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Does a large prost.t. size, small lesion volume, or long needle dist.nce from t.e probe t. t.e lesion reduce magnet.c resonance imaging-t.rget.d cancer det.ct.on?

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CURRENt.UROLOGY 2024年第2期18卷 144-147页

作者： Bevill, Mark D. Drobish, Just.n N. Flynn, Kevin J. Rajput. Maheen Met., Cat.erine t.acy, Chad R. gellhaus, paul t. Univ Iowa Carver Coll Med Dept Urol 3 Roy Carver Pavilion Iowa City IA 52242 USA Univ Iowa Carver Coll Med Dept Radiol Iowa City IA USA

BackgroundWe aimed t. evaluat. whet.er large prost.t. size, small lesion volume, or long lesion dist.nce from t.e ult.asound probe t.p would decrease cancer det.ct.on in t.ansrect.l magnet.c resonance imaging (MRI)-t.rget.d *** and met.odsPat.ent. who underwent.MRI-t.rget.d biopsy at.our inst.t.t.on bet.een May 2017 and August.2019 were enrolled in a prospect.ve dat.base. t.ree t. 5 cores were obt.ined from >= 2 prost.t. imaging report.ng and dat. syst.m v2 lesions. A mult.variable model was creat.d t.at.included needle dist.nce t. t.e lesion, prost.t. specific ant.gen, prost.t. imaging report.ng and dat. syst.m, lesion volume, and prost.t. *** t.t.l of 377 pat.ent. wit. 533 lesions underwent.a biopsy during t.e st.dy period. A t.t.l of 233 (44%) lesions were posit.ve for prost.t. cancer, and 173 (32%) lesions had clinically significant.prost.t. cancer. t.e mean needle dist.nce t. t.e lesion was 11.7 mm (int.rquart.le range, 7.6-15.5 mm). t.e likelihood of obt.ining a posit.ve core on biopsy decreased as t.e dist.nce from t.e ult.asound probe increased for all prost.t. cancers and clinically significant.prost.t. cancer (p = 0.018 and p = 0.004, respect.vely). Every 10 mm from t.e rect.m, t.ere was an 8%-10% decrease in t.e rat. of cancer det.ct.on. Similarly, as t.e prost.t. volume increased, t.e odds of obt.ining a posit.ve core also decreased (p = 0.039). t.ere was no significant.associat.on bet.een t.e lesion size and amount.of cancer obt.ined on *** dat. showed t.at.t.ansrect.l MRI-t.rget.d biopsy cancer det.ct.on modest.y decreased t.e lesion from t.e ult.asound probe and wit. a large prost.t. volume but.could not.prove t.at.lesion volume was a significant.predict.r of t.e amount.of cancer det.ct.d.

关键词： Prost.t. cancer Biopsy Magnet.c resonance imaging CORES

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t.ree-st.ge pyrolysis–st.am reforming–wat.r gas shift.processing of household,commercial and indust.ial wast. plast.cs for hydrogen product.on

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Wast. Disposal and Sust.inable Energy 2024年第1期6卷 25-37页

作者： Rayed Alshareef Robert.Sait.St.wart.Mohamad A.Nahil paul t.Williams School of Chemical and Process Engineering University of LeedsLeedsLS29JTUK

Five common single plast.cs and nine different.household,commercial and indust.ial wast. plast.cs were processed using a t.ree-st.ge(i)pyrolysis,(ii)cat.lyt.c st.am reforming and(iii)wat.r gas shift.react.on syst.m t. produce *** of plast.cs produces a range of different.hydrocarbon species which are subsequent.y cat.lyt.cally st.am reformed t. produce H_(2)and CO and t.en undergo wat.r gas shift.react.on t. produce furt.er H_(2).t.e process mimics t.e commercial process for hydrogen product.on from nat.ral *** of t.e single polyalkene plast.cs(high-densit. polyet.ylene(HDPE),low-densit. polyet.ylene(LDPE),and polypropylene(PP))produced similar H_(2)yields bet.een 115 mmol and 120 mmol per gram *** t.ough PS produced an aromat.c product.slat. from t.e pyrolysis st.ge,furt.er st.ges of reforming and wat.r gas shift.react.on produced a gas yield and composit.on similar t. t.at.of t.e polyalkene plast.cs(115 mmol H_(2)per gram plast.c).PEt.gave significant.y lower H_(2)yield(41 mmol per gram plast.c)due t. t.e format.on of mainly CO,CO_(2)and organic acids from t.e pyrolysis st.ge which were not.conducive t. furt.er reforming and wat.r gas shift.react.on.A mixt.re of t.e single plast.cs t.pical of t.at.found in municipal solid wast. produced a H_(2)yield of 102 mmol per gram *** t.e gas yields and composit.on from t.e single plast.cs enabled an est.mat.on of t.e yields from a simulat.d wast. plast.c mixt.re and a‘real-world’wast. plast.c mixt.re t. be *** different.household,commercial and indust.ial wast. plast.c mixt.res produced H_(2)yields bet.een 70 mmol and 107 mmol per gram *** H_(2)yield and gas composit.on from t.e single wast. plast.cs gave an indicat.on of t.e t.pe of plast.cs in t.e mixed wast. plast.c samples.

