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A facile strategy for tuning the density of surface-grafted biomolecules for melt extrusion-based additive manufacturing applications

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Bio-Design and Manufacturing 2024年第3期7卷 277-291页

作者： I.A.O.Beeren G.Dos Santos P.J.Dijkstra c.Mota J.Bauer h.Ferreira Rui L.Reis N.Neves S.camarero-Espinosa M.B.Baker L.Moroni Department of complex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal IcVS/3B’s-PT Government Associate Laboratory 4806-909 Braga/GuimarãesPortugal POLYMAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKERBASQUE Basque Foundation for Science48009 BilbaoSpain

Melt extrusion-based additive manufacturing(ME-AM)is a promising technique to fabricate porous scaffolds for tissue engi-neering ***,most synthetic semicrystalline polymers do not possess the intrinsic biological activity required to control cell *** of biomolecules on polymeric surfaces of AM scaffolds enhances the bioactivity of a construct;however,there are limited strategies available to control the surface ***,we report a strategy to tune the surface density of bioactive groups by blending a low molecular weight poly(ε-caprolactone)5k(PcL5k)containing orthogonally reactive azide groups with an unfunctionalized high molecular weight PcL75k at different *** porous three-dimensional(3D)scaf-folds were then fabricated using a high weight percentage(75 wt.%)of the low molecular weight PcL *** a proof-of-concept test,we prepared films of three different mass ratios of low and high molecular weight polymers with a thermopress and reacted with an alkynated fluorescent model compound on the surface,yielding a density of 201-561 pmol/cm^(2).Subsequently,a bone morphogenetic protein 2(BMP-2)-derived peptide was grafted onto the films comprising different blend compositions,and the effect of peptide surface density on the osteogenic differentiation of human mesenchymal stromal cells(hMScs)was *** two weeks of culturing in a basic medium,cells expressed higher levels of BMP receptor II(BMPRII)on films with the conjugated *** addition,we found that alkaline phosphatase activity was only significantly enhanced on films contain-ing the highest peptide density(i.e.,561 pmol/cm^(2)),indicating the importance of the surface *** together,these results emphasize that the density of surface peptides on cell differentiation must be considered at the cell-material ***,we have presented a viable strategy for ME-AM community that desires to tune the bulk and surface functionality via blending of(m

关键词： Additive manufacturing Blending Surface functionalization Surface density click chemistry human

Location of Asymmetric Ground Fault Using Virtual Injected current Ratio and Two-stage Recovery Strategy in Distribution Networks

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cSEE Journal of Power and Energy Systems 2024年第1期10卷 151-161页

作者： haiting Shan Luliang Zhang Q.h.Wu Mengshi Li School of Electric Power Engineering South China University of Technology(SCUT)Guangzhou 510641China

Sparse measurements challenge fault location in distribution *** paper proposes a method for asymmetric ground fault location in distribution networks with limited measurements.A virtual injected current vector is formulated to estimate the fault line,which can be reconstructed from voltage sags measured at a few buses using compressive sensing(cS).The relationship between the virtual injected current ratio(VIcR)and fault position is deduced from circuit analysis to pinpoint the ***,a two-stage recovery strategy is proposed for improving reconstruction accuracy of the current vector,where two different sensing matrixes are utilized to improve the *** proposed method is validated in IEEE 34 node test *** results show asymmetric ground fault type,resistance,fault position and access of distributed generators(DGs)do not significantly influence performance of our *** addition,it works effectively under various scenarios of noisy measurement and line parameter *** on 134 node test feeders prove the proposed method is also suitable for systems with more complex structure.

关键词： Distribution networks fault location reconstruction accuracy two-stage recovery virtual injected current ratio

Tau in the pancreas:understanding the link between type 2 diabetes mellitus and Alzheimer's disease

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Signal Transduction and Targeted Therapy 2024年第1期9卷 6-7页

作者： Wenlu Li Steffen Tiedt Eng h.Lo Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMA02129USA consortium International pour la Recherche circadienne sur l’AVc(cIRcA) BostonUSA Institute for Stroke and Dementia Research LMU University HospitalLMU MunichMunichGermany

A recent study published in Molecular Psychiatry proposes a cellular mechanism that may contribute to decreased insulin production in individuals with type 2 diabetes mellitus(T2DM).1 Using a combination of cell culture experiments,animal models and studies in T2DM patients,the authors show that an up-regulation of tau inβ-islet cells can inhibit pancreatic insulin secretion through changes in microtubule assembly.

