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Serum metabolism alteration behind different etiology, diagnosis, and prognosis of disorders of consciousness

中华神经外科杂志(英文) 2024年第03期10卷 199-210页

作者： Ge Qianqian Lu Hezhen geng xiaoli Chen Xueling Liu Xiaoyan Sun Haidan Guo Zhengguang Sun Jiameng Qi Feng Niu Xia Wang Aiwei He Jianghong Sun Wei Xu Long Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China China-Japan Union Hospital of Jilin University Changchun China Core Instrument Facility Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College Beijing China China National Clinical Research Center for Neurological Diseases (NCRC-ND) Beijing China

Background Patients with disorders of consciousness (DoC) exhibit varied revival outcomes based on different etiologies and diagnoses, the mechanisms of which remain largely unknown. The fluctuating clinical presentations in DoC pose challenges in accurately assessing consciousness levels and prognoses, often leading to misdiagnoses. There is an urgent need for a deeper understanding of the physiological changes in DoC and the development of objective diagnostic and prognostic biomarkers to improve treatment *** To explore biomarkers and understand the biological processes, we conducted a comprehensive untargeted metabolomic analysis on serum samples from 48 patients with DoC. Patients were categorized based on etiology (TBI vs. non-TBI), CRS-R scores, and prognosis. Advanced analytical techniques, including PCA and OPLS-DA models, were employed to identify differential *** Our analysis revealed a distinct separation in metabolomic profiles among the different groups. The primary differential metabolites distinguishing patients with varying etiologies were predominantly phospholipids, with a notable decrease in glycerophospholipids observed in the TBI group. Patients with higher CRS-R scores exhibited a pattern of impaired carbohydrate metabolism coupled with enhanced lipid metabolism. Notably, serum concentrations of both LysoPE and PE were reduced in patients with improved outcomes, suggesting their potential as prognostic *** Our study underscores the critical role of phospholipid metabolism in the brain’s metabolic alterations in patients with DoC. It identifies key biomarkers for diagnosis and prognosis, offering insights that could lead to novel therapeutic targets. These findings highlight the value of metabolomic profiling in understanding and potentially treating DoC.

关键词： Disorders of consciousness Serum biomarkers Untargeted metabolomic analysis

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甲型流感病毒合并多重感染的临床特征

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护理研究 2024年第1期38卷 17-23页

作者：刘宁静贾艳霞耿晓丽山西医科大学公共卫生学院山西030001 山西医科大学第一医院

目的:调查新型冠状病毒大面积感染后(2023年)病人的呼吸道病原学监测结果,并与疫情前(2018—2019年)及疫情防控期间(2020—2022年)结果比较,分析呼吸道病毒感染趋势变化及甲型流感病毒(IFVA)与混合感染的临床特点。方法:收集2023年2月—... 详细信息

目的:调查新型冠状病毒大面积感染后(2023年)病人的呼吸道病原学监测结果,并与疫情前(2018—2019年)及疫情防控期间(2020—2022年)结果比较,分析呼吸道病毒感染趋势变化及甲型流感病毒(IFVA)与混合感染的临床特点。方法:收集2023年2月—3月就诊于山西医科大学第一医院的2902例呼吸道疾病病人和疫情前(n=1216)、疫情防控期间(n=3113)同期就诊的呼吸道疾病病人外周血病原体IgM检测结果进行分析,根据感染情况将阳性病人分为IFVA组、IFVA+肺原支原体(MP)组、IFVA+呼吸道合胞病毒(RSV)组和IFVA+乙型流感病毒(IFVB)组,对混合感染组与单纯感染组的临床特征及血常规进行比较。结果:2023年的2902例呼吸道感染病人血清中,病原体IgM阳性的病例数为1207例,其中IFVA-IgM阳性率最高,2种及以上抗体组合检出共计393例;疫情防控期间的3113例呼吸道感染病人血清中病原体IgM阳性病例数为794例,其中IFVA-IgM阳性率最高,2种及以上抗体组合检出总计194例;疫情前的1216例呼吸道感染病人血清中病原体IgM阳性病例数为393例,其中IFVA-IgM阳性率最高,2种及以上抗体组合检出总计63例。Logistic回归分析结果显示,年龄是IFVA+MP感染的独立影响因素,年龄、血小板计数(PLT)是IFVA+RSV感染的独立影响因素;PLT升高、有喘息气短胸闷症状、存在基础疾病是IFVA+IFVB感染的独立影响因素。在受试者工作特征(ROC)曲线中,年龄预测IFVA+MP感染的ROC曲线下面积为0.715[95%CI(0.657,0.773)],年龄预测IFVA+RSV感染的ROC曲线下面积为0.742[95%CI(0.690,0.794)]。结论:新型冠状病毒感染期间严格的防控措施可以遏制呼吸道病原体的传播。经历新型冠状病毒大面积感染后,人们免疫力水平普遍下降,更易发生病毒感染和混合感染,临床医生可根据病人的临床症状、体征及实验室检查指标,及时预判是否发生混合感染并进行对症治疗。