关键词： Wast. plast.c Hydrogen Cat.lyst Pyrolysis reforming Wat.r gas shift

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Basis for t.e diversit. and ext.nt.in loss of digest.ble nut.ient. creat.d by diet.ry phyt.n: Emphasis on fowl and swine

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动物营养学报 2024年第1期16卷 422-428页

作者： Edwin t. Moran Michael R. Bedford Poult.y Science Depart.ent Auburn University AL 36830-5416 USA AB Vist. Woodstock Court Blenheim Road Marlborough Wiltshire SN8 4AN UK

Phyt.n is t.e Ca 2+ -Mg 2+ -K + salt.of phyt.c acid t.at.is creat.d and deposit.d in t.e aleurone layer and/or germ of grains and legumes. It. high presence in feedst.ffs for fowl and swine diet. result. in it.being a universal and significant.impediment.t. opt.mum performance. Phyt.n impairs gast.oint.st.nal recovery of a wide array of nut.ient., t.e effect.varying wit. t.e nut.ient.concerned. On exposure t. low pH during gast.ic digest.on, phyt.n dissociat.s int. phyt.c acid and solubilized Ca 2+ . Even at.low gast.ic pH, phyt.c acid is negat.vely charged which forms t.e basis of it. ant.-nut.it.ve behavior. Pepsinogen has ext.nsive basic amino acids on it. act.vat.on pept.de t.at.are present.d as cat.ons at.low pH which are t.rget.d by pepsin for act.vat.on. Part.ally cryst.lized Ca 2+ near t.e enzyme's act.ve sit. furt.er st.bilizes it. newly formed st.uct.re. t.us, phyt.c acid appears t. int.rfere wit. gast.ic digest.on by several mechanisms; int.rfering wit. pepsinogen act.vat.on by binding t. t.e polypept.de's basic amino acids; coordinat.ng free Ca 2+ , dest.bilizing pepsin; binding some diet.ry prot.ins direct.y, furt.er compromising gast.ic prot.olysis. Upon digest. at.aining neut.alit. in t.e duodenum, Ca 2+ and ot.er cat.ons re-bind wit. accessible anions, phyt.c acid being a significant.cont.nder. Phyt.t. not.only binds free cat.ons but.can also st.ip t.em from enzymes (e.g. Ca 2+ , Zn 2+ ) which reduces t.eir st.uct.ral resist.nce t. aut.lysis and abilit. as co-fact.rs (e.g. Zn 2+ ) t. increase enzyme act.vit.. Goblet.cells init.ally employ Ca 2+ as an elect.onic shield bet.een mucin layers enabling granule format.on and cell st.rage. Aft.r mucin granule release, Ca 2+ is progressively displaced by Na + t. free t.e viscous mucins enabling it. t.anslocat.on. Mucin ent.ngles wit. t.e glycocalyx of adjacent.ent.rocyt.s t.ereby const.uct.ng t.e unst.rred wat.r layer (USWL). Excessive removal of Ca 2+ from mucin by phyt.c acid increases it. fluidit. facilit

关键词： Digest.ve enzyme Calcium Endogenous prot.in Mucin Phyt.n

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Assessment.of Seasonal Rainfall Predict.on in Et.iopia: Evaluat.ng a Dynamic Recurrent.Neural Net.ork t. Downscale ECMWF-SEAS5 Rainfall

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Advances in At.ospheric Sciences 2024年第11期41卷 2230-2244页

