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Asian Journal of Andrology 2003年第4期5卷 315-324页

作者： Vincent.W. Aoki Douglas t. Carrell Andrology and IVF Laborat.ries Universit. of Ut.h School of Medicine Salt Lake City UT 84108 USAAndrology and IVF Laboratories University of Utah School of Medicine Salt Lake City UT 84108 USA

During spermiogenesis, t.e prot.mine prot.ins play an int.gral role in spermat.d chromat.n compact.on. Recent.research has focused on many facet. of prot.mine biology, including prot.mine gene and prot.in st.uct.re/ f... 详细信息

t.act.During spermiogenesis, t.e prot.mine prot.ins play an int.gral role in spermat.d chromat.n compact.on. Recent.research has focused on many facet. of prot.mine biology, including prot.mine gene and prot.in st.uct.re/ funct.on relat.onships, mechanisms of prot.mine expression regulat.on and involvement.of t.e prot.mines in male fert.lit.. In t.is paper, we review our current.underst.nding of t.e st.uct.re and funct.on of t.e prot.mine-1 (P1) and prot.mine-2 (P2) prot.ins and genes, t.e expression and regulat.on of t.ese genes and t.e relat.onship bet.een t.e prot.mines and male fert.lit.. In addit.on, we offer a brief out.ook on fut.re invest.gat.on int. prot.mine prot.ins.

关键词： prot.mines spermat.ds male infert.lit. spermat.d t.ansit.on prot.ins

A novel near-infrared light.responsive 4D print.d nanoarchit.ct.re wit. dynamically and remot.ly cont.ollable t.ansformat.on

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Nano Research 2019年第6期12卷 1381-1388页

作者： Hait.o Cui Shida Miao t.mot.y Eswort.y se-jun Lee Xuan Zhou Sung Yun Hann t.omas J.Webst.r Brent.t.Harris Lijie Grace Zhang Depart.ent.of Mechanical and Aerospace Engineering The George Washington UniversityWashingtonDC 20052USA Depart.ent.of Chemical Engineering Northeastern UniversityBostonMA 02115USA Depart.ent.of Neurology and Pat.ology Georgetown UniversityWashingtonDC 20007USA Depart.ent. of Elect.ical and Comput.r Engineering The George Washington UniversityWashingtonDC 20052USA Depart.ent.of Biomedical Engineering The George Washington UniversityWashingtonDC 20052USA Depart.ent.of Medicine The George Washington UniversityWashingtonDC 20052USA

Four-dimensional (4D) print.ng is an emerging and highly innovat.ve addit.ve manufact.ring process by which t. fabricat. pre-designed,self-assembly st.uct.res wit. t.e abilit. t. t.ansform over ***,one of t.e crit.cal challenges of 4D print.ng is t.e lack of advanced 4D print.ng syst.ms t.at.not.only meet.all t.e essent.al requirement. of shape change but.also possess smart.dynamic capabilit.es t. spat.ot.mporally and inst.nt.y cont.ol t.e shape-t.ansformat.on ***,we present.a facile 4D print.ng plat.orm which incorporat.s nanomat.rials int. t.e convent.onal st.muli-responsive polymer,allowing t.e 4D print.d object.t. achieve a dynamic and remot. cont.olled,on-t.me and posit.on shape t.ansformat.on.A proof-of-concept.4D print.d brain model was creat.d using near-infrared light.(NIR) responsive nanocomposit. t. evaluat. t.e capacit. for cont.ollable 4D t.ansformat.on,and t.e feasibilit. of phot.t.ermal st.mulat.on for modulat.ng neural st.m cell *** novel 4D print.ng st.at.gy can not.only be used t. creat. dynamic 3D pat.erned biological st.uct.res t.at.can spat.ot.mporally cont.ol t.eir shapes or behaviors of t.ansformat.on under a human benign st.mulus (NIR),but.can also provide a pot.nt.al met.od for building complex self-morphing object. for widespread applicat.ons.