关键词：呼吸道病毒流感病毒混合感染病原学检测流行特征

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基于Jetson Nano的饮料瓶盖分类检测设计

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计算机应用文摘 2024年第13期40卷 70-72,75页

作者：耿小利和姗姗河南水利与环境职业学院郑州450000

文章采用YOLOv5目标检测模型实现了一种基于Jetson Nano的饮料瓶盖分类检测系统。传统瓶盖分类方法通常需要耗费大量的人力和时间资源,存在准确性和效率低的问题。为提高瓶盖分类的准确性和效率,文章利用计算能力强和功耗低的Jetson Nan... 详细信息

文章采用YOLOv5目标检测模型实现了一种基于Jetson Nano的饮料瓶盖分类检测系统。传统瓶盖分类方法通常需要耗费大量的人力和时间资源,存在准确性和效率低的问题。为提高瓶盖分类的准确性和效率,文章利用计算能力强和功耗低的Jetson Nano搭建了YOLOv5模型,并对饮料瓶进行了精确的分类检测。其中,首先介绍了YOLOv5模型的原理和特点,其次详细描述了基于Jetson Nano的饮料瓶盖分类检测系统的设计和实现过程。该系统在饮料瓶盖分类检测方面的准确性和效率较高,具有很高的应用价值。

关键词： Jetson Nano YOLOv5 饮料瓶盖分类目标检测计算能力

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外科护理学课程思政元素挖掘与应用——以《乳腺癌患者护理》章节为例

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医学教育管理 2024年第2期10卷 186-191页

作者：耿晓莉崔一凡王欣然首都医科大学宣武医院普外科北京100053

在“三全育人”理念下,将思政教育融入医学课程教学过程中,培养满怀家国情怀、具有创新意识和强烈社会责任感的合格护理人才。本文以外科护理学课程中《乳腺癌患者护理》教学为例,从教学过程与生命教育、辩证思维、职业素养、创新思维... 详细信息

在“三全育人”理念下,将思政教育融入医学课程教学过程中,培养满怀家国情怀、具有创新意识和强烈社会责任感的合格护理人才。本文以外科护理学课程中《乳腺癌患者护理》教学为例,从教学过程与生命教育、辩证思维、职业素养、创新思维、爱伤观念和科学思维6个方面的融合,探索医学思政教育实践的基本路径,也对其他专业课程践行“立德树人”有一定的借鉴意义。

关键词：外科护理思想政治有效融合人才培养医学教育

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Expression patterns and functional divergence of homologous genes accompanied by polyploidization in cotton(Gossypium hirsutum L.)

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Science China(Life Sciences) 2020年第10期63卷 1565-1579页

作者： Zhen Peng Hua Cheng Gaofei Sun Zhaoe Pan Xiao Wang xiaoli geng Shoupu He Xiongming Du Research Base Anyang Institute of TechnologyState Key Laboratory of Cotton Biology/Institute of Cotton ResearchChinese Academy of Agricultural Science(ICRCAAS)Anyang 455000China Zhengzhou Research Base State Key Laboratory of Cotton BiologyZhengzhou UniversityZhengzhou 450001China Anyang Institute of Technology Anyang 455000China

