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Antihypertensive drugs in pregnancy

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Family Medicine and Community Health 2013年第1期1卷 37-50页

作者： ROSE GASNIER EDIMARLEI GONSALES VALERIO jose geraldo LOPES RAMOS Post Graduate Program in Medicine Universidade Federal do Rio Grande do SulHospital de Clinicas de Porto AlegreBrazil Service of Obstetrician and Gynecology Hospital de Clinicas de Porto AlegreBrazil Universidade Federal do Rio Grande do Sul Porto AlegreBrazil

Chronic hypertension complicates 3%-5% of pregnancies and gestational hypertension occurs in 6% of *** complicates 25% of the pregnancies with chronic hypertension,and approximately 15%-45% of the patients with gestational hypertension will develop preeclampsia,a dangerous condition that harms the maternal and fetal *** medication is used to treat severe hypertension to prevent serious maternal and fetal complications,but there is no consensus on when and how to treat mild-to-moderate hypertension in *** article reviews the usage,effect and safety of first,second and third line antihypertensive drugs for mild-to-moderate hypertension in pregnancy.

关键词： Gestational hypertension Mild-to-moderate hypertension Antihypertensive drugs

Artificial equilibrium points and bi-impulsive maneuvers to observe 243 Ida

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Chinese Journal of Aeronautics 2021年第1期34卷 410-423页

作者： Allan Kardec de ALMEIDA Jr geraldo Magela Couto OLIVEIRA Antonio Fernando Bertachini de Almeida PRADO National Institute for Space Research(INPE) Sao Jose dos Campos 12227-010Brazil Federal Center for Technological Education of Minas Gerais(CEFET-MG) Belo Horizonte 30421-169Brazil

In the restricted three-body problem,the traditional Lagrange points L1 and L2 are the only equilibrium points near the asteroid 243 *** thrust generated by a solar sail over a spacecraft enables the existence of new artificial equilibrium points,which depend on the position of the spacecraft with respect to the asteroid and the attitude of the solar *** equilibrium points generate new spots to observe the body from above or below the plane of *** points are very good observational locations due to their stationary *** work provides a preliminary analysis to observe Ida through the use of artificial equilibrium points as spots combined with transfer maneuvers between *** combination can be used to observe the asteroid from more different points of view in comparison to fixed *** analyses are made for a spacecraft equipped with a solar sail and capable of performing bi-impulsive *** solar radiation pressure is used both to maintain the equilibrium condition and to reduce the costs of the transfers and/or to create transfers with longer *** is a new aspect of the present research,because it combines the continuous thrust with initial and final small impulses,which are feasible for most of the spacecraft,because the magnitudes of the impulses are very *** combined maneuvers may reduce the transfer times of the maneuvers in most of the cases,compared with the maneuvers based only on continuous *** options involved in these transfers are shown,like to minimize the fuel spent(Dv)as a function of the transfer time or to extend the duration of the travel between the *** transfer times can be useful when observations are required during the transfers.

关键词： Artificial equilibrium points Astrodynamics Orbital transfers Solar radiation pressure Solar sail

Acaricidal activity of Derris floribunda essential oil and its main constituent

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Asian Pacific Journal of Tropical Biomedicine 2017年第9期7卷 791-796页

作者： Ana Claudia Fernandes Amaral Aline de SRamos Marcia Reis Pena jose Luiz Pinto Ferreira Jean Michel SMenezes geraldo JNVasconcelos Neliton Marques da Silva Jefferson Rocha de Andrade Silva Lab de Plantas Medicinais e Derivados Depto de Quimica de Produtos NaturaisFarmanguinhosFundacao Oswaldo CruzRio de JaneiroRJBrazil Lab de Entomologia e Acarologia Agricola Faculdade de Ciencias AgrariasUniversidade Federal do AmazonasManausAMBrazil Lab de Cromatografia Depto de QuímicaUniversidade Federal do AmazonasManausAMBrazil 4Instituto de Ciencias Exatas e TecnologiaUniversidade Federal do AmazonasItacoatiaraAMBrazil

Objective: To evaluate the acaricidal activity of the essential oil obtained from roots of Derris floribunda(D. floribunda)(Miq.) Benth, and its main constituent nerolidol against the Mexican mite Tetranychus mexicanus(T. mexicanus)(Mc Gregor).Methods: The essential oil from the roots of D. floribunda collected in the Amazon region(Brazil) was obtained by hydrodistillation. Its chemical composition was determined by GC–MS analysis. The acaricidal activities of this essential oil and nerolidol,were evaluated by recording the number of dead females(mortality) and eggs(fertility).Results: The essential oil showed sesquiterpenes as major volatile components. Nerolidol, the main component, represented 68.5% of the total composition of the essential oil. D. floribunda essential oil and nerolidol showed acaricidal activity, with LC_(50) of9.61 mg/m L air and 9.2 mg/m L air, respectively, over a 72 h period. In addition, both the essential oil and nerolidol significantly reduced the fecundity of T. ***: Due to the economic importance of T. mexicanus and the lack of new pesticides, our data are very promising in the search for efficient and safer acaricidal products. Furthermore, this is the first report about the chemical composition and bioactivity of the essential oil of the Amazon plant species D. floribunda.

