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Critical considerations for the management of acute abdomen in transplant patients

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World Journal of Transplantation 2024年第2期14卷 8-12页

作者： Efstathios T Pavlidis georgios Katsanos Athanasios Kofinas georgios Tsoulfas Ioannis N Galanis Theodoros E Pavlidis The 2^(nd)Department of Propaedeutic surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece Department of Transplantation surgery Center for Research and Innovation in Solid Organ TransplantationAristotle University of ThessalonikiSchool of MedicineThessaloniki 54642Greece

The number of solid organ transplantations performed annually is increasing and are increasing in the following order:Kidney,liver,heart,lung,pancreas,small bowel,and uterine ***,the outcomes of transplants are impro-ving(organ survival>90%after the 1st year).Therefore,there is a high probability that a general surgeon will be faced with the management of a transplant patient with acute *** problems in immunocompromised patients may not only include graft-related problems but also nongraft-related *** perioperative regulation of immunosuppression,the treatment of accompanying problems of immunosuppression,the administration of cortisol and,above all,the realization of a rapidly deteriorating situation and the accurate evaluation and interpretation of clinical manifestations are particularly important in these *** perioperative assessment and preparation includes evaluation of the patient’s cardiovascular system and determining if the patient has hypertension or suppression of the hypothalamic-pituitary-adrenal axis,or if the patient has had any coagulation mechanism abnormalities or thromboembolic *** in transplant patients is associated with the use of calci-neurin inhibitors,corticosteroids,and antiproliferation *** times,the clinical picture is atypical,resulting in delays in diagnosis and treatment and leading to increased morbidity and *** computed tomo-graphy is of utmost importance for early diagnosis and *** recipients are prone to infections,especially specific infections caused by cytomegalovirus and Clostridium difficile,and they are predisposed to intraop-erative or postoperative complications that require great care and *** is necessary to follow evidence-based therapeutic ***,it is required that the clinician choose the correct therapeutic plan for the patient(conservative,emergency open surgery or minimally invasive s

关键词： Acute abdomen Abdominal emergency surgery Transplantation Immunocompromised patients Immuno-suppression Posttransplantation surgery

Hidden army within:Harnessing the microbiome to improve cancer treatment outcomes

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World Journal of Clinical Cases 2024年第28期12卷 6159-6164页

作者： Ippokratis Messaritakis georgios Vougiouklakis Asimina Koulouridi Aris P Agouridis Nikolaos spernovasilis Department of Microbiology German Oncology Center&Yiannoukas Labs LTDBioiatriki GroupLimassol 4108Cyprus Department of Internal Medicine German Oncology CenterLimassol 4108Cyprus Department of Oncology German Oncology CenterLimassol 4108Cyprus school of Medicine European University CyprusNicosia 2404Cyprus Department of Infectious Diseases German Oncology CenterLimassol 4108Cyprus

The gut microbiome has emerged as a critical player in cancer pathogenesis and treatment ***,an imbalance in the gut microbial community,impacts tumor initiation,progression,and therapy *** bacterial species have been associated with either promoting or inhibiting tumor growth,offering potential targets for therapeutic *** gut microbiome in-fluences the efficacy and toxicity of conventional treatments and cutting-edge immunotherapies,highlighting its potential as a therapeutic target in cancer ***,translating microbiome research into clinical practice requires addres-sing challenges such as standardizing methodologies,validating microbial bio-markers,and ensuring ethical ***,we provide a comprehensive overview of the gut microbiome's role in cancer highlighting the need for on-going research,collaboration,and innovation to harness its full potential for im-proving patient outcomes in *** current editorial aims to explore these insights and emphasizes the need for standardized methodologies,validation of microbial biomarkers,and interdisciplinary collaboration to translate microbiome research into clinical ***,it underscores ethical consider-ations and regulatory challenges surrounding the use of microbiome-based ***,this article advocates for ongoing research,collaboration,and innovation to realize the full potential of microbiome-guided oncology in impro-ving patient care and outcomes.

关键词： Gut microbiome Cancer treatment Immunotherapy Microbiome-based interventions Dysbiosis Precision oncology

Death due to fracture of thin calvarial hones after a fall： A forensic approach

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Chinese Journal of Traumatology 2017年第3期20卷 180-182页

作者： Georgios.sioutas Maria-Valeria Karakasi stylianos Kapetanakis Pavlos Pavlidis Department of Anatomy School of Medicine Democritus University of Thrace Dragana GR 68100 Alexandroupolis Greece Laboratory of Forensic sciences School of Medicine Democritus University of Thrace Dragana GR 68100 Alexandroupolis Greece

A 45-year-old male was autopsied. He had fallen backwards from a two-stairs height to the ground and passed away. A skull fracture was detected in the left occipital area, extending up to the left side of the skul! base. The patient＇s death occurred due to the very low thickness of the calvarial bones, which led to the aforementioned fracture, and in turn resulted in subarachnoid hemorrhage and death. The cortical thickness was measured and compared with average values at standardized points. Uniform bone thinning was confirmed rather than localized. Calvarial thinning may result from various conditions. In the present case study, however, the exact mechanism which led to the low thickness of the calvarial bones of the patient is undetermined. Death due to the susceptible structure and fracture of calvarial bones has rarely been reported throughout relevant literature.