关键词： near-infrared light responsive four-dimensional (4D) print.ng dynamically and remot.ly cont.ollable graphene brain neural st.m cell

A t.me t. Event.Analysis of Adverse Drug React.ons Due t. t.nofovir, Zidovudine and St.vudine in a Cohort.of Pat.ent. Receiving Ant.ret.oviral t.eat.ent.at.an Out.at.ent.Clinic in Zimbabwe

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Pharmacology & Pharmacy 2015年第3期6卷 201-206页

作者： t.nashe Mudzvit. Nyasha t. Mudzongo Samuel Gavi Cleophas Chimbet.t. Charles C. Maponga gene D. Morse School of Pharmacy University of Zimbabwe Harare Zimbabwe Newlands Clinic Harare Zimbabwe Depart.ent.of Clinical Pharmacology College of Health Sciences Harare Zimbabwe Cent.r of Excellence in Bioinformat.cs and Life Sciences and t.e School of Pharmacy and Pharmaceut.cal Sciences University at Buffalo SUNY Buffalo NY USA

Background: Achieving t.e long t.rms goals of ant.ret.oviral t.eat.ent.(ARt. requires a careful approach during t.eat.ent.init.at.on t.at.t.kes int. account.pat.ent.s psychosocial st.t., availabilit. and accessibilit. of t.eat.ent.combinat.ons, and adherence support. Adverse drug react.ons t.at.occur during t.e init.al phases have a bearing on t.eat.ent.out.omes and t.us need t. be monit.red and t.eat.d. Object.ve: t.is st.dy was done t. assess lengt. of t.me (survival t.me) it.t.ok for clinically significant.adverse drug react.ons t. occur in pat.ent. t.king Nucleoside Reverse t.anscript.se Inhibit.rs (N(t.Rt.) available for t.eat.ent.of Human Immunodeficiency Virus (HIV) infect.on in Zimbabwe. Met.ods: A ret.ospect.ve cohort.of pat.ent.dat. collect.d from January 2009 t. December 2012 was ext.act.d from an Elect.onic Healt. Record dat.base. Dat. from pat.ent. who were init.at.d on ant.ret.oviral (ARV) drug regimens cont.ining N(t.Rt. drugs were analysed for survival t.me. A sample of 205 pat.ent.files was ext.act.d for t.e t.me period for survival analysis using adverse drug react.ons due t. N(t.Rt. drugs. Result.: Aft.r dat. ext.act.on, a t.t.l of 205 pat.ent.records were used in det.rmining t.e t.me t. event.analysis of ADR’s in t.e cohort. t.e age range for t.e pat.ent. included in t.e st.dy was 9 - 76 wit. a mean of 41 years (s.d = 14.8). Pat.ent. init.at.d on st.vudine had a lower survival t.me before a clinically significant.ADR compared t. t.nofovir (-365 days, p-value t.ent. on zidovudine also had a less t.me before a significant.react.on compared t. t.ose on t.nofovir (-230 days;p-value = 0.008). Pat.ent. on zidovudine fared bet.er compared t. t.ose on st.vudine (-134 days;p-value t.e mean survival t.me was highest.for t.nofovir (618 days), followed by zidovudine (388 days), and t.en st.vudine (254 days).Conclusion: Pat.ent. on t.nofovir have a longer survival t.me before a clinically significant.adverse react.on. t.eat.ent.program

关键词： Survival Analysis Elect.onic Medical Records Adverse Drug React.ons

Cold-inducible RNA-binding prot.in act.vat.s splenic t.cells during sepsis in a t.R4-dependent.manner

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Cellular & Molecular Immunology 2018年第1期15卷 38-47页

作者： Alexandra C Bolognese Archna Sharma Weng-Lang Yang Jeffrey Nicast.o gene F Coppa Ping Wang Elmezzi Graduat. School of Molecular Medicine Manhasset11030NYUSA Depart.ent.of Surgery Hofstra Northwell School of MedicineManhasset11030NYUSA Cent.r for Immunology and Inflammat.on The Feinstein Institute for Medical ResearchManhasset11030NYUSA

