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Lessons learned from hepatocellular carcinoma may cause a paradigm shift in intraductal papillary mucinous neoplasms:a narrative review and discussion of conceptual similarities in tumor progression and recurrence

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Journal of Pancreatology 2022年第1期5卷 36-40页

作者： georgios Antonios Margonis Nikolaos Andreatos Jane Wang Matthew J.Weiss Christopher L.Wolfgang Department of Surgery Memorial Sloan Kettering Cancer CenterNew YorkNY Department of Internal Medicine and Taussig Cancer Institute Cleveland ClinicClevelandOH Department of Surgery University of California San FranciscoSan FranciscoCA Department of Surgery Northwell Health Cancer Institute and Zucker School of Medicine at HofstraL ake Success Department of Surgery NYU Grossman School of MedicineNew YorkNYUSA

Although the natural history of recurrence/progression in patients with intraductal papillary mucinous neoplasms (IPMN) of the pancreas has not been studied thoroughly, the three principal mechanisms have been identified: (a) presence of residual disease at the transection margin, (b) presence of intraductal/intraparenchymal metastases and (c) development of new primary lesions. Mechanisms (a) and (b) result in metastatic lesions that are genetically related to the primary, while new primary lesions (mechanism c) are genetically distinct. Interestingly, recurrence/progression in IPMN displays conceptual parallels with the well-established paradigm of disease recurrence in patients with hepatocellular carcinoma (HCC). Specifically, patients with HCC may also develop recurrent tumors due to microscopic residual disease/intrahepatic metastasis which are genetically similar to the primary while the development of genetically unrelated, de novo HCC after curative-intent resection is also common. The latter has been attributed to the presence of a widespread genetic abnormality ( "field defect" ) in the liver (ie, cirrhosis). Given the conceptual similarities between IPMN and HCC, a pancreatic "field defect" may also be hypothesized to exist. This review does not suggest that HCC and IPMN have identical pathogeneses, but rather that they have conceptual similarities in tumor recurrence/progression;thus, lessons learned from HCC could be applied to IPMN research and subsequent management. Conceptual similarities in tumor progression and recurrence may also be observed between IPMN and other malignancies. However, HCC was selected because it is well studied and can serve as a paradigm.

关键词： Field defect Hepatocellular carcinoma Intraductal papillary mucinous neoplasm Progression Recurrence

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希腊科林斯-帕特雷裂谷西部活断层的几何学和运动学特征及其地震构造意义

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地震地质译丛 1993年第6期15卷 23-30页

作者： Theodor Doustsos georgios Poulimenos 墨宏山

引言爱琴海区是世界上大陆扩张速率最大的区域之一(Mckenzie 1978,Angelier 1979,

关键词：地震构造活断层几何学运动学

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Liver metastases from pancreatic ductal adenocarcinoma:is there a place for surgery in the modern era?

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Journal of Pancreatology 2020年第2期3卷 81-85页

作者： Imai Katsunori Margonis georgios A. Wang Jaeyun Wolfgang Christopher L. Baba Hideo Weiss Matthew J. Department of Gastroenterological Surgery Graduate School of Life SciencesKumamoto UniversityKumamotoJapan Department of Surgery Johns Hopkins University School of MedicineBaltimoreMDNYUSA Northwell Health Cancer Institute Lake SuccessNYUSA

Pancreatic ductal adenocarcinoma(PDAC)represents one of the most aggressive malignancies,and the majority of patients with PDAC present with metastatic disease,mainly in the liver,at the time of *** resection is the only treatment that can offer prolonged survival and possible ***,the indications for surgery for patients with PDAC metastases remain extremely limited to highly selected patients with localized disease,and metastatic disease is generally regarded as a contraindication to ***,however,the advent of more effective chemotherapy has changed the treatment strategy for metastatic *** fact,cases in which resection of synchronous or metachronous PDAC liver metastases lead to prolonged survival in highly selected patients have been *** this review,we provide current data regarding survival outcomes after surgery,and discuss the role of surgical resection and selection criteria for patients with PDAC liver metastases in the modern era.

