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Role of gut.liver axis and glucagon-like pept.de-1 recept.r agonist. in t.e t.eat.ent.of met.bolic dysfunct.on-associat.d fat.y liver disease

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World Journal of Gast.oent.rology 2024年第23期30卷 2964-2980页

作者： Jakub Rochoń Piot. Kalinowski Ksenia Szymanek-Majchrzak MichałGrąt Depart.ent.of General Transplant and Liver SurgeryMedical University of WarsawWarsaw 02-097Poland Depart.ent.of Medical Microbiology Medical University of WarsawWarsaw 02-004Poland

Met.bolic dysfunct.on-associat.d fat.y liver disease(MAFLD)is a hepat.c manifest.t.on of t.e met.bolic *** is one of t.e most.common liver diseases worldwide and shows increasing prevalence rat.s in most.*** is a progressive disease wit. t.e most.severe cases present.ng as advanced fibrosis or cirrhosis wit. an increased risk of hepat.cellular *** microbiot. play a significant.role in t.e pat.ogenesis and progression of MAFLD by disrupt.ng t.e gut.liver *** mechanisms involved in maint.ining gut.liver axis homeost.sis are *** crit.cal aspect.involves preserving an appropriat. int.st.nal barrier permeabilit. and levels of int.st.nal lumen met.bolit.s t. ensure gut.iver axis *** increase in int.st.nal barrier permeabilit. induces met.bolic endot.xemia t.at.leads t. ***,alt.rat.ons in t.e absorpt.on of various met.bolit.s can affect.liver met.bolism and induce liver st.at.sis and ***-like pept.de-1 recept.r agonist.(GLP-1 RAs)are a class of drugs developed for t.e t.eat.ent.of t.pe 2 diabet.s *** are also commonly used t. combat.obesit. and have been proven t. be effect.ve in reversing hepat.c *** mechanisms report.d t. be involved in t.is effect.include an improved regulat.on of glycemia,reduced lipid synt.esis,β-oxidat.on of free fat.y acids,and induct.on of aut.phagy in hepat.c ***,mult.ple pept.de recept.r agonist. have been int.oduced and are expect.d t. increase t.e effect.veness of t.e t.eat.ent.A modulat.on of gut.microbiot. has also been observed wit. t.e use of t.ese drugs t.at.may cont.ibut. t. t.e ameliorat.on of *** review present. t.e current.underst.nding of t.e role of t.e gut.iver axis in t.e development.of MAFLD and use of members of t.e GLP-1 RA family as pleiot.opic agent. in t.e t.eat.ent.of MAFLD.

关键词： Met.bolic dysfunct.on-associat.d fat.y liver disease Met.bolic dysfunct.on-associat.d st.at.hepat.t.s Nonalcoholic fat.y liver disease Non-alcoholic st.at.hepat.t.s Met.bolic syndrome Obesit. Gast.oint.st.nal microbiot. Glucagon-like pept.de-1 Glucagon-like pept.de-2 Bariat.ic surgery

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A Rapid Paramet.r of Enzyme-t.eat.d Cellulosic Mat.rial Revealed by Reducing Sugar Release

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Journal of Renewable Mat.rials 2024年第3期12卷 539-551页

作者： Verônica t.villa Ferreira Silva Adriane Maria Ferreira Milagres Depart.ment. de Biot.cnologia Escola de Engenharia de LorenaUniversidade de São PauloLorenaSP12602-810Brazil

t.is st.dy was conduct.d t. evaluat. t.e effect.veness of enzymes in purifying and reducing t.e degree of polymerizat.on of cellulose for t.e product.on of dissolving *** goal was t. det.rmine t.e cont.ibut.ons of xylanase(X)and endoglucanase(EG)in t.e t.eat.ent.of pulp,specifically by quant.fying t.e format.on of soluble and insoluble reducing sugars using t.e dinit.osalycilic acid(DNS)***,t.e release of soluble reducing sugars(RSSol)was enhanced aft.r xylanase t.eat.ent.while endoglucanase(EG)t.eat.ent.led t. changes in insoluble reducing sugars(RSIns).t.e maximum synergism was observed for RSIns when a high rat.o of endoglucanase t. xylanase(320EG:5X/g pulp)was *** relat.ve cont.ibut.on of endoglucanase t. RSins was det.rmined t. be 15.6%of t.e t.t.l reducing *** viscosit. of pulps t.eat.d wit. xylanase decreased only by 7%,whereas endoglucanase t.eat.ent.significant.y reduced viscosit. by 45%.Modificat.ons in t.e part.cle size were observed aft.r pulp t.eat.ent.wit. t.e combinat.on of endoglucanase and *** summary,t.e DNS t.st.is a rapid and effect.ve met.od for evaluat.ng t.e efficiency of enzyme t.eat.ent. on *** measurement.of RSIns correlat.s wit. changes in pulp viscosit. t. different.ext.nt.,providing valuable insight. int. t.e effect.veness of enzyme t.eat.ent..

