检索结果-南通市图书馆

维普期刊数据库

Reviewing Threats to Wild Rhodiola sachalinensis,A Medicinally Valuable yet Vulnerable Species

在线全文

学校读者我要写书评

暂无评论

World Journal of Traditional Chinese Medicine 2021年第3期7卷 299-306页

作者： Josef A.brinckmann Anthony b.cunningham David E.V.Harter Traditional Medicinals Sustainability Department4515 Ross RoadSebastopolCalifornia95472USA School of Life Sciences University of KwaZulu-NatalKing Edward AvenuePietermaritzburg3209South Africa School of Veterinary and Life Sciences Murdoch University90 South St.MurdochWA6150Australia bundesamt für Naturschutz(bfN) Konstantinstr.110Bonn53179Germany

Occurring in China,DPR Korea,Japan,and Russian Federation and classified in the Red List of Chinese Flora as a vulnerable species,Rhodiola sachalinensis *** used increasingly in cosmetics,dietary supplements,and Traditional Chinese Medicines(TCMs).The aim of this study was to evaluate the(i)conservation status,harvesting and trade levels of ***,(ii)current state of experimental and commercial farming,and(iii)evidence of substitution or interchangeable use of *** with other Rhodiola *** assessed data from multiple disciplines and languages including studies on *** biology and ecology,information on impacts of wild harvest,management measures,and current levels of *** assessment shows that while *** is increasingly produced by cultivation,wild populations are decreasing and face multiple *** include(a)habitat loss including due to oil and gas infrastructure development on Sakhalin island,(b)climate change impacts on alpine ecosystems,and(c)overexploitation of wild plants to satisfy the growing commercial *** of the conservation status of *** should commence in each Range State,as well as resource assessments and monitoring of harvesting and trade of wild *** with increased reliance on cultivation,biodiversity conservation,and genetic diversity in wild populations are relevant to future use of this species.

关键词： Conservation Rhodiola rosea ssp.sachalinensis Rhodiola sachalinensis sustainable production Traditional Chinese Medicine

维普期刊数据库

Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating b7H3

在线全文

学校读者我要写书评

暂无评论

Oncology research 2025年第1期33卷 103-121页

作者： Yan Lu Kang Wang Yuanhong Peng Meng Chen Lin Zhong Luji Huang F U Cheng Xindan Sheng Xin Yang Manzhao Ouyang george A Calin Zhiwei He China-America Cancer Research Institute Guangdong Medical University Dongguan 523808 China. GCP Center Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. Department of Gastrointestinal Surgery Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. The Second School of Clinical Medicine Southern Medical University Guangzhou 510080 China. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Oncology Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China.

background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors, but the currently used immune checkpoint inhibitors targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte antigen-4 (CTLA-4) show limited clinical efficacy in many breast cancers. b7H3 has been widely reported as an immunosuppressive molecule, but its immunological function in breast cancer patients remains unclear.Methods:We analyzed the expression of b7H3 in breast cancer samples using data from the Cancer Genome Atlas Program (TCGA) and the Gene Expression Omnibus (GEO) databases. MicroRNAs were selected using the Tarbase, miRTarbase, and miRbase databases. The regulatory role of the microRNA hsa-miR-214-3p on b7H3 was investigated through dual-luciferase reporter assays, which identified the specific action sites of interaction. The expression levels of b7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR (qPCR). experiments were performed to observe the effects of modulating the expression of b7H3 or hsa-miR-214-3p on breast cancer cell proliferation and apoptosis. Additionally, the regulatory impact of hsa-miR-214-3p on b7H3 was examined. Enzyme-linked immunosorbent assays (ELISA) and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells (PbMCs) on immune cells and associated cytokines.Results:In breast cancer tissues, the expression level of b7H3 is inversely correlated with that of hsa-miR-214-3p, as well as with the regulatory effects on breast cancercell behavior. Hsa-miR-214-3p was found to inhibit breast cancer cell growth by downregulating b7H3. Importantly, our research identified, for the first time, two binding sites for hsa-miR-214-3p on the 3' UTR of b7H3, both of which exert similar effects independently. Co-culture experime

关键词： b7H3 breast cancer Hsa-miR-214-3p Immunotherapy

Expression of octopaminergic receptor genes in 4 nonneural tissues in female Nicrophorus vespilloides beetles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2015年第4期22卷 495-502页

作者： Christopher b. cunningham Mary K. Douthit Allen J. Moore Department of Genetics University of Georgia Athens GA 30602 USA

