检索结果-南通市图书馆

Hidden army within:Harnessing the microbiome to improve cancer treatment outcomes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第28期12卷 6159-6164页

作者： Ippokratis Messaritakis georgios Vougiouklakis Asimina Koulouridi Aris P Agouridis Nikolaos Spernovasilis Department of Microbiology German Oncology Center&Yiannoukas Labs LTDBioiatriki GroupLimassol 4108Cyprus Department of Internal Medicine German Oncology CenterLimassol 4108Cyprus Department of Oncology German Oncology CenterLimassol 4108Cyprus School of Medicine European University CyprusNicosia 2404Cyprus Department of Infectious Diseases German Oncology CenterLimassol 4108Cyprus

The gut microbiome has emerged as a critical player in cancer pathogenesis and treatment ***,an imbalance in the gut microbial community,impacts tumor initiation,progression,and therapy *** bacterial species have been associated with either promoting or inhibiting tumor growth,offering potential targets for therapeutic *** gut microbiome in-fluences the efficacy and toxicity of conventional treatments and cutting-edge immunotherapies,highlighting its potential as a therapeutic target in cancer ***,translating microbiome research into clinical practice requires addres-sing challenges such as standardizing methodologies,validating microbial bio-markers,and ensuring ethical ***,we provide a comprehensive overview of the gut microbiome's role in cancer highlighting the need for on-going research,collaboration,and innovation to harness its full potential for im-proving patient outcomes in *** current editorial aims to explore these insights and emphasizes the need for standardized methodologies,validation of microbial biomarkers,and interdisciplinary collaboration to translate microbiome research into clinical ***,it underscores ethical consider-ations and regulatory challenges surrounding the use of microbiome-based ***,this article advocates for ongoing research,collaboration,and innovation to realize the full potential of microbiome-guided oncology in impro-ving patient care and outcomes.

关键词： Gut microbiome Cancer treatment Immunotherapy Microbiome-based interventions Dysbiosis Precision oncology

Stent A pancreaticojejunostomy after pancreatoduodenectomy:Is it always necessary?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Methodology 2024年第3期14卷 23-29页

作者： Dimitrios Symeonidis Dimitris Zacharoulis georgios Tzovaras Labrini Kissa Athina A Samara Eleana Petsa Konstantinos Tepetes Department of Surgery University Hospital of LarissaLarissa 41110Greece Department of General Surgery University Hospital of LarissaLarissa 41110Greece

The establishment of a postoperative pancreatic fistula(POPF)is considered the most common and,concomitantly,the most serious complication associated with pancreaticoduodenectomy(PD).The search for either technical modifications of the operative technique or pharmaceutical interventions that could possibly aid in decreasing the incidence of this often-devastating complication appears *** stenting of the pancreatic duct,with the use of either internal or external stents,has been evaluated in this *** theory,it is an approach that could eliminate many pathophysiological factors responsible for the occurrence of a *** purpose of the present study was to review the current data regarding the role of pancreatic duct stenting on the incidence of POPF,after PD,by using PubMed and Reference Citation *** general,previous studies seem to highlight the superiority of external stents over their internal counterparts in regard to the incidence of POPF;this is at the cost,however,of increased morbidity associated mainly with the stent ***,the use of an internal stent is a less invasive approach with acceptable results and is definitely deprived of the drawbacks arising through the complete diversion of pancreatic juice from the gastrointestinal *** in mind the scarcity of high-quality data on the subject,an approach of reserving stent placement for the high-risk for POPF patients and individualizing the selection between the use of an internal or an external stent according to the distinct characteristics of each individual case scenario appears appropriate.

关键词： Pancreaticoduodenectomy Postoperative pancreatic fistula Pancreatic stent Pancreaticojejunostomy

Effect of growth hormone on colonic anastomosis after intraperitoneal administration of 5-fluorouracil, bleomycin and cisplatin: An experimental study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第8期16卷 2679-2688页

作者： Ioannis Lambrou Ioannis Mantzoros Orestis Ioannidis Dimitrios Tatsis Elissavet Anestiadou Vasiliki Bisbinas Manousos-georgios Pramateftakis Efstathios Kotidis Barbara Driagka Ourania Kerasidou Savvas Symeonidis Stefanos Bitsianis Freideriki Sifaki Konstantinos Angelopoulos Haralabos Demetriades Stamatios Angelopoulos Fourth Department of Surgery Medical SchoolAristotle University of ThessalonikiThessaloniki 57010Greece Department of ENT Royal Cornwall Hospitals NHS TrustCornwall TR13LJUnited Kingdom