Cold-inducible RNA-binding prot.in (CIRP) is a novel inflammat.ry mediat.r t.at.st.mulat.s t.e release of proinflammat.ry cyt.kines from macrophages in sepsis. Given t.e immune dysregulat.on t.at.charact.rizes sepsis, t.e effect.of CIRP on ot.er immune cells is an area of increasing int.rest.t.at.has not.yet.been st.died. In t.e present.st.dy, we hypot.esized t.at.ext.acellular CIRP promot.s act.vat.on of t.lymphocyt.s in t.e spleen during sepsis. We observed t.at.mice subject.d t. sepsis by cecal ligat.on and punct.re showed significant.y higher expression of t.e early act.vat.on markers CD69 and CD25 at.20 h on CD4+ splenic t.cells, and significant.y higher CD69 expression on CD8+ splenic t.cells compared wit. sham-operat.d cont.ols. Furt.ermore, at.20 h aft.r receiving int.avenous inject.on of recombinant.murine CIRP (rmCIRP, 5 mg/kg body weight.(BW)) or PBS (vehicle), t.ose mice receiving rmCIRP showed significant.y increased expression of CD69 and CD25 on bot. CD4+ and CD8+ splenic t.cells. t.is effect. however, was not.seen in t.R4-deficient.mice aft.r rmCIRP inject.on. In addit.on, t.eat.ent.wit. CIRP predisposed CD4+ t.cells t. a t.1 hyperinflammat.ry response profile, and influenced CD8+ t.cells t.ward a cyt.t.xic profile. t.ken t.get.er, our findings indicat. t.at.CIRP is a proinflammat.ry mediat.r t.at.plays an import.nt.role in t.cell dysregulat.on during sepsis in a t.R4-dependent.manner.

关键词： CIRP immune response lymphocyt.s sepsis t.cell act.vat.on

Human genes influence t.e int.ract.on bet.een St.ept.coccus mut.ns and host.caries suscept.bilit.: a genome-wide associat.on st.dy in children wit. primary dent.t.on

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Int.rnat.onal Journal of Oral Science 2019年第2期11卷 143-150页

作者： Ying Meng t.ngt.ng Wu Ronald Billings Dorot. t. Kopycka-Kedzierawski Jin Xiao School of Nursing University of RochesterRochesterNYUSA Depart.ent.of Biost.t.st.cs and Comput.t.onal Biology University of RochesterRochesterNYUSA East.an Inst.t.t. for Oral Healt. University of Rochester Medical CenterRochesterNYUSA

St.ept.coccus mut.ns is a well-known cause of dent.l caries,due t. it. acidogenicit.,aciduricit.,and abilit. t. synt.esize exopolysaccharides in dent.l ***,not.all children who carry *** manifest.caries,even wit. similar charact.0}t.cs in oral hygiene,diet.and ot.er environment.l *** phenomenon suggest. t.at.host.suscept.bilit. pot.nt.ally plays a role in t.e development.of dent.l caries;however,t.e associat.on bet.een host.genet.cs,***,and dent.l caries remains ***,t.is st.dy examined t.e influence of host.*** int.ract.on on dent.l ***-wide associat.on analyses were conduct.d in 709 US children (t.e dbGap dat.base acquired from t.e cent.r for oral healt. research in appalachia (COHRA) and t.e Iowa Head St.rt.programmes (GEIRS).A generalized est.mat.ng equat.on was used t. examine t.e *** int.ract.on effect. on t.e out.omes (decayed and missing/filled primary t.et. due t. caries).sequent.ally,t.e COHRA and GEIRS dat. were used t. ident.fy pot.nt.al int.ract.ons and replicat. t.e *** loci at.t.e genes int.rleukin 32 (IL32),galact.kinase 2 (GALK2),and CUGBP,Elav-like family member 4 (CELF4) were linked t. *** carriage,and t.ere was a severit. of caries at.a suggest.ve significance level among COHRA children (P t.a nominal significance level among GEIRS children (P = 0.047–0.001).t.e genet.c risk score t.at.combined t.e t.ree loci also significant.y int.ract.d wit. *** (P t.onal analyses indicat.d t.at.t.e ident.fied genes are involved in t.e host.immune response,galact.se carbohydrat. met.bolism,and food-rewarding syst.m,which could pot.nt.ally be used t. ident.fy children at.high risk for caries and t. develop personalized caries prevent.on st.at.gies.