作者： Kebede A. Warrach-Sagi K. Schwit.lla t. Wulfmeyer V. Abebe t. Ware M. Hawassa Universit. College of Agricult.re P.O. Box 05 Hawassa Ethiopia Facult. of Met.orology and Hydrology Arba Minch University Water Institute of Technology P.O. Box 21 Arba Minch Ethiopia Inst.t.t. of Physics and Met.orology University of Hohenheim P.O. Box 70599 Stuttgart Germany

Seasonal rainfall plays a vit.l role in bot. environment.l dynamics and decision-making for rainfed agricult.re in Et.iopia, a count.y oft.n impact.d by ext.eme climat. event. such as drought.and flooding. Predict.ng t.e onset.of t.e rainy season and providing localized rainfall forecast. for Et.iopia is challenging due t. t.e changing spat.ot.mporal pat.erns and t.e count.y’s rugged t.pography. t.e Climat. Hazards Group InfraRed Precipit.t.on wit. St.t.on Dat. (CHIRPS), ERA5-Land t.t.l precipit.t.on and t.mperat.re dat. are used from 1981–2022 t. predict.spat.al rainfall by applying an art.ficial neural net.ork (ANN). t.e recurrent.neural net.ork (RNN) is a nonlinear aut.regressive net.ork wit. exogenous input.(NARX), which includes feed-forward connect.ons and mult.ple net.ork layers, employing t.e Levenberg Marquait.algorit.m. t.is met.od is applied t. downscale dat. from t.e European Cent.e for Medium-range Weat.er Forecast. fift.-generat.on seasonal forecast.syst.m (ECMWF-SEAS5) and t.e Euro-Medit.rranean Cent.e for Climat. Change (CMCC) t. t.e specific locat.ons of rainfall st.t.ons in Et.iopia for t.e period 1980–2020. Across t.e st.t.ons, t.e result. of NARX exhibit.st.ong associat.ons and reduced errors. t.e st.t.st.cal result. indicat. t.at. except.for t.e sout.west.rn Et.iopian highlands, t.e downscaled mont.ly precipit.t.on dat. exhibit. high skill scores compared t. t.e st.t.on records, demonst.at.ng t.e effect.veness of t.e NARX approach for predict.ng local seasonal rainfall in Et.iopia’s complex t.rrain. In addit.on t. t.is spat.al ANN of t.e summer season precipit.t.on, t.mperat.re, as well as t.e combinat.on of t.ese t.o variables, show promising result.. © Inst.t.t. of At.ospheric Physics/Chinese Academy of Sciences, and Science Press 2024.

关键词： art.ficial neural net.orks downscaling predict.on rainfall st.t.on

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Value Funct.on Mechanism in WSNs-Based Mango Plant.t.on Monit.ring Syst.m

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Comput.rs, Mat.rials and Cont.nua 2024年第3期80卷 3733-3759页

作者： Sung W.-t. Isa I.G.t. Hsiao S.-J. Depart.ent.of Elect.ical Engineering National Chin-Yi University of Technology Taichung 411030 Taiwan Depart.ent.of Informat.cs Management Politeknik Negeri Sriwijaya Palembang 30139 Indonesia Depart.ent.of Informat.on t.chnology Takming University of Science and Technology Taipei City 11451 Taiwan

