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有覆层土体中部分埋入式表面波屏障

工程力学 2020年第S01期37卷 249-253页

作者：葛倩倩于桂兰北京交通大学土木建筑工程学院北京100044

周期结构具有带隙特性,位于带隙频率范围内的振动或波动无法在结构中传播。该文针对土体存在覆层的情况,设计了周期部分埋入式Rayleigh表面波屏障,讨论了不同覆层厚度、波屏障不同埋入深度对带隙的影响,并对El Centro地震波进行了频域... 详细信息

周期结构具有带隙特性,位于带隙频率范围内的振动或波动无法在结构中传播。该文针对土体存在覆层的情况,设计了周期部分埋入式Rayleigh表面波屏障,讨论了不同覆层厚度、波屏障不同埋入深度对带隙的影响,并对El Centro地震波进行了频域响应分析。结果表明,部分埋入工字型截面板式波屏障对El Centro地震波有较好的隔震效果。

关键词：周期结构隔震覆层土体波屏障表面波

The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage

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Neural Regeneration Research 2025年第7期20卷 1829-1848页

作者： Wenjing Ning Shi Lv qian Wang Yuzhen Xu Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Central Laboratory The Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong ProvinceChina

Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter ***,which are the key immune cells in the central nervous system,maintain homeostasis in the neural environment,support neurons,mediate apoptosis,participate in immune regulation,and have neuroprotective *** evidence has shown that microglia play a pivotal role in the pathogenesis of subarachnoid hemorrhage and affect the process of injury and the prognosis of subarachnoid ***,microglia play certain neuroprotective roles in the recovery phase of subarachnoid *** approaches aimed at modulating microglia function are believed to attenuate subarachnoid hemorrhage *** provides new targets and ideas for the treatment of subarachnoid ***,an in-depth and comprehensive summary of the role of microglia after subarachnoid hemorrhage is still *** review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm,neuroinflammation,neuronal apoptosis,blood–brain barrier disruption,cerebral edema,and cerebral white matter *** also discusses the neuroprotective roles of microglia during recovery from subarachnoid hemorrhage and therapeutic advances aimed at modulating microglial function after subarachnoid ***,microglia in subarachnoid hemorrhage are targeted with TLR inhibitors,nuclear factor-κB and STAT3 pathway inhibitors,glycine/tyrosine kinases,NLRP3 signaling pathway inhibitors,Gasdermin D inhibitors,vincristine receptorαreceptor agonists,ferroptosis inhibitors,genetic modification techniques,stem cell therapies,and traditional Chinese ***,most of these are still being evaluated at the laboratory *** clinical studies and data on subarachnoid hemorrhage are required to improve the treatment of subarachnoid hemor

关键词： apoptosis blood–brain barrier brain edema microglia neuroinflammation neuron neuroprotection subarachnoid hemorrhage vasoconstriction white matter injury

不同水平的蒲公英提取物对肉鸡生长性能、血清生化指标及免疫力的影响

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饲料研究 2024年第2期47卷 36-40页

作者：汪珊葛倩倩信阳职业技术学院河南信阳464000 湖南农业大学湖南长沙410082

试验旨在研究不同水平的蒲公英提取物对肉鸡生长性能、血清生化指标及免疫功能的影响。将2000只健康的1日龄的AA肉鸡分成4组,每组10个重复,每个重复50只肉鸡。各组肉鸡分别饲喂含有0(对照组)、0.1%、0.2%及0.4%的蒲公英提取物的试验饲... 详细信息

试验旨在研究不同水平的蒲公英提取物对肉鸡生长性能、血清生化指标及免疫功能的影响。将2000只健康的1日龄的AA肉鸡分成4组,每组10个重复,每个重复50只肉鸡。各组肉鸡分别饲喂含有0(对照组)、0.1%、0.2%及0.4%的蒲公英提取物的试验饲粮。试验期42 d。结果表明,与对照组相比,0.2%和0.4%的蒲公英提取物提高了肉鸡42日龄体重(P<0.05);22~42日龄,0.2%的蒲公英提取物提高了平均日增重(P<0.05),0.2%和0.4%的蒲公英提取物降低了料重比(P<0.05);1~42日龄,0.2%和0.4%的蒲公英提取物提高了平均日增重(P<0.05),0.2%的蒲公英提取物降低了料重比(P<0.05)。与对照组相比,0.2%和0.4%的蒲公英提取物提高了血清中总蛋白和白蛋白水平(P<0.05),降低了尿素氮、胆固醇和甘油三酯水平(P<0.05);0.2%的蒲公英提取物降低了谷丙转氨酶和谷草转氨酶活性(P<0.05)。与对照组相比,0.2%和0.4%的蒲公英提取物提高了肉鸡42日龄的脾脏指数、胸腺指数(P<0.05);0.1%、0.2%和0.4%的蒲公英提取物提高了新城疫抗体效价(P<0.05),0.2%和0.4%的蒲公英提取物提高了免疫球蛋白M、免疫球蛋白A和免疫球蛋白G水平(P<0.05)。研究表明,饲粮中添加适量的蒲公英提取物可以提高肉鸡的生长性能及机体免疫力,改善部分血清生化指标,且蒲公英提取物的适宜添加水平为0.2%。