关键词： Calvarial thinning Thin neurocranial bones skull fractures Cortical thickness Accidents Forensic pathology

Fragility assessment of wood sheathing panels and roof-to-wall connections subjected to wind loading

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Frontiers of structural and Civil Engineering 2021年第4期15卷 867-876页

作者： Amira Gill Aikaterini s.GENIKOMsOU georgios P.BALOMENOs Department of Civil Engineering Queen’s UniversityKingstonK7L 3N9Canada Department of Civil Engineering McMaster UniversityHamiltonL8S 4L7Canada

The performance of the wood-frame buildings after tornadoes has shown that the majority of the wind damage resulted from building envelope failure most typically due to the loss of the *** assess the performance and the reliability of low-rise wood-frame residential buildings with a focus on the roofs,fragility analysis can be used to estimate the probability of failure of a roof when constructed with specified nails and sheathing ***,this paper examines the fragility of specific types of nails,roof-to-wall(RW)connection details,and sheathing sizes based on the damaged roofs that were previously assessed in the Dunrobin area in Ottawa(Ontario)that was hit with an Enhanced Fujita(EF3)tornado on september 21,*** presented fragility analysis considers four scenarios,including different sheathing and nail *** loads,wind loads,and resistance on the sheathing panels were compiled and analyzed to determine the failure of the examined *** eight fragility models suggest that the safest roof sheathing(Rs)is the 1.22 m×1.22 m sheathing panel with 8 d nails,and the safest RW connections is achieved by using H2.5 hurricane clips.

关键词： tornadoes wind loads low-rise buildings fragility analysis risk assessment structural failures

The Ca^(2+)-sensing receptor and the pocketome:comparing nature's complexity with human intervention in receptor modulation

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signal Transduction and Targeted Therapy 2024年第8期9卷 3153-3154页

作者： Edda s.F.Matthees Carsten Hoffmann Institut fur Molekulare Zellbiologie CMB-Center for Molecular BiomedicineUniversitatsklinikum JenaHans-Knoll StraBe 2D-07745 JenaGermany Friedrich-schiller-Universitat Jena Hans-KnollStraBe2D-07745 JenaGermany

In a recent paper published in Nature,the relatively understudied Ca^(2+)-sensing,receptor(CasR)within the Gprotein-coupled receptor(GPCR)family C,gained attention due to pioneering research led by georgios skiniotis ... 详细信息

关键词： stanford gained skin

An unusual case of prolonged post-endoscopic retrograde cholangiopancreatography jaundice

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Hepatobiliary & Pancreatic Diseases International 2016年第2期15卷 220-222页

作者： georgios Tziatzios Paraskevas Gkolfakis Ioannis s Papanikolaou George Dimitriadis Konstantinos Triantafyllou Hepatogastroenterology Unit 2nd Department of Internal Medicine and Research Institute "Attikon" University General Hospital Medical School University of Athens

Despite the effectiveness of endoscopic retrograde cholangiopancreatography（ERCP） for the treatment of choledocholithiasis, various complications have been described. We herein report the first case of prolonged postERCP jaundice due to toxicity of the contrast agent Iobitridol（~174;XENETIX, Guerbet, Roissy Cd G Cedex, France） in a patient who underwent ERCP with sphincterectomy and common bile duct stone removal. While clinical improvement and normalization of aminotransferases and cholestatic enzymes after the procedure, an unexplained increase of direct bilirubin was noticed. A second ERCP was performed one week later, excluding possible remaining choledocholithiasis. Nevertheless, serum direct bilirubin increased further up to 15 mg/d L. Other potential causes of direct hyperbilirubinemia were ruled out and patient＇s liver biopsy was compatible with drug-induced liver toxicity. Additionally, the cause-result time connection between the use of Iobitridol and bilirubin increase indicated the possibility of a toxic effect related to the repeated use of the particular contrast agent. Iobitridol, a contrast agent, can induce prolonged direct hyperbilirubinemia.