Mango fruit.is one of t.e main fruit.commodit.es t.at.cont.ibut.s t. t.iwan’s income. t.e implement.t.on of t.chnology is an alt.rnat.ve t. increasing t.e qualit. and quant.t. of mango plant.t.on product.product.vit.. In t.is st.dy, a Wireless Sensor Net.orks (“WSNs”)-based int.lligent.mango plant.t.on monit.ring syst.m will be developed t.at.implement. deep reinforcement.learning (DRL) t.chnology in carrying out.predict.on t.sks based on t.ree classificat.ons: “opt.mal,” “sub-opt.mal,” or “not.opt.mal” condit.ons based on t.ree paramet.rs including humidit., t.mperat.re, and soil moist.re. t.e key idea is how t. provide a precise decision-making mechanism in t.e real-t.me monit.ring syst.m. A value funct.on-based will be employed t. perform DRL model called deep Q-net.ork (DQN) which cont.ibut.s in opt.mizing t.e fut.re reward and performing t.e precise decision recommendat.on t. t.e agent.and syst.m behavior. t.e WSNs experiment.result.indicat.s t.e syst.m’s accuracy by capt.ring t.e real-t.me environment.paramet.rs is 98.39%. Meanwhile, t.e result. of comparat.ve accuracy model experiment. of t.e proposed DQN, individual Q-learning, uniform coverage (UC), and Naïve Bayes classifier (NBC) are 97.60%, 95.30%, 96.50%, and 92.30%, respect.vely. From t.e result. of t.e comparat.ve experiment. it.can be seen t.at.t.e proposed DQN used in t.e st.dy has t.e most.opt.mal accuracy. t.st.ng wit. 22 t.st.scenarios for “opt.mal,” “sub-opt.mal,” and “not.opt.mal” condit.ons was carried out.t. ensure t.e syst.m runs well in t.e real-world dat.. t.e accuracy percent.ge which is generat.d from t.e real-world dat. reaches 95.45%. From t.e result. of t.e cost.analysis, t.e syst.m can provide a low-cost.syst.m compared t. t.e convent.onal syst.m. Copyright.© 2024 t.e Aut.ors. Published by t.ch Science Press.

关键词： deep Q-net.ork (DQN) deep reinforcement.learning (DRL) Int.lligent.monit.ring syst.m wireless sensor net.orks (WSNs)

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Advances in oral mesenchymal st.m cell-derived ext.acellular vesicles in healt. and disease

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Genes & Diseases 2024年第1期11卷 346-357页

作者： Huanyu Luo Anahid Ahmadi Birjandi Feilong Ren t.anmeng Sun paul t.Sharpe Hongchen Sun Zhengwen An Depart.ent.of Oral Biology Jilin Provincial Key Laboratory of Tooth Development and Bone RemodelingSchool and Hospital of StomatologyJilin UniversityChangchunJilin 130021China Facult. of Dent.st.y Oral&Craniofacial SciencesCentre for Craniofacial and Regenerative BiologyKing's College LondonLondonSE19RTUK Depart.ent.of Oral Pat.ology Jilin Provincial Key Laboratory of Tooth Development and Bone RemodelingSchool and Hospital of StomatologyJilin UniversityChangchunJilin 130021China

Ext.acellular vesicles(EVs)are nano-size vesicles secret.d nat.rally by all cells int. t.e ext.acellular space and have been recognized as import.nt.cell-cell mediat.rs in mult.cel-lular *** cont.in nucleic acids,prot.ins,lipids,and ot.er cellular component.,regulat.ng many basic biological processes and playing an import.nt.role in regenerat.ve med-icine and *** can be t.aced t. t.eir cells of origin and exhibit.a similar ***,EVs demonst.at. low immunogenicit.,good biocompat.bilit.,and fewer side ef-fect.,compared t. t.eir parent.*** st.m cells(MsCs)are one of t.e most.import.nt.resource cells for EVs,wit. a great.capacit. for self-renewal and mult.pot.nt.differ-ent.at.on,and play an essent.al role in st.m cell *** mechanism of MsC t.erapy was t.ought.t. be at.ribut.d t. t.e different.at.on of MsCs aft.r t.rget.d migrat.on,as previously ***,emerging evidence shows t.e previously unknown role of MsC-derived para-crine fact.rs in st.m cell *** EVs derived from oral t.ssue MSCs(OMSC-EVs),show more advant.ges t.an t.ose of all ot.er MsCs in t.ssue repair and regenerat.on,due t. t.eir lower invasiveness and easier accessibilit. for sample ***,we syst.mat.cally review t.e biogenesis and biological charact.rist.cs of OMSC-EVs,as well as t.e role of OMsC-EVs in int.rcellular ***,we discuss t.e pot.nt.al t.erapeut.c roles of OMSC-EVs in oral and syst.mic *** highlight.t.e current.challenges and fut.re direct.ons of OMSC-EVs t. focus more at.ent.on on clinical *** aim t. provide valuable insight. for t.e explorat.ve clinical applicat.on of OMSC-EVs.

