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Hepatocellular carcinoma and metabolic syndrome: The times are changing and so should we

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World Journal of Gastroenterology 2019年第29期25卷 3842-3848页

作者： georgios Tsoulfas Department of Surgery Aristotle University of Thessaloniki

Although hepatocellular carcinoma (HCC) is as prevalent as ever as a cancerrelated mortality, and some would even argue that it is increasing, the pattern of its etiologies has been changing. Specifically, the domination of viral hepatitis C virus is being overcome, partly because of the emergence of the antiviral treatments, and partly because of the significant increase, especially in developed countries, of the combination of obesity, diabetes, metabolic syndrome, nonalcoholic fatty liver disease and non-alcoholic steatohepatitis. This editorial will explore the interconnection of this group of diseases and how they are linked to HCC. More importantly, it will argue that this shift in HCC etiology essentially means that we have to change how we approach the treatment of HCC, by changing our focus (and resources) to earlier stages of the disease development in order to prevent the appearance and progression of HCC.

关键词： Hepatocellular carcinoma Diabetes Obesity Steatosis Non-alcoholic fatty liver disease Body-mass index Non-alcoholic steatohepatitis

Risk of colorectal neoplasm in patients with acromegaly: A meta-analysis

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World Journal of Gastroenterology 2008年第22期14卷 3484-3489页

作者： Theodoros Rokkas Dimitrios Pistiolas Panos Sechopoulos georgios Margantinis georgios Koukoulis Gastroenterology Clinic Henry Dunant Hospital 107 Messogion Ave. Athens 11526 Greece

AIM: To examine the risk of colorectal neoplasm in acromegalic patients by meta-analyzing all relevant controlled studies. METHODS: Extensive English language medical literature searches for human studies, up to December 2007, were performed using suitable keywords. Pooled estimates [odds ratio (OR) with 95% confidence intervals (CI)] were obtained using either the fixed or random-effects model as appropriate. Heterogeneity between studies was evaluated with the Cochran Q test whereas the likelihood of publication bias was assessed by constructing funnel plots. Their symmetry was estimated by the adjusted rank correlation test. RESULTS: For hyperplastic polyps the pooled ORs with 95% CI were 3.557 (2.587-4.891) by fixed effects model and 3.703 (2.565-5.347) by random effects model. The Z test values for overall effect were 7.81 and 6.984, respectively (P < 0.0001). For colon adenomas the pooled ORs with 95% CI were 2.486 (1.908-3.238) (fixed effects model) and 2.537 (1.914-3.364) (random effects model). The Z test values were 6.747 and 6.472, respectively (P < 0.0001). For colon cancer the pooled OR with 95% CI was identical for both fixed and random effects model (OR, 4.351; 95% CI, 1.533-12.354; Z = 2.762, P = 0.006]. There was no significant heterogeneity and no publication bias in all the above meta-analyses. CONCLUSION: Acromegaly is associated with an increased risk of colorectal neoplasm.

关键词： Acromegaly Colon cancer Colon polyps Colon neoplasia Meta-analysis

Anion effect on Li/Na/K hybrid electrolytes for Graphite//NCA(LiNi_(0.8)Co_(0.15)Al_(0.05)O_(2))Li-ion batteries

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Journal of Energy Chemistry 2022年第1期31卷 451-462,I0012页

作者： Aiman Jrondi georgios Nikiforidis Meriem Anouti Laboratoire PCM2E Universite de ToursFaculte des sciences et technologiePare de Grandmont37200 ToursFrance LE STUDIUM Institute for Advanced Studies 45000 OrleansFrance