Octopamine regulates the function of many tissues and physiological processes in invertebrates. The expression of octopamine receptor genes has been examined in multiple tissue types in several different insect orders. However, little work has addressed this issue in Coleoptera. Most studies characterize individual genes in different tissue types, but here we describe the expression of 6 octopamine receptor genes in thoracic musculature, oviducts, Malpighian tubules, and fat body of female Nicrophorus vespilloides beetles to characterize both different genes and different tissues within a single study. We then compare the gene expression profiles found in this beetle to other insects to examine the extent to which expression profiles are conserved across insects. We also examine the relative involvement of octopamine verses octopamine/tyramine receptors based on receptor gene expression in each tissue to help elucidate if tyramine plays a role in the regulation of these tissues. We find a high degree of overlap in the expression profile of the 6 genes examined in the thoracic muscula^tre, a moderate amount for the oviducts, and divergent profiles for Malpighian tubules and fat body. based on expression difference in receptor subtypes, our results also support the suggestion that tyramine is a biogenic amine with physiological actions separate from octopamine.

关键词： biogenic amines Coleoptera G-protein coupled receptors quantitative real-time PCR

From Ghana to the dry-hot valleys of China:assessing factors influencing fruit yield in agroforestry species Vitellaria paradoxa after 54 years of cultivation outside Africa

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Circular Agricultural Systems

Circular Agricultural Systems 2023年第1期3卷 56-63页

作者： Gaojuan Zhao Sailesh Ranjitkar Aurele Gnetegha Ayemele Tianliang Li Xinyu Wang Liqing Wu Anthony b.cunningham Xiaohui Han Haiqin Qin Shiyu Zhang Center for Mountain Futures Kunming Institute of BotanyKunming Yunnan 650201China Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglun Yunnan 666303China N.Gene Solutions of Natural InnovationKathmanduGPO44614Nepal Lumbini buddhist University School of Development Studies&Applied SciencesLumbini 32901Nepal Mid-West University Institute of Cooperation and Development(MICD) Naya BatoLalitpur 44600Nepal School of Life Sciences University of KwaZulu-NatalKing Edward AvenuePietermaritzburg3209South Africa School of Science Mae Fah Luang UniversityChiang Rai57100Thailand

Although distributed across the Sudano-Sahelian region as an agroforestry system tree species,Vitellaria paradoxa has yet to be reported as successfully established outside of Africa,significantly limiting its yield and further *** this paper,in order to assess a well-established population of *** in the Yuanjiang dry-hot valley of China and examine the relationships between morphological-geological factors and fruit yield,we monitored dendrometric traits and fruiting across 844 shea trees located on different aspects,and applied partial least square regression to build a yield model based on dendrometric and geographical *** revealed climatic resemblance of the introduction site in Yuanjiang to the natural habitat in Ghana,and the growth performance and fruit yield were also comparable,but accumulated precipitation of about 600 mm was better for fruit yield when heat accumulation reached about 2,*** from crown diameter(pbasal diameter,basal area and tree height)had positively weak relationships with fruit *** the contrary,aside from north and northeast aspect,other aspects showed a strong negative *** findings presented that growth and productivity of *** increased with dendrometric parameters and monthly average temperature on shady and semi-shady slope,providing a theoretical basis for the development of shea tree and construction of agroforestry system in dry tropical areas outside Africa.

关键词： outside valley assessing

Friction surfacing of AISI 316 over mild steel: A characteriation study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2018年第4期14卷 306-312页

作者： R.george Sahaya Nixon b.S.Mohanty R.Sathish Department of Mechanical Sathyabama University Department of Mechanical Engineering St.Joseph's College of Engineering Department of Mechanical Engineering SRM Easwari

An attempt has been made with overlaying of stain-less steel on mild steel by the technique of friction surfacing. This investigation elaborates the excellence acquired by different combination of the process parameters used in friction surfacing specifically traverse speed of the cross slide, speed of rotation of the spindle and the uniaxial compressive load. Excellent overlaying has been obtained amongst the chosen materials. To which, the coating can be done with various set of process parameters. It has been observed that the bond strength of the coating was found to be at a maximum of 502 MPa by ram tensile *** upon this results the surface methodology was characterized with scanning electron *** authenticating the results, the coated specimen was subjected to salt spray test. The bonding microstructure was characterized using optical microscopy and X-ray diffraction. Corrosion resistance of surfaced coatings was found to be more inferior to that of mechtrode material and greater with the substrate.