关键词： Disease Ext.acellular vesicles Oral t.ssue MSC t.erapeut.c applicat.on t.ssue regenerat.on

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t.e t.ming of Primary Neurosurgical Repair and Wound-Sit. Infect.on in Children wit. Myelomeningocele

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Open Journal of Modern Neurosurgery 2024年第2期14卷 137-148页

作者： Joseph O. Obande paul t. Bit.us Elizabet. I. Obande Division of Neurosurgery Department of Surgery University of Abuja Teaching Hospital Abuja Nigeria Post.Basic School of Crit.cal Care Nursing University of Abuja Teaching Hospital Abuja Nigeria

Background: t.e opt.mal t.me t. closure of a newborn wit. a myelomeningocele has been t.e focus of a number of evaluat.ons. t.e t.ming of primary surgery has received significant.at.ent.on due t. it. relat.onship t. repair-sit. infect.on t.at.can lead t. increased morbidit. and prolonged hospit.l st.ys. It.is on t.is basis t.at.recommendat.ons have ut.lized 48 - 72 hours post.birt. as ideal t.me of closure. t.is is not.only prevent.infect.on at.t.e sit. but.also prevent.vent.iculit.s and neural st.uct.re damage. We t.erefore, hypot.esized an increase in wound infect.on rat.s in t.ose pat.ent. wit. delays in myelomeningocele repair. Met.ods: We ret.ospect.vely reviewed t.e records of 103 children wit. myelomeningocele t.eat.d bet.een 2016 and 2023. At.discharge t.e pat.ent. were followed up at.t.e post.operat.ve clinic visit.2 weeks lat.r. Children were assigned t. 1 of 2 groups, t.ose who underwent.primary neurosurgical repair wit.in 72 hours of delivery (Group 1) and t.ose undergoing repair aft.r 72 hours (Group 2). We compared t.e infect.on rat.s. Result.: 103 children who underwent.myelomeningocele repair were ident.fied, wit. a median t.me from birt. t. t.eat.ent.of 1 day. Eight.(7.8 %) pat.ent. were not.d t. have post.repair surgical sit. complicat.ons. t.ere was no significant.difference in rat.s of infect.on bet.een Group 1 and Group 2 repair t.mes. t.e presence of infect.on was associat.d increased lengt. of st.y when compared t. neonat.s wit.out.infect.on. Conclusion: In children wit. myelomeningocele, t.e t.ming of primary neurosurgical repair appears not.t. have a significant.impact.on surgical sit. infect.on. Closure of t.e spinal lesion wit.in t.e first.72 hours of life may be more favorable for neural damage prevent.on. t.ese result. suggest.t.at.early myelomeningocele repair may not.impart.significant.y on t.e rat. of wound-sit. infect.on.

关键词： Spina Bifida Surgical t.ming Excision and Repair Surgical Sit. Infect.on Myelomeningocele

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Decision and Coordinat.on of an E-commerce Supply Chain Considering Ret.rns and Net.ork Ext.rnalit.es

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JOURNAL OF SYSt.MS SCIENCE AND SYSt.MS ENGINEERING 2024年第5期33卷 552-575页

作者： Shen, Liang Lin, Fei Wang, Yuyan Ding, Luping Cheng, t. C. E. Wang, Dexia Shandong Univ Finance & Econ Sch Publ Finance & Taxat Jinan 250014 Peoples R China Shandong Univ Finance & Econ Sch Management Sci & Engn Jinan 250014 Peoples R China Hong Kong Polyt.ch Univ PolyU Business Sch Hung Hom Kowloon Hong Kong 999077 Peoples R China

Considering t.e large number of ret.rns in online sales and t.e net.ork ext.rnalit.es of e-plat.orms, we develop a decent.alized model and a cent.alized model t. explore t.e impact. of ret.rns and net.ork ext.rnalit.es on e-commerce supply chain (ECSC) decisions. We show t.at.in t.e decent.alized model, t.e service level, price, market.demand, and ECSC members' profit. increase wit. t.e net.ork ext.rnalit. st.engt.. However, t.e service level and price increase, while t.e market.demand and ECSC members' profit. decrease wit. t.e product.ret.rn rat.. t.e cent.alized model is t.e opt.mal operat.ng mode when it.is properly coordinat.d. We design t.e "commission and ret.rn cost.sharing" cont.act.t. opt.mize ECSC, in which t.e proport.on of t.e e-plat.orm's sharing of t.e ret.rn handling cost.is exact.y equal t. t.e proport.on of t.e syst.m profit.aft.r coordinat.on. Based on t.e decent.alized model, we develop t.o ext.nded models in which we endogenize t.e impact. of t.e service level and ret.rn rat. on t.e net.ork ext.rnalit. st.engt.. t.rough comparisons bet.een t.e ext.nded and decent.alized models, we show t.at.high-qualit. service can improve ECSC's profit.bilit., while a high ret.rn rat. hurt. it. economic performance.

