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Journal of Mountain Science 2017年第1期14卷 205-218页

作者： geoffrey MUKwADA Desmond MANATSA Geography Department and Afromontane Research Unit University of Free State Phuthaditjhaba 9866 South Africa Bindura University of Science Bindura Zimbabwe

The assessment of the policy framework governing Invasive Alien Species(IAS) control is of critical importance in conservation. The undertaking of a SwOT analysis of such a framework is necessary because it enhances the efficacy of IAS control. The aim of this study is to carry out a SwOT analysis of the policy framework guiding the control of the spreading of Acacia mearnsii and other IAS in the Golden Gate Highlands National Park in South Africa,as well as the implementation of restorative measures in the park and adjacent communities in line with the recommendations of the Convention on Biodiversity. A comparative analysis of this framework and the hierarchical framework that was developed during the European Union Conference on Freshwater Invasives- Networking for Strategy in 2013 is undertaken. The results indicate the need to strengthen parkcommunity relations,upgrade existing legislation,and boost the technical capacity of South African national parks to identify,detect,monitor and predict IAS invasions,both within the parks and their surroundings. This knowledge is important for developing future policies on IAS control in South Africa.

关键词： Convention on biodiversity Geographic Information Systems Golden Gate Highlands National Park Invasive alien species MalutiDrakensberg Mountains Protected Areas Policy Framework SwOT

It takes more than tau to tangle:using proteomics to determine how phosphorylated tau mediates toxicity in neurodegenerative diseases

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Neural Regeneration Research 2021年第11期16卷 2211-2212页

作者： geoffrey Pires Eleanor Drummond Center for Cognitive Neurology Department of NeurologyNew York University School of MedicineNew YorkNYUSA Alzheimer’s and Prion Diseases Team Paris Brain InstituteCNRSUMR 7225INSERM 1127Sorbonne University UM75ParisFrance

Two of the most common causes of dementia are Alzheimer’s disease(AD)and frontotemporal dementia(FTD).AD is an irreversible,progressive neurodegenerative disorder that is clinically characterized by severe memory loss and behavioral impairment that eventually interferes with everyday *** is neuropathologically defined by the presence of extracellularβ-amyloid plaques and intracellular accumulation of neurofibrillary tangles(NFTs)that primarily contain aggregated,hyperphosphorylated tau(pTau).Intriguingly,pTau is also the central protein in multiple subtypes of FTD(*** degeneration,progressive supranuclear palsy,Pick’s disease).FTD is an umbrella term for a group of neurological conditions that primarily affect the temporal and frontal regions of the *** in the tau gene(MAPT)can cause familial FTD,providing further evidence of the integral role of tau in ***,tau regulates microtubule structure and dynamics,as well as axonal transport through interaction with *** is also involved in neuronal development and *** AD and FTD,tau becomes hyperphosphorylated and undergoes major conformational changes,causing it to aggregate into the characteristic neuropathological lesions that define AD and *** the known involvement of tau in these diseases,exactly how tau mediates toxicity is still unclear.

关键词： tau involvement media

Modelling of a post-combustion carbon dioxide capture absorber using potassium carbonate solvent in Aspen Custom Modeller

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Chinese Journal of Chemical Engineering 2018年第11期26卷 2327-2336页

作者： Yue wu Fan wu Guoping Hu Nouman R.Mirza geoffrey w.Stevens Kathryn A.Mumford Department of Chemical and Biomolecular Engineering The University of Melbourne Peter Cook Centre for CCS Research The University of Melbourne Particulate Fluids Processing Centre (PFPC) The University of Melbourne

The process models for an equilibrium CO_2 absorber and a rate based CO_2 absorber using potassium carbonate(K2 CO3) solvents were developed in Aspen Custom Modeller(ACM) to remove CO_2 from a flue gas. The process model utilised the Electrolyte Non-Random Two Liquid(ENRTL) thermodynamic model and various packing correlations. The results from the ACM equilibrium model shows good agreement with an inbuilt Aspen Plus?model when using the same input conditions. By further introducing a Murphree efficiency which is related to mass transfer and packing hydraulics, the equilibrium model can validate the experimental results from a pilot plant within a deviation of 10%. A more rigorous rate based model included mass and energy flux across the interface and the enhancement effect resulting from chemical reactions. The rate based model was validated using experimental data from pilot plants and was shown to predict the results to within 10%. A parametric sensitivity analysis showed that inlet flue gas flowrate and K2 CO3 concentration in the lean solvent has significant impact on CO_2 recovery. Although both models can provide reasonable predictions based on pilot plant results, the rate based model is more advanced as it can explain mass and heat transfer, transport phenomena and chemical reactions occurring inside the absorber without introducing an empirical Murphree efficiency.

