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Antinociceptive and anti-inflammatory activities of leaf extracts from Annona tomentosa ***

Journal of Integrative Medicine 2017年第5期15卷 379-387页

作者： Lilian Uchoa Carneiro Ilna Gomes da Silva Mirian Eliza Alves de Souza Wellington da Silva Cortes Mário geraldo de Carvalho Bruno Guimaraes Marinho Postgraduate Program in Physiological Sciences Institute of Biological and Health SciencesFederal Rural University of Rio de JaneiroRio de Janeiro 23890-000Brazil Laboratory of Pharmacology Department of Physiological SciencesInstitute of Biological Sciences and HealthFederal Rural University of Rio de JaneiroRio de Janeiro 23890-000Brazil Postgraduate Program in Chemistry Department of ChemistryInstitute of Exact SciencesFederal Rural University of Rio de JaneiroRio de Janeiro 23890-000Brazil

OBJECTIVE：Annona tomentosa *** is a species not endemic to Brazil that belongs to the phytogeographic areas of the Amazon,Cerrado and *** known as“araticum rasteiro”or“araticum de moita”,*** is edible and tea made from the leaves has been used as an antiinflammatory by native *** is no scientific evidence for these uses of ***,especially those related to the control of pain and *** this reason,in the present study we evaluated the antinociceptive and anti-inflammatory activities of partitions from the methanolic extract of *** leaves（*** leaf methanolic extract（ATFM）in hexane partition：ATFM-H;ATFM in dichloromethane partition：ATFM-D;ATFM in ethyl acetate partition：ATFM-Ac;ATFM in butanol partition：ATFM-B）in ***：The antinociceptive effects of leaf extracts from *** were evaluated by abdominal writhing and tail-flick tests,while the anti-inflammatory effects were evaluated by paw oedema and air-pouch *** locomotor activity was evaluated with the open-field ***,we evaluated the possible action mechanism of ***,using naloxone,nitro-L-arginine methyl ester,glibenclamide,atropine,naltrindole and norbinaltorphimine in tail-flick *** productions of tumor necrosis factorα（TNF-α）and interleukin（IL）-1βwere also ***：The chromatographic fractionation of the partitions of the methanolic extract from the leaves of *** revealed the presence of diterpenes,flavonoids,and steroids *** the analysis of the hexane partition kaurenoic acid was identified as the major ***-H and ATFM-D had a significant antinociceptive effect in acute pain models in *** ATFM-H showed central antinociceptive effect from the involvement of theδopioid receptors,without causing alterations in the locomotor activity of the mice,while ATFM-D was effective in decreasing paw oedema and TNF-α and IL-1β ***：These results demon

关键词： Annona tomentosa cytokines opioid nociception

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Differences between species in seed bank and vegetation helps to hold functional diversity in a floodable Neotropical savanna

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Journal of Plant Ecology 2021年第4期14卷 605-615页

作者： Evaldo Bde Souza Francielli Bao geraldo A.Damasceno Junior Arnildo Pott Programa de Pos-graduacao em Ecologia e Conservacao Instituto de BiocienciasUniversidade Federal de Mato Grosso do SulCampo GrandeBrazil Programa de Pos-graduacao em Biologia Vegetal Instituto de BiocienciasUniversidade Estadual PaulistaRio ClaroSPBrazil Programa de Pos-graduacao em Biologia Vegetal Instituto de BiociênciasUniversidade Federal de Mato Grosso do SulCampo GrandeBrazil

Aims Our objective was to quantify the contributions of the seed bank and the established vegetation to the species composition,functional composition and diversity,and discuss the implications of these differences in regeneration and persistence of floodplain plant *** We sampled all ground cover vegetation up to 1.5 m height and seed bank in 25 plots(10 m×1 m)distributed across five sites in dry and rainy seasons in a periodically flooded savanna in the Pantanal wetland,*** evaluated the soil seed bank by seedling emergence *** Findings The seed bank species had traits that conferred regeneration to the communities,while persistence traits characterized the *** seed bank had higher functional richness and lower functional evenness than the *** existence of different plant traits between seed bank and vegetation allowed the coexistence of species with functionally contrasting persistence and regeneration traits,which may help maintain functional *** may allow the community to be more resilient when dealing with different environmental filters such as drought,fire and flood.

