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Impact of the Pacific–Japan Teleconnection Pattern on July Sea Fog over the Northwestern Pacific: Interannual Variations and Global Warming Effect

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Advances in Atmospheric Sciences 2016年第4期33卷 511-521页

作者： Jingchao LONG Suping ZhanG Yang CHEN Jingwu LIU geng han Physical Oceanography Laboratory Ocean-Atmosphere Interaction and Climate LaboratoryOcean University of China Meteorological bureau of Quanzhou

The northwestern Pacific （NWP） is a fog-prone area, especially the ocean east of the Kuril Islands. The present study analyzes how the Pacific-Japan （PJ） teleconnection pattern influences July sea fog in the fog-prone area using independent datasets. The covariation between the PJ index and sea fog frequency （SFF） index in July indicates a close correlation, with a coefficient of 0.62 exceeding the 99% confidence level. Composite analysis based on the PJ index, a case study, and model analysis based on GFDL-ESM2M, show that in high PJ index years the convection over the east of the Philippines strengthens and then triggers a Rossby wave, which propagates northward to maintain an anticyclonic anomaly in the midlatitudes, indicating a northeastward shift of the NWP subtropical high. The anticyclonic anomaly facilitates the formation of relatively stable atmospheric stratification or even an inversion layer in the lower level of the troposphere, and strengthens the horizontal southerly moisture transportation from the tropical-subtropical oceans to the fog-prone area. On the other hand, a greater meridional SST gradient over the cold flank of the Kuroshio Extension, due to ocean downwelling, is produced by the anticyclonic wind stress anomaly. Both of these two aspects are favorable for the warm and humid air to cool, condense, and form fog droplets, when air masses cross the SST front. The opposite circumstances occur in low PJ index years, which are not conducive to the formation of sea fog. Finally, a multi-model ensemble mean projection reveals a prominent downward trend of the PJ index after the 2030s, implying a possible decline of the SFF in this period.

关键词： Pacific-Japan teleconnection sea fog frequency northwestern Pacific global warming

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Microwave-assisted Green and Efficient Synthesis of N^6-(2-Hydroxyethyl)adenosine and its Analogues

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Chinese Chemical Letters 2006年第9期17卷 1149-1151页

作者： Gui Rong QU Ming Wei geng Su Hui han Zhi Guang ZhanG Feng XUE College of Chemistry and Environmental Science Henan Normal University Xinxiang 453007

An efficient protocol for the synthesis of N^6-（2-Hydroxyethyl）adenosine and its analogues through nucleophilic substitution was developed. All the reactions were completed in 10 rain under microwave irradiation. Us... 详细信息

关键词： N^6 -(2-Hydroxyethyl)adenosine nucleoside analogues microwave irradiation.

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Stellar activity cycles as revealed by long-term beat-like patterns from light curves of Kepler

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Research in Astronomy and Astrophysics 2021年第6期21卷 301-313页

作者： Heng-geng han Kai-Ming Cui Ji-Feng Liu Hui-Qin Yang Xuan Fang Rui-Ning Zhao CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China WHU-NAOC Joint Center for Astronomy Wuhan UniversityWuhan 430072China Department of Physics&Laboratory for Space Research Faculty of Sciencethe University of Hong KongHong KongChina

Stellar activity cycles have been found on many stars through different *** in debate,an empirical relation has been found where a period of stellar activity cycle Pcyc is positively correlated with rotation period Prot along some segregated *** this work,we built a systematic process to search for the Kepler objects that are analogous to the long-term solar brightness variations and investigate their possible *** a rigorous selection,we obtained 43 objects that all exhibit clear long-term beat-like patterns and their variability(amplitude of rotational modulation)periods and rotation periods were *** to the 4-year duration of the Kepler mission,our targets are located in the region where the cycle periods are longer than~1 yr and shorter than~2.5 ***,all of our targets exhibit clear and notable quasi-periodic variations in variability,yet we cannot confirm any linear trends that were predicted by previous research *** may suggest that in the Kepler realm of the Pcyc-Prot diagram,these relations would mix with each other or the beat-like patterns may not be related to the stellar cycle unless other evidence is provided.