关键词： Liver metastases Pancreatic cancer Surgery

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Dual mobility cups in total hip arthroplasty

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World Journal of Orthopedics 2014年第3期5卷 180-187页

作者： Ivan De Martino georgios Konstantinos Triantafyllopoulos Peter Keyes Sculco Thomas Peter Sculco Department of Orthopaedic Surgery Division of Adult Reconstruction and Joint ReplacementHospital for Special SurgeryNew YorkNY 10021United States

Total hip arthroplasty(THA)is considered one of the most successful surgical procedures in *** the increase in the number of THAs performed in the world in the next decades,reducing or preventing medical and mechanical complications such as post-operative THA instability will be of paramount importance,particularly in an emerging health care environment based on quality control and patient *** mobility acetabular component(also known as unconstrained tripolar implant)was introduced in France at the end of the 1970s as an alternative to standard sockets,to reduce the risk of THA dislocation in patients undergoing primary THA in *** mobility cups have recently gained wider attention in the United States as an alternative option in the prevention and treatment of instability in both primary and revision THA and offer the benefit of increased stability without compromising clinical outcomes and implant *** this article,we review the use of dual mobility cup in total hip arthroplasty in terms of its history,biomechanics,outcomes and complications based on more than20 years of medical literature.

关键词： Dual mobility Total hip arthroplasty Dislocation Revision total hip arthroplasty Instability

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中国充电器标准化带来的变化

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电子设计应用 2007年第10期 68-69页

作者： Takashi Kanamori georgios Paparrizos 千江水（译）美国Summit微电子公司不详

中国政府率先开始了手机充电器的标准化，其目的是让用户更换手机终端后可继续使用原来的充电器，从而通过削减废弃物达到保护环境的目的。

关键词：手机充电器中国政府标准化手机终端保护环境废弃物

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Optimization of Routing Considering Uncertainties

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Journal of Marine Science and Application 2012年第1期11卷 10-17页

作者： georgios I. Papatzanakis (1) Apostolos D. Papanikolaou (1) papa@deslab.ntua.gr Shukui Liu (1) Ship Design Laboratory National Technical University of AthensAthens 15773Greece

A route optimization methodology in the frame of an onboard decision support/guidance system for the ship＇s master has been developed and is presented in this paper. The method aims at the minimization of the fuel voyage cost and the risks related to the ship＇s seakeeping performance expected to be within acceptable limits of voyage duration. Parts of this methodology were implemented by interfacing alternative probability assessment methods, such as Monte Carlo, first order reliability method （FORM） and second order reliability method （SORM）, and a 3-D seakeeping code, including a software tool for the calculation of the added resistance in waves of NTUA-SDL. The entire system was integrated within the probabilistic analysis software PROBAN. Two of the main modules for the calculation of added resistance and the probabilistic assessment for the considered seakeeping hazards with respect to exceedance levels of predefined threshold values are herein elaborated and validation studies proved their efficiency in view of their implementation into an on-board optimization system.

关键词： AKeywords: routing system operational risk assessment multi-objective optimization epistemic and aleatoryuncertainties

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A Triethyleneglycol C60 Mono-adduct Derivative for Efficient Electron Transport in Inverted Perovskite Solar Cells

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Chinese Journal of Chemistry 2023年第4期41卷 431-442页

作者： Azhar Fakharuddin Konstantina-Kalliopi Armadorou Leandros P.Zorba Marinos Tountas Tobias Seewald Anastasia Soultati Polychronis Tsipas Emilia R.Schütz Nikolaos Tzoganakis Stylianos Panagiotakis Konstantina Yannakopoulou Athanasios Dimoulas Vassilis Psycharis Emmanuel Kymakis Abd Rashid bin Mohd Yusoff Konstantinos Aidinis Lukas Schmidt-Mende georgios C.Vougioukalakis Mohammad Khaja Nazeeruddin Maria Vasilopoulou Department of Physics University of Konstanz78457 KonstanzGermany Institute of Nanoscience and Nanotechnology National Center for Scientific Research DemokritosAgia Paraskevi15341 AthensGreece Department of Chemistry National and Kapodistrian University of Athens15771 AthensGreece Department of Electrical&Computer Engineering Hellenic Mediterranean UniversityEstavromenosHeraklionGR-71410 CreteGreece Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)PohangGyeongbuk37673 Republic of Korea Department of Electrical and Computer Engineering Ajman UniversityP.O.Box 346AjmanUnited Arab Emirates Center of Medical and Bio-allied Health Sciences Research AjmanUnited Arab Emirates Institute of Chemical Sciences and Engineering École Polytechnique Fédérale de Lausanne(EPFL)Rue de l'Industrie 17CH-1951 SionSwitzerland