关键词： T2DM Alzheimer tau

Parkland trees on smallholder farms ameliorate soil physical-chemical properties in the semi-arid area of Tigray,Ethiopia

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Journal of Arid Land 2024年第1期16卷 1-13页

作者： Selam LJALEM Emiru BIRhANE Kassa TEKA Daniel h BERhE Department of Land Resources Management and Environmental Protection College of Dryland Agriculture and Natural ResourcesMekelle UniversityMekelle 231Ethiopia Institute of climate and Society Mekelle UniversityMekelle 231Ethiopia Faculty of Environmental Sciences and Natural Resource Management Norwegian University of Life Sciences(NMBU)Ås 1432Norway Department of Natural Resources Management Adigrat UniversityAdigrat 50Ethiopia

Proposed agroforestry options should begin with the species that farmers are most familiar with,which would be the native multipurpose trees that have evolved under smallholder farms and socioeconomic *** African birch(Anogeissus leiocarpa(Dc.)Guill.&Perr.)and pink jacaranda(Stereospermum kunthianum cham.)trees are the dominant species in the agroforestry parkland system in the drylands of Tigray,*** farmers highly value these trees for their multifunctional uses including timber,firewood,charcoal,medicine,*** trees also could improve soil ***,the amount of soil physical and chemical properties enhanced by the two species must be determined to maintain the sustainable conservation of the species in the parklands and to scale up to similar agroecological ***,we selected twelve isolated trees,six from each species that had similar dendrometric characteristics and were growing in similar environmental *** divided the canopy cover of each tree into three radial distances:mid-canopy,canopy edge,and canopy gap(control).At each distance,we took soil samples from three different *** collected 216 soil samples(half disturbed and the other half undisturbed)from each canopy position and soil *** density(BD),soil moisture content(SMc),soil organic carbon(SOc),total nitrogen(TN),available phosphorus(AP),available potassium(AK),p h,electrical conductivity(Ec),and cation exchange capacity(cEc)were *** revealed that soil physical and chemical properties significantly improved except for soil texture and Ec under both species,cEc under ***,and soil p h under ***,all the studied soils were improved under both species canopy as compared with canopy ***,TN,AP,and AK under canopy of these trees were respectively 24.1%,11.1%,55.0%,and 9.3% higher than those soils under *** two parkland agroforestry species significantly enhanced soil fertility near the canopy of top

关键词： agroforestry bulk density carbon stock dispersed tree soil texture tree canopy

A simplified noncryogenic strategy to transport mesenchymal stem cells: Potential applications in cell therapy and regenerative medicine

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Genes & Diseases 2024年第3期11卷 26-29页

作者： Xiangyu Dong Yannian Gou Meichun Guo Jiamin Zhong Aohua Li Ailing hao Wei Zeng Rex c.haydon hue h.Luu Russell R.Reid Tongchuan he Yan Xu Jiaming Fan Ministry of Education Key Laboratory of Diagnostic Medicine And Department of Clinical BiochemistryCollege of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Department of Interventional Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China Laboratory of craniofacial Suture Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Institute of Sports Medicine Beijing Key Laboratory of Sports InjuriesPeking University Third HospitalBejing 100191China

With the rapid advances in stem cell research and po-tential cell-based therapies,there is an urgent need to develop safe and reliable cell transport *** for autologous stem cell-based therapies,allogeneic stem cell therapies and ex vivo genetically engineered cell therapies would require safe,efficient,and reliable cell preservation and transport methods.

