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Report on First Asia-Pacific Forum on Andrology (17-21 October 2002, Shanghai, China)

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Asian Journal of Andrology 2002年第4期 312-314页

作者： geoffrey M.H.waites,mail.usyd.edu.au> Previous President of ISA and previous Manager of the WHO Male Task Force. Address: ANZAC Research Institute University of Sydney Australia. Email mhw

Editorial Note: The Executive Council members of the Asian Society of Andrology, the Editorial Board members of the Asian Journal of Andrology and the Organizing Committee members of the Forum available on 16 October 2002 held a joint meeting to select scientists who had made distinguished contributions to andrology, especially for their work for Asia's development and its achievements in this field. Four scientists were nominated: Professor Arif Adimoelja (Indonesia), Professor David

关键词： October 2002 Report on First Asia-Pacific Forum on Andrology Shanghai China Asia ICSI

Evolving paradigms for natural-product drug discovery

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National Science Review 2022年第11期9卷 10-11页

作者： geoffrey A.Cordell College of Pharmacy University of Florida Natural Products Inc.

Natural products are an essential aspect of global human health. Integration of contemporary technologies based on the Fourth Industrial Revolution (4IR) and the Quintuple Helix is needed to discover additional metabo...

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Modeling limit force capacities of high force to volume lead extrusion dampers

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Frontiers of Structural and Civil Engineering 2021年第3期15卷 609-622页

作者： V.VISHNUPRIYA geoffrey.W.RODGERS J.geoffrey CHASE Department of Mechanical Engineering University of CanterburyChristchurch8140New Zealand QuakeCoRE NZ Centre for Earthquake Resilience Christchurch8041New Zealand

Lead extrusion dampers are supplemental energy-dissipation devices that are used to mitigate seismic structural *** volumetric sizes and high force capacities define high-force-to-volume(HF2V)devices,which can absorb significant response energy without sacrificial ***,the design of such devices for specific force capacities has proven difficult based on the complexities of their internal reaction mechanisms,leading to the adoption of empirical *** study developed upper-and lower-bound force capacity estimates from analytical mechanics based on direct and indirect metal extrusion for guiding *** derived equations are strictly functions of HF2V device geometric parameters,lead material properties,and extrusion *** upper-bound estimates from direct and indirect extrusion are denoted as(F_(UB,1),F_(UB,2))and(F_(UB,3),F_(UB,4)),respectively,and the lower-bound estimates are denoted as(F_(LB),F_(LB,1))based on the combination of extrusion and friction *** proposed models were validated by comparing the predicted bounds to experimental force capacity data from 15 experimental HF2V device *** experimental device forces all lie above the lower-bound estimates(F_(LB),F_(LB,1))and below the upper-bound estimates(F_(UB,1),F_(UB,2),F_(UB,4)).Overall,the(F_(LB),F_(UB,2))pair provides wider bounds and the(F_(LB,1),F_(UB,4)/F_(UB,1))pair provides narrower ***(F_(LB,1),F_(UB,1))pair has a mean lower-bound gap of 36%,meaning the lower bound was 74%of the actual device force on *** mean upper-bound gap was 33%.The bulge area and cylinder diameter of HF2V devices are key parameters affecting device *** relatively tight bounds provide useful mechanics-based predictive design guides for ensuring that device forces are within the targeted design range after manufacturing.

关键词： extrusion lead dampers upper and lower bound analytical modelling limit force

Contaminated open fracture and crush injury: a murine model

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Bone Research 2015年第1期3卷 31-39页

作者： Shawn R Gilbert Justin Camara Richard Camara Lynn Duffy Ken waites Hyunki Kim Kurt Zinn Department of Surgery University of Alabama at Birmingham AL USA Loma Linda School of Medicine Loma LindaCAUSA Departments of Pathology University of Alabama at BirminghamAL USA Department of Radiology University of Alabama at BirminghamAL USA

Modern warfare has caused a large number of severe extremity injuries, many of which become infected. In more recent conflicts, a pattern of co-infection with Acinetobacter baumannii and methicillin-resistant Staphylococcus aureus has emerged. We attempted to recreate this pattern in an animal model to evaluate the role of vascularity in contaminated open fractures. Historically, it has been observed that infected bones frequently appear hypovascular, but vascularity in association with bone infection has not been examined in animal models. Adult rats underwent femur fracture and muscle crush injury followed by stabilization and bacterial contamination with A. baumannii complex and methicillin-resistant Staphylococcus *** and perfusion were assessed by micro CT angiography and SPECT scanning, respectively, at 1, 2 and 4 weeks after injury. Quantitative bacterial cultures were also obtained. Multi-bacterial infections were successfully created, with methicillin-resistant S. aureus predominating. There was overall increase in blood flow to injured limbs that was markedly greater in bacteria-inoculated limbs. Vessel volume was greater in the infected group. Quadriceps atrophy was seen in both groups, but was greater in the infected group. In this animal model, infected open fractures had greater perfusion and vascularity than non-infected limbs.