关键词： Endoglucanase xylanase cellulose fiber pulp synergism

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Féet.n(B-L gauge boson)dark mat.er for t.e 511-keV gamma-ray excess and t.e predict.on of low-energy neut.ino flux

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Chinese Physics C 2024年第8期48卷 76-82页

作者： Jie Sheng Yu Cheng Weikang Lin t.ut.mu t.Yanagida t.ung-Dao Lee Inst.t.t.&School of Physics and Ast.onomy Shanghai Jiao Tong UniversityChina Key Laborat.ry for Part.cle Ast.ophysics and Cosmology(MOE)&Shanghai Key Laborat.ry for Part.cle Physics and Cosmology Shanghai Jiao Tong UniversityShanghai 200240China Sout.-West.rn Inst.t.t. For Ast.onomy Research Yunnan UniversityKunming 650500China Kavli IPMU(WPI) UTIASUniversity of TokyoKashiwa277-8583Japan

t.e féet.n is t.e gauge boson of t.e U(1)_(B−L) gauge *** t.e gauge coupling const.nt.is ext.emely small,t.e féet.n becomes a candidat. for dark *** show t.at.it. decay t. a pair of an elect.on and a posit.on explains t.e observed Galact.c 511-keV gamma-ray excess in a consist.nt.*** féet.n dark mat.er decays mainly int. pairs neut.ino and *** low-energy experiment. wit. improved direct.onal capabilit. will enable capt.ring t.ese neut.ino *** seesaw-mot.vat.d paramet.r space predict. a relat.vely short.féet.n lifet.me t.at.is comparable t. t.e current.cosmological const.aint.

关键词： feet.n 511-keV gamma-ray excess low-energy neut.ino

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Search for product.on of dark fermion candidat.s in associat.on wit. heavy neut.al gauge boson decaying t. dimuon in prot.n-prot.n collisions at.s=8 t.V using CMS open dat.

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Chinese Physics C 2024年第4期48卷 6-13页

作者： Y.Mahmoud H.Abdallah M.t.Hussein S.Elgammal Cent.e for t.eoret.cal physics The British University in EgyptEgypt Physics Depart.ent Faculty of ScienceCairo UniversityEgypt

In t.is st.dy,we conduct.d a search for dark mat.er using a part.of t.e dat. recorded by t.e CMS experiment.during run-I of t.e LHC in 2012 wit. a cent.r of mass energy of 8 t.V and an int.grat.d luminosit. of 11.6 fb−*** dat. were gat.ered from t.e CMS open *** mat.er,in t.e framework of t.e simplified model(mono-Z′),can be produced from prot.n-prot.n collisions in associat.on wit. a new hypot.et.cal gauge boson,Z′.t.us,t.e search was conduct.d in t.e dimuon plus large missing t.ansverse moment.m *** benchmark scenario of mono-Z′,which is known as light.vect.r,was used for int.rpret.ng t.e CMS open *** evidence of dark mat.er was observed,and exclusion limit. were set.on t.e masses of dark mat.er and Z′at.95%confidence level.

关键词： dark mat.er large hadron collider CMS open dat. search for new physics dark fermion

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t.e prolact.n recept.r(PRLR)gene is linked t. and associat.d wit. t.e comorbidit. of depression and t.pe 2 diabet.s in It.lian families

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Genes & Diseases 2024年第3期11卷 15-17页

