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Asian Pacific Journal of Tropical biomedicine 2017年第2期7卷 121-125页

作者： Solomon Habtemariam george Kabakasseril Varghese Pharmacognosy Research Laboratories&Herbal Analysis Services Medway School of ScienceUniversity of GreenwichChatham-MaritimeKent ME4 4TBUK Department of botany St.Berchmans'CollegeChanganasseryKottayam 686101KeralaIndia

Objective: To investigate the antioxidant, anti-a-glucosidase and pancreatic b-cell protective potential of Ensete superbum(E. superbum) ***: A variety of in vitro assays including radical scavenging, reducing power potential, phenolic content determination, a-glucosidase assay and pancreatic b-cell(1.4E7 cells) viability were employed for assessing the effect of methanolic extract of E. superbum ***: The radical scavenging and reducing power effects comparable with the standard rutin were obtained while the enzyme inhibitory activity of the extract was 68-fold better than the standard antidiabetic drug, acarbose. The seed extract of E. superbum was packed-full of polyphenols with mean percentage gallic acid equivalent value of(38.2 ± 1.8)(n = 3). The protection of pancreatic cells from massive onslaught of hydrogen peroxide was far superior to that obtained for ***: The reputed antidiabetic therapeutic uses of the seeds extract of E. superbum may be justified on the basis of inhibition of carbohydrate enzymes, antioxidant effects and pancreatic b-cell protection.

关键词： Ensete superbum Musaceae Seeds Antioxidant Pancreatic beta-cell protection Alpha-glucosidase inhibition

Occult Hepatitis C Virus Infection:A Review

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Journal of Clinical and Translational Hepatology 2018年第2期6卷 155-160页

作者： Alyssa Austria george Y.Wu Division of Gastroenterology-Hepatology Department of MedicineUniversity of Connecticut Health CenterFarmingtonCT 06030USA

Occult hepatitis C virus(HCV)infection(OCI),first described in 2004,is defined as the presence of HCV RNA in hepatocytes or peripheral blood mononuclear cells without detectable HCV RNA in the ***,we aimed to review the epidemiology,diagnostic methods,clinical implications and potential man-agement recommendations currently described in the litera-ture,as well as the future directions for investigation of this *** and Cochrane databases were searched with combination of the following keywords:"occult","hepatitis C virus",and"occult HCV infection".There are data to support OCI as a potential culprit in cryptogenic liver *** are also consistent data demonstrating the existence of OCI in specific populations,such as dialysis,human immunodefi-ciency virus-infected and hepatitis b virus-infected patients,and also in the general *** the gold standard for diagnosis is liver biopsy,examination of peripheral blood mononuclear cells may be a reliable,safer alternative method of *** HCV infection is likely associated with liver fibrosis and progression of liver *** studies are required to determine the infectivity of OCI patients,as well as clarify the natural course and specific clinical implications of ***,studies are needed to determine whether treat-ment of OCI leads to decreased morbidity and/or mortality.

关键词： Occult hepatitis C virus OCI HCV infection

Optimization of process conditions for drying of catfish(Clarias gariepinus)using Response Surface Methodology(RSM)

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Food Science and Human Wellness 2019年第1期8卷 46-52页

作者： Elijah george Ikrang Kingsley Charles Umani Department of Agricultural and Food Engineering Faculty of EngineeringUniversity of UyoUyoAkwa Ibom StateNigeria Department of Agricultural Engineering Faculty of EngineeringAkwa Ibom State UniversityMkpat EninAkwa Ibom StateNigeria

Drying is applied to lower the moisture content of fish to a level that can prevent the growth of mould and infestation of micro-organism and thus minimizes microbial *** goal of this work was to optimize the process conditions during electrical oven drying of *** content(MC)was quantitatively investigated during the drying process of catfish sizes using response surface methodology(RSM)to obtain minimum moisture *** independent process variables for the drying process were temperature(50–70◦C),product thickness(10–20 mm),salt concentration(0–20%)and drying time(480–600 min.).Two factorial interaction(2FI)regression model describing the effects of independent drying process variables on the moisture content was *** effects of temperature and drying time were more pronounced for MC than the thickness and salt *** optimum conditions were found to be temperature=63.43◦C,product thickness=14.81 mm,salt concentration=9.07%and drying time=600 *** these optimum conditions,moisture content was found to be 2.64%*** of experimental results with the empirical model was evaluated using coefficient of correlation(R2)which was found for the model equation as,R2=0.994.

