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Effect of serum testosterone and percent tumor volume on extra-prostatic extension and biochemical recurrence after laparoscopic radical prostatectomy

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Asian Journal of Andrology 2016年第1期18卷 54-59页

作者： Eu Chang hwang Seong Hyeon Yu Yang Hyun Jo Seung I1 Jung taek Won Kang Dong Deuk Kwon Chan Choi Suk Hee Heo Jun Eul hwang Sung-Hoon Jung tae-Young Jung Department of Urology Chonnam National University Medical School Gwangju Republic of Korea Department of Pathology Chonnam National University Medical School Gwangju Republic of Korea Department of Radiology Chonnam National University Medical School Gwangju Republic of Korea Department of Hemato-oncology Chonnam National University Medical School Gwangju Republic of Korea Department of Neurosurgery Chonnam National University Medical Schoo Gwangju Republic of Korea

Several studies have revealed that the preoperative serum testosterone and percent tumor volume （PTV） predict extra-prostatic extension （EPE） and biochemical recurrence （BCR） after radical prostatectomy. This study investigated the prognostic significance of serum testosterone and PTV in relation to EPE and BCR after laparoscopic radical prostatectomy （LRP）. We reviewed 520 patients who underwent LRP between 2004 and 2012. PTV was determined as the sum of all visually estimated tumor foci in every section. BCR was defined as two consecutive increases in the postoperative prostate-specific antigen （PSA）〉0.2 ng ml^-1. The threshold for serum total testosterone was 3.0 ng ml^-1, Multivariate logistic regression was used to define the effect of variables on the risk of EPE and BCR. A low serum testosterone （〈3.0 ng ml^-1） was associated with a high serum PSA, Gleason score, positive core percentage of the prostate biopsy, PTV, and all pathological variables. On multivariate analysis, similar to previous studies, the serum PSA, biopsy positive core percentage, Gleason score, and pathological variables predicted EPE and BCR. In addition, low serum testosterone （〈3.0 ng ml^-1, adjusted OR, 8.52; 95% CI, 5.04-14.4, P = 0.001） predicted EPE and PTV （adjusted OR, 1.02; 95% CI, 1.01-1.05, P = 0.046） predicted BCR. In addition to previous predictors of EPE and BCR, low serum testosterone and PTV are valuable predictors of EPE and BCR after LRP.

关键词： biochemical recurrence extra-prostatic extension prostate neoplasms prostatectomy testosterone tumor burden

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White luminescence of Ho^(3+)/Tm^(3+)/Yb^(3+)-codoped CaWO_4 synthesized via citrate complex route assisted by microwave irradiation

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Transactions of Nonferrous Metals Society of China 2014年第S1期24卷 134-140页

作者： Hyun CHO Seok Min hwang Jae Bin LEE Dong Hyun KA tae Wan KIM Bo Seul LEE Ji Young LEE Jung-Il LEE Jeong Ho RYU Department of Nanomechatronics Engineering Pusan National University50 Cheonghak-ri Miryang Gyeongnam 627-706 Korea Department of Materials Science and Engineering Korea National University of Transportation Chungju Chungbuk 380-702 Korea

The nanocrystalline Ho3+/Tm3+/Yb3+ co-doped CaWO4 upconversion(UC) phosphors were successfully synthesized by a modified citrate complex method using microwave irradiation. The citrate complex precursors were heat-treated at temperature ranging from 300 to 700 °C for 3 h. Crystallization of the Ho3+/Tm3+/Yb3+ co-doped CaWO4 was detected at 400 °C, and entirely completed at 600 °C. The Ho3+/Tm3+/Yb3+ co-doped CaWO4 heat-treated at 600 °C showed primarily spherical and homogeneous morphology. Under the laser excitation of 980 nm, Ho3+/Tm3+/Yb3+ co-doped CaWO4 shows the bright white upconversion(UC) emission visible to the naked eye, which is composed of a blue emission at 475 nm from Tm3+, and green and red emissions at 543 and 651 nm respectively from Ho3+. The coordinates of Ho3+/Tm3+/Yb3+ co-doped CaWO4 in the Commission International De'eclairage(CIE) chromaticity diagram could be controlled from a cool to a warm white color depending on the Tm3+ and Ho3+ concentrations. The UC luminescent properties on Tm3+ and Ho3+ concentrations and related mechanism based on laser pump power were discussed in detail.