The electrolyte is an essential component of a battery system since it is responsible for the conduction of ions between the *** the quest for cheaper alternatives to common organic electrolytes for lithium-ion batteries(LIB),we formulated hybrid electrolytes comprising a mixture of Na,K,and Li alkaline salts with ethylene carbonate(EC),ethyl methyl carbonate(EMC),and lithium hexafluorophosphate(LiPF_(6)),giving a total salt concentration of 1.5 M;we determined their physicochemical properties and investigated their electrochemical behavior on a nickel cobalt aluminum oxide(NCA)cathode and graphite(Gr)*** electrolytes demonstrated a melting transition peak(T_(m)).eutectic behavior,and ionic conductivities(-13 mS cm^(-1))close to those of a commercial LIB electrolyte(SE,EC/EMC+1 M LiPF_(6))and activation energies of ca.3 kJ mol^(-1).The half-cell coin cells revealed high coulombic efficiency(99%),specific capacity(175 mAh g^(-1) at C/10),and capacity retention(92% for NaCF_(3)SO_(3))for the NCA cathode and a moderate performance(coulombic efficiency of 98%for 20 cycles)on the graphite anode after the formation of the SEI *** hybrid electrolytes were cycled at 25℃ in a Gr//NCA cell yielding specific capacities of ca.225 mAh g^(-1) at a C/5 rate,corroborating that the anion plays a key role and highlighting their potential for energy storage applications.

关键词： Hybrid electrolyte Alkali salts NCA//Li cell Li-ion battery

A concomitant review of the effects of diabetes mellitus and hypothyroidism in wound healing

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World Journal of Gastroenterology 2006年第17期12卷 2721-2729页

作者： Konstantinos A Ekmektzoglou georgios C Zografos Laboratory of Experimental Surgery and Surgical Research Athens School of Medicine AthensGreece 1st University Department of General Surgery Athens School of Medicine Hippocration HospitalAthensGreece

This paper reviews the negative impact of diabetes mellitus or hypothyroidism on wound healing, both in experimental and clinical settings. Since both are metabolic disorders of great clinical importance, special attention is given, not only to their pathophysiology, but also to their biochemical and histological effects on tissue integrity and regeneration. Also, special focus is awarded on wound healing of the gastrointestinal tract, i.e. in intestinal anastomosis, and how these disorders can lead to wound dehiscence. Since diabetes mellitus and hypothyroidism can coexist in clinical settings, more research must be directed on their influence on wound healing, considering them as one clinical entity.

关键词： Diabetes mellitus Hypothyroidism Wound healing Anastomosis

Prediction of severe acute pancreatitis:Current knowledge and novel insights

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World Journal of Gastroenterology 2008年第41期14卷 6273-6275页

作者： georgios I Papachristou Department of Medicine Division of Gastroenterology Hepatology and Nutrition University of Pittsburgh Medical Center

Acute pancreatitis (AP) is a common and potentially lethal acute inflammatory process with a highly variable clinical course. It is still unclear why some patients progress to organ failure and others do not. Physicians, ability to predict which patients will develop severe disease is limited. Routine clinical and laboratory data and multi-factorial clinical scores measured on admission and during the first 48 h of hospitalization are currently the standards of care used to estimate the magnitude of the inflammatory response to injury. Current literature highlights several common environmental, metabolic and genetic factors that increase the risk of AP development and subsequent adverse sequelae. Several cytokines have been found to play a critical role in the pathogenesis of AP by driving the subsequent inflammatory response, to include tumor necrosis factor-α (TNF-α), Interleukin-1 (IL-1), IL-6 and monocyte chemotactic protein-1 (MCP-1). Large, prospective studies are still needed to address these questions by identifying AP risk factors and serum biomarkers of severe disease.

关键词： Acute pancreatitis Prediction Severity Monocyte chemotactic protein-1

An accurate model for the thin film flow

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Acta Mechanica Sinica 2008年第4期24卷 375-380页

作者： Hamid Ait Abderahmane georgios H.Vatistas Department of Mechanical and Industrial Engineering Concordia University 1455 de Maisonneuve Blvd West Montreal OC H3G 1M8 Canada

This paper deals with the linear stability of a liquid film flowing down an inclined plane. The Navier-Stokes equations were reduced into four evolution equations that describe the development of the film depth, the flow rate, the free surface velocity, and the wall shear stress, using the Karman-Polhausen boundary layer integral method. Thus, we were able to determine the stability threshold and approach well the critical wave number for long waves. The obtained results were found to be in good agreement with the experiments of Liu et al.