关键词：蒲公英提取物肉鸡生长性能血清生化指标免疫功能

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光催化型超疏水自清洁涂层研究现状

表面技术 2023年第12期52卷 298-314页

作者：张应轩鲁浈浈葛倩倩陈健张晓青重庆交通大学土木工程学院重庆400074

光催化型超疏水自清洁涂层是在超疏水涂层的基础上通过物理、化学方法复合光催化材料获得光催化性能,使涂层可以在光照作用下将有机附着物进行分解并通过超疏水表面达到自清洁的效果。本文对国内外光催化型超疏水自清洁涂层的构建方式... 详细信息

光催化型超疏水自清洁涂层是在超疏水涂层的基础上通过物理、化学方法复合光催化材料获得光催化性能,使涂层可以在光照作用下将有机附着物进行分解并通过超疏水表面达到自清洁的效果。本文对国内外光催化型超疏水自清洁涂层的构建方式进行总结,将其归纳为表面构造法、共混法、包覆法3类,构造方法的不同对涂层性能的影响方面也有所区别。与单一功能的超疏水涂层相比光催化型超疏水自清洁涂层更能解决实际应用中所面临的问题。此外,本文对光催化型超疏水自清洁涂层的相关性能进行了横向对比,对影响涂层性能较为关键的耐久性能进行了整体的整理分析,并归纳了目前研究当中的光催化型超疏水自清洁涂层的机械耐磨性、耐腐蚀性、耐冲击性和自愈性能,分析了其耐久性提升机制。最后,对光催化型超疏水自清洁涂层未来的应用前景进行了展望,建议从超疏水-光催化协同作用机制、基底结合强度提升、成本控制和复合涂层自修复等方面对光催化型超疏水自清洁涂层进行研究。

关键词：超疏水与光催化复合涂层结合方式耐久性自清洁

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Interannual variability of boreal summer intraseasonal oscillation over the northwestern Pacific influenced by the Pacific Meridional Mode

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 6-11页

作者： Haoyu Zhou Pang-Chi Hsu Lin Chen Yitian qian Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environmental Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological DisastersNanjing University of Information Science and TechnologyNanjingChina

During the boreal summer,intraseasonal oscillations exhibit significant interannual variations in intensity over two key regions:the central-western equatorial Pacific(5°S-5°N,150°E-150°W)and the subtropical Northwestern Pacific(10°-20°N,130°E-175°W).The former is well-documented and considered to be influenced by the ENSO,while the latter has received comparatively less attention and is likely influenced by the Pacific Meridional Mode(PMM),as suggested by partial correlation analysis *** elucidate the physical processes responsible for the enhanced(weakened)intraseasonal convection over the subtropical northwestern Pacific during warm(cold)PMM years,the authors employed a moisture budget *** findings reveal that during warm PMM years,there is an increase in summer-mean moisture over the subtropical northwestern *** increase interacts with intensified vertical motion perturbations in the region,leading to greater vertical moisture advection in the lower troposphere and consequently resulting in convective *** a process is pivotal in amplifying intraseasonal convection *** observational findings were further verified by model experiments forced by PMM-like sea surface temperature patterns.

关键词： Boreal summer intraseasonal oscillation Interannual variability Pacific Meridional Mode Moisture budget analysis

The Mechanism of Heating Rate on the Secondary Recrystallization Evolution in Grain Oriented Silicon Steel

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 275-282页

作者： GAO qian LI Jun WANG Xianhui CAO Laifu GONG Jian LI Bo Central Iron and Steel Research Institute Group Beijing 100081China Shougang Zhixin Electromagnetic Material R&D(Beijing)Co. Ltd.Beijing 101300China Beijing Shougang Co. Ltd.Qian’an 064404China