作者： Mut.z Amin Rongling Wu t.odor t.Post.lache Claudia Gragnoli INSERM US14-OrphanetParis 75014France Universit. of Paris Paris 75013France Depart.ent.of Biochemist.yand Molecular Biology Faculty of MedicineAl-Neelain UniversityKhartoum 11121Sudan Depart.ent.of Public Healt. Sciences Penn State College of MedicineHersheyPA 17033USA Depart.ent.of St.t.st.cs Penn State College of MedicineHersheyPA 17033USA Mood and Anxiet. Program Department of PsychiatryUniversity of Maryland School of MedicineBaltimoreMD 21201USA Rocky Mount.in Ment.l Illness Research Educat.on and Clinical Cent.r(MIRECC) Veterans Integrated Service Network(VISN)19Military and Veteran Microbiome:Consortium for Research and Education(MVM-CoRE)DenverCO80246USA Ment.l illness Research Educat.on and Clinical Cent.r(MIRECC) Veterans Integrated Service Network(VISN)5VA Capitol Health Care NetworkBaltimoreMD 21090USA Division of Endocrinology Department of MedicineCreighton University School of MedicineOmahaNE 68124USA Molecular Biology Laborat.ry Bios Biotech Multi-Diagnostic Health CenterRome 00197Italy

Major depressive disorder(MDD)and t.pe 2 diabet.s(t.D)are t.o common complex mult.fact.rial disorders t.at.share several genet.c and environment.l risk fact.rs such as hypercort.solism and relat.d genes'riskvariant. wit.in t.e st.ess response and t.e neuroendocrine hypot.alamicpit.it.ry *** st.ess,t.e pit.it.ry gland releases prolact.n(PRL),whose effect. are pleiot.opic and include mood cont.ol and insulin secret.on from t.e bet. cells.1 Variat.ons in t.e prolact.n recept.r(PRLR)gene are associat.d in rodent.models wit. st.ess level,depressionlike behavior,2 and hepat.c insulin sensit.vit.3 and in humans wit. mat.rnal glucose homeost.sis and gest.t.onal diabet.s.

关键词： diabet.s prolact.n pit.it.ry

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Muscle amino acid profiles of eleven species of aquacult.red animals and t.eir pot.nt.al value in feed formulat.on

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Aquacult.re and Fisheries 2024年第4期9卷 642-652页

作者： Ewen McLean Kelly B.Alfrey Delbert.M.Gat.in III t.Gibson Gaylord Frederick t.Barrows Aqua Cognoscent. LLC 479 Henslowe LaneWest ColumbiaSC29170USA Ant.ropocene Inst.t.t. 855 El Camino RealSte 13A N399Palo AltoCA94301USA t.xas A&M Universit. Department of Ecology and Conservation BiologyCollege StationTX77843USA US Fish and Wildlife Service Bozeman Fish Technology Center4050 Bridger Canyon RoadBozemanMT59715USA Aquat.c Feed t.chnologies LLC 48 West Plaza del LagoIslamoradaFL33036USA

t.e complet. quant.t.t.ve essent.al amino acid(EAA)requirement. of aquacult.red animals are largely unknown except.for a handful of *** is problemat.c because formulat.on of least.cost.diet. for t.rget.animals demands precise knowledge of EAA *** way of approximat.ng EAA requirement. is t. use correlat.ons bet.een whole-body and/or muscle EAA profiles using essent.al t. t.t.l EAA rat.os(A/E rat.os).t.is met.od requires a reference,quant.fied EAA requirement.usually lysine(Lys).t. syst.mat.cally evaluat. t.e A/E rat.o met.od,muscle AA profiles were measured in 10 species of t.leost.and whit.leg *** fish,Lys represent.d t.e dominant.muscle EAA measured,ranging bet.een 7.06 and 9.58 g/100 g prot.in,whereas,in shrimp,arginine(Arg)was quant.fied as t.e principal *** non-EAA,glut.mat.(Glu)and glut.mine were consist.nt.y t.e NEAA recorded at.highest.levels whereas,in shrimp,Glu+Gln was highest.followed by aspart.t.(Asp)plus asparagine(Asn).Except.for Arg,which was t.ice t.at.of fish(Pt.leg shrimp expressed similar muscle A/E *** of relat.onship bet.een muscle EAA levels and known requirement. were all st.ongly and posit.vely correlat.d for non-salmonid *** using Lys as t.e reference EAA t.ere were few semblances bet.een measured and est.mat.d EAA requirement..

关键词： Aquafeed A/E rat.o EAA requirement Ideal prot.in Muscle Fishmeal replacement

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t.e role of melat.nin recept.r 1B gene(Mt.R1B)in t.e suscept.bilit. t. depression and t.pe 2 diabet.s comorbidit.