关键词： cent.r for oral healt. research in appalachia(COHRA) Iowa Head St.rt programmes(GEIRS) CUGBP,Elav-like family member 4(CELF4)

Drought.St.ess and Preharvest.Aflat.xin Cont.minat.on in Agricult.ral Commodit.: genet.cs, Genomics and Prot.omics

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Journal of Int.grat.ve Plant.Biology 2008年第10期50卷 1281-1291页

作者： Baozhu Guo Zhi-Yuan Chen R. Dewey Lee Brian t. Scully Crop Prot.ct.on and Management.Research Unit Agricultural Research Service US Department of Agriculture Tifton Georgia 31793 USA Depart.ent.of Plant.Pat.ology and Crop Physiology Louisiana State University Baton Rouge Louisiana 70803 USA Depart.ent.of Crop and Soil Sciences University of Georgia Tifton Georgia 31793 USA

t.roughout.t.e world, aflat.xin cont.minat.on is considered one of t.e most.serious food safet. issues concerning healt.. Chronic problems wit. preharvest.afiat.xin cont.minat.on occur in t.e sout.ern US, and are part.cularly t.oublesome in corn, peanut. cot.onseed, and t.ee nut.. Drought.st.ess is a major fact.r t. cont.ibut. t. preharvest.afiat.xin cont.minat.on. Recent.st.dies have demonst.at.d higher concent.at.on of defense or st.ess-relat.d prot.ins in corn kerners of resist.nt.genot.pes compared wit. suscept.ble genot.pes, suggest.ng t.at.preharvest.field condit.on （drought.or not.drought. influences gene expression different.y in different.genot.pes result.ng in different.levels of ＂end product.＂： PR（pat.ogenesis-relat.d） prot.ins in t.e mat.re kernels. Because of t.e complexit. of Aspergillus-plant.int.ract.ons, bet.er underst.nding of t.e mechanisms of genet.c resist.nce will be needed using genomics and prot.omics for crop improvement. genet.c improvement.of crop resist.nce t. drought.st.ess is one component.and will provide a good perspect.ve on t.e efficacy of cont.ol st.at.gy. Prot.omic comparisons of corn kernel prot.ins bet.een resist.nt.or suscept.ble genot.pes t. Aspergillus flavus infect.on have ident.fied st.ess-relat.d prot.ins along wit. ant.fungal prot.ins as associat.d wit. kernel resist.nce. gene expression st.dies in developing corn kernels are in agreement.wit. t.e prot.omic st.dies t.at.defense-relat.d genes could be upregulat.d or downregulat.d by abiot.c st.esses.

关键词： abiot.c st.ess drought.st.ess host.resist.nce preharvest.aflat.xin cont.minat.on.

Let.t.ere be light. a bright.fut.re for Ca2＋ signaling

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Science Bullet.n 2018年第16期63卷 1029-1031页

作者： Guolin Ma Jindou Liu Nhung t. Nguyen Yubin Zhou Youjun Wang Cent.r for t.anslat.onal Cancer Research Institute of Biosciences and Technology College of Medicine Texas A&M University Houston TX 77030 USA Beijing Key Laborat.ry of gene Resource and Molecular Development College of Life Sciences Beijing Normal University Beijing 100875 China

Calcium ion(Ca^(2+))is a ubiquit.us second messenger in eukaryot.c *** response t. elect.ical,hormonal,or mechanical st.mulat.on,cyt.solic Ca^(2+)levels increase due t. Ca^(2+) influxes t.rough ion channels embedded i... 详细信息

关键词： Ca2+ 信号控制真核细胞肌肉收缩新陈代谢钙离子细胞内神经质

A proposal:a comprehensive plat.orm t. charact.rize t.mors in Chinese and improve success in cancer drug discovery and development

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Chinese Journal of Cancer 2011年第6期30卷 363-367页

作者： Pearl S. Huang Pet.r t. Ho Kang Zhang Beigene Lt.. Beijing 102206 P. R. China Molecular Medicine Cent.r West China Hospital Sichuan University Chengdu SJchuan 610041 P. R. China Inst.t.t. for Genomic Medicine and Shiley Eye Cent.r University of California at San Diego La Jolla CA 92093 USA.

Cancer is a collect.on of complex diseases in which cell proliferat.on and apopt.sis are dysregulat.d due t. t.e acquisit.on of genet.c changes in cancer *** genet.c changes,combined wit. t.e int.rrelat.d physiologic adapt.t.ons of neo-angiogenesis,recruit.ent.of st.omal support.t.ssues,and suppression of immune recognit.on,are measurable charact.3}t.cs in t.mor gene expression profiles and biochemical *** measures can lead t. ident.ficat.on of disease drivers and,ult.mat.ly,can be used t. assign *** advances in RNA sequencing t.chnologies,t.e abilit. t. simult.neously measure all genet.c and gene expression changes wit. a single t.chnology is now *** abilit. t. creat. a comprehensive cat.log of genot.pic and phenot.pic changes in a collect.on of hist.logically similar but.ot.erwise dist.nct.t.mors should allow for a more precise posit.oning of exist.ng t.rget.d t.erapies and ident.ficat.on of new t.rget. for int.rvent.on.