关键词： upconversion CaWO4 microwave irradiation white luminescence

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Verification of Damage Detection Algorithm by Prototype Building Structure Test

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Engineering（科研） 2013年第10期5卷 827-835页

作者： Ji-Hyun hwang Ki-tae Park Structural Engineering Research Division Korea Institute of Construction Technology Goyang South Korea

Safety related accidents of buildings and civil engineering structures have been reported all over the world. With the increasing importance of securing the safety of social infrastructure and optimum performance levels to prevent these accidents, a lot of attention has been concentrated on monitoring performance degradation due to structural defects and deterioration. In this study, the algorithm was developed to evaluate the safety of structures by analyzing signals of time domain and frequency domain, and the developed algorithm was verified through a forced vibration test. From the results of time-domain and frequency-domain data analysis, the damage detection results by each sensor location with a high degree of accuracy were derived in both methods.

关键词： Infrastructure Algorithm Vibration Test Damage Detection

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Profitability Prediction Model for NPD Projects Under RisK

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Management Studies 2017年第2期5卷 108-119页

作者： tae Yeon hwang Hoo-Gon Choi VMS Solutions Daejeon Republic of Korea Sungkyunkwan University Suwon Republic of Korea

Only a few successful new product development （NPD） projects are continuously supported by the firm when they are expected to assure profitability in the market. The profitability of a project is measured as profit ratio （PR）, the profit is divided by the cost. The profit figure is changed depending on either internal risks or uncertainties occurring externally. More risks require higher response costs to them and uncontrollable uncertainties affect NPD projects either positively or negatively. In this study, a PR model is developed to predict the profitability of a project at a given time. The model minimizes the response cost computed under two extreme response strategies, such as ＂Avoid＂ and ＂Acceptance＂ for the internal threats. Also, the model reflects the sales volume changes due to external uncertainties. The linear programming （LP） method determines the optimal probability of the response strategy under three scenarios of defining the relationship between risk avoidance and risk acceptance. It can be utilized to make a GO/NOGO decision on the project based on the prediction results at any gate of the NPD process. The solving procedure is provided to apply the developed model for real cases.

关键词： NPD risk assessment response costs profit ratio model profitability prediction GO/NOGO decisionmaking

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Association between preoperative high sensitive troponin I levels and cardiovascular events after hip fracture surgery in the elderly

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Journal of Geriatric Cardiology 2018年第3期15卷 215-221页

作者： Bum Sung Kim tae-Hoon Kim Jeong-Hwan Oh Chang Hee Kwon Sung Hea Kim Hyun-Joong Kim Heung Kon hwang Sang-Man Chung in-gu Seoul Republic of Korea Department of Orthopedic surgery Konkuk University Medical Center 120-1 Neungdong-ro Hwayang-dong Gwangjin-guSeoulRepublic of Korea

Objective Cardiovascular complications contribute to postoperative morbidity and mortality in elderly hip fracture patients. Limited data are available regarding which preoperative risk factors predict cardiovascular course following hip fracture surgery （HFS）. We used high sensitive troponin I （hs-TnI） assays and clinical parameters to identify preoperative risk factors associated with major adverse cardiac events （MACE） in elderly hip frac^u＇e patients. Method From August 2014 to November 2016, 575 patients with hip fracture were enrolled in a retrospective, single-center registry. A total of 262 of these patients underwent HFS and hs-TnI assays. MACE was defined as postoperative all-cause deaths, heart failure （HF）, new-onset atrial fibrillation （AF）, myocardial infarction （MI） and cardiovascular re-hospitalization that occurred within 90 days postoperative. Results Of 262 HFS patients, MACE developed following HFS in 65 （24.8%）. Patients with MACE were older and had higher rates of renal insufficiency, coronary artery disease, prior HF, low left ventricular ejection fraction and use of beta blockers; higher levels of hs-Tnl and N-terminal pro-brain natriuretic peptide （NT-proBNP） and higher revised cardiac risk index. A preoperative hs-TnI≥ 6.5 ng/L was associated with high risk of postoperative HF, new-onset AF and MACE. In multivariable analysis, pre-operative independent predictors for MACE were age 〉 80 years [adjusted hazard ratio （HR）： 1.79, 95% confident interval （CI）： 1.03-3.13, P = 0.04], left ventricular ejection fraction （LVEF）〈 50% （adjusted HR： 3.17, 95% CI： 1.47-5.82, P 〈 0.01） and hs-TnI 〉 6.5 ng/L （adjusted HR： 3.75, 95% CI： 2.09~5.17, P 〈 0.01）. Conclusion In elderly patients with hip fracture who undergo HFS, a preoperative assessment of hs-TnI may help the risk refinement of cardiovascular complications.