关键词： MRSA Contaminated open fracture and crush injury a murine model

Natural heritage values and comparative analyses of Kanas,China

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Journal of Arid Land 2010年第3期2卷 197-206页

作者： geoffrey WALL University of Waterloo

Kanas is a National Nature Reserve and National 5A Scenic Area,and it is also high on China’s National Natural Heritage List. In this paper,with an integrated analysis and comparative geo-graphical approach,the genesis and current features of the Kanas landscape are analyzed systematically according to the criteria for outstanding universal values that must be met for designation by the United Nations as World Natural Heritage. It is concluded that Kanas has outstanding universal values in geosciences,biology and aesthetics. Through comparison with other World Natural Heritage sites of the same geological types,in the same biogeographic zone and in the same latitude,it is concluded that Kanas meets criteria vii,viii,ix and x for designation as World Natural Heritage. Thus,this work establishes a scientific foundation for nomination of Kanas for such a status.

关键词： natural landscape characteristics heritage value comparative analyses Kanas of Xinjiang

Schistosomiasis:progress and problems

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World Journal of Gastroenterology 2000年第1期6卷 12-19页

作者： Wu GY Halim mh Department of Medicine Division of Gastroenterology-Hepatology-University of Connecticut Health CenterFarmingtonCT USA Department of Biochemistry National Research CentreCairoDokkiEgypt

INTRODUCTIONSchistosomiasis,also commonly known asbilharziasis,is one of the most significant parasiticdiseases of humans.A report of World HealthOrganization in 1996 estimated that over 200 millionpeople were infeste... 详细信息

关键词： Subject headings schistosomiasis development immune response diagnosis treatment

Acacia mearnsii management in a South African National Parks：SWOT analysis using hot topics in biological invasion as a guide

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Journal of Mountain Science 2017年第1期14卷 205-218页

作者： geoffrey MUKWADA Desmond MANATSA Geography Department and Afromontane Research Unit University of Free State Phuthaditjhaba 9866 South Africa Bindura University of Science Bindura Zimbabwe

The assessment of the policy framework governing Invasive Alien Species(IAS) control is of critical importance in conservation. The undertaking of a SWOT analysis of such a framework is necessary because it enhances the efficacy of IAS control. The aim of this study is to carry out a SWOT analysis of the policy framework guiding the control of the spreading of Acacia mearnsii and other IAS in the Golden Gate Highlands National Park in South Africa,as well as the implementation of restorative measures in the park and adjacent communities in line with the recommendations of the Convention on Biodiversity. A comparative analysis of this framework and the hierarchical framework that was developed during the European Union Conference on Freshwater Invasives- Networking for Strategy in 2013 is undertaken. The results indicate the need to strengthen parkcommunity relations,upgrade existing legislation,and boost the technical capacity of South African national parks to identify,detect,monitor and predict IAS invasions,both within the parks and their surroundings. This knowledge is important for developing future policies on IAS control in South Africa.

关键词： Convention on biodiversity Geographic Information Systems Golden Gate Highlands National Park Invasive alien species MalutiDrakensberg Mountains Protected Areas Policy Framework SWOT

It takes more than tau to tangle:using proteomics to determine how phosphorylated tau mediates toxicity in neurodegenerative diseases

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Neural Regeneration Research 2021年第11期16卷 2211-2212页

作者： geoffrey Pires Eleanor Drummond Center for Cognitive Neurology Department of NeurologyNew York University School of MedicineNew YorkNYUSA Alzheimer’s and Prion Diseases Team Paris Brain InstituteCNRSUMR 7225INSERM 1127Sorbonne University UM75ParisFrance

Two of the most common causes of dementia are Alzheimer’s disease(AD)and frontotemporal dementia(FTD).AD is an irreversible,progressive neurodegenerative disorder that is clinically characterized by severe memory loss and behavioral impairment that eventually interferes with everyday *** is neuropathologically defined by the presence of extracellularβ-amyloid plaques and intracellular accumulation of neurofibrillary tangles(NFTs)that primarily contain aggregated,hyperphosphorylated tau(pTau).Intriguingly,pTau is also the central protein in multiple subtypes of FTD(*** degeneration,progressive supranuclear palsy,Pick’s disease).FTD is an umbrella term for a group of neurological conditions that primarily affect the temporal and frontal regions of the *** in the tau gene(MAPT)can cause familial FTD,providing further evidence of the integral role of tau in ***,tau regulates microtubule structure and dynamics,as well as axonal transport through interaction with *** is also involved in neuronal development and *** AD and FTD,tau becomes hyperphosphorylated and undergoes major conformational changes,causing it to aggregate into the characteristic neuropathological lesions that define AD and *** the known involvement of tau in these diseases,exactly how tau mediates toxicity is still unclear.

关键词： tau involvement media

Molecular Arrangement of a Bolaamphiphilic Anthrancene Derivative in Langmuir-Blodgett Film

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Chinese Chemical Letters 2001年第12期12卷 1105-1108页

作者： Lu, Q Liu, mh Chinese Acad Sci Lab Colloid & Interface Sci Ctr Mol Sci Inst Chem Beijing 100080 Peoples R China

This paper reports the molecular assembly in the LB film of a novel bolaamphiphilic anthracene derivative (BISANS) in comparison with that of one-headed amphiphilic anthracene derivative (ANS). While ANS formed a stretched monolayer at the air/water interface, BISANS underwent aggregation to form crystal film on the water surface. Both of the H-aggregates and J-aggregates exist in the transferred LB films of bolaamphiphilic BISANS, only J-aggregates formed in the LB film of ANS.

关键词： bolaamphiphile air/water interface stretched monolayer