Hidden army within:Harnessing the microbiome to improve cancer treatment outcomes

作     者：Ippokratis Messaritakis Georgios Vougiouklakis Asimina Koulouridi Aris P Agouridis Nikolaos Spernovasilis 

作者机构：Department of MicrobiologyGerman Oncology Center&Yiannoukas Labs LTDBioiatriki GroupLimassol 4108Cyprus Department of Internal MedicineGerman Oncology CenterLimassol 4108Cyprus Department of OncologyGerman Oncology CenterLimassol 4108Cyprus School of MedicineEuropean University CyprusNicosia 2404Cyprus Department of Infectious DiseasesGerman Oncology CenterLimassol 4108Cyprus 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2024年第12卷第28期

页      面：6159-6164页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Gut microbiome Cancer treatment Immunotherapy Microbiome-based interventions Dysbiosis Precision oncology 

摘      要：The gut microbiome has emerged as a critical player in cancer pathogenesis and treatment ***,an imbalance in the gut microbial community,impacts tumor initiation,progression,and therapy *** bacterial species have been associated with either promoting or inhibiting tumor growth,offering potential targets for therapeutic *** gut microbiome in-fluences the efficacy and toxicity of conventional treatments and cutting-edge immunotherapies,highlighting its potential as a therapeutic target in cancer ***,translating microbiome research into clinical practice requires addres-sing challenges such as standardizing methodologies,validating microbial bio-markers,and ensuring ethical ***,we provide a comprehensive overview of the gut microbiome s role in cancer highlighting the need for on-going research,collaboration,and innovation to harness its full potential for im-proving patient outcomes in *** current editorial aims to explore these insights and emphasizes the need for standardized methodologies,validation of microbial biomarkers,and interdisciplinary collaboration to translate microbiome research into clinical ***,it underscores ethical consider-ations and regulatory challenges surrounding the use of microbiome-based ***,this article advocates for ongoing research,collaboration,and innovation to realize the full potential of microbiome-guided oncology in impro-ving patient care and outcomes.