关键词： Equilibrium Rate based Modelling Absorber Potassium carbonate

Fungal-derived selenium nanoparticles and their potential applications in electroless silver coatings for preventing pin-tract infections

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Regenerative Biomaterials 2022年第1期9卷 41-51页

作者： Xinjin Liang Shuai Zhang geoffrey Michael Gadd John McGrath David w.Rooney Qi Zhao The Bryden Centre School of Chemical and Chemistry EngineeringQueen’s University BelfastUniveristy RoadBelfast BT71NNUK Geomicrobiology Group School of Life SciencesUniversity of DundeeDow StreetDundee DD15EHUK School of Pharmacy Queen’s University BelfastLisburn RoadBelfast BT97BLUK State Key Laboratory of Heavy Oil Processing Beijing Key Laboratory of Oil and Gas Pollution ControlCollege of Chemical Engineering and EnvironmentChina University of Petroleum18 Fuxue RoadChangping DistrictBeijing 102249China School of Biological Sciences Queen’s University BelfastChlorine GardensBelfast BT95DLUK School of Chemistry and Chemical Engineering Queen’s University BelfastStranmillis RoadBelfast BT95AGUK School of Science and Engineering University of DundeeNethergateDundee DD14HNUK

Pin-tract infections(PTIs)are a common complication of external fixation of fractures and current strategies for preventing PTIs have proven to be *** advances show that the use of anti-infection coatings with local antibacterial activity may solve this *** has been considered as a promising anti-infection agent owing to its antibacterial and antibiofilm *** this study,selenium nanoparticles(SeNPs)were synthesized via a cost-effective fungi-mediated biorecovery approach and demonstrated excellent stability and *** investigate their anti-infection potential,the SeNPs were doped in silver coatings through an electroless plating process and the silver–selenium(Ag–Se)coatings were tested for antibacterial and antibiofilm properties against Staphylococcus aureus F1557 and Escherichia coli wT F1693 as well as corrosion resistance in simulated body *** was found that the Ag–Se coating significantly inhibited *** growth and biofilm formation on the surface,reducing 81.2%and 59.7%of viable bacterial adhesion when compared with Ag and Ag–PTFE-coated surfaces after 3 *** Ag–Se coating also exhibited improved corrosion resistance compared with the Ag coating,leading to a controlled release of Ag^(+),which in turn reduced the risk of cytotoxicity against *** results suggest that the fungal-derived SeNPs may have potential in use as implant coatings to prevent PTIs.

关键词： infection coating silver selenium fungi

Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation

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world Journal of Gastroenterology 2014年第36期20卷 13088-13104页

作者： Devanshi Seth Alastair Duly Paul C Kuo geoffrey w McCaughan Paul S Haber Drug Health Services Royal Prince Alfred Hospital Camperdown NSW 2050 Australia Garvan Institute Darlinghurst NSW 2010 Australia Central Clinical School of Medicine the University of Sydney Sydney NSW 2050 Australia Department of Surgery Loyola University Medica Centre Maywood IL 60153 United States Aw Morrow Gastroenterology and Liver Centre RPAH Camperdown NSW 2050 Australia

AIM: To investigate over-expression of Osteopontin (OPN) pathway expression and mechanisms of action in human alcoholic liver disease (ALD), in vivo and in vitro acute alcohol models.