关键词： stars:activity starspots stars:rotation

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Endoscopic features and treatments of gastric cystica profunda

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World Journal of Gastroenterology 2024年第7期30卷 673-684页

作者： Zi-han geng Yan Zhu Pei-Yao Fu Yi-Fan Qu Wei-Feng Chen Xia Yang Ping-Hong Zhou Quan-Lin Li Endoscopy Center and Endoscopy Research Institute Zhongshan HospitalFudan UniversityShanghai 200032China

BACKGROUND Gastric cystica profunda(GCP)represents a rare condition characterized by cystic dilation of gastric glands within the mucosal and/or submucosal *** is often linked to,or may progress into,early gastric cancer(EGC).AIM To provide a comprehensive evaluation of the endoscopic features of GCP while assessing the efficacy of endoscopic treatment,thereby offering guidance for diagnosis and *** This retrospective study involved 104 patients with GCP who underwent endoscopic *** demographic and clinical data,regular patient followups were conducted to assess local *** Among the 104 patients diagnosed with GCP who underwent endoscopic resection,12.5%had a history of previous gastric *** primary site predominantly affected was the cardia(38.5%,n=40).GCP commonly exhibited intraluminal growth(99%),regular presentation(74.0%),and ulcerative mucosa(61.5%).The leading endoscopic feature was the mucosal lesion type(59.6%,n=62).The average maximum diameter was 20.9±15.3 mm,with mucosal involvement in 60.6%(n=63).Procedures lasted 73.9±57.5 min,achieving complete resection in 91.3%(n=95).Recurrence(4.8%)was managed via either surgical intervention(n=1)or through endoscopic resection(n=4).Final pathology confirmed that 59.6%of GCP cases were associated with *** analysis indicated that elderly males were more susceptible to GCP associated with ***,multivariate analysis identified lesion morphology and endoscopic features as significant risk *** analysis demonstrated no statistically significant difference in recurrence between GCP with and without EGC(P=0.72).CONCLUSION The findings suggested that endoscopic resection might serve as an effective and minimally invasive treatment for GCP with or without EGC.

关键词： Gastric cystica profunda Early gastric cancer Endoscopic features Endoscopic resection Endoscopy

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Human colorectal cancer cells frequently express IgG and display unique Ig repertoire

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World Journal of Gastrointestinal Oncology 2019年第3期11卷 195-207页

作者： Zi-han geng Chun-Xiang Ye Yan Huang Hong-Peng Jiang Ying-Jiang Ye Shan Wang Yuan Zhou Zhan-Long Shen Xiao-Yan Qiu Department of Immunology School of Basic Medical SciencesPeking University NHC Key Laboratory of Medical Immunology (Peking University) Key Laboratory of Molecular Immunology Chinese Academy of Medical Sciences Department of Gastrointestinal Surgery Peking University People's Hospital Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research Institute of Computational Medicine School of Artificial Intelligence Hebei University of Technology Department of Biomedical Informatics School of Basic Medical Sciences Center for Noncoding RNA Medicine Peking University

BACKGROUND There is growing evidence proving that many human carcinomas, including colon cancer, can overexpress immunoglobulin(Ig); the non B cancer cell-derived Ig usually displayed unique V(D)J rearrangement pattern that are distinct from B cell-derived Ig. Especially, the cancer-derived Ig plays important roles in cancer initiation, progression, and metastasis. However, it still remains unclear if the colon cancer-derived Ig can display unique V(D)J pattern and sequencing, which can be used as novel target for colon cancer *** To investigate the Ig repertoire features expressed in human colon cancer *** Seven cancerous tissue samples of colon adenocarcinoma and corresponding noncancerous tissue samples were sorted by fluorescence-activated cell sorting using epithelial cell adhesion molecule as a marker for epithelial cells. Ig repertoire sequencing was used to analyze the expression profiles of all 5 classes of Ig heavy chains(IgH) and the Ig repertoire in colon cancer cells and corresponding normal epithelial *** We found that all 5 IgH classes can be expressed in both colon cancer cells and normal epithelial cells. Surprisingly, unlike the normal colonic epithelial cells that expressed 5 Ig classes, our results suggested that cancer cells most prominently express IgG. Next, we found that the usage of Ig in cancer cells caused the expression of some unique Ig repertoires compared to normal cells. Some VH segments, such as VH3-7, have been used in cancer cells, and VH3-74 was frequently present in normal epithelial cells. Moreover, compared to the normal cell-derived Ig, most cancer cell-derived Ig showed unique VHDJH ***, even if the same VHDJH pattern was seen in cancer cells and normal cells, cancer cell-derived IgH always displayed distinct hypermutation hot *** We found that colon cancer cells could frequently express IgG and unique IgH repertoires, which may be involved in carcinogenesis of colon