关键词： Acaricidal activity Essential oil Nerolidol Organic agriculture Sesquiterpenes Timb

Analysis of Fatigue Fracture with Scanning Electron Microscopy of Valve Spring Steel

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Journal of Mechanics Engineering and Automation 2014年第5期4卷 422-426页

作者： Marcelo Sampaio Martins Daniel Julien Barros da Silva Sampaio jose geraldo Trani Brandao jose Elias Tomazini Department of Mechanical Faculty of Engineering Guaratinguet6 UNESP (Univ. Estadual Paulista Julio de Mesquita Filho)Guaratingueta/SP 12516-410 Brazil

Valve spring steel for engines, belonging to the class of super clean steel, must be supported due to their application, high numbers of cycles in fatigue and cannot suffer any type of failure, which would be catastrophic for the vehicle. From these considerations, it was tested in axial fatigue, a test that can detect possible internal defects in their structure, caused by inclusions, a class of valve spring steel, where it aimed to discover the values of their fatigue life, followed by an analysis ofmicrostructural fracture surface by SEM （scanning electron microscopy）. It was proved, after testing, the specimens tested broke up a number of cycles always compatible with the life work of a valve spring and that fractures always occurred by surface defects in the specimens.

关键词： Valve spring steel axial fatigue SEM.

Economic Viability Analysis of Investment Alternatives for the Use of Biogas in a Pig Farming in the Middle East Area of Brazil

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Journal of Energy and Power Engineering 2013年第8期7卷 1433-1439页

作者： Elder geraldo Domingues1 Tauler Teixeira Borges Wilson Bueno Garces Junio~ Aylton jose Alves Wesley Pacheco Calixto jose Luis Domingos Nucleus of Research and Extension in Sustainable Process Technology Federal Institute of Goias Goiania 74(~00 Brazil Agro-industrial Chemical Technology Federal Institute of Goias Goiania 74900 Brazil

This paper presents an economic viability analysis of two investment alternatives for a pig farming located in the city of Jatai, Goias State, Brazil. The first investment alternative consists of the implementation of a biodigester, being the biogas burned in a flare. The second alternative also consists of a biodigester, nevertheless the produced biogas is used to generate electricity. The methodologies to estimate the methane production in anaerobic reactors are presented, as well as those for the quantification of the baseline and project emissions and of the electricity that can be generated. The results showed that the use of biogas for the electricity generation is the alternative more economically viable.

关键词： Renewable energy biogas pig farming carbon credits economic viability.

Study of a Photodegradant Polymeric Composite Containing TiO_(2) and Glass Residue

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Open Journal of Civil Engineering 2017年第4期7卷 553-560页

作者： Pedro de Almeida Carisio jose Anceloann Lago Grande Martins geraldo Batista de Melo Joao Fernando Dias Civil Engineering Postgraduate Program of Federal University of Uberlandia Federal University of UberlandiaUberlandiaBrazil Institute of Biomedical Sciences of Federal University of Uberlandia Federal University of UberlandiaUberlandiaBrazil

Photodegradation or photocatalysis is a chemical degradation process that occurs when an inorganic semiconductor is exposed to ultraviolet (UV) light. UV light (wavelength 320 - 400 nm) has enough energy to detach an electron from the last layer of the semiconductor, leading to the conduction band, leaving a hole in the valence band. In these bands, chemical reduction and oxidation reactions occur, respectively. These reactions degrade diverse surface dirt, dissociating them into simpler and less offensive substances such as CO2 and H2O. In this work, we studied the potential of photocatalysis of a composite based on a semiconductor encapsulated in epoxy resin, in the degradation of Staphylococcus aureus, pathogen with a high degree of hospital contamination, in order to apply it to the construction in hospital facilities. The experiments were carried out with a fabrication of only epoxy resin tablets and tablets with the composite, at various concentrations of the semiconductor and glass powder. Through contamination of these tablets and their exposure to sunlight and the ambient light, contamination on their surfaces was verified. The results indicated potential photodegradation capacity of the composite.