Inverted perovskite solar cells(PSCs)have attracted increasing attention in recent years owing to their low-temperature fabrication proces ***,they suffer from a limited number of electron transport materials available with[6,6]-phenyl C61 butyric acid methyl ester(PCBM)to be the most widely studied based on its appropriate energy levels and high electron *** low relative permittivity and aggregation tendency upon illumination of PCBM,however,compromises the solar cell efficiency whereas its modest hydrophobicity negatively impacts on the device *** electron transport materials with desired properties and appropriate degree of hydrophobicity are thus desirable for further developments in inverted ***,we synthesize a triethyleneglycol C60 mono-adduct derivative(termed as EPF03)and test it as a novel electron transport material to replace PCBM in inverted PSCs based on a quadruple cation(RbCsMAFA)*** also compare this derivative with two novel fullerenes decorated with two(EPF01)or one dodecyl(EPF02)long side *** latter two fail to perform efficiently in inverted PSCs whereas the former enabled a power conversion efficiency of 18.43%,which represents a 9%improvement compared to the reference device using PCBM(17.21%).The enhanced performance mainly stems from improved electron extraction and reduced recombination enabled by the insertion of the large relative permittivity amongst other properties of ***,our results indicate that triethylene glycol side chains can also passivate perovskite trap states,suppress ion migration and enhance photostability and long-term stability of EPF03 based perovskite solar cells.

关键词： Electron transport layer Defect passivation Biexponential trap flling Charge transfer Fullerenes

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Persistent post-surgical pain and neuropathic pain after total knee replacement

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World Journal of Orthopedics 2015年第7期6卷 528-536页

作者： georgios I Drosos Triantafilia Triantafilidou Athanasios Ververidis Cristina Agelopoulou Theodosia Vogiatzaki Konstantinos Kazakos Department of Orthopaedic Surgery Medical School Democritus University of Thrace University General Hospital of Alexandroupolis Department of Neurology Medical School Democritus University of Thrace University General Hospital of Alexandroupolis Department of Anaesthesia Medical School Democritus University of Thrace University General Hospital of Alexandroupolis

AIM: To study the prevalence of persistent post-surgical pain(PPSP) and neuropathic pain(NP) after total knee replacement(TKR).METHODS: MEDLINE and Embase databases were searched for articles published until December 2014 in English language. Published articles were included if they referred to pain that lasts at least 3 mo after primary TKR for knee osteoarthritis, and measured pain with pain specific instruments. Studies that referred to pain caused by septic reasons and implant malalignment were excluded. Both prospective and retrospective studies were included and only 14 studies that match the inclusion criteria were selected for this ***: The included studies were characterized by the heterogeneity on the scales used to measure pain and pre-operative factors related to PPSP and NP. The reported prevalence of PPSP and NP seems to be relatively high, but it varies among different studies. There is also evidence that the prevalence of post-surgical pain is related to the scale used for pain measurement. The prevalence of PPSP is ranging at 6 mo from 16% to 39% and at 12 mo from 13.1% to 23% and even 38% of the patients. The prevalence of NP at 6 mo post-operatively is ranging from 5.2% to13%. Pre-operative factors related to the development of PPSP also differ, including emotional functioning, such as depression and pain catastrophizing, number of comorbidities, pain problems elsewhere and operations in knees with early grade of ***: No firm conclusions can be reached regarding the prevalence of PPSP and NP and the related factors due to the heterogeneity of the studies.