BACKGROUND Growth hormone(GH)plays a crucial role in wound healing and tissue repair in postoperative *** particular,colonic anastomosis healing following colorectal surgery is impaired by numerous chemotherapy *** To investigate whether GH can improve the healing of a colonic anastomosis following the adverse effects of intraperitoneal administration of 5-fluorouracil(5-FU),bleomycin and *** Eighty Wistar rats underwent laparotomy and a 1 cm-resection of the transverse colon,followed by an end-to-end anastomosis under general *** rats were blindly allocated into four equal groups and administered a different daily intraperitoneal therapeutic regimen for 6 *** control group(A)received normal *** B received chemotherapy with 5-FU(20 mg/kg),bleomycin(4 mg/kg)and cisplatin(0.7 mg/kg).Group C received GH(2 mg/kg),and group D received the aforementioned combination chemotherapy and GH,as *** rats were sacrificed on the 7th postoperative day and the anastomoses were macroscopically and microscop-ically *** weight,bursting pressure,hydroxyproline levels and inflammation markers were *** All rats survived until the day of sacrifice,with no infections or other complications.A decrease in the body weight of group D rats was observed,not statistically significant compared to group A(P=1),but significantly different to groups C(P=0.001)and B(P<0.01).Anastomotic dehiscence rate was not statistically different between the *** pressure was not significantly different between groups A and D(P=1.0),whereas group B had a significantly lower bursting pressure compared to group D(P<0.001).All groups had significantly more adhesions than group ***,as a measurement of collagen deposition,was significantly higher in group D compared to group B(P<0.05),and higher,but not statistically significant,compared to group *** changes in group D were recorded,compared to group A

关键词： Growth hormone Colonic anastomosis Adhesion Bursting pressure Collagen Hydroxyproline Inflammation Neoangiogenesis Chemotherapy

Incidence, risk factors and clinical outcome of multidrug-resistant organisms after heart transplantation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Transplantation 2024年第2期14卷 107-118页

作者： Sophia Hatzianastasiou Paraskevas Vlachos georgios Stravopodis Dimitrios Elaiopoulos Afentra Koukousli Josef Papaparaskevas Themistoklis Chamogeorgakis Kyrillos Papadopoulos Theodora Soulele Despoina Chilidou Kyriaki Kolovou Aggeliki Gkouziouta Michail Bonios Stamatios Adamopoulos Stavros Dimopoulos Microbiology Department and Infection Control Office Onassis Cardiac Surgery CenterAthens 17674Greece Heart Transplantation Unit Onassis Cardiac Surgery CenterAthens 17674Greece Cardiac Surgery Intensive Care Unit Onassis Cardiac Surgery CenterAthens 17674Greece

BACKGROUND Transplant recipients commonly harbor multidrug-resistant organisms(MDROs),as a result of frequent hospital admissions and increased exposure to antimi-crobials and invasive *** To investigate the impact of patient demographic and clinical characteristics on MDRO acquisition,as well as the impact of MDRO acquisition on intensive care unit(ICU)and hospital length of stay,and on ICU mortality and 1-year mortality post heart *** This retrospective cohort study analyzed 98 consecutive heart transplant patients over a ten-year period(2013-2022)in a single transplantation *** was collected regarding MDROs commonly encountered in critical *** Among the 98 transplanted patients(70%male),about a third(32%)acquired or already harbored MDROs upon transplantation(MDRO group),while two thirds did not(MDRO-free group).The prevalent MDROs were Acinetobacter baumannii(14%),Pseudomonas aeruginosa(12%)and Klebsiella pneumoniae(11%).Compared to MDRO-free patients,the MDRO group was characterized by higher body mass index(P=0.002),higher rates of renal failure(P=0.017),primary graft dysfunction(10%vs 4.5%,P=0.001),surgical re-exploration(34%vs 14%,P=0.017),mechanical circulatory support(47%vs 26%P=0.037)and renal replacement therapy(28%vs 9%,P=0.014),as well as longer extracorporeal circulation time(median 210 vs 161 min,P=0.003).The median length of stay was longer in the MDRO group,namely ICU stay was 16 vs 9 d in the MDRO-free group(P=0.001),and hospital stay was 38 vs 28 d(P=0.006),while 1-year mortality was higher(28%vs 7.6%,log-rank-χ2:7.34).CONCLUSION Following heart transplantation,a predominance of Gram-negative MDROs was *** acquisition was associated with higher complication rates,prolonged ICU and total hospital stay,and higher post-transplantation mortality.