关键词： Hepatic stellate cells Liver cirrhosis Plasmin Steatosis Fibrogenesis Transforming growth factor β Osteopontin isoform

Controlling the properties of surface acoustic waves using graphene

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Nano Research 2016年第3期9卷 685-691页

作者： Lokeshwar Bandhu geoffrey R. Nash College of Engineering Mathematics and Physical Sciences University of Exeter Exeter EX4 4QF UK

Surface acoustic waves （SAws） are elastic waves that propagate on the surface of a solid, much like waves on the ocean, with SAw devices used widely in communication and sensing. The ability to dynamically control the properties of SAws would allow the creation of devices with improved performance or new functionality. However, so far it has proved extremely difficult to develop a practical way of achieving this control. In this paper we demonstrate voltage control of SAws in a hybrid graphene-lithium niobate device. The velocity shift of the SAws was measured as the conductivity of the graphene was modulated using an ion-gel gate, with a 0.1% velocity shift achieved for a bias of approximately 1 V. This velocity shift is comparable to that previously achieved in much more complicated hybrid semiconductor devices, and optimization of this approach could therefore lead to a practical, cost-effective voltage-controlled velocity shifter. In addition, the piezoelectric fields associated with the SAw can also be used to trap and transport the charge carriers within the graphene. Uniquely to graphene, we show that the acoustoelectric current in the same device can be reversed, and switched off, using the gate voltage.

关键词： graphene sensors surface acoustic wave charge transport

Recent advances in carbon dioxide capture and utilization with amines and ionic liquids

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Green Chemical Engineering 2020年第1期1卷 16-32页

作者： Yuxin wu Jianhong Xu Kathryn Mumford geoffrey w.Stevens weiyang Fei Yundong wang The State Key Laboratory of Chemical Engineering Department of Chemical EngineeringTsinghua UniversityBeijing100084China Department of Chemical Engineering The University of MelbourneParkvilleVictoria3010Australia

Global warming and climate change due to anthropogenic carbon dioxide(CO_(2))have aroused significant concerns at the global scale due to rapid economic growth in industries and other ***,CO_(2)capture,use,and storage have become particularly *** this review,general background and methods for CO_(2)capture and separation,in particular,on ionic liquids(ILs)-based solvents and materials,are *** surveys of ILs for CO_(2)absorption are presented,which focused mainly on experimental researches,and then the concept is extended to functionalized absorbents and recent developments for CO_(2)*** advantages and disadvantages of amines-based and ILs-based absorbents are discussed in this *** of traditional amines(MEA,MDEA,DEA,AMP,PZ,etc.)and ILs(conventional ILs,functionalized ILs,etc.)are ***,research progresses on CO_(2)separation are also introduced focusing mainly on amines and ILs-based membranes(*** amines membranes,SILMs).Futhermore,the fixation of CO_(2)into cyclic carbonates catalyzed by ILs(pure ILs,complex catalyst system with ILs,supported ILs,etc.)is summarized,clearly explaining the mechanism of CO_(2)fixation with ***,exploration of some recent studies about CO_(2)capture and conversion by ILs and challenges for further progress are presented and related suggestions are put forward.

关键词： Carbon dioxide Capture Separation Amines Ionic liquids Cycloaddition

Prediction of dispersed phase holdup in pulsed disc and doughnut solvent extraction columns under different mass transfer conditions

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Chinese Journal of Chemical Engineering 2016年第2期24卷 226-231页

作者： Yong wang Kathryn H.Smith Kathryn Mumford Teobaldo F.Grabin Zheng Li geoffrey w.Stevens Particulate Fluids Processing Centre Department of Chemical and Biomolecular EngineeringThe University of Melbourne

Using experimental data from a number of pulsed disc and doughnut solvent extraction columns, a unified correla- tion for the prediction of dispersed phase holdup that considers the effects of mass transfer is presented. Pulsed disc and doughnut solvent extraction columns （PDDC） have been used for a range of important applications such as ura- nium extraction and nuclear fuel recycling. Although the dispersed phase holdup in a PDDC has been presented by some researchers, there is still the need to develop a robust correlation that can predict the experimental dispersed phase holdup over a range of operating conditions including the effects of mass transfer direction. In this study, dis- persed phase holdup data from different literature sources for a PDDC were used to refit constants for the correlation presented by Kumar and Hartland lind. Eng. Chem. Res.,27 （1988）,131-138] which did not consider the effect of col- umn geometry. In order to incorporate the characteristic length of the PDDC （i.e. the plate spacing）, the unified cor- relation for holdup proposed by Kumar and Hartland based on data from eight different types of columns [Ind. Eng. Chem. Res.,34 （1995） 3925-3940] was refitted to the PDDC data. New constants have been presented for each hold- up correlation for a PDDC based on regression analysis using published holdup data from PDDCs that cover a range of onerating conditions and nhwical nronerties and consider the direction of mass transfer.