关键词： Total knee replacement Pain Chronic pain Neuropathic pain Post-operative pain Persistent postsurgical pain

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Risk assessment instruments for screening bone mineral density in a Mediterranean population

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World Journal of Orthopedics 2016年第9期7卷 577-583页

作者： Sotirios Christodoulou georgios I Drosos Athanasios Ververidis Antonios Galanos George Anastassopoulos Konstantinos Kazakos Department of Orthopaedic Surgery Democritus University of Thrace University General Hospital of Alexandroupolis Laboratory for Research of the Musculoskeletal System University of Athens KAT Hospital Medical Informatics Laboratory Medical School Democritus University of Thrace

AIM To evaluate the power of six osteoporosis-screening instruments in women in a Mediterranean *** Data concerning several osteoporosis risk factors were prospectively collected from 1000 postmenopausal women aged 42-87 years who underwent dual-energy X-ray absorptiometry(DEXA) screening. Six osteoporosis risk factor screening tools were applied to this sample to evaluate their performance and choose the most appropriate tool for the study *** The most important screening tool for osteoporosis status was the Simple Calculated Osteoporosis Risk Estimation, which had an area under the curve(AUC)of 0.678, a sensitivity of 72%, and a specificity of 72%, with a cut-off point of 20.75. The most important screening tool for osteoporosis risk was the Osteoporosis Self-assessment Tool, which had an AUC of 0.643, a sensitivity of 77%, and a specificity of 46%,with a cut-off point *** Some commonly used clinical risk instruments demonstrate high sensitivity for distinguishing individuals with DEXA-ascertained osteoporosis or reduced bone mineral density.

关键词： Osteoporosis Bone mineral density Risk assessment Dual X-ray absorptiometry Osteopenia

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The role of technetium Tc99m-tetrofosmin as head and neck tumor-seeking agent:a preliminary report

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 133-138页

作者： Chrissa Sioka Thomas Exarchopoulos Vlasis Skloupiotis Vaios Papathanassiou Vasileios Ragos Maria Argyropoulou Anna Gousia Periklis Tsekeris georgios Exarchakos Dimitrios Assimakopoulos Andreas Fotopoulos Department of Nuclear Medicine University of Ioannina School of MedicineUniversity CampusIoannina 45110Greece Department of Radiotherapy University of Ioannina School of MedicineUniversity CampusIoannina 45110Greece Department of Ear Nose and Throat University of Ioannina School of MedicineUniversity CampusIoannina 45110Greece Department of Maxillofacial Surgery University of Ioannina School of MedicineUniversity CampusIoannina 45110Greece Department of Radiology University of Ioannina School of MedicineUniversity CampusIoannina 45110Greece Department of Pathology University of Ioannina School of MedicineUniversity CampusIoannina 45110Greece

Aim:To evaluate the diagnostic value of technetium Tc99m-tetrofosmin(^(99m)Tc-TF)in primary cancers of the head and ***:Single photon emission computer tomography with planar imaging of the neck for primary site evaluation and whole body scanning for assessment of metastases in 12 patients with newly diagnosed head and neck ***-to-background index(T/Bg)was derived in patients with positive findings(tumor or lymph nodes).Results:The tomographic images showed increased tracer uptake in pathological sites(primary tumor or lymph node)in 9 patients(overall sensitivity 75%).Primary tumor was visualised in 7 patients(sensitivity 58%)and infiltrated lymph nodes in 4 out 7 patients(sensitivity 57%).Mean values for T/Bg index were 5.44±1.28 for primary tumor and 4.25±1.67 for lymph *** values for T/Bg index were 4.5±0.71 for patients with in situ and grade I carcinoma and 6.68±0.36 for patients with tumor grade II and III(P=0.034,Mann-Whitney U test).Conclusion:The present study demonstrates that ^(99m)Tc-TF is a valuable radiotracer for head and neck cancer *** determine the potential role of this imaging protocol in clinical practice will require a larger sample size.

关键词： Head and neck cancer radionuclide imaging single photon emission computer tomography ^(99m)Technetium-tetrofosmin

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