut Healthcare SystemWest HavenConnecticutUSA Regenstrief Institute IndianapolisIndianaUSA Department of Neurology Indiana University School of MedicineIndianapolisIndianaUSA Department of Internal Medicine Indiana University School of MedicineIndianapolisIndianaUSA

Objective Anaemia is associated with higher mortality among patients with non-stroke cardiovascular conditions;less is known regarding the relationship between anaemia and mortality among patients with acute ischaemic *** Medical records were abstracted for n=3965 veterans from 131 Veterans Health Administration facilities who were admitted with ischaemic stroke in fiscal year *** values within 24 hours of admission were classified as≤27%,28%-32%,33%-37%,38%-42%,43%-47% or≥48%.Multivariate logistic regression was used to examine the relationship between anaemia and in-hospital,30-day,6-month and 1-year mortality,adjusting for age,medical comorbidities,modified Acute Physiology and Chronic Health Evaluation-III and stroke *** factors were calculated to standardise comparisons between haematocrit tier and other *** Among n=3750 patients included in the analysis,the haematocrit values were≤27%in 2.1%(n=78),28%-32% in 6.2%(n=234),33%-37%in 17.9%(n=670),38%-42% in 36.4%(n=1366),43%-47% in 28.2%(n=1059)and≥48% in 9.1%(n=343).Patients with haematocrit≤27%,compared with patients in the 38%-42% range,were more likely to have died across all follow-up intervals,with statistically significant adjusted ORs(aORs)ranging from 2.5 to *** with polycythaemia(ie,haematocrit≥48%)were at increased risk of in-hospital mortality(aOR=2.9;95%CI 1.4 to 6.0),compared with patients with mid-range admission *** differences between patients receiving and not receiving blood transfusion limited our ability to perform a propensity *** factors in the 1-year mortality model were 0.46(severe anaemia),0.06(cancer)and 0.018(heart disease).Conclusions Anaemia is independently associated with an increased risk of death throughout the first year post stroke;high haematocrit is associated with early poststroke *** anaemia is associated with 1-year mortality to a greater degree than cancer or heart dise

关键词： mortality admitted transfusion