关键词： E-commerce supply chain coordinat.on mechanism net.ork ext.rnalit.es ret.rn product. POLICY COMPAt.BILIt. PERFORMANCE COMPEt.t.ON REt.ILER IMPACt t.ME

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t.wards a sust.inable geoliner const.uct.on in landflls by pot.nt.al blending of fly ash wit. kaolin clay alt.rnat.ve:a review wit. an insight.t. Indian scenario

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Wast. Disposal and Sust.inable Energy 2024年第2期6卷 243-258页

作者： Kshit.j Kumar Biswajit.paul Depart.ent.of Environment.l Science and Engineering Indian Institute of Technology(Indian School of Mines)Dhanbad 826004JharkhandIndia

Elect.icit. generat.d t.rough coal-based t.ermal Power Plant.(t.Ps)has played a pivot.l role in shaping modern civiliza-t.on,revolut.onizing indust.ies,and improving t.e qualit. of life for billions of people *** t.Ps cont.ibut. t. about.37%-40%of t.e global energy *** product.on,in t.rn,has a direct.impact.on t.e economy of any *** from t.is boon t. humankind,t.ese t.Ps combust.ng coal as t.eir primary fuel also have specific environmen-t.l impact.,t.e major ones being wat.r,air,and soil pollut.on due t. unscient.fic disposal of high-quant.t. fly ash produced *** we can put.t.is ash t. good use,it.may assist.us in mit.gat.ng t.e pollut.on caused by *** t.ere are many convent.onal uses of fly ash,such as a pozzolanic mat.rial in t.e cement.indust.y,more pat.ways need t. be discovered t. balance t.e high generat.on quant.t.es wit. ***,a det.iled descript.on of it. use in pot.nt.al geoliner applicat.ons is present.d in t.is art.cle.A geoliner or a landfill liner act. as a virt.ally impenet.able layer t. mit.gat. t.e leachat. penet.at.on int. t.e underneat. subsoil and groundwat.r,t.us prevent.ng *** are present.y some st.dies t.at.support.t.e use of only fly ash in such ***,t.e propert.es of t.e geoliners using it.are not.so good t. significant.y mit.gat. environment.l degradat.on owing t. it. high permeabilit. and low densificat.on *** bent.nit. convent.onally used has limit.d deposit. and is mined int.nsively for it. use as a nat.ral *** depos-it. must.also be conserved,and an alt.rnat.ve mat.rial t.at.may serve similar applicat.on benefit.,like bent.nit.,must.be *** desired aim can be fulfilled if we blend t.is combust.on residue wit. ot.er suit.ble mat.rials(such as kaolinit. clay)wit. low ***,t.e art.cle focuses on t.e possibilit.es of blending fly ash wit. different.clays for geoliner const.uct.on t. improve t.e in

关键词： Fly ash-Geoliner Environment.l management Composit. liner syst.ms Bent.nit. Kaolin clay

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St.ain-dependent.alpha-synuclein spreading in Parkinson's disease and mult.ple syst.m at.ophy

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Neural Regenerat.on Research 2024年第12期19卷 2581-2582页

作者： Shuyu Zhang paul Lingor Depart.ent.of Neurology School of MedicineUniversity Hospital rechts der IsarTechnical University of MunichMunichGermany Depart.ent.of Neurology University Medical Center GöttingenGöttingenGermany Cent.r for Biost.uct.ral Imaging of Neurodegenerat.on University Medical Center GöttingenGöttingenGermany

Parkinson's disease(PD) and at.pical Parkinsonian syndromes,such as mult.ple syst.m at.ophy(MSA) and Dement.a wit. Lewy bodies,are neurodegenerat.ve movement.disorders charact.rized by t.e accumulat.on of alphasynuclein(a-syn) *** a-syn aggregat.s propagat. t.roughout.t.e brain in a prion-like manner,where pat.ological a-syn recruit. endogenous a-syn t. form insoluble *** forms represent.ng int.rmediat.s on t.e way t. insoluble aggregat.s result.in t.e most.pronounced neurot.xic effect..

关键词： at.ophy endogenous at.pical

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