Grain-oriented silicon steels were prepared at different heating rates during high temperature annealing,in which the evolution of magnetic properties,grain orientations and precipitates were *** illustrate the Zener factor,the diameter and number density of precipitates of interrupted testing samples were statistically *** effect of precipitate ripening on the Goss texture and magnetic property was *** indicated that the trend of Zener factor was similar under different heating rates,first increasing and then decreasing,and that the precipitate maturing was greatly inhibited as the heating rate *** recrystallization was developed at the temperature of 1010℃when a heating rate of 5℃/h was used,resulting in Goss,Brass and{110}oriented grains growing abnormally and a magnetic induction intensity of ***,increasing the heating rate to 20℃/h would inhibit the development of undesirable oriented grains and obtain a sharp Goss ***,when the heating rate was extremely fast,such as 40℃/h,poor secondary recrystallization was developed with many island grains,corresponding to a decrease in magnetic induction intensity to 1.87 *** a suitable heating rate of 20℃/h,the sharpest Goss texture and the highest magnetic induction of 1.94 T with an onset secondary recrystallization temperature of 1020℃were found among the experimental variables in this *** heating rate affected the initial temperature of secondary recrystallization by controlling the maturation of precipitates,leading to the deviation and dispersion of Goss texture,thereby reducing the magnetic properties.

关键词： high temperature annealing heating rate secondary recrystallization grain oriented silicon steel

不同浓度磺胺二甲嘧啶对中国对虾APND、ECOD和GST活性的影响

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中国海洋大学学报（自然科学版） 2016年第10期46卷 16-23页

作者：孙铭翟倩倩常志强葛倩倩李健赵法箴中国海洋大学水产学院山东青岛266003 中国水产科学研究院黄海水产研究所山东青岛266071 青岛海洋科学与技术国家实验室海洋渔业科学与食物产出过程功能实验室山东青岛266235

为研究药物代谢酶对磺胺二甲嘧啶作用的响应及其在中国对虾代谢磺胺二甲嘧啶过程中的作用,以50、100和150mg/kg(干重)磺胺二甲嘧啶连续投喂中国对虾5d,于投喂后的第1、2、3、4、5天和停止投喂药物的第1、2、3、4、5、7、10天取样,测定... 详细信息

为研究药物代谢酶对磺胺二甲嘧啶作用的响应及其在中国对虾代谢磺胺二甲嘧啶过程中的作用,以50、100和150mg/kg(干重)磺胺二甲嘧啶连续投喂中国对虾5d,于投喂后的第1、2、3、4、5天和停止投喂药物的第1、2、3、4、5、7、10天取样,测定中国对虾肝胰腺、鳃和血清中的氨基比林-N-脱甲基酶(Aminopyrine-N-demethylase,APND)、7-乙氧基香豆素-O-脱乙基酶(7-ethoxycoumarin-O-Deethylase,ECOD)和谷胱甘肽还原转移酶活性(Glutathione-S-transferase,GST)的含量。研究表明:磺胺二甲嘧啶对中国对虾肝胰腺、鳃和血清中I相药物代谢酶(APND、ECOD)活性的抑制作用均具有剂量依赖性。投喂药物期间,酶活性呈逐渐下降趋势,而停止投喂后,酶活性呈逐渐上升趋势,至实验结束时均恢复至对照组水平。在整个实验周期内,高浓度组的血清GST活性呈现抑制作用,其它浓度磺胺二甲嘧啶组的各组织中GST活性呈现诱导作用。磺胺二甲嘧啶对中国对虾肝胰腺和鳃ECOD活性发生抑制作用的时间较ANPD晚。结果表明:中国对虾对磺胺二甲嘧啶的代谢,一方面通过抑制I相代谢酶的活性,抑制药物的活化,另一方面通过诱导II相代谢酶的活性,加速药物的解毒与代谢。在实际生产中,磺胺类药物通常会与增效剂甲氧苄啶合用以提高药效,应考虑磺胺二甲嘧啶对药物代谢酶的抑制作用,以减轻甲氧苄啶可能在体内的蓄积和毒效作用。

关键词：磺胺二甲嘧啶中国对虾氨基比林-N-脱甲基酶(APND) 7-乙氧基香豆素-O-脱乙基酶(ECOD) 谷胱甘肽还原转移酶(GST)

Increased excitatory amino acid transporter 2 levels in basolateral amygdala astrocytes mediate chronic stress–induced anxiety-like behavior

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Neural Regeneration Research 2025年第6期20卷 1721-1734页

作者： Xirong Xu Shoumin Xuan Shuai Chen Dan Liu qian Xiao Jie Tu Shenzhen Key Laboratory of Neuroimmunomodulation for Neurological Diseases Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina CAS Key Laboratory of Brain Connectome and Manipulation Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Brain Connectome and Behavior the Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina University of Chinese of Academy of Sciences BeijingChina Faculty of Life and Health Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