Naturally allotetraploid cotton has been widely used as an ideal model to investigate gene expression remodeling as a consequence of ***,the global gene pattern variation during early fiber development was *** this study,through RNA-seq technology,we comprehensively investigated the expression patterns of homologous genes between allotetraploid cotton(***)and its diploid progenitors(*** and ***)at the fiber early development *** tetraploid cotton,genes showed expression level dominance(ELD)bias toward the A *** phenomenon was explained by the up-/downregulation of the homologs from the nondominant progenitor(D genome).Gene ontology(GO)enrichment results indicated that the ELD-A genes might be a prominent cause responsible for fiber property change through regulating the fatty acid biosynthesis/metabolism and microtubule procession,and the ELD-D genes might be involved in transcription regulation and stress *** addition,the number and proportion of completely A-and D-subfunctionalized gene were similar at different fiber development ***,for neofunctionalization,the number and proportion of reactivated D-derived genes were greater than those of A at 3 and 5 ***,we found that some homologous genes belonging to several specific pathways might create novel asymmetric transcripts between two subgenomes during polyploidization and domestication process,further making the fiber property meet the human *** study identified determinate pathways and their involved genes between allotetraploid cotton and their progenitors at early fiber development stages,providing new insights into the mechanism of cotton fiber evolution.

关键词： Gossypium fiber development polyploid evolution expression level dominance sub-and neofunctionalization

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不中断交通条件下的悬索桥吊索更换方案及托换装置设计

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现代交通与冶金材料 2024年第2期4卷 77-81,94页

作者：尚进杜高明耿晓丽朱沈阳谷强华设设计集团股份有限公司江苏南京210014 江苏华通工程技术有限公司江苏南京210014

为研究不中断交通条件下的长吊索更换技术,本文以某悬索桥吊索更换工程为背景,根据原吊索的构造特点,考虑托换装置在主缆上的不同安装方式,设计出骑跨式和销耳式2套吊索更换托换装置。通过对托换装置、张拉系统、反力梁的设计构造分析,... 详细信息

为研究不中断交通条件下的长吊索更换技术,本文以某悬索桥吊索更换工程为背景,根据原吊索的构造特点,考虑托换装置在主缆上的不同安装方式,设计出骑跨式和销耳式2套吊索更换托换装置。通过对托换装置、张拉系统、反力梁的设计构造分析,换索过程中结构的受力性能分析,比较了2套方案的优劣。结果表明:吊索更换过程中2套托换装置的传力路径基本一致,由于销耳式托换装置设计方案中锁夹的构造形式与永久索夹相同,施工时选用了销耳式托换装置。

关键词：悬索桥吊索维修托换装置

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Approximate constructions of counterdiabatic driving withNMR quantum systems

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Chinese Physics B 2024年第9期33卷 83-91页

作者： Hui Zhou xiaoli Dai Jianpei geng Yunlan Ji Xinhua Peng School of Physics Hefei University of TechnologyHefei 230009China Chinese Academy of Sciences Key Laboratory of Microscale Magnetic Resonance and School of Physical Sciences University of Science and Technology of ChinaHefei 230026China Chinese Academy of Sciences Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China

Counterdiabatic driving (CD) offers a fast and robust route to manipulate quantum systems, which has widespreadapplications in quantum technologies. However, for higher-dimensional complex systems, the exact CD term involving thespectral properties of the system is difficult to calculate and generally takes a complicated form, impeding its experimentalrealization. Recently, many approximate methods have been proposed for designing CD passages in many-body systems. Inthis topical review, we focus on the CD formalism and briefly introduce several experimental constructions and applicationsof approximate CD driving in spin-chain models with nuclear magnetic resonance (NMR) systems.

关键词： nuclear magnetic resonance quantum simulation quantum state engineering

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Efficacy of gefitinib as a first-line single agent treatment in patients with advanced non-small cell lung cancer

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Journal of Nanjing Medical University 2009年第6期23卷 392-397页

作者： Yongmei Yin Yiting geng Xiaodong Li xiaoli Hu Xiaofeng Chen Wei Li Yongqian Shu Department of Oncology the First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China