关键词： Heart transplantation Multi drug resistant organisms Transplantation complications Transplantation outcome

Cryoablation of osteoid osteomas:Is it a valid treatment option?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Radiology 2024年第9期16卷 389-397页

作者： Antonios Michailidis Athanasios Panos Efthimios Samoladas georgios Dimou Georgia Mingou Panagiotis Kosmoliaptsis Maria Arvaniti Christos Giankoulof Evangelos Petsatodis Department of Interventional Radiology Georgios Papanikolaou General Hospital of ThessalonikiThessaloniki 57010Greece Department of 1st Orthopaedic Clinic Georgios Papanikolaou General Hospital of ThessalonikiAristotle University of ThessalonikiThessaloniki 57010Greece Dental School EKPAAthens 15773Greece

BACKGROUND Osteoid osteoma is a benign bone tumor with characteristic clinical *** selected method for its treatment is percutaneous radiofrequency ***,percutaneous cryoablation is an alternative method with certain *** To evaluate percutaneous computed tomography(CT)-guided cryoablation for the treatment of osteoid osteoma in young patients and *** A total of 25 patients were treated with percutaneous CT-guided cryoablation for osteoid osteomas between October 2020 and March 2023 at a single *** patients were above 14-years-old(mean age,24-years-old),and all procedures were performed under local *** the 25 patients,8 were female and 17 were *** sites included the femur(n=9),medial malleolus(n=4),sacral ala(n=4),facets(n=4),humerus(n=3),and tibia(n=1).One cryoprobe was used in each procedure and,when possible,the lesion was covered by the ice-ball using an extraosseous position without penetrating the *** necessary thermal protective techniques were used depending on the anatomical structure at *** All patients treated had complete response(100%clinical success rate)starting on the day of the *** success was achieved in all *** analog scale(VAS)scores at 1 year were 0,compared to a mean VAS score of 8.5±1(SD)before the *** recurrences were reported at the 1-year follow-up and no complications were *** 11/25 cases,an extraosseous position of the cryoprobe was used with less procedural time achieving technical and clinical success and no complications with less patient *** patients were discharged from the hospital on the same day as the *** Cryoablation of osteoid osteomas is an efficacious and safe procedure with durable clinical *** greatest advantage is that the procedure can be performed under local anesthesia using an extraosseous position of the cryoprobe when possible.

关键词： Cryoablation Osteoid osteoma Computed tomography guidance Interventional radiology Orthopedics Bone tumors

Circadian rhythm disruption and endocrine-related tumors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2024年第7期15卷 818-834页

作者： Christos Savvidis Efthymia Kallistrou Eleni Kouroglou Sofia Dionysopoulou georgios Gavriiloglou Dimitra Ragia Vasiliki Tsiama Stella Proikaki Konstantinos Belis Ioannis Ilias Department of Endocrinology Hippocration General HospitalAthens GR-11527Greece

This review delved into the intricate relationship between circadian clocks and physiological processes,emphasizing their critical role in maintaining *** by interlocked clock genes,the circadian timekeeping system regulates fundamental processes like the sleep-wake cycle,energy metabolism,immune function,and cell *** central oscillator in the hypothalamic suprachiasmatic nucleus synchronizes with light-dark cycles,while peripheral tissue clocks are influenced by cues such as feeding *** disruption,linked to modern lifestyle factors like night shift work,correlates with adverse health outcomes,including metabolic syndrome,cardiovascular diseases,infec-tions,and *** explored the molecular mechanisms of circadian clock genes and their impact on metabolic disorders and cancer *** associ-ations between circadian disruption and endocrine tumors,spanning breast,ovarian,testicular,prostate,thyroid,pituitary,and adrenal gland cancers,are *** work is associated with increased breast cancer risk,with PER genes influencing tumor progression and drug *** gene expression correlates with cisplatin resistance in ovarian cancer,while factors like aging and intermittent fasting affect prostate *** review underscored the intricate interplay between circadian rhythms and cancer,involving the regulation of the cell cycle,DNA repair,metabolism,immune function,and the tumor *** advocated for integrating biological timing into clinical consider-ations for personalized healthcare,proposing that understanding these connec-tions could lead to novel therapeutic *** supports circadian rhythm-focused therapies,particularly chronotherapy,for treating endocrine *** review called for further research to uncover detailed connections between circadian clocks and cancer,providing essential insights for targeted *** emphasized the importance of pub

关键词： Circadian rhythm Circadian disruption Shift work CLOCK gene Cancer Endocrine tumors Chronotherapy

COVID-19 in pregnancy:Perinatal outcomes and complications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Virology 2024年第4期13卷 62-73页

作者： Karolina Akinosoglou georgios Schinas Evangelia Papageorgiou Theodoros Karampitsakos VasilikiDimakopoulou Eleni Polyzou Argyrios Tzouvelekis Markos Marangos Despoina Papageorgiou Nikolaos Spernovasilis George Adonakis Department of Medicine University of PatrasPatras 26504Greece Department of Obstetrics and Gynecology University General Hospital of PatrasPatras 26504Greece Department of Pneumonology University General Hospital of PatrasPatras 26504Greece Department of Infectious Diseases German Oncology CenterLimassol 4108LimassolCyprus