关键词： Liquid film Linear stability Flow model

On the refracted patterns produced by liquid vortices

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Acta Mechanica Sinica 2007年第1期23卷 11-15页

作者： Yasser Aboelkassem georgios H.Vatistas McGill University MontrealQCH3A-2K6Canada Concordia University MontrealQCH3G 1M8Canada

A theoretical analysis of the refracted shadows produced by steady and time-decaying liquid vortices under uniform illumination from above is given in this article. An expression for the induced shadow intensity is derived and found to be a function of the vortex＇s free surface profile, i.e., function of the static pressure distribution. The patterns for different focusing depth are given and compared with previous visualization results from the literature. The phenomenon is examined and illustrated as a bench mark case by using both steady and time-decaying algebraic vortex models. However, this study can be extended to check the feasibility of recovering the main flow properties by analyzing the luminous image intensity of the refracted patterns. The present analysis is valid only when the swirl velocity is order of magnitude higher than the meridional flow components and the vorticity is concentrated within the core region and of intense conditions.

关键词： Fluid dynamics - Vortices - Dark shadows Intensity - Time decay

Strength, deformability and permeability of kakiritic rocks from the Gotthard base tunnel

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第9期15卷 2224-2237页

作者： Martin Vogelhuber Erich Pimentel georgios Anagnostou ETH Zurich ZurichSwitzerland

The 57-km long,new Gotthard Base Tunnel(GBT)crosses over a 1.1-km long stretch containing kakirites,*** rocks which,depending on the degree of tectonisation,may exhibit severe squeezing behaviour upon tunnel *** tunnel stretch was already identified as a key problem in the early planning phase,necessitating intensive geological exploration and laboratory investigations over a 14-year period,including research and development in experimental *** laboratory investigations for the GBT provided not only a considerable amount of data about the geotechnical parameters of the kakirites,but also valuable information about their basic behaviour and the adequacy of various testing techniques for this type of ***,by using specially designed testing equipment and procedures,it was shown that,(1)conventional rock mechanics triaxial tests cannot provide reliable results for kakirites;(2)the kakirites obey the principle of effective stress in Terzaghi’s classical form and consequently it is indispensable to measure the pore pressure during triaxial testing,analogously to the consolidated drained(CD)and consolidated undrained(CU)tests in soil mechanics;(3)the effects of a possible loss of water and desaturation during sampling,transport,storage and preparation of specimens can be successfully mitigated by subjecting the specimens to flow-through before the actual triaxial testing;and,(4)CD tests on partially saturated specimens that are obtained by means of flow-through can provide reliable and reproducible *** saves a significant amount of time,allows a greater number of tests to be performed,and allows results to be obtained more quickly,which is particularly important for decision-making during tunnel advance.

关键词： Squeezing Pore pressure Triaxial testing

Surgical treatment of hepatic metastases from colorectal cancer

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World Journal of Gastrointestinal Oncology 2011年第1期3卷 1-9页

作者： georgios Tsoulfas Manousos georgios Pramateftakis Ioannis Kanellos Department of Surgery Aristoteleion University of ThessalonikiThessaloniki 54622Greece

Colorectal carcinoma is one of the most frequent cancers in Western societies with an incidence of around 700 per million *** half of the patients develop metastases from the primary tumor and liver is the primary metastatic *** survival rates after hepatectomy for metastatic colorectal cancer have been reported in the last few years and these may be the result of a variety of factors,such as advances in systemic chemotherapy,radiographic imaging techniques that permit more accurate determination of the extent and location of the metastatic burden,local ablation methods,and in surgical techniques of hepatic *** have led to a more aggressive approach towards liver metastatic disease,resulting in longer *** goal of this paper is to review the role of various forms of surgery in the treatment of hepatic metastases from colorectal cancer.

关键词： Hepatic metastases Colorectal cancer Liver resection