关键词： Immunoglobulin repertoire Sequencing Colorectal cancer VDJ pattern VJ pattern

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Indinavir Resistance Evolution in One Human Immunodeficiency Virus Type 1 Infected Patient Revealed by Single-Genome Amplification

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Virologica Sinica 2010年第5期25卷 316-328页

作者： Qing-mao geng han-ping LI Zuo-yi BAO Yong-jian LIU Dao-min ZHUANG Lin LI Si-yang LIU Jing-yun LI State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology Beijing100071 China

Human Immunodeficiency Virus Type 1 exists in vivo as quasispecies, and one of the genome's characteristics is its diversity. During the antiretroviral therapy, drug resistance is the main obstacle to effective viral prevention. Understanding the molecular evolution process is fundamental to analyze the mechanism of drug resistance and develop a strategy to minimize resistance. Objective: The molecular evolution of drug resistance of one patient who had received reverse transcriptase inhibitors for a long time and had treatment which replaced Nevirapine with Indinavir was analyzed, with the aim of observing the drug resistance evolution pathway. Methods: The patient, XLF, was followed-up for six successive times. The viral populations were amplified and sequenced by single-genome amplification. All the sequences were submitted to the Stanford HIV Drug Resistance Database for the analysis of genotypic drug resistance. Results: 149 entire protease and 171 entire reverse transcriptase sequences were obtained from these samples, and all sequences were identified as subtype B. Before the patient received Indinavir, the viral population only had some polymorphisms in the protease sequences. After the patient began Indinavir treatment, the variants carrying polymorphisms declined while variants carrying the secondary mutation G73S gained the advantage. As therapy was prolonged, G73S was combined with M46I/L90M to form a resistance pattern M46I/G73S/L90M, which then became the dominant population. 97.9% of variants had the M46I/G73S/L90M pattern at XLF6. During the emergence of protease inhibitors resistance, reverse transcriptase inhibitors resistance maintained high levels. Conclusion: Indinavirresistance evolution was observed by single-genome amplification. During the course of changing the regimen to incorporate Indinavir, the G73S mutation occurred and was combined with M46I/L90M.

关键词： Single-Genome Amplification Indinavir Resistance Evolution M46I/G73S/L90M Mutation Pattern

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工业文明背景下民间美术的存在样态与保护——以中国木版年画为例

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天津大学学报（社会科学版） 2013年第4期15卷 319-323页

作者：耿涵天津大学建筑学院天津300072 天津大学冯骥才文学艺术研究院天津300072

工业文明进程正在威胁着中国的传统文化,深层次民间文化传统的断裂终将导致全民族在工业化生产中对自己"身份"的遗忘。当下的民间美术呈现着濒危化、产业化与自生自发传承等多样化的生存样态。在对其进行保护的过程中,应当既遵循文化自... 详细信息

工业文明进程正在威胁着中国的传统文化,深层次民间文化传统的断裂终将导致全民族在工业化生产中对自己"身份"的遗忘。当下的民间美术呈现着濒危化、产业化与自生自发传承等多样化的生存样态。在对其进行保护的过程中,应当既遵循文化自身的规律,不破坏传统文化本质性的精神内核;同时也注重当代生活中人的精神需要,在现有条件的基础上不断保护、重建传统。只有这样,才能使民间美术持续焕发活力,传承民族的文化基因,一如既往地通向全民的精神故土。

关键词：工业文明民间美术木版年画非物质文化遗产保护

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Submucosal tunneling endoscopic biopsy and myotomy for management of unknown esophageal stenosis

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Gastroenterology Report 2022年第1期10卷 635-637页

