Occult Hepatitis C Virus Infection:A Review

作     者：Alyssa Austria George Y.Wu 

作者机构：Division of Gastroenterology-HepatologyDepartment of MedicineUniversity of Connecticut Health CenterFarmingtonCT 06030USA 

出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)

年 卷 期：2018年第6卷第2期

页      面：155-160页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：a grant from Alexion Corp.are gratefully acknowledged 

主　　题：Occult hepatitis C virus OCI HCV infection 

摘      要：Occult hepatitis C virus(HCV)infection(OCI),first described in 2004,is defined as the presence of HCV RNA in hepatocytes or peripheral blood mononuclear cells without detectable HCV RNA in the ***,we aimed to review the epidemiology,diagnostic methods,clinical implications and potential man-agement recommendations currently described in the litera-ture,as well as the future directions for investigation of this *** and Cochrane databases were searched with combination of the following keywords:occult,hepatitis C virus,andoccult HCV infection.There are data to support OCI as a potential culprit in cryptogenic liver *** are also consistent data demonstrating the existence of OCI in specific populations,such as dialysis,human immunodefi-ciency virus-infected and hepatitis B virus-infected patients,and also in the general *** the gold standard for diagnosis is liver biopsy,examination of peripheral blood mononuclear cells may be a reliable,safer alternative method of *** HCV infection is likely associated with liver fibrosis and progression of liver *** studies are required to determine the infectivity of OCI patients,as well as clarify the natural course and specific clinical implications of ***,studies are needed to determine whether treat-ment of OCI leads to decreased morbidity and/or mortality.