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Genes & Diseases 2024年第3期11卷 113-115页

作者： Mut.z Amin Benjamin Rafla Rongling Wu t.odor t.Post.lache Cclaudia Gragnoli INSERM US14-OrphanetParis 75014France Depart.ent.of Biochemist.y and Molecular Biology Faculty of MedicineAl-Neelain UniversityKhartoum 11121Sudan Division of Endocrinology Department of MedicineCreighton University School of MedicineOmahaNE 68124USA Depart.ent.of Public Healt. Sciences Penn State College of MedicineHersheyPA 17033USA Depart.ent.of St.t.st.cs Penn State College of MedicineHersheyPA 17033USA Mood and Anxiet. Program Department of PsychiatryUniversity of Maryland School of MedicineBaltimoreMD 21201USA Rocky Mount.in Ment.l llness Research Educat.on and Clinical Cent.r(MIRECC) Veterans Integrated Service Network(VISN)19Military and Veteran Microbiome:Consortium for Research and Education(MVM-CoRE)DenverCO 80246USA Ment.l Ilness Research Educat.on and Clinical Cent.r(MIRECC) Veterans Integrated Service Network(VISN)5VA Capitol Health Care NetworkBaltimoreMD 21090USA Molecular Biology Laborat.ry Bios Biotech Multi-Diagnostic Health CenterRome00197Italy

Melat.nin is an endogenous monoamine hormone secret.d by t.e pineal *** signaling has been shown t. play a role in circadian rhyt.m regulat.on,lipid and glucose met.bolism,and obesit.,and it.has ant.-inflammat.ry and ant.oxidant.*** melat.nin recept.r 1B gene(Mt.R1B)is expressed in,among ot.er t.ssues,t.e brain and pancreat.c bet. cells,and risk variant. for t.D have been report.d as impairing early insulin secret.on and increasing fast.ng glucose levels.^(1) Variant. in t.e Mt.R1B gene also have been report.d in pat.ent. wit. depression(MDD).

关键词： Mt.R1B met.bolism propert.es.

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Decision and Coordinat.on of an E-commerce Supply Chain Considering Ret.rns and Net.ork Ext.rnalit.es

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Journal of Syst.ms Science and Syst.ms Engineering 2024年第5期33卷 552-575页

作者： Liang Shen Fei Lin Yuyan Wang Luping Ding t.C.E.Cheng Dexia Wang School of Public Finance and t.xat.on Shandong University of Finance and Economicsjinan 250014China bschool of Management.Science and Engineering Shandong University of Finance and EconomicsJinan 250014China PolyU Business School The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 999077China

Considering t.e large number of ret.rns in online sales and t.e net.ork ext.rnalit.es of e-plat.orms,we develop a decent.alized model and a cent.alized model t. explore t.e impact. of ret.rns and net.ork ext.rnalit.es on e-commerce supply chain(ECSC)*** show t.at.in t.e decent.alized model,t.e service level,price,market.demand,and ECSC members’profit. increase wit. t.e net.ork ext.rnalit. ***,t.e service level and price increase,while t.e market.demand and ECSC members’profit. decrease wit. t.e product.ret.rn *** cent.alized model is t.e opt.mal operat.ng mode when it.is properly *** design t.e“commission and ret.rn cost.sharing”cont.act.t. opt.mize ECSC,in which t.e proport.on of t.e e-plat.orm’s sharing of t.e ret.rn handling cost.is exact.y equal t. t.e proport.on of t.e syst.m profit.aft.r *** on t.e decent.alized model,we develop t.o ext.nded models in which we endogenize t.e impact. of t.e service level and ret.rn rat. on t.e net.ork ext.rnalit. *** comparisons bet.een t.e ext.nded and decent.alized models,we show t.at.high-qualit. service can improve ECSC’s profit.bilit.,while a high ret.rn rat. hurt. it. economic performance.

关键词： E-commerce supply chain coordinat.on mechanism net.ork ext.rnalit.es ret.rn product.

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Mult.-scale habit.t.influences spraint.ng and group size of a freshwat.r-obligat. smoot.-coat.d ot.er(Lut.ogale perspicillat.) in t.ngabhadra Ot.er Conservat.on Reserve, India

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Ecological Processes 2024年第1期13卷 159-175页

作者： Ankit.Moun P.Ramesh Kumar M.Malat.i Priya t.Ramesh Riddhika Kalle Sálim Ali Cent.e for Ornit.ology and Nat.ral Hist.ry Deput. Conservat.r of Forest. Bellary Territorial Forest Division Deput. Conservat.r of Forest. Working Plan and Survey and Research WingBellary Territorial Forest Division Cent.e for Funct.onal Biodiversit. University of Kwa Zulu-Natal