关键词： Friction surfacing Rotational speed Traverse speed Axial load Salt spray test Microstructure XRD analysis Ram tensile test

维普期刊数据库

Exploring the configuration space of elemental carbon with empirical and machine learned interatomic potentials

在线全文

学校读者我要写书评

暂无评论

npj Computational Materials 2023年第1期9卷 987-998页

作者： george A.Marchant Miguel A.Caro bora Karasulu Livia b.Pártay Department of Chemistry University of WarwickCoventry CV47ALUK Department of Chemistry and Materials Science Aalto University02150 EspooFinland

We demonstrate how the many-body potential energy landscape of carbon can be explored with the nested sampling algorithm,allowing for the calculation of its pressure-temperature phase *** compare four interatomic potential models:Tersoff,EDIP,GAP-20 and its recently updated version,*** evaluation is focused on their macroscopic properties,melting transitions,and identifying thermodynamically stable solid structures up to at least 100 *** phase diagrams of the GAP models show good agreement with experimental ***,we find that the models’description of graphite includes thermodynamically stable phases with incorrect layer *** adding a suitable selection of structures to the database and re-training the potential,we have derived an improved model—GAP-20U+gr—that suppresses erroneous local minima in the graphitic energy *** extreme high pressure nested sampling identifies two novel stable structures in the GAP-20 model,however,the stability of these is not confirmed by electronic structure calculations,highlighting routes to further extend the applicability of the GAP models.

关键词： carbon potential configuration

Tricube Weighted Linear Regression and Interquartile for Cloud Infrastructural Resource Optimization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Systems Science & Engineering 2023年第6期45卷 2281-2297页

作者： Neema george b.K.Anoop Vinodh P.Vijayan Srinivas University MangaloreIndia Mangalam College of Engineering KottayamIndia

Cloud infrastructural resource optimization is the process of precisely selecting the allocating the correct resources either to a workload or *** workload execution,accuracy,and cost are accurately stabilized in opposition to the best possible framework in real-time,efficiency is *** addition,every workload or application required for the framework is characteristic and these essentials change over ***,the existing method was failed to ensure the high Quality of Service(QoS).In order to address this issue,a Tricube Weighted Linear Regression-based Inter Quartile(TWLR-IQ)for Cloud Infrastructural Resource Optimization is introduced.A Tricube Weighted Linear Regression is presented in the proposed method to estimate the resources(i.e.,CPU,RAM,and network bandwidth utilization)based on the usage history in each cloud ***,Inter Quartile Range is applied to efficiently predict the overload hosts for ensuring a smooth *** results show that our proposed method is better than the approach in Cloudsim under various performance *** results clearly showed that the proposed method can reduce the energy consumption and provide a high level of commitment with ensuring the minimum number of Virtual Machine(VM)Migrations as compared to the state-of-the-art methods.

关键词： Cloud infrastructure tricube weighted linear regression inter quartile CPU RAM network bandwidth utilization

Endocannabinoid immune and vascular signaling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2000年第12期21卷 16-26页

作者： george b STEFANO beth Israel Deaconess Medical Center boston MA 02215 NY 11568 and Mind body Medical Institute Neuroscience Research Institute P O box 210 State University of New York at Old Westbury USA

HISTORY Hemp has been cultivated for 7000 to 8000 yearsc. The Sumerian/babylonian term for cannabis hemp is K (a)N(a)b(a), and it is one of the longest surviving root words in Indo-Semitic-European language. In 2700 bC, Shen Nung, a contributor to early Chinese medicine, mentions cannabis in the pharmacopoeia. Around 500 bC Zoroaster, a Persian prophet, in the Zend-Avesta, listing 10 000 medicinal plants, includes hemp. In the first century AD the Chinese begin making paper from hemp as an inexpensive means of preserving information. In 800 AD the Islamic prophet Mohammed allows cannabis use. In 1100, Moslems use cannabis to start

关键词： anandamide nitric oxide 2-arachi-donyl-glyceral cannabinoid receptors vascular endothe-lium hemp immune cells

High-throughput computational discovery of In_(2)Mn_(2)O_(7) as a high Curie temperature ferromagnetic semiconductor for spintronics

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

npj Computational Materials 2019年第1期5卷 529-535页

作者： Wei Chen Janine george Joel b.Varley Gian-Marco Rignanese Geoffroy Hautier Institute of Condensed Matter and Nanoscicence(IMCN) Universitécatholique de Louvain1348 Louvain-la-NeuveBelgium Lawrence Livermore National Laboratory LivermoreCA 94550USA

Materials combining strong ferromagnetism and good semiconducting properties are highly desirable for spintronic applications(e.g.,in spin-filtering devices).In this work,we conduct a search for concentrated ferromagnetic semiconductors through highthroughput computational *** screening reveals the limited availability of semiconductors combining ferromagnetism and a low effective *** identify the manganese pyrochlore oxide In_(2)Mn_(2)O_(7) as especially promising for spin transport as it combines low electron effective mass(0.29m0),a large exchange splitting of the conduction band(1.1 eV),stability in air,and a Curie temperature(about 130 K)among the highest of concentrated ferromagnetic *** rationalise the high performance of In_(2)Mn_(2)O_(7) by the unique combination of a pyrochlore lattice favouring ferromagnetism with an adequate alignment of O–2p,Mn–3d,and In–5s forming a dispersive conduction band while enhancing the Curie temperature.

关键词： temperature ferromagnetic semiconductors