关键词： transport methods simplified

The multi-impurity system in cdSe nanoplatelets:electronic structure and thermodynamic properties

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communications in Theoretical Physics 2024年第3期76卷 165-173页

作者： D A Baghdasaryan V A harutynyan E M Kazaryan h A Sarkisyan Russian-Armenian University H Emin 1230051YerevanArmenia Institute of Applied Problems of Physics 25 Nersisyan St0014YerevanArmenia

This paper theoretically studies the impurity states and the effects of impurity concentration and configuration on the optical,electrical,and statistical properties of cdSe nanoplatelets(NPLs).An image charge-based model of electron-impurity interaction is *** charge-carrier energy spectra and corresponding wave functions depending on the impurity number and configuration are *** electron binding energies are calculated for different NPL *** is shown that the image charge-based interaction potential that arises due to the dielectric constants mismatch is much stronger than the interaction potential that does not take such a mismatch into ***,it is demonstrated that the binding energies are increasing with the number of *** calculate the canonical partition function using the energy levels of the electron,which in turn is used to obtain the mean energy,heat capacity,and entropy of the non-interacting electron *** thermodynamic properties of the non-interacting electron gas that depend on the geometric parameters of the NPL,impurity number,configuration,and temperature are studied.

关键词： nanoplateletes thermodynamic properties impurity states

Imprints of a gravitational wave through the weak field deflection of photons

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chinese Physics c 2024年第8期48卷 240-245页

作者： Reggie c.Pantig AliÖvgün Physics Department Mapúa University658 Muralla St.IntramurosManila 1002Philippines Physics Department Eastern Mediterranean UniversityFamagusta99628 North Cyprusvia Mersin 10Turkiye

In this study,we investigate the novel phenomenon of gravitational lensing experienced by gravitational waves traveling past a Schwarzschild black hole perturbed by a specific,first-order,polar gravitational *** apply the Gauss-Bonnet theorem,finding a topological contribution to the deflection of light rays passing near the black *** demonstrate that the deflection angle can be determined by analyzing a region entirely outside the path of the light ray,leading to a calculation based solely on the parameters of the perturbing wave(Legendre polynomial order,l;frequency,σ).This approach offers a unique perspective on gravitational lensing and expands our understanding of black hole interactions with gravitational waves.

关键词： supermassive black holes gravitational waves chaos weak deflection angle Gauss-Bonnet theorem

canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk

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Genes & Diseases 2024年第1期11卷 103-134页

作者： Kevin Qin Michael Yu Jiaming Fan hongwei Wang Piao Zhao Guozhi Zhaoo Wei Zeng connie chen Yonghui Wang Annie Wang Zander Schwartz Jeffrey hong Lily Song William Wagstaff Rex c.haydon hue h.Luu Sherwin h.ho Jason Strelzow Russell R.Reid Tong-chuan he Lewis L.Shi chicago Medical School Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Departments of Orthopaedic Surgery and Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Interventional Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China Department of clinical Laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China School of Biomedical Engineering Vanderbilt UniversityNashvilleTN 37235USA Laboratory of craniofacial Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA

Wnt signaling plays a major role in regulating cell proliferation and *** Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing the signal either throughβ-catenin in the canonical pathway or through a series of other proteins in the nonca-nonical *** of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body,establishing the complex interplay between Wnt signaling and other signaling *** crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ ***-regulation of this system has been implicated in many diseases affecting a wide array of organ systems,including cancer and embryological defects,and can even cause embryonic *** complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic ***,both stimulatory and inhibitory treatments come with potential risks that need to be *** review synthesized much of the current knowl-edge on the Wnt signaling pathway,beginning with the history of Wnt *** thoroughly described the different variants of Wnt signaling,including canonical,noncanonical Wnt/PcP,and the noncanonical Wnt/ca2+*** description involved each of its components and their involvement in other cellular ***,this review explained the various other pathways and processes that crosstalk with Wnt signaling.

关键词： β-catenin canonical Wnt Noncanonical Wnt Signal transduction Signaling crosstalk

IgE-Mast cell mediated allergy: a sensor of food quality

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Signal Transduction and Targeted Therapy 2024年第1期9卷 8-9页

作者： christopher c.Udoye Rudolf A.Manz Institute for Systemic Inflammation Research University of LübeckLübeckGermany

In two recent studies published in Nature,Florsheim et *** Plum et *** that allergic-specific reactions induced by immunoglobulin(Ig)E mediated mast cell activation is crucial for the timely induction of antigen-avoidance behaviour.1,2 These studies prove the concept that allergic sensitization triggers the formation of avoidance behaviour and define the underlying molecular mechanism.

关键词： allergic mechanism