关键词： Cardiovascular complication High sensitive troponin I Hip fracture surgery

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Feasibility of ABO-incompatible adult living donor liver transplantation for acute-on-chronic liver failure

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Hepatobiliary & Pancreatic Diseases International 2017年第6期16卷 662-664页

作者： Seok-Hwan Kim Gi-Won Song Shin hwang Chul-Soo Ahn Deok-Bog Moon tae-Yong Ha Sung-Gyu Lee Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul 05505 Korea

To the Editor:In Korea,the annual number of deceased donors for or gan transplantation per million people is still less ***,approximately 40%of patients with acute liver failure or acute-on-chronic liver failure undergo living donor liver transplantation（LDLT）.;Although the use of ABO-incompatible（ABOi）living donors is an attrac tive option,ABOi LDLT has very restricted applications

关键词： ABO Feasibility of ABO-incompatible adult living donor liver transplantation for acute-on-chronic liver failure RIT

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Biliary drainage for obstructive jaundice caused by unresectable hepatocellular carcinoma: the endoscopic versus percutaneous approach

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Hepatobiliary & Pancreatic Diseases International 2012年第6期11卷 636-642页

作者： Jongkyoung Choi Ji Kon Ryu Sang Hyub Lee Dong-Won Ahn Jin-Hyeok hwang Yong-tae Kim Yong Bum Yoon Joon Koo Han Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Korea Department of Internal Medicine National Medical Center Seoul Korea Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi-do Korea Department of Internal Medicine Seoul National University Boramae Medical Center Seoul Korea Department of Radiology Seoul National University College of Medicine Seoul Korea

BACKGROUND: For palliative treatment of the obstructive jaundice associated with unresectable hepatocellular carcinoma (HCC), percutaneous transhepatic biliary drainage (PTBD) or endoscopic retrograde biliary drainage (ERBD) has been performed. PTBD is preferred as an initial procedure. Little is known about the better option for patients with obstructive jaundice caused by unresectable HCC. METHODS: Sixty patients who had received ERBD or PTBD for the palliative treatment of obstructive jaundice caused by unresectable HCC between January 2006 and May 2010 were included in this retrospective study. Successful drainage, drainage patency, and the overall survival of patients were evaluated. RESULTS: Univariate analysis revealed that the overall frequency of successful drainage was higher in the ERBD group (22/29, 75.9%) than in the PTBD group (15/31, 48.4%) (P=0.029); but multivariate analysis showed marginal significance (P=0.057). The duration of drainage patency was longer in the ERBD group than in the PTBD group (82 vs 37 days, respectively, P=0.020). Regardless of what procedure was performed, the median survival time of patients who had a successful drainage was much longer than that of the patients who did not have a successful drainage (143 vs 38 days, respectively, P<0.001).CONCLUSION: Besides PTBD, ERBD may be used as the initial treatment option to improve obstructive jaundice in patients with unresectable HCC if there is a longer duration of drainage patency after a successful drainage.

关键词： hepatocellular carcinoma obstructive jaundice endoscopic retrograde biliary drainage percutaneous transhepatic biliary drainage

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Rosai-Dorfman disease in the spleen of a pediatric patient:A case report

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World Journal of Clinical Cases 2021年第21期9卷 6032-6040页

作者： Hwaseong Ryu Jae-Yeon hwang Yong-Woo Kim tae-Un Kim Joo-Yeon Jang Su-Eun Park Eu-Jeen Yang Dong-Hoon Shin Department of Radiology Pusan National University Yangsan HospitalYangsan 50612South Korea Department of Pediatrics Pusan National University Children’s HospitalYangsan 50612South Korea Department of Pathology Pusan National University Yangsan HospitalYangsan 50612South Korea

BACKGROUND Rosai–Dorfman disease(RDD)is a rare histiocytic proliferation of unknown etiology commonly found in children and *** common manifestation of RDD is massive and painless bilateral cervical lymphadenopathy with extranodal *** extranodal involvement in RDD is common,the spleen is an infrequent site of *** SUMMARY We report a 10-mo-old female infant with RDD presenting multiple splenic masses without cervical *** had fever,and blood tests showed leukocytosis,anemia,and elevated erythrocyte sedimentation rate and Creactive ***,computed tomography,and magnetic resonance images demonstrated multiple splenic *** antibiotic therapy,her symptoms were not *** underwent diagnostic splenectomy and was discharged with *** In pediatric patients with refractory infectious symptoms or hematological abnormalities,clinicians should suspect RDD,even in patients without significant lymphadenopathy.