关键词： Solvent extraction Liquid extraction Pulsed disc and doughnut columns Solvent extraction column design Holdup Dispersed phase holdup Hydrodynamics of extraction columns

Precipitation study of CO2-loaded glycinate solution with the introduction of ethanol as an antisolvent

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Frontiers of Chemical Science and Engineering 2020年第3期14卷 415-424页

作者： Siming Chen Yue wu geoffrey wStevens Guoping Hu wenshou Sun Kathryn AMumford College of Environmental Sciences and Engineering Qingdao UniversityQingdao 266071China Peter Cook Centre for Carbon Capture and Storage Research(PCC) Particulate Fluids Processing Centre(PFPC)Department of Chemical EngineeringUniversity of MelbourneParkvilleVictoria 3010Australia

Focused beam reflectance measurement(FBRM)and 13C nuclear magnetic resonance(13C NMR)analysis were used to study the precipitation process of CO2-loaded potassium glycinate(KGLY)solutions at different CO2 loadings,during the addition of ethanol as an antisolvent at a rate of 10 mL·min−*** volume ratio of ethanol added to the KGLY solution(3.0 mol·L−1,340 mL)ranged from 0 to *** solid-liquid-liquid phases were formed during the precipitation *** FBRM results showed that the number of particles formed increased with CO2 loading and ethanol addition for CO2-unsaturated KGLY solutions,whilst for CO2-saturated KGLY solution it first increased then decreased to a stable value with ethanol addition.13C NMR spectroscopic analysis showed that the crystals precipitated from the CO2-unsaturated KGLY solutions consisted of glycine only,and the quantity crystallised increased with CO2 loading and ethanol ***,a complex mixture containing glycine,carbamate and potassium bicarbonate was precipitated from CO2-saturated KGLY solution with the maximum precipitation percentages of 94.3%,31.4%and 89.6%,respectively,at the ethanol volume fractions of 1.6,2.5 and 2.3.

关键词： crystallization precipitation glycinate FBRM 13C NMR

Characteristics and Inpatient Outcomes of Primary Biliary Cholangitis and Autoimmune Hepatitis Overlap Syndrome

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Journal of Clinical and Translational Hepatology 2021年第3期9卷 392-398页

作者： Yi Jiang Bing-Hong Xu Brandon rodgers Nikolaos Pyrsopoulos Department of Medicine Rutgers New Jersey Medical SchoolNewarkNew JerseyUSA Liver Center&Center for Asian Health RWJBH-Saint Barnabas Medical CenterFlorham ParkNew JerseyUSA Division of Gastroenterology and Hepatology Rutgers New Jersey Medical SchoolNewarkNew JerseyUSA

Background and Aims:Primary biliary cholangitis(PBC)and autoimmune hepatitis(AIH)are hepatobiliary diseases of presumed immune-mediated origin that have been shown to *** aim of this retrospective trial was to use national data to examine the characteristics and outcomes of patients hospitalized with overlapping PBC and AIH(PBC/AIH).Methods:The National Inpatient Sample was used to identify hospitalized adult patients with PBC,AIH,and PBC/AIH from 2010 to 2014 by International Classification of Diseases-Ninth Edition Revision codes;patients with hepatitis B virus and hepatitis C virus infection were *** outcomes measures were in-hospital outcomes that included mortality,respiratory failure,septic shock,length of stay,and total hospital *** outcomes were the clinical characteristics of PBC/AIH,including the comorbid extrahepatic autoimmune disease pattern and complications of ***:A total of 3,478 patients with PBC/AIH were included in the ***/AIH was associated with higher rates of Sjögren’s syndrome(pwer rates of Crohn’s disease(pwhen compared to PBC or AIH *** were similar rates of mortality between the PBC/AIH,PBC,and AIH *** PBC/AIH group had higher rates of septic shock when compared to the PBC group(pwith a lower rate of Crohn’s disease,a higher rate of Sjögren’s syndrome,higher rates of cirrhosis-related complications,and significantly increased risk of septic shock compared to PBC and AIH individually.

关键词： Primary biliary cholangitis Autoimmune hepatitis Extrahepatic autoimmune diseases Cirrhosis-related complications Septic shock Hospital burden