Objective： To assess the efficacy and toxicity of gefitinib as a single agent treatment in Chinese patients with advanced non-small cell lung cancer （NSCLC）. Methods： Forty-five patients with advanced NSCLC were treated with gefitinib at 250 mg daily until the disease progressed or the patient could not tolerate the toxicity. Results： None of the patients achieved a complete response （CR）, while 15 patients achieved a partial remission （PR） and 17 experienced a stable disease （SD）. Thirteen patients continued to have a progressive disease （PD）. The response rate and the disease control rate were 33.3% and 71.1%, respectively. The symptom remission rate was 72.5%, and the median remission time was 8 days. The median survival time was 15.3 months. The median progression-free survival time was 6.0 months. The most common toxicities included rash （53.3%） and diarrhea （33.3%）. Dehydration and pruritus of the skin developed in 26.7% and 22.2% of the patients, respectively. Hepatic toxicity occurred in 6.7% of patients and oral ulceration occurred in 4.4% of patients. Conclusion： Single agent treatment with gefitinib is effective against advanced NSCLC, and is well tolerated in Chinese patients.

关键词： gefitinib non-small cell lung cancer (NSCLC) first-line treatment

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Genetic diversity and population structure of Gossypium arboreum L. collected in China

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Journal of Cotton Research 2018年第3期1卷 1-8页

作者： JIA Yinhua PAN Zhaoe HE Shoupu GONG Wenfang geng xiaoli PANG Baoyin WANG Liru DU Xiongming Institute of Cotton Research of Chinese Academy of Agricultural Sciences State Key Laboratory of Cotton Biology Key Laboratory of Biology andGenetic Improvement of Cotton Ministry of Agriculture

Background: Gossypium arboreum is a diploid species cultivated in the Old World. It possesses favorable characters that are valuable for developing superior cotton ***: A set of 197 Gossypium arboreum accessions were genotyped using 80 genome-wide SSR markers to establish patterns of the genetic diversity and population structure. These accessions were collected from three major G. arboreum growing areas in China. A total of 255 alleles across 80 markers were identified in the genetic diversity ***: Three subgroups were found using the population structure analysis, corresponding to the Yangtze River Valley, North China, and Southwest China zones of *** growing areas in China. Average genetic distance and Polymorphic information content value of G. arboreum population were 0.34 and 0.47, respectively, indicating high genetic diversity in the G. arboreum germplasm pool. The Phylogenetic analysis results concurred with the subgroups identified by Structure analysis with a few exceptions. Variations among and within three groups were observed to be 13.61% and 86.39%, ***: The information regarding genetic diversity and population structure from this study is useful for genetic and genomic analysis and systematic utilization of economically important traits in G. arboreum.

关键词： Gossypium arboreum L. Population structure Genetic diversity Genetic differentiation Simple sequence repeat(SSR) markers

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QTL mapping of agronomic and economic traits for four F_(2)populations of upland cotton

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Journal of Cotton Research 2021年第1期4卷 12-23页

作者： LI Hongge PAN Zhaoe HE Shoupu JIA Yinhua geng xiaoli CHEN Baojun WANG Liru PANG Baoyin DU Xiongming State Key Laboratory of Cotton Biology/Institute of Cotton Research Chinese Academy of Agricultural SciencesAnyangHenan 455000China

Background:Upland cotton(Gossypium hirsutum)accounts for more than 90%of the annual world cotton output because of its high yield ***,yield and fiber quality traits often show negative *** constructed four F_(2)populations of upland cotton,using two normal lines(4133B and SGK9708)with high yield potential but moderate fiber quality and two introgression lines(Suyuan04–3 and J02–247)with superior fiber quality,and used them to investigate the genetic basis underlying complex traits such as yield and fiber quality in upland *** also phenotyped eight agronomic and economic traits and mapped quantitative trait loci(QTLs).Results:Extensive phenotype variations and transgressive segregation were found across the segregation *** constructed four genetic maps of 585.97 centiMorgan(cM),752.45 cM,752.45 cM,and 1163.66 cM,one for each of the four F_(2)*** QTLs were identified across the four populations(7 for plant height,27 for fiber quality and 16 for yield).The same QTLs were identified in different populations,including qBW4 and qBW2,which were linked to a common simple sequence repeat(SSR)marker,NAU1255.A QTL cluster containing eight QTLs for six different traits was characterized on linkage group 9 of the 4133B×Suyuan04–3 ***:These findings will provide insights into the genetic basis of simultaneous improvement of yield and fiber quality in upland cotton breeding.

关键词： Upland cotton Yield traits Fiber quality traits QTL mapping Simultaneous improvement

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