BACKGROUND The risk of severe coronavirus disease 2019(COVID-19)in pregnant women is *** To examine the outcomes of pregnant women with COVID-19 and report perinatal outcomes and complications,while providing a brief review of current *** The study included pregnant women presenting from April 2020 to February 2022 to the emergency department(ED)of a tertiary *** retrospectively recorded the maternal and perinatal files,including patient epidemiological and clinical characteristics,laboratory values,outcomes,treatment modalities and associations were *** Among the 60 pregnant women,25%required hospitalization,all of whom were *** delivery occurred in 30%of *** percent of neonates required admission to the neonatal intensive care unit,and 5%were classified as small for their gestational *** mothers survived COVID-19 and pregnancy,with 6.6%requiring invasive mechanical *** delivery rates did not differ between hospitalized and non-hospitalized pregnant women;composite unfavorable perinatal outcomes,including stillbirth,small for gestational age,or neonatal intensive care unit(ICU)admission,did not significantly increase in the cases hospitalized for COVID-19(P=0.09).The odds of hospitalization increased 2.3-fold for each day of delayed ED presentation[***(95%CI:1.46-3.624),P<0.001].Comorbidity status was an independent predictor of hospitalization,albeit with marginal significance[***=16.13(95%CI:1.021-255.146),P=0.048].No independent predictors of adverse fetal outcome(composite)were identified,and eventual hospitalization failed to reach statistical significance by a slight margin(P=0.054).CONCLUSION Delayed ED presentation and comorbidities increase hospitalization *** study highlights the importance of continuous and specific guidance for managing pregnant COVID-19 patients,including timely and appropriate interventions to minimize maternal and perinatal morbidity an

关键词： SARS-CoV-2 COVID-19 Pregnancy Maternal outcomes Preterm delivery

A Study on Refractive Index Sensors Based on Optical Micro-Ring Resonators

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Photonic Sensors 2017年第3期7卷 217-225页

作者： georgios N. TSIGARIDAS Department of Physics School of Applied Mathematical and Physical Sciences National Technical University of Athens Zografou Campus GR-15780 Zografou Athens Greece

In this work, the behavior of refractive index sensors based on optical micro-ring resonators is studied in detail. Using a result of waveguide perturbation theory in combination with numerical simulations, the optimum design parameters of the system, maximizing the sensitivity of the sensor, are determined. It is found that, when optimally designed, the sensor can detect relative refractive index changes of the order of △n/n≈3×10^-4, assuming that the experimental setup can detect relative wavelength shifts of the order of △λ/λ≈3×10^-5. The behavior of the system as bio-sensor has also been examined. It is found that, when optimally designed, the system can detect refractive index changes of the order of △n≈ 10^-3 for a layer thickness of t=- 10 nm, and changes in the layer thickness of the order of △t≈0.24 nm, for a refractive index change of △n=0.05.

关键词： Optical micro-ring resonators refractive index sensors bio-sensors nano-photonic sensors

Model Reference Adaptive Control for Networked Distributed Systems with Strong Interconnections and Communication Delays

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2018年第1期31卷 38-68页

作者： LYMPEROPOULOS georgios IOANNOU Petros Department of Electrical Engineering University of Southern California

In recent years, networked distributed control systems（NDCS） have received research attention. Two of the main challenges that such systems face are possible delays in the communication network and the effect of strong interconnections between agents. This paper considers an NDCS that has delays in the communication network, as well as strong interconnections between its agents. The control objective is to make each agent track efficiently a reference model by attenuating the effect of strong interconnections via feedback based on the delayed information. First, the authors assume that each agent knows its own dynamics, as well as the interconnection parameters, but receives information about the states of its neighbors with some communication delay. The authors propose a distributed control scheme and prove that if the interconnections can be weakened and if the communication delays are small enough, then the proposed scheme guarantees that the tracking error of each agent is bounded with a bound that depends on the size of the weakened interconnections and delays, and reduces to zero as these uncertainties reduce to zero. The authors then consider a more realistic situation where the interconnections between agents are unknown despite the cooperation and sharing of state information. For this case the authors propose a distributed adaptive control scheme and prove that the proposed scheme guarantees that the tracking errors are bounded and small in the mean square sense with respect to the size of the weakened interconnections and delays, provided the weakened interconnections and time delays are small enough. The authors then consider the case that each agent knows neither its dynamics nor the interconnection matrices. For this case the authors propose a distributed adaptive control scheme and prove that the proposed scheme guarantees that the tracking errors are bounded and small in the mean square sense provided the weakened interconnections and time delays are

关键词： Adaptive control network distributed control delay systems