关键词： Rosai–Dorfman disease Sinus histiocytosis with massive lymphadenopathy Ultrasonography Computed tomography Magnetic resonance imaging Case report

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Effects of transcranial ultrasound stimulation pulsed at 40 Hz on Aβplaques and brain rhythms in 5×FAD mice

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Translational Neurodegeneration 2021年第4期10卷 630-642页

作者： Mincheol Park Gia Minh Hoang Thien Nguyen Eunkyung Lee Hyun Jin Jung Youngshik Choe Moon Hwan Lee Jae Youn hwang Jae Gwan Kim tae Kim Department of Biomedical Science and Engineering Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Korea Brain Research Institute Daegu 41062Republic of Korea Department of Information and Communication Engineering Daegu Gyeongbuk Institute of Science and TechnologyDaegu 42988Republic of Korea

Background:Alzheimer's disease(AD)is the most common cause of dementia,and is characterized by amyloid-β(Aβ)plaques and *** Aβhas been considered a major AD treatment strategy in pharmacological and non-pharmacological *** of gamma oscillations,which play an important role in perception and cognitive function,has been shown in mouse AD models and human ***,the therapeutic effect of gamma entrainment in AD mouse models has been *** that ultrasound is an emerging neuromodulation modality,we investigated the effect of ultrasound stimulation pulsed at gamma frequency(40 Hz)in an AD mouse ***:We implanted electroencephalogram(EEG)electrodes and a piezo-ceramic disc ultrasound transducer on the skull surface of 6-month-old 5×FAD and wild-type control mice(n=12 and 6,respectively).Six 5×FAD mice were treated with two-hour ultrasound stimulation at 40 Hz daily for two weeks,and the other six mice received sham *** and insoluble Aβlevels in the brain were measured by enzyme-linked immunosorbent *** EEG gamma power was computed by wavelet analysis,and the brain connectivity was examined with phase-locking value and cross-frequency phase-amplitude ***:We found that the total Aβ42 levels,especially insoluble Aβ42;in the treatment group decreased in pre-and infra-limbic cortex(PIL)compared to that of the sham treatment group.A reduction in the number of Aβplaques was also observed in the *** was no increase in microbleeding in the transcranial ultrasound stimulation(tUS)*** addition,the length and number of microglial processes decreased in PIL and ***-phalographic spontaneous gamma power was increased,and cross-frequency coupling was normalized,implying functional improvement after tUS ***:These results suggest that the transcranial ultrasound-based gamma-band entrainment technique can be an effective therapy for AD by

关键词： Transcranial ultrasound stimulation Gamma band oscillation Amyloid-βplaques Alzheimer’s disease

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Appendectomy in patient with suspected COVID-19 with negative COVID-19 results: A case report

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World Journal of Clinical Cases 2020年第10期8卷 1944-1949页

作者： Changho Kim Jong Kun Kim In Hwan Yeo Jae Young Choe Jeong Eun Lee So Jeong Kang Chan Sub Park Ki tae Kwon Soyoon hwang Department of Emergency Medicine School of MedicineKyungpook National UniversityDaegu 41944South Korea Department of Anesthesiology and Pain Medicine School of MedicineKyungpook National UniversityKyungpook National University HospitalDaegu 41944South Korea Department of Surgery School of MedicineKyungpook National UniversityKyungpook National University HospitalDaegu 41944South Korea Department of Internal Medicine School of MedicineKyungpook National UniversityDaeguKoreaDepartment of Infection ControlKyungpook National University Chilgok HospitalDaegu 41944South Korea

BACKGROUND Even at present,we are in the middle of the novel coronavirus disease 2019(COVID-19)pandemic and are facing challenges in trial and ***,emergency surgery for patients with suspected COVID-19 is burdensome not only for patients but also for healthcare ***,we established a surveillance system in the emergency room and established principles for managing patients suspected of COVID-19 who require emergency *** SUMMARY A 67-year-old man was diagnosed with appendicitis in March *** wife was diagnosed with COVID-1910 d earlier,and the patient was in close contact with *** patient tested negative twice on an upper respiratory COVID-19 reverse transcription–polymerase chain reaction screening test,but chest X-ray and chest computed tomography revealed patchy ground-glass opacity in both upper lobes of the patient’s *** same emergency surgery procedure for patients with confirmed COVID-19 was applied to this patient suspected of having the disease to ensure that surgery was not delayed while waiting for the reverse transcription–polymerase chain reaction results.A few hours after surgery,the upper respiratory tract specimen taken in the emergency room was negative for COVID-19 but the lower respiratory tract specimen was found to be positive for the *** When COVID-19 is suspected,emergency surgery should be performed as for confirmed COVID-19 without delay.

关键词： COVID-19 Appendicitis Appendectomy Emergency room Infection control Case report

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