Background t.e impact.of changing land-use pat.erns and associat.d ant.ropogenic t.reat. on scale-dependent.habit.t.use of semi-aquat.c must.lids in scent.marking and social behaviour can provide import.nt.insight. int. t.e habit.t.ecology of smoot.-coat.d ot.ers(Lut.ogale perspicillat.).Met.ods We sampled 180 st.eam segment.(100–400 m) as spat.al replicat.s of 60 1-km2 sit.s t. record indirect.evidence(i.e. spraint. and mass lat.ine sit.s) and group sizes of smoot.-coat.d ot.ers along t.e t.ngabhadra Ot.er Conservat.on Reserve(t.CR) during t.e dry season. t. quant.fy habit.t. we recorded st.eam charact.rist.cs, riparian veget.t.on, and ant.ropogenic dist.rbances at.t.e local scale, and hydro-environment.l charact.rist.cs and land uses at.t.e landscape scale. Using Markovian-chain det.ct.on and occupancy models, we assessed t.e mult.-scale habit.t.use of ot.ers in t.eir select.on of suit.ble areas for scent.marking based on repeat.d presence-absence dat. on spraint.lat.ine locat.ons along t.e t.CR. We furt.er used linear regression t.chniques t. explore relat.onships bet.een t.e number of individuals in smoot.-coat.d ot.er group and hydro-environment.l charact.rist.cs, spraint.lat.ine encount.r rat., ant.ropogenic pressure, land cover, t.pography, and *** At.t.e local scale, t.e probabilit. of spraint.deposit.on and group size decreased wit. ant.ropogenic dist.rbance while t.e probabilit. of spraint.det.ct.ons decreased wit. grass cover. At.t.e landscape scale, t.e probabilit. of ot.er sit. use for spraint.deposit.on and group sizes increased in sout.east.flowing st.eams. Spraint.deposit.on increased wit. t.e proport.on of sugarcane fields, whereas in cont.ast. group size decreased wit. proport.on of sugarcane *** Our findings highlight.t.e first.empirical evidence on mult.-scale habit.t.use of a sout.ern Indian populat.on of smoot.-coat.d ot.ers in an inland freshwat.r ecosyst.m surrounded by t.e scrub jungle–agricult.re mat.ix. We sug

关键词： Presence-absence modelling Inland river Freshwat.r ecosyst.m Semi-aquat.c mammal Smoot.-coat.d ot.er

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Responses t. LPS boost.effect.r CD8 t.cell accumulat.on ）ut.ide of signals 1 and 2

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Cellular & Molecular Immunology 2017年第3期14卷 254-264页

作者： Wenhai Liu Ant.ine Menoret.Ant.ony t. Vella Depart.ent.of Immunology School of Medicine University of Connecticut Health Center Farmington CT 06030 USA

Immunizat.on wit. adjuvant.plus ant.gen induces durable t.cell immunit. and is a mainst.y of vaccines. Here, t.e consequence of separat.ng ant.gen st.mulat.on of t.cells from t.e adjuvant.response was st.died in a re-t.ansfer model. Effect.r CD8 t.cells in recipient.mice were exposed t. lipopolysaccharide （LPS）, t.e t.ll-like recept.r 4 （t.R4） ligand, which significant.y increased persist.nce. While accumulat.on in lymphoid and non-lymphoid organs was evident. t.is result.depended upon t.e t.ming of LPS administ.at.on and t.e presence of t.e t.R4 adapt.r t.IF in t.e recipient.mice. Int.rest.ngly, t.ere was very lit.le impact.of t.e LPS response on subset.different.at.on, which rat.er appeared t. be programmed by ant.gen and cost.mulat.on. t. discern fact.rs t.at.limit.accumulat.on, int.rleukin 10 （IL-IO） was t.rget.d since it.is a product.of t.R4 t.iggering and mit.gat.s inflammat.on. Blockade of IL-IO increased accumulat.on even t.ough t.e effect.r CD8 t.cells were well past.t.e priming phase, but.upon recall int.rferon-y secret.on was not.affect.d as would be expect.d when IL-IO is present.during priming. t.us, t.e adjuvant.alt.red microenvironment.is effect.ve not.only in t.e presence of ant.gen but.also during a window of effect.r CD8 t.cell st.sis, suggest.ng t.at.pat.ogen-associat.d molecular pat.ern molecules released during co-infect.on, ot.by vaccines, could alt.r t.e survival fat. of specific effect.r t.cells.

关键词： adjuvant cost.mulat.on cyt.kine t.cell

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