关键词： Optimization Oven drying Drying parameters Catfish Response surface methodology

Nano zinc, an alternative to conventional zinc as animal feed supplement:A review

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Animal Nutrition 2016年第3期2卷 134-141页

作者： Partha S.Swain Somu b.N.Rao Duraisamy Rajendran george Dominic Sellappan Selvaraju ICAR National Dairy Research Institute ICAR-National Dairy Research Institute National Institute of Animal Nutrition and Physiology

The uniqueness of Zn is that, it is the second most abundant trace element in the animal body but can't be stored in the body, thus regular dietary intake is required. Zinc oxide(ZnO) nanoparticles(NP) particles are being extensively used in paints, skin lotions pigments, food, electronics appliances, biological and pharmaceutical applications and many more. Zinc oxide nanoparticles are the specially prepared mineral salt having particle size of 1 to 100 nm. It promotes growth can act as antibacterial agent,modulates the immunity and reproduction of the animals. both in lower and higher doses of specifications it has exhibited a variety of effects on animal performances. Apart from being highly bioavailable, reports have already pointed out the growth promoting, antibacterial, immuno-modulatory and many more effects of nano zinc(nZn). These can be used at lower doses and can provide better result than the conventional Zn sources and indirectly prevents environmental contamination also. The toxicological studies provide mixed results in animal models. Studies been undertaken in diversified animal species and encouraging effects have been reported with nZn supplementation. However, there is a need to optimize the dose and duration of ZnO NP supplementation for human and livestock,depending on its biological effects. Actual bioavailability of ZnO NP in livestock is still to be worked *** this review we have attempted to summarize, conclude the beneficial effects of nZnO and its possible usage as mineral supplement to different categories of human and livestock.

关键词： Antibacterial agent Feed additive Human Livestock Nano zinc

Operator Equations and Duality Mappings in Sobolev Spaces with Variable Exponents

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Chinese Annals of Mathematics,Series b 2013年第5期34卷 639-666页

作者： Philippe G.CIARLET george DINCA Pavel MATEI Department of Mathematics City University of Hong Kong83 Tat Chee AvenueKowloonHong KongChina Faculty of Mathematics and Computer Science University of Bucharest14 Academiei Street010014 BucharestRomania. Technical University of Civil Engineering Department of Mathematics and Computer Science124 Lacul Tei Blvd.020396 BucharestRomania.

After studying in a previous work the smoothness of the space where dr- measF0 〉 O, with p（.） E C（~） and p（x）〉 1 for all x E , the authors study in this paper the strict and uniform convexity as well as some special properties of duality mappings defined on the same space. The results obtained in this direction are used for proving existence results for operator equations having the form Ju = Niu, where J is a duality mapping on Uro corresponding to the gauge function ~, and Nf is the Nemytskij operator generated by a Caratheodory function f satisfying an appropriate growth condition ensuring that Nf may be viewed as acting from Ur0 into its dual.

关键词： Monotone operators Smoothness Strict convexity Uniform convexity Duality mappings Sobolev spaces with a variable exponent Nemytskijoperators

Experimental study of hollow rectangular bridge column performance under vertical and cyclically bilateral loads

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Earthquake Engineering and Engineering Vibration 2013年第3期12卷 433-445页

作者： Han Qiang Du Xiuli Yihui Zhou george C. Lee Key Laboratory of Urban Security and Disaster Engineering of MOE Beijing University of Technology MCEER University at Buffalo State University of New York