The conventional perception of astrocytes as mere supportive cells within the brain has recently been called into question by empirical evidence, which has revealed their active involvement in regulating brain function and encoding behaviors associated with ***, astrocytes in the basolateral amygdala have been found to play a role in the modulation of anxiety-like behaviors triggered by chronic stress. Nevertheless, the precise molecular mechanisms by which basolateral amygdala astrocytes regulate chronic stress–induced anxiety-like behaviors remain to be fully elucidated. In this study, we found that in a mouse model of anxiety triggered by unpredictable chronic mild stress, the expression of excitatory amino acid transporter 2 was upregulated in the basolateral amygdala. Interestingly, our findings indicate that the targeted knockdown of excitatory amino acid transporter 2 specifically within the basolateral amygdala astrocytes was able to rescue the anxiety-like behavior in mice subjected to stress. Furthermore, we found that the overexpression of excitatory amino acid transporter 2 in the basolateral amygdala, whether achieved through intracranial administration of excitatory amino acid transporter 2agonists or through injection of excitatory amino acid transporter 2-overexpressing viruses with GfaABC1D promoters, evoked anxiety-like behavior in mice. Our single-nucleus RNA sequencing analysis further confirmed that chronic stress induced an upregulation of excitatory amino acid transporter 2 specifically in astrocytes in the basolateral amygdala. Moreover, through in vivo calcium signal recordings, we found that the frequency of calcium activity in the basolateral amygdala of mice subjected to chronic stress was higher compared with normal *** knocking down the expression of excitatory amino acid transporter 2 in the basolateral amygdala, the frequency of calcium activity was not significantly increased, and anxiety-like behavior was ob

关键词： anxiety astrocytes basolateral amygdala behavior dihydrokainic acid excitatory amino acid transporter 2 fiber photometry glutamate LDN-212320 transporter

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超疏水涂层在沥青路面上的抗凝冰性能分析

表面技术 2022年第7期51卷 324-333,352页

作者：鲁浈浈葛倩倩陈健梁杨魏鹏重庆交通大学土木工程学院重庆400074 重庆交通大学交通土建工程材料国家地方联合工程实验室重庆400074 重庆市政设施管理局重庆400014

目的分析超疏水涂层在沥青路面应用时的抗凝冰性能,解决中国北方和高海拔地区路面结冰易引发交通事故的问题。方法以疏水纳米SiO_(2)粉末和聚氨酯改性聚硅氧烷为主要材料,制备出超疏水SiO_(2)/聚硅氧烷复合溶液,使用浸涂法在沥青马歇尔... 详细信息

目的分析超疏水涂层在沥青路面应用时的抗凝冰性能,解决中国北方和高海拔地区路面结冰易引发交通事故的问题。方法以疏水纳米SiO_(2)粉末和聚氨酯改性聚硅氧烷为主要材料,制备出超疏水SiO_(2)/聚硅氧烷复合溶液,使用浸涂法在沥青马歇尔试件表面形成超疏水涂层。分析涂层的耐磨性、透光性、化学稳定性、疏水性等,同时模拟雨滴结冰试验、落锤除冰试验、低温抗冻试验,评价超疏水涂层的耐磨性、透明性、耐酸碱腐蚀性、抗凝冰性、易除冰性和低温抗冻性,并通过扫描电子显微镜对涂层表面形貌进行分析。结果当制备的超疏水复合溶液中纳米SiO_(2)的质量分数为7.5%时,涂层的透光率为76.3%,水滴的接触角能达到160.9°±0.7°,即使试件表面被雨水冲刷5 h,依旧可以维持一定的疏水性能。在低温箱中,将完整的试件与表面磨损的试件同时放置在−20~0℃环境下1 h,完整试件的接触角仍大于150°,表面磨损的试件也能保持一定的疏水性能;在−5℃的低温箱中,将水滴匀速喷洒在完整的超疏水沥青混凝土试件和磨损试件表面,以模拟结冰,发现完整试件表面未出现结冰现象,磨损试件表面有少量结冰;即使超疏水沥青混凝土试件表面结冰,通过“落锤”试验模拟行车荷载对试件表面冰层进行冲击,冰层也可轻易除去。除此之外,使用Abaqus软件模拟超疏水沥青路面的除冰机理,对模型仅施加车辆荷载,计算得到冰层内部的最大拉应变为3.25×10^(−4),最大剪切应变为4.25×10^(−4),均大于冰层的极限破坏拉应变(2.2×10^(−4))和极限破坏剪切应变(2.4×10^(−4))。结论纳米SiO_(2)粒子在涂层表面团聚形成了微纳粗糙结构,使涂层具有超疏水性。涂层的超疏水性可以降低水与路面之间的黏结力,使水滴落在超疏水沥青混凝土涂层表面时即刻滚落,有效减小了路面的结冰量,提高了沥青路面的抑冰、除冰性能。

关键词：超疏水涂层沥青混凝土 SiO_(2) 改性聚硅氧烷复合结构抗凝冰软件模拟