Endothelin and neonatal capsaicin regulate gastric resistance to injury in BDL rats
Endothelin and neonatal capsaicin regulate gastric resistance to injury in BDL rats作者机构：Department of Medicine Potiguar University GI Research LabGastrocentro Department of Medicine Faculty of Medical Sciences University of Campinas Division of Gastroenterology Faculty of Medicine University of Calgary
出 版 物：《World Journal of Gastrointestinal Pathophysiology》 (世界胃肠病理生理学杂志（英文版）（电子版）)
年 卷 期：2012年第3卷第4期
页 面：85-91页
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
基 金：Supported by A fellowship from Fundaao de Amparo a Pes-quisa do Estado de Sao Paulo, FAPESP, Brazil (to Cmara PRS) a research grant from FAPESP (to Ferraz JGP)
主 题：Endothelins Tachykinins Portal hypertension Gastropathy Cirrhosis
摘 要：AIM: To investigate the relationship between primary afferent neurons, endothelin (ET) and the role of its receptors on ethanol-induced gastric damage in cirrhotic rats. METHODS: Cirrhosis and portal hypertension were induced in rats by bile duct ligation (BDL) while controls had a sham operation. The association between ET and afferent neurons on the gastric mucosa was evaluated by capsaicin treatment in newborn rats, the use of ET agonists or antagonists, gastric ET-1 and -3 mRNA and synthetic capacity. Ethanol-induced damage was assessed using ex vivo gastric chamber *** blood flow was measured by laser-Doppler flow-metry. RESULTS: ET-3 and an ETB receptor antagonist sig- nificantly reduced the extent of ethanol-induced gastric damage in BDL rats. Gastric ET-1 and -3 levels were 30% higher in BDL rats compared to control rats. Cap-saicin treatment restored the gastric resistance and blood flow responses to topical application of ethanol in BDL rats and ET-1 and -3 production to levels observed in controls. CONCLUSION: Our results suggest that the reduced resistance of the gastric mucosa of cirrhotic rats to ethanol-induced injury is a phenomenon modulated by ET through the ET B receptor and by sensory afferent neurons.
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