To investigate the seismic performance of hollow reinforced concrete （RC） bridge columns of rectangular cross section under constant axial load and cyclically biaxial bending, five specimens were tested. A parametric study is carried out for different axial load ratios, longitudinal reinforcement ratios and lateral reinforcement ratios. The experimental results showed that all tested specimens failed in the flexural failure mode and their ultimate performance was dominated by flexural capacity, which is represented by the rupture/buckling of tensile longitudinal rebars at the bottom of the bridge columns. biaxial force and displacement hysteresis loops showed significant stiffness and strength degradations, and the pinching effect and coupling interaction effect of both directions severely decrease the structural seismic resistance. However, the measured ductility coefficient varying from 3.5 to 5.7 and the equivalent viscous damping ratio varying from 0.19 and 0.26 can meet the requirements of the seismic design. The hollow RC rectangular bridge columns with configurations of lateral reinforcement in this study have excellent performance under bidirectional earthquake excitations, and may be considered as a substitute for current hollow RC rectangular section configurations described in the Guideline for Seismic Design of Highway bridges （JTG/T b02-01-2008）. The length of the plastic hinge region was found to approach one sixth of the hollow RC rectangular bridge column height for all specimen columns, and it was much less than those specified in the current JTG/T. Thus, the length of the plastic hinge region is more concentrated for RC rectangular hollow bridge columns.

关键词： bridge columns hollow section cyclic loading test biaxial bending seismic performance

Antigen Processing by Autoreactive b Cells Promotes Determinant Spreading

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Cellular & Molecular Immunology 2005年第3期2卷 169-175页

作者： Yang D. Dai george Carayanniotis Eli Sercarz Division of Immune Regulation Torrey Pines Institute for MolecularStudies San Diego California USA Faculty of Medicine Memorial University of Newfoundland St. John＇sNewfoundland Canada

Acute primary immune responses tend to focus on few immunodominant determinants using a very limited number of T cell clones for expansion, whereas chronic inflammatory responses generally recruit a large number of different T cell clones to attack a broader range of determinants of the invading pathogens or the inflamed tissues. In T cell-mediated organ-specific autoimmune disease, a transition from the acute to the chronic phase contributes to pathogenesis, and the broadening process is called determinant spreading. The cellular components catalyzing the spreading reaction are not identified. It has been suggested that autoreactive b cells may play a central role in diversifying autoreactive T cell responses, possibly through affecting antigen processing and presentation. The clonal identity and diversity of the b cells and antibodies seem critical in regulating T cell activity and subsequent tissue damage or repair. Here, we use two autoimmune animal models, experimental autoimmune thyroiditis （EAT） and type 1 diabetes （T1D）, to discuss how autoreactive b cells or antibodies alter the processing and presentation of autoantigens to regulate specific T cell response. Cellular ＆ Molecular Immunology. 2005;2（3）：169-175.

关键词： antigen processing b cell epitope spreading autoimmunity experimental autoimmune thyroiditis type 1 diabetes

3种平台Delta-Omicron嵌合RbD二聚体新型冠状病毒疫苗的免疫原性头对头比较

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科学通报 2024年第10期69卷 1351-1360页

作者：杨康吉徐坤张丽君韩雨旋周东明夏乾峰戴连攀高福海南医学院热带医学院热带转化医学教育部重点实验室海口571199 中国科学院北京生命科学研究院免疫与健康联合研究中心北京100101 中国科学院微生物研究所中国科学院病原微生物与免疫学重点实验室北京100101 天津医科大学基础医学院天津300070

新型冠状病毒(新冠病毒)在全球范围内流行,对公共卫生和人民生命健康造成了巨大威胁,新冠病毒疫苗的研发和使用对预防疾病和控制疫情起到了关键作用.基于包括重组蛋白亚单位、病毒载体、mRNA脂纳米颗粒在内的多种技术平台开发的疫苗都... 详细信息