关键词： environmental filters functional diversity hydrochoric dispersal Pantanal wetland persistence regeneration

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Switching of Capacitors in an Asymmetric Induction Motor with Single-Phase Power,Triggering Several Applied Loads

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Journal of Energy and Power Engineering 2020年第3期14卷 90-99页

作者： Prado Wellington Marcos Antonio geraldo Caixeta Guimarães IFG Electrotechnical CoordinationItumbiaraGOBrazil Electrical Machinery Laboratory Faculty of Electrical EngineeringFederal University of UberlândiaCampus Santa MônicaUberlândiaMGBrazil

xThis study has as its objective to collaborate with the expansion in the market of electric energy in rural areas,offering as such an innovative prospect to the solution of associated problems through use of the asymmetric three-phase induction motor,supplied by a single-phase *** this system,capacitor switching is applied during operation,while theoretical and practical results are presented for the application of this switching in a three-phase asymmetric induction motor of 20 hp.

关键词： Startup current capacitor switching three-phase induction motor asymmetric motor power factor

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Evaluation of Weather Research and Forecasting Model Parameterizations under Sea-Breeze Conditions in a North Sea Coastal Environment

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Journal of Meteorological Research 2016年第6期30卷 998-1018页

作者： SALVADOR Nadir REIS Jr. Neyval Costa SANTOS Jane Meri ALBUQUERQUE Taciana Toledo de Almeida LORIATO Ayres geraldo DELBARRE Herve AUGUSTIN Patrick SOKOLOV Anton MOREIRA Davidson Martins Federal University of Espirito Santo Vitoria Espirito Santo Brazil Federal University of Minas Gerais Belo Horizonte Minas Gerais Brazil Universite Lille Nord de France Lille France Integrated Center for Manufacturing and Technology Salvador Bahia Brazil

Three atmospheric boundary layer （ABL） schemes and two land surface models that are used in the Weather Research and Forecasting （WRF） model, version 3.4.1, were evaluated with numerical simulations by using data from the north coast of France （Dunkerque）. The ABL schemes YSU （Yonsei University）, ACM2 （Asymmetric Convective Model version 2）, and MYJ （Mellor-Yamada-Janjic） were combined with two land surface models, Noah and RUC （Rapid Update Cycle）, in order to determine the performances under sea-breeze conditions. Particular attention is given in the determination of the thermal internal boundary layer （TIBL）, which is very important in air pollution scenarios. The other physics parameterizations used in the model were consistent for all simulations. The predictions of the sea-breeze dynamics output from the WRF model were compared with observations taken from sonic detection and ranging, light detection and ranging systems and a meteorological surface station to verify that the model had reasonable accuracy in predicting the behavior of local circulations. The temporal comparisons of the vertical and horizontal wind speeds and wind directions predicted by the WRF model showed that all runs detected the passage of the sea-breeze front. However, except for the combination of MYJ and Noah, all runs had a time delay compared with the frontal passage measured by the instruments. The proposed study shows that the synoptic wind attenuated the intensity and penetration of the sea breeze. This provided changes in the vertical mixing in a short period of time and on soil temperature that could not be detected by the WRF model simulations with the computational grid used. Additionally, among the tested schemes, the combination of the local- closure MYJ scheme with the land surface Noah scheme was able to produce the most accurate ABL height compared with observations, and it was also able to capture the TIBL.

关键词： sea-breeze detection WRF model parameterizations

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How does Cariniana estrellensis respond to different irradiance levels?

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Journal of Forestry Research 2019年第1期30卷 31-44页

作者： Flávia Carolina Santos Portela Bernardo Pretti Becacici Macieira Leonardo Valandro Zanetti Vinícius Novo Gama Diolina Moura Silva Camilla Rozindo Dias Milanez geraldo Rogério Faustini Cuzzuol Department of Biological Sciences Federal University of Espírito Santo

Based on reports that variables related to photosynthesis(net assimilatory ratio and chloroplast pigments)are more plastic than the morphological and biochemical variables in a climax tropical species,Cariniana estrellensis,under contrasting irradiance,we hypothesised that plasticity of gas exchange variables is higher in relation to growth,biochemical and anatomical *** that were 14 months old were subjected to200 up to 2000 lmol m^(-2)s^(-1) of photo synthetically active radiation(PAR)for 140 *** increased up to1400 lmol m^(-2)s^(-1)PAR and then decreased at 2000 lmol m^(-2)s^(-1) PAR(full sunlight).This was related to the rate of photosynthesis(A)which showed the same tendency as photosystem Ⅱ performance index(PI_(ABS)).The greater thickness of the secondary xylem at 1400 lmol m^(-2)s^(-1) PAR indicated a higher water conductance *** decrease in specific leaf area,elongation of mesophyll cells,and increase in stomatal density observed at higher irradiances were associated with higher leaf fructose and sucrose *** concluded that the better growth in partial shade was due to higher photosynthetic *** the other hand,photosynthesis was inhibited equally in full sun and deep *** high adjustment capacity of *** to wide amplitudes of irradiance was provided by greater plasticity of gas exchange variables in relation to growth,anatomical,and biochemical variables.