关键词： Photodegradation Semiconductor Epoxy Resin Composite

Correlation between Late Cord Clamping and Phototherapy and Other Neonatal Unfavorable Outcomes: A Randomized Clinical Trial

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Open Journal of Obstetrics and Gynecology 2022年第3期12卷 193-200页

作者： Janete Vettorazzi Gabriela Françoes Rostirolla Maria Alexandrina Zanatta Edimárlei Gonsales Valério Charles Francisco Ferreira jose geraldo Lopes Ramos Postgraduation Program in Health Sciences: Gynecology and Obstetrics Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil Department of Gynecology and Obstetrics Faculty of Medicine (FAMED) Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil Department of Gynecology and Obstetrics Faculty of Medicine (FAMED) Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil Department of Gynecology and Obstetrics Faculty of Medicine Universidade de Caxias do Sul (UCS)

Background: Recently, late umbilical cord clamping is generally recommended, which decreases neonatal anemia;however, it may also increase neonatal jaundice and some other poor outcomes. Objectives: We here attempted to determine whether late clamping actually increases the incidence of phototherapy for jaundice and other poor outcomes of the term “low-risk newborns”. Methods: With the approval of the Brazilian Registry of Clinical Trials (REBEC), a total of 357 low-risk newborns (singleton, uncomplicated pregnancy/delivery, in a Brazilian public institution) were randomized into two groups: group I (n = 114): cord clamping 1 minute (early clamping) or group II (n = 243): cord clamping between 1 - 3 minutes (late clamping). Statistics were used appropriately (i.e., measures of central tendency, dispersion for continuous variables, Shapiro-Wilk, Mann-Whitney test, or Chi-square test). Results: Phototherapy was performed in 5.3% in both groups. Also, there were no statistical differences in the occurrence of secondary outcomes, such as sepsis, neonatal ICU admission, and transient tachypnea of the newborns: i.e., 0.9%, 15.8%, and 3.5%, respectively for group I versus 1.2%, 15.6%, and 5.8%, respectively for group II. Conclusion: Late umbilical cord clamping does not increase the need for phototherapy in low-risk neonates. This result corroborates the current recommendation of late cord clamping, whenever appropriate.

关键词： Phototherapy Neonatal Anemia Neonatal Jaundice Late Cord Clamping

Improvements in the score matrix calculation method using parallel score estimating algorithm

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Journal of Biophysical Chemistry 2013年第2期4卷 47-51页

作者： geraldo F.D.Zafalon Evandro A.Marucci Julio C.Momente jose R.A.Amazonas Liria M.Sato jose M.Machado Escola Politecnica University of Sao Paulo Av.Prof.Luciano Gualberto Sao PauloBrazil Departamento de Ciencias de Computacao e Estatistica Sao Paulo State University Rua Cristovao ColomboSao Jose do Rio PretoSao PauloBrazil

The increasing amount of sequences stored in genomic databases has become unfeasible to the sequential analysis. Then, the parallel computing brought its power to the Bioinformatics through parallel algorithms to align and analyze the sequences, providing improvements mainly in the running time of these algorithms. In many situations, the parallel strategy contributes to reducing the computational complexity of the big problems. This work shows some results obtained by an implementation of a parallel score estimating technique for the score matrix calculation stage, which is the first stage of a progressive multiple sequence alignment. The performance and quality of the parallel score estimating are compared with the results of a dynamic programming approach also implemented in parallel. This comparison shows a significant reduction of running time. Moreover, the quality of the final alignment, using the new strategy, is analyzed and compared with the quality of the approach with dynamic programming.

关键词： Algorithms Scoring Matrix Parallel Programming Alignment Quality

Endothelin and neonatal capsaicin regulate gastric resistance to injury in BDL rats

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World Journal of Gastrointestinal Pathophysiology 2012年第4期3卷 85-91页

作者： Paula RS Cmara Gerson JN Ferraz Licio A Velloso José Murilo R Zeitune Fernando AB Suassuna jose geraldo P Ferraz Department of Medicine Potiguar University GI Research Lab Gastrocentro Department of Medicine Faculty of Medical Sciences University of Campinas Division of Gastroenterology Faculty of Medicine University of Calgary

AIM: To investigate the relationship between primary afferent neurons, endothelin (ET) and the role of its receptors on ethanol-induced gastric damage in cirrhotic rats. METHODS: Cirrhosis and portal hypertension were induced in rats by bile duct ligation (BDL) while controls had a sham operation. The association between ET and afferent neurons on the gastric mucosa was evaluated by capsaicin treatment in newborn rats, the use of ET agonists or antagonists, gastric ET-1 and -3 mRNA and synthetic capacity. Ethanol-induced damage was assessed using ex vivo gastric chamber *** blood flow was measured by laser-Doppler flow-metry. RESULTS: ET-3 and an ETB receptor antagonist sig- nificantly reduced the extent of ethanol-induced gastric damage in BDL rats. Gastric ET-1 and -3 levels were 30% higher in BDL rats compared to control rats. Cap-saicin treatment restored the gastric resistance and blood flow responses to topical application of ethanol in BDL rats and ET-1 and -3 production to levels observed in controls. CONCLUSION: Our results suggest that the reduced resistance of the gastric mucosa of cirrhotic rats to ethanol-induced injury is a phenomenon modulated by ET through the ET B receptor and by sensory afferent neurons.

关键词： Endothelins Tachykinins Portal hypertension Gastropathy Cirrhosis