新型冠状病毒(新冠病毒)在全球范围内流行,对公共卫生和人民生命健康造成了巨大威胁,新冠病毒疫苗的研发和使用对预防疾病和控制疫情起到了关键作用.基于包括重组蛋白亚单位、病毒载体、mRNA脂纳米颗粒在内的多种技术平台开发的疫苗都获得了使用.然而,由于抗原设计的差异、免疫剂量和注射间隔的差别,不同疫苗平台之间的免疫效果无法直接比较.因此,本研究以Delta-Omicron嵌合RbD二聚体为免疫原,对广泛使用的3个疫苗平台(重组蛋白亚单位疫苗、腺病毒载体疫苗和mRNA疫苗)进行了免疫原性头对头比较,通过小鼠模型比较了它们同源接种和序贯接种所诱导的体液免疫和细胞免疫反应的差异.结果显示,小鼠在免疫同源的两剂疫苗后,m RNA疫苗诱导的结合抗体和中和抗体滴度都最高,其次分别是重组蛋白亚单位疫苗和腺病毒载体疫苗;异源加强免疫的结果显示,不管是以重组蛋白亚单位疫苗、腺病毒载体疫苗或者mRNA疫苗初免,以mRNA疫苗作为第2针加强免疫均能诱导更强的体液免疫反应.此外,在疫苗激发的细胞免疫方面,mRNA疫苗诱导了较强的CD4^(+)T细胞反应,腺病毒载体疫苗诱导了较强的CD8^(+)T细胞反应,而亚单位疫苗刺激的细胞免疫反应以CD4^(+)T细胞为主,但在强度上较弱.本研究具有重要的应用价值,为未来新一代的新冠病毒疫苗研发和接种策略提供了指导.

关键词：新型冠状病毒亚单位疫苗腺病毒载体疫苗 m RNA疫苗抗体 T细胞

Research on the feature extraction of DC space charge behavior of oil-paper insulation

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Science China(Technological Sciences) 2011年第5期54卷 1315-1324页

作者： TANG Chao LIAO RuiJin CHEN george YANG LiJun College of Engineering and Technology Southwest University Chongqing 400715 China The State Key Laboratory of Power Transmission Equipment & System Security and New Technology Chongqing University Chongqing 400044 China School of Electronics and Computer Science University of Southampton Southampton SO17 3B J UK

As the ultra high DC voltage grid comes into an important stage in the ‘Twelfth Five-year Plan’ of China, the requirement on the operation safety of power equipment needs to be improved. Oil-paper insulation plays a significant role as the main insulation material of many key power equipments. The space charge behaviors of oil-paper insulation not only affect the dielectric strength, but also relate to the stability and security of power transmission facilities. Until now, the research on the space charge behaviors of oil-paper insulation remains on the stage of objective description and phenomenon explanation, thus it is very urgent to make some feature extractions on the test results in order to further investigate the DC space charge behaviors of oil-paper insulation. In this paper, based on the large numbers of test data in the first stage, data mining and feature extractions were performed on the DC space charge behavior of oil-paper insulation. The variation laws of some key characteristic parameters obtained in different experiment conditions such as the total charge injection amount, apparent charge mobility, and trap energy distribution were analyzed. In addition, the distribution of trapping level inside oil-paper was calculated by using the PEA test results based on the mechanism of the isothermal decay current, which realized the approximate calculation of trap depth by charge decay characteristics. What’s more, the exponential injection and decay equations of DC space charge changing with time were acquired for the first time, and the physical meanings of related parameters were defined. This has laid a foundation for the prediction and simulation of space charge in the oil-paper insulation.

关键词： oil-paper insulation space charge DC feature extraction

LOCAL CONVERGENCE OF INEXACT NEWTON-LIKE METHOD UNDER WEAK LIPSCHITZ CONDITIONS

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Acta Mathematica Scientia 2020年第1期40卷 199-210页

作者： Ioannis KARGYROS Yeol Je CHO Santhosh george Yibin XIAO Department of Mathematical Sciences Cameron UniversityLawtonOK 73505USA School of Mathematical Sciences University of Electronic Science and Technology of ChinaChengdu 611731China Department of Mathematics Education Gyeongsang National UniversityJinju 52828Korea Department of Mathematical and Computational Sciences National Institute of TechnologyKarnataka757025 India

The paper develops the local convergence of Inexact Newton-Like Method(INLM)for approximating solutions of nonlinear equations in banach space *** employ weak Lipschitz and center-weak Lipschitz conditions to perform the error *** obtained results compare favorably with earlier ones such as[7,13,14,18,19].A numerical example is also provided.

关键词： inexact Newton method banach space semilocal convergence weak and center-weak Lipschitz condition recurrent functions Kantorovich hypotheses