关键词： Anatomy Ecophysiology Gas exchange Phenotypic plasticity Soluble carbohydrates

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An Approximation Method for a Maximum Likelihood Equation System and Application to the Analysis of Accidents Data

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Open Journal of Statistics 2017年第1期7卷 132-152页

作者： Assi N’Guessan Issa Cherif geraldo Bezza Hafidi Laboratoire Paul Painlevé (UMR CNRS 8524) Université de Lille 1 Villeneuve d’Ascq France Department of Mathematics and Computer science Université Catholique de l’Afrique de l’Ouest-Unité Universitaire du Togo Lomé Togo Department of Mathematics Faculty of Science University Ibn Zohr Agadir Morocco

There exist many iterative methods for computing the maximum likelihood estimator but most of them suffer from one or several drawbacks such as the need to inverse a Hessian matrix and the need to find good initial approximations of the parameters that are unknown in practice. In this paper, we present an estimation method without matrix inversion based on a linear approximation of the likelihood equations in a neighborhood of the constrained maximum likelihood estimator. We obtain closed-form approximations of solutions and standard errors. Then, we propose an iterative algorithm which cycles through the components of the vector parameter and updates one component at a time. The initial solution, which is necessary to start the iterative procedure, is automated. The proposed algorithm is compared to some of the best iterative optimization algorithms available on R and MATLAB software through a simulation study and applied to the statistical analysis of a road safety measure.

关键词： Constrained Maximum Likelihood Partial Linear Approximation Schur’s Complement Iterative Algorithms Road Safety Measure Multinomial Model

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The effects of neem [Azadirachta indica A. Juss (meliaceae)] oil on Fusarium oxysporum f. sp. medicagenis and Fusarium subglutinans and the production of fusaric acid toxin

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Advances in Bioscience and Biotechnology 2010年第1期1卷 1-6页

作者： Marcia Regina Ferreira geraldo Carla Cristina Arroteia Carlos Kemmelmeier 不详

Fungi of the genus Fusarium are well known plant pathogens, cause several vascular diseases and are producers of toxins. In vitro assays evaluated the effects of Neem (Azadirachta indica) oil on the diameter of colonies, dry weight, spore production, spore viability and production of Fusaric Acid toxin on Fusarium oxysporum f. sp. medicagenis and Fusarium subglutinans isolates. Effects of Neem oil were analyzed at concentrations 0.25%, 0.5% and 1% in Czapek Yeast Agar medium. The production of Fu- saric acid was determined by Thin Layer Chromatography and quantified by UV spectrophotometry. Neem oil showed inhibitory effects on the isolates tested, although they varied according to type of isolate and oil concentration. Neem oil was efficient in reducing the colonies’ diameter and dry weight in concentration-dependent manner. Neem oil was efficacious at higher concentration in the decrease of sporulation. Spore germination was affected by Neem oil when the spore was grown in Neem-contained medium as when the spore emerged from a culture in a Neem medium. Neem oil decreased and even inhibited the production of Fusaric acid by the assayed isolates. Since these isolates are plant pathogens and producers of Fusaric acid, Neem oil may be introduced as an integral item in the management of host plants.

关键词： Fusarium Azadirachta Indica Fusaric Acid Antifungal Activity

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Grain Yield Differences of Soybean Cultivars Due to Solar Radiation Interception

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American Journal of Plant Sciences 2017年第11期8卷 2795-2810页

作者： Mariele Müller Miroslava Rakocevic Andréia Caverzan geraldo Chavarria Faculty of Agronomy and Veterinary Medicine Agronomy Post-Graduate Program University of Passo Fundo Passo Fundo Brazil Embrapa Agriculture Informatics Campinas Brazil

Soybean [Glycine max (L.) Merr.] growth rate and grain yield are modified by the interception and solar radiation use efficiency. Thus, it is desirable that the most of plant photosynthetic structures intercepting solar radiation in order to have increment in carbon fixation and reflection on growth and yield. The goal of this study was to assess if soybean cultivars differ in grain yield in relation to solar radiation interception. Four soybean cultivars were evaluated at stages V6, V9, R2, R4, R6 and R8. To determine the photosynthetically active radiation interception by the canopy, the plants were divided into two parts (upper and lower strata). For grain yield components, the plants were divided into three parts (upper, middle and lower thirds). Of the photosynthetically active radiation intercepted by the vegetative canopy at the reproductive stages, the maximum observed intercept was 5.2% in the lower stratum of the plants. The number of infertile nodes increased in the lower third of plants due to low interception of solar radiation in this plant region. Thus, the soybean cultivars more efficient in intercepting photosynthetically active radiation inside the vegetative canopy showed higher grain yields.