作者： Xiao-Yue Xu Zi-han geng Tian-Yin Chen Quan-Lin Li Ming-Yan Cai Jia-Xin Xu Dan-Feng Zhang Jian-Wei Hu Ping-Hong Zhou Endoscopy Center and Endoscopy Research Institute Zhongshan HospitalFudan UniversityShanghai Collaborative Innovation Center of EndoscopyShanghaiP.R.China

Introduction Esophageal stenosis is usually congenital or secondary to esophageal injury,esophagitis,and esophageal neoplasia[1,2].The mainstay treatment for benign esophageal stenosis is dilatation with either balloons or esophageal bougienage[3,4].A self-expandable metal stent(SEMS)is recommended for malignant and refractory esophageal stenosis[5].The treatment can be distinct according to different *** ultrasonography-guided fine-needle aspiration/biopsy(EUS-FNA/FNB)may be conducive to clarifying the etiology of esophageal ***,the small amount of tissue obtained by EUS-FNA/FNB may provide less pathological *** we report a new technique—submucosal tunneling endoscopic biopsy and myotomy(STEBM)derived from the peroral endoscopic myotomy(POEM)procedure to relieve stenosis and get a sufficient amount of tissue to make a definite diagnosis.

关键词： esophageal stenosis biopsy

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排水性沥青混合料抗车辙能力及其敏感性分析

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建筑材料学报 2013年第4期16卷 603-607页

作者：李立寒王浩仰耿韩同济大学道路与交通工程教育部重点实验室上海201804 东南大学交通学院江苏南京210096

采用沥青路面分析仪(APA)对排水性沥青混合料(DA混合料)和SMA混合料进行标准条件和重载交通条件下的车辙试验,采用车辙深度指标分析DA混合料的抗车辙能力及其对加载水平、加载次数及温度的敏感性.结果表明:采用高黏度沥青、适当级配组... 详细信息

采用沥青路面分析仪(APA)对排水性沥青混合料(DA混合料)和SMA混合料进行标准条件和重载交通条件下的车辙试验,采用车辙深度指标分析DA混合料的抗车辙能力及其对加载水平、加载次数及温度的敏感性.结果表明:采用高黏度沥青、适当级配组成并予以充分压实,DA混合料的抗车辙能力可有效提高;DA混合料抗车辙能力对加载水平、加载次数以及温度的敏感性均低于SMA混合料.

关键词：道路工程排水性沥青混合料抗车辙能力车辙试验

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高黏度沥青黏度的评价方法与评价指标

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建筑材料学报 2010年第3期13卷 352-356,362页

作者：李立寒耿韩孙艳娜同济大学道路与交通工程教育部重点实验室上海200092

对高黏度改性沥青、SBS改性沥青以及A-70基质沥青进行真空减压毛细管试验和动态剪切速率扫描试验,得到沥青的毛细管黏度和零剪切黏度.基于2种黏度试验的试验原理以及沥青在路面结构中受力状态的分析,对比2种黏度试验中沥青所受的剪切速... 详细信息

对高黏度改性沥青、SBS改性沥青以及A-70基质沥青进行真空减压毛细管试验和动态剪切速率扫描试验,得到沥青的毛细管黏度和零剪切黏度.基于2种黏度试验的试验原理以及沥青在路面结构中受力状态的分析,对比2种黏度试验中沥青所受的剪切速率水平及其与路面结构中沥青所受剪切速率水平之间的关系.结果表明:对于黏度大于3×104Pa.s的高黏度沥青,零剪切黏度所对应的第一牛顿流区范围的剪切速率与沥青在路面结构中所受的剪切速率水平一致,零剪切黏度可以较为合理地表征高黏度沥青在路面结构中的黏结特性;而高黏度沥青在毛细管试验中的剪切速率过小,毛细管黏度不宜用于评价高黏度沥青材料的黏度特性.OGFC-13沥青混合料的飞散试验结果验证了上述分析结果.建议采用动态剪切速率扫描试验方法并以零剪切黏度指标来评价高黏度沥青的黏度特性.

关键词：指标沥青高黏度剪切速率毛细管黏度零剪切黏度 Carreau模型飞散试验

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