关键词：药物发现肿瘤基因表达谱开发抗癌中国平台基因变化

Analyt.cal Opt.mizat.on of geneXpert.Ult.a for Det.ct.on of t.berculosis in CSF Samples

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Journal of t.berculosis Research 2023年第3期11卷 129-138页

作者： Vict.ria L. Campodónico Derek t. Armst.ong gene Olinger Erin A. Merrit. Ryan Howard Margaret.Megan Lemmon Nikki Parrish Depart.ent.of Pat.ology The Johns Hopkins University School of Medicine Baltimore Maryland USA MRIGlobal Gaithersburg Maryland USA

Det.ct.on of Mycobact.rium t.berculosis complex (Mt.C) in ext.apulmonary specimens can be challenging due t. t.eir paucibacillary nat.re. t.is difficult. is especially t.ue for cerebrospinal fluid (CSF), and t.e low sensit.vit. and specificit. for diagnosis hampers rapid det.ct.on and t.eat.ent.in vulnerable populat.ons. geneXpert.Mt./RIF Ult.a has been shown t. provide rapid result. for det.ct.on of Mt.C and associat.d Rifampin resist.nce, but.t.ere is limit.d dat. regarding st.ndardized met.ods for CSF processing on t.is assay. In t.is st.dy, we sought.t. provide guidance regarding t.e best.met.ods for CSF processing, including opt.mal volumes t. t.st. lengt. of incubat.on wit. sample reagent.and finally effect. of long-t.rm freezing on det.ct.on.

关键词： geneXpert.Ult.a t.berculous Meningit.s Mycobact.rium t.berculosis CSF

Monit.ring t.e Expression of Maize genes in Developing Kernels under Droug ht.St.ess usingOligo-microarray

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Journal of Int.grat.ve Plant.Biology 2010年第12期52卷 1059-1074页

作者： Meng Luo Jia Liu R. Dewey Lee Brian t. Scully Baozhu Guo t.e Universit. of Georgia Department of Crop and Soil Sciences Tifton GA 31793 USA J. Craig Vent.r Inst.t.t. Rockville MD 20850 USA US D-epart.ent.of Agricult.re Agricultural Research Service Crop Protection and Management Research Unit Tifton GA 31793 USA

Preharvest.aflat.xin cont.minat.on of grain grown on t.e US sout.east.rn Coast.Plain is provoked and aggravat.d by abiot.c st.ess. t.e primary abiot.c st.ess is drought.along wit. high t.mperat.res. t.e object.ves of t.e present.st.dy were t. monit.r gene expression in developing kernels in response t. drought.st.ess and t. ident.fy drought.responsive genes for possible use in germplasm assessment. t.e maize breeding line t.x6 was used, and gene expression profiles were analyzed in developing kernels under drought.st.ess verses well-wat.red condit.ons at.t.e st.ges of 25, 30, 35, 40, 45 d aft.r pollinat.on （DAP） using t.e 70 mer maize oligo-arrays. A t.t.l of 9 573 posit.ve array spot. were det.ct.d wit. unique gene IDs, and 7 988 were common in bot. st.essed and well-wat.red samples. Expression pat.erns of some genes in several st.ess response-associat.d pat.ways, including abscisic acid, jasmonic acid and phenylalanine ammonia-lyase, were examined, and t.ese specific genes were responsive t. drought.st.ess posit.vely. Real-t.me quant.t.t.ve polymerase chain react.on validat.d microarray expression dat.. t.e comparison bet.een t.x6 and B73 revealed t.at.t.ere were significant.differences in specific gene expression, pat.erns and levels. several defense-relat.d genes had been downregulat.d, even t.ough some defense-relat.d or drought.responsive genes were upregulat.d at.t.e lat.r st.ges.

关键词： Drought.st.ess gene expression Drought genes St.ess Uses Wat.r Acids Breeds (animals) Maize