关键词： Glycine Max Leaf Area Index Efficiency of Solar Radiation Interception Extinction Coefficient Solar Radiation Use Efficiency

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Role of lysophosphatidic acid and its receptors in health and disease:novel therapeutic strategies

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Signal Transduction and Targeted Therapy 2021年第3期6卷 630-647页

作者： Luiz Henrique Medeiros geraldo Tania Cristina Leite de Sampaio Spohr Rackele Ferreira do Amaral Anna Carolina Carvalho da Fonseca Celina Garcia Fabio de Almeida Mendes Catarina Freitas Marcos Fabio dosSantos Flavia Regina Souza Lima Institute de Ciencias BiomedicasUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Universite de Paris PARCCINSERMF-75015 ParisFrance Institute Estadual do Cerebro Paulo Niemeyer-Secretaria de Estado de Saude Rio de JaneiroBrazil Instituto de Saiide de Nova Friburgo Universidade Federal Fluminense28625-650 Nova FriburgoBrazil

Lysophosphatidic acid(LPA)is an abundant,bioactive phospholipid,with multiple functions both in development and in pathological ***,we review the literature about the differential signaling of LPA through its specific receptors,which makes this lipid a versatile signaling *** differential signaling is important for understanding how this molecule can have such diverse effects during central nervous system development and angiogenesis;and also,how it can act as a powerful mediator of pathological conditions,such as neuropathic pain,neurodegenerative diseases,and cancer ***,we review the preclinical and clinical uses of Autotaxin,LPA,and its receptors as therapeutic targets,approaching the most recent data of promising molecules modulating both LPA production and *** review aims to summarize the most update knowledge about the mechanisms of LPA production and signaling in order to understand its biological functions in the central nervous system both in health and disease.

关键词： therapeutic clinical diseases

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Phenolic composition and insights into the use of pink pepper (Schinus terebentifolius Raddi) fruit against lipid oxidation in food systems

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FOOD BIOSCIENCE 2023年第3期53卷 40-57页

作者： Vieira, Jonathas de Souza de Oliveira, Vanessa Sales Carneiro, Mara Junqueira da Silva, Tatiana Labre Augusta, Ivanilda Maria de Carvalho, Mario geraldo Sawaya, Alexandra Christine Helena Frankland Saldanha, Tatiana Univ Fed Rural Rio de Janeiro Inst Technol Dept Food Technol Rodovia Br 465 BR-23890000 Seropedica RJ Brazil Univ Estadual Campinas Fac Pharmaceut Sci UNICAMP Campinas SP Brazil Univ Fed Rural Rio de Janeiro Inst Exact Sci Dept Chem Rodovia Br 465 BR-23890000 Seropedica RJ Brazil

Pink pepper (Schinus terebinthifolius Raddi) has received the scientific community's attention due to its antiox-idant properties and potential as a natural additive to limit lipid oxidation in foods. This review presents a comprehensive description of phenolic compounds in pink pepper fruit, which are mostly phenolic acids and flavonoids. Among the flavonoids, the glycosylated forms and biflavonoids are predominant. Moreover, tannins and stilbenes have also been found in pink pepper fruit. Therefore, the extensively reported antioxidant capacity of this fruit is mainly attributed to its rich phenolic composition. The current insights into the use of pink pepper fruit as a natural antioxidant are also described. This application has been investigated mostly by considering the use of extracts (directly in the food or incorporated into active packing), but the direct addition of the fruit has also been studied, as well as the use of residues from the pink pepper agroindustry. The literature revealed promising results, as pink pepper reduced the formation of harmful compounds, such as cholesterol oxides, and minimized lipid oxidation in numerous food matrices. Pink pepper is highlighted as an alternative to replace synthetic antioxidants in processed food. Besides, the published studies concerning the direct addition of fruits also indicate their use in domestic preparations aiming to reduce lipid oxidation damage. However, further studies are needed to elucidate pink pepper's proper use by the food industry, which relies on research on aspects such as safe and effective concentrations, methods of application, and consumer acceptance of the final product.

关键词： Aroeira fruit Brazilian pepper tree Phenolic compounds Antioxidant capacity Natural additives

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