关键词： endoscopic retrograde cholangiopancreatography jaundice adverse effect Iobitridol

Real-time impact of power balancing on power system operation with large scale integration of wind power

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Journal of Modern Power systems and Clean Energy 2017年第2期5卷 202-210页

作者： Abdul BAsIT Anca D.HANsEN Poul E.sØRENsEN georgios GIANNOPOULOs Department of Wind Energy Technical University of DenmarkFrederiksborgvej 3994000 RoskildeDenmark sino-Danish Center for Education and Research Niels Jensens Vej 28000 AarhusDenmark ELIA sYsTEM OPERATOR Keizerslaan 201000 BrusselsBelgium

Highly wind power integrated power system requires continuous active power regulation to tackle the power imbalances resulting from the wind power forecast errors. The active power balance is maintained in real-time with the automatic generation control and also from the control room, where regulating power bids are activated manually. In this article, an algorithm is developed to simulate the activation of regulating power bids, as performed in the control room, during power imbalance between generation and load demand. In addition, the active power balance is also controlled through automatic generation control, where coordinated control strategy between combined heat and power plants and wind power plant enhances the secure power system operation. The developed algorithm emulating the control room response,to deal with real-time power imbalance, is applied and investigated on the future Danish power system model. The power system model takes the hour-ahead regulating power plan from power balancing model and the generation and power exchange capacities for the year 2020 into *** real-time impact of power balancing in a highly wind power integrated power system is assessed and discussed by means of simulations for different possible scenarios.

关键词： Wind power plant(WPP) simulation power Balancing model(simBa) Centralised or de-centralised combined heat and power plant(CHP or DCHP) Automatic generation control(AGC) Rolling balance

Revisiting the determination of Mount Olympus Height(Greece)

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Journal of Mountain science 2023年第4期20卷 1026-1034页

作者： Dimitrios AMPATZIDIs georgios MOsCHOPOULOs Antonios MOURATIDIs Michael sTYLLAs Alexandros TsIMERIKAs Vasileios-Klearchos DELIGIANNIs Nikolaos VOUTsIs Triantafyllia-Maria PERIVOLIOTI georgios s.VERGOs Alexandra PLACHTOVA Genie Lab Department of Surveying and Geoinformatics EngineeringInternational Hellenic UniversityTerma Magnisias62124SerresGreece EO.Lab Department of Physical&Environmental Geography Aristotle University54124ThessalonikiGreece Geoservice LTD Eirinis 14 Str55236ThessalonikiGreece Nomotechniki Pierias Dim.Dimadi 560100KateriniGreece Paths of Greece Karneadou 34-36Athens10676Greece Laboratory of Gravity Field Research and Applications-GravLab Aristotle University of Thessaloniki University Box 44054124ThessalonikiGreece Faculty of science Department of Applied Geoinformatics and Cartography Charles UniversityAlbertov 612843Praha 2Czechia Balkan Center Center for Interdisciplinary Research and Innovation(CIRI-AUTH)AUTH Campus54124ThessalonikiGreece

The present study deals with the determination of Mount Olympus summit(Mytikas),exploiting modern observations such as Global Navigation satellite systems(GNss)and existing geodetic *** last official Olympus height determination goes back 102 years by the swiss surveyor *** then,only unofficial measurement campaigns have taken *** is a variety of released heights,which range from 2917 to 2919 *** september and October of 2022,we conducted a GNss campaign,focusing on the area of highest Olympus *** precise GNss measurements(accuracy of 1-3 cm),in conjunction with height information from Greece’s National Triangulation Network(5-10 cm accuracy)and an appropriate,recent geoid model(5-6 cm accuracy),we estimate through the so-called GNss-levelling,the height of Olympus to 2917.727 m with respect to Greece’s officially accepted mean sea level and 2918.390 m with respect to the global vertical *** estimation of Olympus highest peak shows remarkable consistency at the level of 12.8 cm to that of *** in 1921.

关键词： Olympus Greece Mountain height determination GNss leveling surveying

On the refracted patterns produced by liquid vortices

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Acta Mechanica sinica 2007年第1期23卷 11-15页

作者： Yasser Aboelkassem georgios H.Vatistas McGill University MontrealQCH3A-2K6Canada Concordia University MontrealQCH3G 1M8Canada

A theoretical analysis of the refracted shadows produced by steady and time-decaying liquid vortices under uniform illumination from above is given in this article. An expression for the induced shadow intensity is derived and found to be a function of the vortex＇s free surface profile, i.e., function of the static pressure distribution. The patterns for different focusing depth are given and compared with previous visualization results from the literature. The phenomenon is examined and illustrated as a bench mark case by using both steady and time-decaying algebraic vortex models. However, this study can be extended to check the feasibility of recovering the main flow properties by analyzing the luminous image intensity of the refracted patterns. The present analysis is valid only when the swirl velocity is order of magnitude higher than the meridional flow components and the vorticity is concentrated within the core region and of intense conditions.

关键词： Fluid dynamics - Vortices - Dark shadows Intensity - Time decay